Works matching AU Perry, Rachel J.

Results: 50

Insulin and cancer: a tangled web.

Published in:

Biochemical Journal, 2022, v. 479, n. 5, p. 583, doi. 10.1042/BCJ20210134

By:

Leitner, Brooks P.;
Siebel, Stephan;
Akingbesote, Ngozi D.;
Xinyi Zhang;
Perry, Rachel J.

Publication type:

Article

A precision medicine approach to metabolic therapy for breast cancer in mice.

Published in:

Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03422-9

By:

Akingbesote, Ngozi D.;
Norman, Aaron;
Zhu, Wanling;
Halberstam, Alexandra A.;
Zhang, Xinyi;
Foldi, Julia;
Lustberg, Maryam B.;
Perry, Rachel J.

Publication type:

Article

Publisher Correction: Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance.

Published in:

2021

By:

Schumann, Tina;
König, Jörg;
von Loeffelholz, Christian;
Vatner, Daniel F.;
Zhang, Dongyan;
Perry, Rachel J.;
Bernier, Michel;
Chami, Jason;
Henke, Christine;
Kurzbach, Anica;
El-Agroudy, Nermeen N.;
Willmes, Diana M.;
Pesta, Dominik;
de Cabo, Rafael;
O´Sullivan, John F.;
Simon, Eric;
Shulman, Gerald I.;
Hamilton, Bradford S.;
Birkenfeld, Andreas L.

Publication type:

Correction Notice

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02279-8

By:

Schumann, Tina;
König, Jörg;
von Loeffelholz, Christian;
Vatner, Daniel F.;
Zhang, Dongyan;
Perry, Rachel J.;
Bernier, Michel;
Chami, Jason;
Henke, Christine;
Kurzbach, Anica;
El-Agroudy, Nermeen N.;
Willmes, Diana M.;
Pesta, Dominik;
de Cabo, Rafael;
O´Sullivan, John F.;
Simon, Eric;
Shulman, Gerald I.;
Hamilton, Bradford S.;
Birkenfeld, Andreas L.

Publication type:

Article

The Impact of Obesity on Tumor Glucose Uptake in Breast and Lung Cancer.

Published in:

JNCI Cancer Spectrum, 2020, v. 4, n. 2, p. 1, doi. 10.1093/jncics/pkaa007

By:

Leitner, Brooks P;
Perry, Rachel J

Publication type:

Article

Leptin revisited: The role of leptin in starvation.

Published in:

Molecular & Cellular Oncology, 2018, v. 5, n. 5, p. 1, doi. 10.1080/23723556.2018.1435185

By:

Perry, Rachel J.

Publication type:

Article

An optimized method for tissue glycogen quantification.

Published in:

Physiological Reports, 2022, v. 10, n. 4, p. 1, doi. 10.14814/phy2.15195

By:

Schaubroeck, Kyle J.;
Leitner, Brooks P.;
Perry, Rachel J.

Publication type:

Article

Imeglimin: Current Development and Future Potential in Type 2 Diabetes.

Published in:

Drugs, 2021, v. 81, n. 2, p. 185, doi. 10.1007/s40265-020-01434-5

By:

Konkwo, Chigoziri;
Perry, Rachel J.

Publication type:

Article

Response to Burgess.

Published in:

Nature Medicine, 2015, v. 21, n. 2, p. 109, doi. 10.1038/nm.3790

By:

Befroy, Douglas E;
Kibbey, Richard G;
Perry, Rachel J;
Petersen, Kitt Falk;
Rothman, Douglas L;
Shulman, Gerald I

Publication type:

Article

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

Published in:

Nature Medicine, 2014, v. 20, n. 7, p. 759, doi. 10.1038/nm.3579

By:

Perry, Rachel J;
Zhang, Xian-Man;
Zhang, Dongyan;
Kumashiro, Naoki;
Camporez, Joao-Paulo G;
Cline, Gary W;
Rothman, Douglas L;
Shulman, Gerald I

Publication type:

Article

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic <sup>13</sup>C magnetic resonance spectroscopy.

Published in:

Nature Medicine, 2014, v. 20, n. 1, p. 98, doi. 10.1038/nm.3415

By:

Befroy, Douglas E;
Perry, Rachel J;
Jain, Nimit;
Dufour, Sylvie;
Cline, Gary W;
Trimmer, Jeff K;
Brosnan, Julia;
Rothman, Douglas L;
Petersen, Kitt Falk;
Shulman, Gerald I

Publication type:

Article

Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.

Published in:

Diabetologia, 2023, v. 66, n. 3, p. 567, doi. 10.1007/s00125-022-05838-8

By:

Gaspar, Rafael C.;
Lyu, Kun;
Hubbard, Brandon T.;
Leitner, Brooks P.;
Luukkonen, Panu K.;
Hirabara, Sandro M.;
Sakuma, Ikki;
Nasiri, Ali;
Zhang, Dongyan;
Kahn, Mario;
Cline, Gary W.;
Pauli, José Rodrigo;
Perry, Rachel J.;
Petersen, Kitt F.;
Shulman, Gerald I.

Publication type:

Article

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

Published in:

FASEB Journal, 2017, v. 31, n. 7, p. 2916, doi. 10.1096/fj.201700001R

By:

Abulizi, Abudukadier;
Perry, Rachel J.;
Camporez, João Paulo G.;
Jurczak, Michael J.;
Petersen, Kitt Falk;
Aspichueta, Patricia;
Shulman, Gerald I.

Publication type:

Article

Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study.

Published in:

Molecular Imaging, 2024, v. 23, p. 1, doi. 10.1177/15353508241301584

By:

Bini, Jason;
Strober, Jordan;
Kapinos, Michael;
Zheng, Ming-Qiang;
Li, Songye;
Ropchan, Jim;
Nabulsi, Nabeel;
Huang, Yiyun;
Perry, Rachel J.;
Vatner, Daniel F.;
Carson, Richard E.

Publication type:

Article

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates.

Published in:

Science Translational Medicine, 2019, v. 11, n. 512, p. 1, doi. 10.1126/scitranslmed.aay0284

By:

Goedeke, Leigh;
Peng, Liang;
Montalvo-Romeral, Valle;
Butrico, Gina M.;
Dufour, Sylvie;
Zhang, Xian-Man;
Perry, Rachel J.;
Cline, Gary W.;
Kievit, Paul;
Chng, Keefe;
Petersen, Kitt Falk;
Shulman, Gerald I.

Publication type:

Article

It's Not Just for Pain: A New Metabolic Function of Aspirin.

Published in:

Endocrinology, 2023, v. 164, n. 4, p. 1, doi. 10.1210/endocr/bqad036

By:

Perry, Rachel J

Publication type:

Article

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08466-w

By:

Perry, Rachel J.;
Rabin-Court, Aviva;
Song, Joongyu D.;
Cardone, Rebecca L.;
Wang, Yongliang;
Kibbey, Richard G.;
Shulman, Gerald I.

Publication type:

Article

A new metabolic signature to predict melanoma recurrence.

Published in:

Clinical & Translational Discovery, 2024, v. 4, n. 2, p. 1, doi. 10.1002/ctd2.288

By:

Vu, Ngan K.;
Perry, Rachel J.

Publication type:

Article

Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk.

Published in:

2020

By:

Perry, Rachel J.;
Kun Lyu;
Rabin-Court, Aviva;
Jianying Dong;
Xiruo Li;
Yunfan Yang;
Hua Qing;
Wang, Andrew;
Xiaoyong Yang;
Shulman, Gerald I.;
Lyu, Kun;
Dong, Jianying;
Li, Xiruo;
Yang, Yunfan;
Qing, Hua;
Yang, Xiaoyong

Publication type:

journal article

Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis.

Published in:

2017

By:

Perry, Rachel J.;
Liang Peng;
Abulizi, Abudukadier;
Kennedy, Lynn;
Cline, Gary W.;
Shulman, Gerald I.;
Peng, Liang

Publication type:

journal article

High‐fat high‐sucrose diet‐induced skeletal muscle insulin resistance in female rats: a new soprano in the DAG chorus.

Published in:

Journal of Physiology, 2023, v. 601, n. 10, p. 1693, doi. 10.1113/JP284661

By:

Panneerselvam, Vijayavalli Thangaraj;
Perry, Rachel J.

Publication type:

Article

Accelerated Aging in Cancer and Cancer Treatment: Current Status of Biomarkers.

Published in:

Cancer Medicine, 2025, v. 14, n. 9, p. 1, doi. 10.1002/cam4.70929

By:

Abraham, Soniya;
Parekh, Jay;
Lee, Seohyuk;
Afrin, Humayra;
Rozenblit, Mariya;
Blenman, Kim R. M.;
Perry, Rachel J.;
Ferrucci, Leah M.;
Liu, Jessica;
Irwin, Melinda L.;
Lustberg, Maryam

Publication type:

Article

The association between the amino acid transporter LAT1, tumor immunometabolic and proliferative features and menopausal status in breast cancer.

Published in:

PLoS ONE, 2023, v. 18, n. 10, p. 1, doi. 10.1371/journal.pone.0292678

By:

Ramshankar, Gautham;
Liu, Ryan;
Perry, Rachel J.

Publication type:

Article

Tissue-specific reprogramming of glutamine metabolism maintains tolerance to sepsis.

Published in:

PLoS ONE, 2023, v. 18, n. 7, p. 1, doi. 10.1371/journal.pone.0286525

By:

Leitner, Brooks P.;
Lee, Won D.;
Zhu, Wanling;
Zhang, Xinyi;
Gaspar, Rafael C.;
Li, Zongyu;
Rabinowitz, Joshua D.;
Perry, Rachel J.

Publication type:

Article

The impact of variance in carnitine palmitoyltransferase-1 expression on breast cancer prognosis is stratified by clinical and anthropometric factors.

Published in:

PLoS ONE, 2023, v. 18, n. 2, p. 1, doi. 10.1371/journal.pone.0281252

By:

Liu, Ryan;
Ospanova, Shyryn;
Perry, Rachel J.

Publication type:

Article

Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma.

Published in:

NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-021-00248-2

By:

Leitner, Brooks P.;
Givechian, Kevin B.;
Ospanova, Shyryn;
Beisenbayeva, Aray;
Politi, Katerina;
Perry, Rachel J.

Publication type:

Article

Multimodal analysis suggests differential immuno-metabolic crosstalk in lung squamous cell carcinoma and adenocarcinoma.

Published in:

NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-021-00248-2

By:

Leitner, Brooks P.;
Givechian, Kevin B.;
Ospanova, Shyryn;
Beisenbayeva, Aray;
Politi, Katerina;
Perry, Rachel J.

Publication type:

Article

Novel Strategies to Treat Hepatic Steatosis and Steatohepatitis.

Published in:

2019

By:

Perry, Rachel J.

Publication type:

journal article

Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo.

Published in:

eLife, 2023, p. 1, doi. 10.7554/eLife.78335

By:

Akingbesote, Ngozi D.;
Leitner, Brooks P.;
Jovin, Daniel G.;
Desrouleaux, Reina;
Owusu, Dennis;
Wanling Zhu;
Zongyu Li;
Pollak, Michael N.;
Perry, Rachel J.

Publication type:

Article

Isotope tracing reveals distinct substrate preference in murine melanoma subtypes with differing anti-tumor immunity.

Published in:

Cancer & Metabolism, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40170-022-00296-7

By:

Zhang, Xinyi;
Halberstam, Alexandra A.;
Zhu, Wanling;
Leitner, Brooks P.;
Thakral, Durga;
Bosenberg, Marcus W.;
Perry, Rachel J.

Publication type:

Article

SGLT2 inhibition slows tumor growth in mice by reversing hyperinsulinemia.

Published in:

Cancer & Metabolism, 2019, v. 7, n. 1, p. 1, doi. 10.1186/s40170-019-0203-1

By:

Nasiri, Ali R.;
Rodrigues, Marcos R.;
Li, Zongyu;
Leitner, Brooks P.;
Perry, Rachel J.

Publication type:

Article

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01143-w

By:

Perry, Rachel J.;
Liang Peng;
Cline, Gary W.;
Butrico, Gina M.;
Yongliang Wang;
Xian-Man Zhang;
Rothman, Douglas L.;
Petersen, Kitt Falk;
Shulman, Gerald I.

Publication type:

Article

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis.

Published in:

Nature Communications, 2015, v. 6, n. 4, p. 6980, doi. 10.1038/ncomms7980

By:

Perry, Rachel J.;
Lee, Sangwon;
Ma, Lie;
Zhang, Dongyan;
Schlessinger, Joseph;
Shulman, Gerald I.

Publication type:

Article

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140837

By:

Vatner, Daniel F.;
Snikeris, Jaclyn;
Popov, Violeta;
Perry, Rachel J.;
Rahimi, Yasmeen;
Samuel, Varman T.

Publication type:

Article

Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation.

Published in:

PLoS ONE, 2019, v. 14, n. 6, p. 1, doi. 10.1371/journal.pone.0218126

By:

Rabin-Court, Aviva;
Rodrigues, Marcos R.;
Zhang, Xian-Man;
Perry, Rachel J.

Publication type:

Article

A New Mitochondrial Uncoupler Improves Metabolic Homeostasis in Mice.

Published in:

Diabetes, 2024, v. 73, n. 3, p. 357, doi. 10.2337/dbi23-0033

By:

Ramshankar, Gautham;
Perry, Rachel J.

Publication type:

Article

Regulation of Hepatic Lipid and Glucose Metabolism by INSP3R1.

Published in:

2022

By:

Perry, Rachel J.

Publication type:

journal article

501-P: Lower Plasma Membrane Sn-1,2-Diacylglycerol Content and PKCepsilon/theta Activity Explain the Athlete's Paradox.

Published in:

Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-501-P

By:

GASPAR, RAFAEL C.;
LYU, KUN;
HUBBARD, BRANDON T.;
LEITNER, BROOKS;
LUUKKONEN, PANU;
HIRABARA, SANDRO;
SAKUMA, IKKI;
NASIRI, ALI;
ZHANG, DONGYAN;
KAHN, MARIO;
CLINE, GARY;
PAULI, JOSÉ R.;
PERRY, RACHEL J.;
PETERSEN, KITT;
SHULMAN, GERALD I.

Publication type:

Article

323-OR: SGLT2 Inhibition Promotes Myocardial Ketone Utilization in the Normal and Failing Heart.

Published in:

Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-323-OR

By:

GOEDEKE, LEIGH;
LEE, JI EUN;
MA, YINA;
HU, XIAOYUE;
ZHANG, JIASHENG;
DONG, JIANYING;
GALSGAARD, KATRINE D.;
GUERRERA, NICOLE;
HAEDERSDAL, SOFIE;
ZHANG, XIAN-MAN;
PERRY, RACHEL J.;
CLINE, GARY;
YOUNG, LAWRENCE H.;
SHULMAN, GERALD I.

Publication type:

Article

1713-P: Adipocyte O-GlcNAc Transferase Regulate Adipogenesis through De Novo Lipogenesis in Mice.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1713-P

By:

MORINO, KATSUTARO;
TSUJI, AKIKO;
OHASHI, NATSUKO;
IDA, SHOGO;
PERRY, RACHEL J.;
UGI, SATOSHI;
FUJITA, YUKIHIRO;
SHULMAN, GERALD I.;
MAEGAWA, HIROSHI

Publication type:

Article

1782-P: Mechanism of Lipid-Induced White Adipose Tissue Insulin Resistance.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-1782-P

By:

ZHANG, YE;
ZHANG, DONGYAN;
LYU, KUN;
SONG, JOONGYU D.;
LI, XIRUO;
PERRY, RACHEL J.;
SAMUEL, VARMAN;
SHULMAN, GERALD I.

Publication type:

Article

165-OR: The Mechanisms by Which Adiponectin Reverses Insulin Resistance in High-Fat Diet Fed Mice.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-165-OR

By:

LI, XIRUO;
ZHANG, DONGYAN;
PERRY, RACHEL J.;
VATNER, DANIEL F.;
GOEDEKE, LEIGH;
ZHANG, YE;
SHULMAN, GERALD I.

Publication type:

Article

99-OR: Leptin Mediates Postprandial Thermogenesis through a Hypothalamic-Adrenomedullary-BAT Axis.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-99-OR

By:

PERRY, RACHEL J.;
RABIN-COURT, AVIVA;
DONG, JIANYING;
LYU, KUN;
LI, XIRUO;
SHULMAN, GERALD I.

Publication type:

Article

97-OR: Leptin's Hunger-Suppressing Effects Are Mediated by the Hypothalamic-Pituitary-Adrenocortical Axis.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-97-OR

By:

PERRY, RACHEL J.;
RESCH, JON;
DOUGLASS, AMELIA M.;
MADARA, JOSEPH;
SONG, JOONGYU D.;
WU, CHEN;
LOWELL, BRADFORD;
SHULMAN, GERALD I.

Publication type:

Article

288-LB: Effects of the Hepatic Mitochondrial Calcium Uniporter on Hepatic Gluconeogenesis and Mitochondrial Metabolism in Awake Mice.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-288-LB

By:

LEE, JI EUN;
GOEDEKE, LEIGH;
ZHANG, YE;
PERRY, RACHEL J.;
GOODMAN, RUSSELL;
MOOTHA, VAMSI;
SHULMAN, GERALD I.

Publication type:

Article

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling.

Published in:

2018

By:

Corbit, Kevin C.;
Camporez, João Paulo G.;
Edmunds, Lia R.;
Tran, Jennifer L.;
Vera, Nicholas B.;
Erion, Derek M.;
Deo, Rahul C.;
Perry, Rachel J.;
Shulman, Gerald I.;
Jurczak, Michael J.;
Weiss, Ethan J.

Publication type:

journal article

The Mammalian INDY Homolog Is Induced by CREB in a Rat Model of Type 2 Diabetes.

Published in:

Diabetes, 2014, v. 63, n. 3, p. 1048, doi. 10.2337/db13-0749

By:

Neuschäfer-Rube, Frank;
Lieske, Stefanie;
Kuna, Manuela;
Henkel, Janin;
Perry, Rachel J.;
Erion, Derek M.;
Pesta, Dominik;
Willmes, Diana M.;
Brachs, Sebastian;
von Loeffelholz, Christian;
Tolkachov, Alexander;
Schupp, Michael;
Pathe-Neuschäfer-Rube, Andrea;
Pfeiffer, Andreas F. H.;
Shulman, Gerald I.;
Püschel, Gerhard P.;
Birkenfeld, Andreas L.

Publication type:

Article

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia.

Published in:

Biochemical Journal, 2018, v. 475, n. 6, p. 1063, doi. 10.1042/BCJ20180063

By:

Yang Qiu;
Perry, Rachel J.;
Camporez, João-Paulo G.;
Xian-Man Zhang;
Kahn, Mario;
Cline, Gary W.;
Shulman, Gerald I.;
Vatner, Daniel F.

Publication type:

Article

A kidney-hypothalamus axis promotes compensatory glucose production in response to glycosuria.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.91540

By:

Faniyan, Tumininu S.;
Xinyi Zhang;
Morgan, Donald A.;
Robles, Jorge;
Bathina, Siresha;
Brookes, Paul S.;
Rahmouni, Kamal;
Perry, Rachel J.;
Chhabra, Kavaljit H.

Publication type:

Article

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes.

Published in:

Nature, 2014, v. 510, n. 7503, p. 84, doi. 10.1038/nature13478

By:

Perry, Rachel J.;
Samuel, Varman T.;
Petersen, Kitt F.;
Shulman, Gerald I.

Publication type:

Article