Works matching AU Perkinton, Michael S.

Results: 22

Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo.

Published in:

Journal of Neuroscience, 2018, v. 38, n. 50, p. 10595, doi. 10.1523/JNEUROSCI.1700-18.2018

By:

Ondrejcak, Tomas;
Klyubin, Igor;
Rowan, Michael J.;
Corbett, Grant T.;
Wei Hong;
Mably, Alexandra J.;
Walsh, Dominic M.;
Fraser, Graham;
Perkinton, Michael S.;
Billinton, Andrew;
Gardener, Matthew;
Hammersley, Jayne

Publication type:

Article

MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 11, p. 7762, doi. 10.1002/alz.14238

By:

Lloyd, Christopher;
Freskgård, Per‐Ola;
Newton, Philip;
Lowne, David;
Nickson, Adrian;
Bogstedt, Anna;
Eketjäll, Susanna;
Höglund, Kina;
Gustavsson, Susanne;
Welsh, Fraser;
Chessell, Tharani;
McFarlane, Mary;
Bhat, Ratan V.;
Turner, Richard;
Perkinton, Michael S.;
Santisteban Valencia, Zulma;
Lindqvist, Eva;
Pomfret, Michael;
Dudley, Amanda D.;
Vaughan, Tristan J.

Publication type:

Article

Tau and Amyloid β Protein in Patient-Derived Aqueous Brain Extracts Act Concomitantly to Disrupt Long-Term Potentiation in Vivo.

Published in:

Journal of Neuroscience, 2023, v. 43, n. 32, p. 5870, doi. 10.1523/JNEUROSCI.0082-23.2023

By:

Ondrejcak, Tomas;
Klyubin, Igor;
Neng-Wei Hu;
O'Malley, Tiernan T.;
Corbett, Grant T.;
Winters, Róisín;
Perkinton, Michael S.;
Billinton, Andy;
Prenderville, Jack A.;
Walsh, Dominic M.;
Rowan, Michael J.

Publication type:

Article

Characterisation of tau in the human and rodent enteric nervous system under physiological conditions and in tauopathy.

Published in:

Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0568-3

By:

Lionnet, Arthur;
Wade, Matthew A.;
Corbillé, Anne-Gaëlle;
Prigent, Alice;
Paillusson, Sébastien;
Tasselli, Maddalena;
Gonzales, Jacques;
Durieu, Emilie;
Rolli-Derkinderen, Malvyne;
Coron, Emmanuel;
Duchalais, Emilie;
Neunlist, Michel;
Perkinton, Michael S.;
Hanger, Diane P.;
Noble, Wendy;
Derkinderen, Pascal

Publication type:

Article

Synaptic NMDA Receptor Activation Stimulates α-Secretase Amyloid Precursor Protein Processing and Inhibits Amyloid-β Production.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 14, p. 4442, doi. 10.1523/JNEUROSCI.6017-08.2009

By:

Hoey, Sarah E.;
Williams, Robert J.;
Perkinton, Michael S.

Publication type:

Article

The ‘glial’ glutamate transporter, EAAT2 (Glt-1) accounts for high affinity glutamate uptake into adult rodent nerve endings.

Published in:

Journal of Neurochemistry, 2003, v. 84, n. 3, p. 522, doi. 10.1046/j.1471-4159.2003.01553.x

By:

Suchak, Sachin K.;
Baloyianni, Nicoletta V.;
Perkinton, Michael S.;
Williams, Robert J.;
Meldrum, Brian S.;
Rattray, Marcus

Publication type:

Article

Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones.

Published in:

Journal of Neurochemistry, 2002, v. 80, n. 2, p. 239, doi. 10.1046/j.0022-3042.2001.00699.x

By:

Perkinton, Michael S.;
Ip, James;
Wood, Gemma L.;
Crossthwaite, Andrew J.;
Williams, Robert J.

Publication type:

Article

AMPA RECEPTORS ACTIVATE THE CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN VIA A PHOSPHATIDYLINOSITOL 3-KINASE-DEPENDENT STIMULATION OF THE MITOGEN-ACTIVATED PROTEIN KINASE CASCADE IN STRIATAL NEURONS.

Published in:

1999

By:

Perkinton, Michael S.;
Williams, Robert J.

Publication type:

Abstract

Hydrogen Peroxide Enhances Signal-Responsive Arachidonic Acid Release from Neurons: Role of Mitogen-Activated Protein Kinase.

Published in:

Journal of Neurochemistry, 1998, v. 70, n. 5, p. 2082, doi. 10.1046/j.1471-4159.1998.70052082.x

By:

Samanta, Sujon;
Perkinton, Michael S.;
Morgan, Michael;
Williams, Robert J.

Publication type:

Article

Presynaptic GABA<sub>B</sub> Receptor Modulation of Glutamate Exocytosis from Rat Cerebrocortical Nerve Terminals: Receptor Decoupling by Protein Kinase C.

Published in:

Journal of Neurochemistry, 1998, v. 70, n. 4, p. 1513, doi. 10.1046/j.1471-4159.1998.70041513.x

By:

Perkinton, Michael S.;
Sihra, Talvinder S.

Publication type:

Article

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 3, p. 503, doi. 10.1007/s00401-019-02114-9

By:

Corbett, Grant T.;
Wang, Zemin;
Hong, Wei;
Colom-Cadena, Marti;
Rose, Jamie;
Liao, Meichen;
Asfaw, Adhana;
Hall, Tia C.;
Ding, Lai;
DeSousa, Alexandra;
Frosch, Matthew P.;
Collinge, John;
Harris, David A.;
Perkinton, Michael S.;
Spires-Jones, Tara L.;
Young-Pearse, Tracy L.;
Billinton, Andrew;
Walsh, Dominic M.

Publication type:

Article

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production.

Published in:

2010

By:

Gray EH;
De Vos KJ;
Dingwall C;
Perkinton MS;
Miller CC;
Gray, Emma H;
De Vos, Kurt J;
Dingwall, Colin;
Perkinton, Michael S;
Miller, Christopher C J

Publication type:

journal article

Deficiency of the Copper Chaperone for Superoxide Dismutase Increases Amyloid-β Production.

Published in:

Journal of Alzheimer's Disease, 2010, v. 21, n. 4, p. 1101, doi. 10.3233/JAD-2010-100717

By:

Gray, Emma H.;
De Vos, Kurt J.;
Dingwall, Colin;
Perkinton, Michael S.;
Miller, Christopher C.J.

Publication type:

Article

Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease.

Published in:

2010

By:

Mitchell JC;
Perkinton MS;
Yates DM;
Lau KF;
Rogelj B;
Miller CC;
McLoughlin DM;
Mitchell, Jacqueline C;
Perkinton, Michael S;
Yates, Darran M;
Lau, Kwok-Fai;
Rogelj, Boris;
Miller, Christopher C J;
McLoughlin, Declan M

Publication type:

journal article

Expression of the Neuronal Adaptor Protein X11α Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease.

Published in:

Journal of Alzheimer's Disease, 2010, v. 20, n. 1, p. 31, doi. 10.3233/JAD-2010-1341

By:

Mitchell, Jacqueline C.;
Perkinton, Michael S.;
Yates, Darran M.;
Lau, Kwok-Fai;
Rogelj, Boris;
Miller, Christopher C. J.;
McLoughlin, Declan M.

Publication type:

Article

Amyloid precursor protein 695 associates with assembled NR2A- and NR2B-containing NMDA receptors to result in the enhancement of their cell surface delivery.

Published in:

Journal of Neurochemistry, 2009, v. 111, n. 6, p. 1501, doi. 10.1111/j.1471-4159.2009.06424.x

By:

Cousins, Sarah L.;
Hoey, Sarah E. A.;
Stephenson, F. Anne;
Perkinton, Michael S.

Publication type:

Article

AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0078155

By:

Hoey, Sarah E.;
Buonocore, Federica;
Cox, Carla J.;
Hammond, Victoria J.;
Perkinton, Michael S.;
Williams, Robert J.

Publication type:

Article

AMPA receptor activation promotes non-amyloidogenic processing of the amyloid precursor protein in neurones

Published in:

2009

By:

Hoey, Sarah E.;
Perkinton, Michael S.;
Williams, Robert J.

Publication type:

Abstract

P1-466: N-methyl-D-aspartate receptor activation stimulates α-secretase amyloid precursor protein processing and inhibits amyloid-β production in cultured cortical neurons

Published in:

2008

By:

Hoey, Sarah E.;
Williams, Robert J.;
Perkinton, Michael S.

Publication type:

Abstract

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production.

Published in:

Human Molecular Genetics, 2013, v. 22, n. 22, p. 4646, doi. 10.1093/hmg/ddt313

By:

Vagnoni, Alessio;
Glennon, Elizabeth B.C.;
Perkinton, Michael S.;
Gray, Emma H.;
Noble, Wendy;
Miller, Christopher C.J.

Publication type:

Article

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 13, p. 2845, doi. 10.1093/hmg/dds109

By:

Vagnoni, Alessio;
Perkinton, Michael S.;
Gray, Emma H.;
Francis, Paul T.;
Noble, Wendy;
Miller, Christopher C.J.

Publication type:

Article

X11β rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 23, p. 4492, doi. 10.1093/hmg/ddp408

By:

Mitchell, Jacqueline C.;
Ariff, Belall B.;
Yates, Darran M.;
Lau, Kwok-Fai;
Perkinton, Michael S.;
Rogelj, Boris;
Stephenson, John D.;
Miller, Christopher C.J.;
McLoughlin, Declan M.

Publication type:

Article