Works matching AU Periasamy, Muthu

Results: 67
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    Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex.

    Published in:
    European Heart Journal, 2015, v. 36, n. 11, p. 686, doi. 10.1093/eurheartj/eht452
    By:
    • Glukhov, Alexey V.;
    • Kalyanasundaram, Anuradha;
    • Qing Lou;
    • Hage, Lori T.;
    • Hansen, Brian J.;
    • Belevych, Andriy E.;
    • Mohler, Peter J.;
    • Knollmann, Björn C.;
    • Periasamy, Muthu;
    • Györke, Sandor;
    • Fedorov, Vadim V.
    Publication type:
    Article
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    Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCPl)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCPl-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.

    Published in:
    Diabetes & Metabolism Journal, 2017, v. 41, n. 5, p. 327, doi. 10.4093/dmj.2017.41.5.327
    By:
    • Periasamy, Muthu;
    • Herrera, Jose Luis;
    • Reis, Felipe C. G.
    Publication type:
    Article
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    Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.

    Published in:
    Journal of Clinical Investigation, 2021, v. 131, n. 4, p. 1, doi. 10.1172/jci141799
    By:
    • Petrosino, Jennifer M.;
    • Longenecker, Jacob Z.;
    • Ramkumar, Srinivasagan;
    • Xianyao Xu;
    • Dorn, Lisa E.;
    • Bratasz, Anna;
    • Lianbo Yu;
    • Maurya, Santosh;
    • Tolstikov, Vladimir;
    • Bussberg, Valerie;
    • Janssen, M. L.;
    • Periasamy, Muthu;
    • Kiebish, Michael A.;
    • Duester, Gregg;
    • von Lintig, Johannes;
    • Ziouzenkova, Ouliana;
    • Accornero, Federica
    Publication type:
    Article
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    A mutation in calsequestrin, CASQ2<sup>D307H</sup>, impairs Sarcoplasmic Reticulum Ca<sup>2+</sup> handling and causes complex ventricular arrhythmias in mice

    Published in:
    Cardiovascular Research, 2007, v. 75, n. 1, p. 69, doi. 10.1016/j.cardiores.2007.03.002
    By:
    • Dirksen, Wessel P.;
    • Lacombe, Veronique A.;
    • Chi, Mei;
    • Kalyanasundaram, Anuradha;
    • Viatchenko-Karpinski, Serge;
    • Terentyev, Dmitry;
    • Zhou, Zhixiang;
    • Vedamoorthyrao, Srikanth;
    • Li, Ning;
    • Chiamvimonvat, Nipavan;
    • Carnes, Cynthia A.;
    • Franzini-Armstrong, Clara;
    • Györke, Sandor;
    • Periasamy, Muthu
    Publication type:
    Article
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    Central IKKβ inhibition prevents air pollution mediated peripheral inflammation and exaggeration of type II diabetes.

    Published in:
    Particle & Fibre Toxicology, 2014, v. 11, n. 1, p. 1, doi. 10.1186/s12989-014-0053-5
    By:
    • Cuiqing Liu;
    • Fonken, Laura K.;
    • Aixia Wang;
    • Maiseyeu, Andrei;
    • Bai, Yuntao;
    • Tse-Yao Wang;
    • Maurya, Santosh;
    • Yi-An Ko;
    • Periasamy, Muthu;
    • Dvonch, Timothy;
    • Morishita, Masako;
    • Brook, Robert D.;
    • Harkema, Jack;
    • Zhekang Ying;
    • Mukherjee, Bhramar;
    • Sun, Qinghua;
    • Nelson, Randy J.;
    • Rajagopalan, Sanjay
    Publication type:
    Article
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