Works by Perfetti, Riccardo

Results: 38

Results of the ACTION‐Galactosemia Kids Study to Evaluate the Effects of Govorestat in Pediatric Patients with Classic Galactosemia.

Published in:

Journal of Clinical Pharmacology, 2025, v. 65, n. 5, p. 575, doi. 10.1002/jcph.6170

By:

Bailey, Evan;
Phan, Han;
Ahmad, Ayesha;
Thomas, Janet;
Ames, Elizabeth G.;
Pritchard, Amanda B.;
Quinonez, Shane C.;
Wang, Stella;
Dayley, Caleb;
Salt, Andrew;
Pick, Christina;
Durrant, Abe;
Johnson, Samuel;
Nicodemus‐Johnson, Jessie;
Dickson, Samuel P.;
Perfetti, Riccardo;
Hendrix, Suzanne B.;
Shendelman, Shoshana

Publication type:

Article

Safety, Pharmacokinetics, and Pharmacodynamics of the New Aldose Reductase Inhibitor Govorestat (AT‐007) After a Single and Multiple Doses in Participants in a Phase 1/2 Study.

Published in:

Journal of Clinical Pharmacology, 2024, v. 64, n. 11, p. 1397, doi. 10.1002/jcph.2495

By:

Perfetti, Riccardo;
Bailey, Evan;
Wang, Stella;
Mills, Richard;
Mohanlal, Ramon;
Shendelman, Shoshana

Publication type:

Article

The Diabetes Unmet Need with Basal Insulin Evaluation (DUNE) study in type 2 diabetes: Achieving HbA1c targets with basal insulin in a real‐world setting.

Published in:

Diabetes, Obesity & Metabolism, 2019, v. 21, n. 6, p. 1429, doi. 10.1111/dom.13673

By:

Meneghini, Luigi F.;
Mauricio, Didac;
Orsi, Emanuela;
Lalic, Nebojsa M.;
Cali, Anna M.G.;
Westerbacka, Jukka;
Stella, Peter;
Candelas, DEA, Christophe;
Pilorget, Valerie;
Perfetti, Riccardo;
Khunti, Kamlesh

Publication type:

Article

Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion.

Published in:

2005

By:

Noushmehr, Houtan;
D'Amico, Eugenio;
Farilla, Loredana;
Hui, Hongxiang;
Wawrowsky, Kolja A.;
Mlynarski, Wojciech;
Doria, Alessandro;
Abumrad, Nada A.;
Perfetti, Riccardo

Publication type:

journal article

Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

Published in:

2005

By:

Hui, Hongxiang;
Khoury, Nasif;
Zhao, Xiaoning;
Balkir, Levent;
D'Amico, Eugenio;
Bullotta, Angela;
Nguyen, Elizabeth D.;
Gambotto, Andrea;
Perfetti, Riccardo

Publication type:

journal article

Glucagon-Like Peptide 1 Induces Differentiation of Islet Duodenal Homeobox-1--Positive...

Published in:

Diabetes, 2001, v. 50, n. 4, p. 785, doi. 10.2337/diabetes.50.4.785

By:

Hongxiang Hui;
Wright, Chris;
Perfetti, Riccardo

Publication type:

Article

Structure and function studies of glucagon-like peptide-1 (GLP-1): the designing of a novel pharmacological agent for the treatment of diabetes.

Published in:

Diabetes/Metabolism Research & Reviews, 2005, v. 21, n. 4, p. 313, doi. 10.1002/dmrr.553

By:

Hui, Hongxiang;
Zhao, Xiaoning;
Perfetti, Riccardo

Publication type:

Article

GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells.

Published in:

Diabetes/Metabolism Research & Reviews, 2003, v. 19, n. 2, p. 115, doi. 10.1002/dmrr.357

By:

Egan, Josephine M.;
Bulotta, Angela;
Hui, Hongxiang;
Perfetti, Riccardo

Publication type:

Article

SWEET - where are we heading with international type 1 diabetes registries?

Published in:

Pediatric Diabetes, 2012, v. 13, p. 1, doi. 10.1111/j.1399-5448.2012.00906.x

By:

Danne, Thomas;
Aschemeier, Bärbel;
Perfetti, Riccardo

Publication type:

Article

Qualitative interviews with adults with Classic Galactosemia and their caregivers: disease burden and challenges with daily living.

Published in:

2022

By:

Randall, Jason A.;
Sutter, Carolyn;
Wang, Stella;
Bailey, Evan;
Raither, Lydia;
Perfetti, Riccardo;
Shendelman, Shoshana;
Burbridge, Claire

Publication type:

journal article

Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Activity After Oral Administration of AMG 221, a Selective 11β-HSD1 Inhibitor.

Published in:

2011

By:

Gibbs, John P.;
Emery, Maurice G.;
McCaffery, Ian;
Smith, Brian;
Gibbs, Megan A.;
Akrami, Anna;
Rossi, John;
Paweletz, Katherine;
Gastonguay, Marc R.;
Bautista, Edgar;
Wang, Minghan;
Perfetti, Riccardo;
Daniels, Oranee

Publication type:

Journal Article

Population Pharmacokinetic/Pharmacodynamic Model of Subcutaneous Adipose 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Activity After Oral Administration of AMG 221, a Selective 11β-HSD1 Inhibitor.

Published in:

Journal of Clinical Pharmacology, 2011, v. 51, n. 6, p. 830, doi. 10.1177/0091270010374470

By:

Gibbs, John P.;
Emery, Maurice G.;
McCaffery, Ian;
Smith, Brian;
Gibbs, Megan A.;
Akrami, Anna;
Rossi, John;
Paweletz, Katherine;
Gastonguay, Marc R.;
Bautista, Edgar;
Wang, Minghan;
Perfetti, Riccardo;
Daniels, Oranee

Publication type:

Article

The short half-life of glucagon-like peptide-1 in plasma does not reflect its long-lasting beneficial effects.

Published in:

European Journal of Endocrinology, 2002, v. 146, n. 6, p. 863, doi. 10.1530/eje.0.1460863

By:

Hui, Hongxiang;
Farilla, Loredana;
Merkel, Patricia;
Perfetti, Riccardo

Publication type:

Article

Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood.

Published in:

European Journal of Endocrinology, 2002, v. 146, n. 2, p. 129, doi. 10.1530/eje.0.1460129

By:

Hui, Hongxiang;
Perfetti, Riccardo

Publication type:

Article

Glucagon-like peptide-1: a major regulator of pancreatic &bgr;-cell function.

Published in:

European Journal of Endocrinology, 2000, v. 143, n. 6, p. 717

By:

Perfetti, Riccardo;
Merkel, Patricia

Publication type:

Article

3,5,3'-Triiodo-L-thyronine enhances the differentiation of a human pancreatic duct cell line (hPANC-1) towards a -cell-Like phenotypeSilvia Misiti and Emanuela Anastasi contributed equally to this work.

Published in:

Journal of Cellular Physiology, 2005, v. 204, n. 1, p. 286, doi. 10.1002/jcp.20293

By:

Silvia Misiti;
Emanuela Anastasi;
Salvatore Sciacchitano;
Cecilia Verga Falzacappa;
Laura Panacchia;
Barbara Bucci;
Daniele Khouri;
Ilaria D'Acquarica;
Ercole Brunetti;
Umberto Di Mario;
Vincenzo Toscano;
Riccardo Perfetti

Publication type:

Article

Comment on: LY2963016 Insulin Glargine: A Review in Type 1 and 2 Diabetes.

Published in:

2018

By:

Perfetti, Riccardo

Publication type:

Letter to the Editor

Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial.

Published in:

Cardiovascular Diabetology, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12933-024-02554-y

By:

Marwick, Thomas H.;
Lam, Carolyn;
Liu, Yuxi;
Del Prato, Stefano;
Rosenstock, Julio;
Butler, Javed;
Ezekowitz, Justin;
Ibrahim, Nasrien E.;
Tang, W. H. Wilson;
Zannad, Faiez;
Perfetti, Riccardo;
Januzzi, James L.

Publication type:

Article

Characterizing diabetic cardiomyopathy: baseline results from the ARISE-HF trial.

Published in:

Cardiovascular Diabetology, 2024, v. 23, n. 1, p. 1, doi. 10.1186/s12933-024-02135-z

By:

Januzzi, James L.;
Del Prato, Stefano;
Rosenstock, Julio;
Butler, Javed;
Ezekowitz, Justin;
Ibrahim, Nasrien E.;
Lam, Carolyn S.P.;
Marwick, Thomas;
Wilson Tang, W. H.;
Liu, Yuxi;
Mohebi, Reza;
Urbinati, Alessia;
Zannad, Faiez;
Perfetti, Riccardo

Publication type:

Article

Low Blood Glucose Index and Hypoglycaemia Risk: Insulin Glargine 300 U/mL Versus Insulin Glargine 100 U/mL in Type 2 Diabetes.

Published in:

Diabetes Therapy, 2020, v. 11, n. 6, p. 1293, doi. 10.1007/s13300-020-00808-y

By:

Kovatchev, Boris;
Meng, Zhaoling;
Cali, Anna M. G.;
Perfetti, Riccardo;
Breton, Marc D.

Publication type:

Article

Lixisenatide Therapy in Older Patients With Type 2 Diabetes Inadequately Controlled on Their Current Antidiabetic Treatment: The GetGoal-O Randomized Trial.

Published in:

2017

By:

Meneilly, Graydon S.;
Roy-Duval, Christine;
Alawi, Hasan;
Dailey, George;
Bellido, Diego;
Trescoli, Carlos;
Manrique Hurtado, Helard;
Guo, Hailing;
Pilorget, Valerie;
Perfetti, Riccardo;
Simpson, Hamish;
GetGoal-O Trial Investigators

Publication type:

journal article

Efficacy and Safety of LixiLan, a Titratable Fixed-Ratio Combination of Lixisenatide and Insulin Glargine, Versus Insulin Glargine in Type 2 Diabetes Inadequately Controlled on Metformin Monotherapy: The LixiLan Proof-of-Concept Randomized Trial.

Published in:

2016

By:

Rosenstock, Julio;
Diamant, Michaela;
Aroda, Vanita R.;
Silvestre, Louise;
Souhami, Elisabeth;
Tianyue Zhou;
Perfetti, Riccardo;
Fonseca, Vivian;
Zhou, Tianyue;
LixiLan PoC Study Group

Publication type:

journal article

Prandial Options to Advance Basal Insulin Glargine Therapy: Testing Lixisenatide Plus Basal Insulin Versus Insulin Glulisine Either as Basal-Plus or Basal-Bolus in Type 2 Diabetes: The GetGoal Duo-2 Trial.

Published in:

2016

By:

Rosenstock, Julio;
Guerci, Bruno;
Hanefeld, Markolf;
Gentile, Sandro;
Aronson, Ronnie;
Tinahones, Francisco J.;
Roy-Duval, Christine;
Souhami, Elisabeth;
Wardecki, Marek;
Ye, Jenny;
Perfetti, Riccardo;
Heller, Simon;
GetGoal Duo-2 Trial Investigators

Publication type:

journal article

The aldose reductase inhibitors AT-001, AT-003 and AT-007 attenuate human keratinocyte senescence.

Published in:

Frontiers in Aging, 2024, p. 1, doi. 10.3389/fragi.2024.1466281

By:

Yepuri, Gautham;
Kancharla, Kushie;
Perfetti, Riccardo;
Shendelman, Shoshana;
Wasmuth, Andrew;
Ramasamy, Ravichandran

Publication type:

Article

Understanding the patient experience of Classic Galactosemia in pediatric and adult patients: increased disease burden, challenges with daily living, and how they evolve over time.

Published in:

Journal of Patient-Reported Outcomes, 2023, v. 7, n. 1, p. 1, doi. 10.1186/s41687-023-00635-2

By:

Randall, Jason A.;
Sutter, Carolyn;
Raither, Lydia;
Wang, Stella;
Bailey, Evan;
Perfetti, Riccardo;
Shendelman, Shoshana;
Burbridge, Claire

Publication type:

Article

Inheritance of the Arg64 Polymorphic Variants of the ß<sub>3</sub>-Adrenergic Receptor is Linked to Impaired Insulin Secretion.

Published in:

International Journal on Disability & Human Development (De Gruyter), 2002, v. 3, n. 2, p. 63

By:

Hui, Hongxiang;
Walston, Jeremy D.;
Perfetti, Riccardo

Publication type:

Article

Rational drug design and PPAR Agonists.

Published in:

Current Diabetes Reports, 2005, v. 5, n. 5, p. 340, doi. 10.1007/s11892-005-0091-3

By:

Perfetti, Riccardo;
D’Amico, Eugenio

Publication type:

Article

379-P: Aldose Reductase Inhibition by AT-001 Prevents Diabetic Cardiomyopathy via Reducing Myocardial Fatty Acid Oxidation Rates.

Published in:

Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-379-P

By:

GOPAL, KESHAV;
KARWI, QUTUBA G.;
DAKHILI, SEYED AMIRHOSSEIN TABATABAEI;
WAGG, CORY S.;
PERFETTI, RICCARDO;
RAMASAMY, RAVICHANDRAN;
USSHER, JOHN R.;
LOPASCHUK, GARY

Publication type:

Article

1043-P: Diabetic Cardiomyopathy: A Systematic Analysis of Epidemiological Studies.

Published in:

Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-1043-P

By:

PERFETTI, RICCARDO;
SHENDELMAN, SHOSHANA

Publication type:

Article

462-P: AT-001, a Next Generation Aldose Reductase Inhibitor with Improved Selectivity and Specificity, Protects from Cellular Damage Associated with Hyperglycemia.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-462-P

By:

PERFETTI, RICCARDO;
YEPURI, GAUTHAM;
QUADRI, NOSIRUDEEN A.;
RAMASAMY, RAVICHANDRAN;
GHANNAM, AMEEN F.;
SHENDELMAN, SHOSHANA

Publication type:

Article

186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM).

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-186-OR

By:

PERFETTI, RICCARDO;
LAWSON, FRANCESCA C.;
ROSENSTOCK, JULIO;
JANUZZI JR., JAMES;
SHENDELMAN, SHOSHANA;
WANG, STELLA;
GHANNAM, AMEEN F.

Publication type:

Article

1080-P: Addressing the Safety Challenges of Aldose Reductase Inhibition: Development of AT-001 for Diabetic Cardiomyopathy, a Potent and Selective Next Generation Aldose Reductase Inhibitor.

Published in:

Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1080-P

By:

PERFETTI, RICCARDO;
YEPURI, GAUTHAM;
QUADRI, NOSIRUDEEN A.;
GHANNAM, AMEEN F.;
RAMASAMY, RAVICHANDRAN;
SHENDELMAN, SHOSHANA

Publication type:

Article

145-LB: Phase 1/2 Safety and Proof of Biological Activity Study of AT-001, an Aldose Reductase Inhibitor in Development for Diabetic Cardiomyopathy.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-145-LB

By:

SHENDELMAN, SHOSHANA;
PERFETTI, RICCARDO

Publication type:

Article

Long Acting GLP-1 for the Treatment of Type I Diabetes.

Published in:

Diabetes, 2007, v. 56, p. A73

By:

Reichstetter, Sandra;
Castillo, Gerardo;
Medarova, Zdravka;
Moore, Anna;
Perfetti, Riccardo;
Leahy, Mark;
Bolotin, Elijah

Publication type:

Article

Differential effects of glucagon-like peptide-1 receptor agonists on heart rate.

Published in:

Cardiovascular Diabetology, 2017, v. 16, p. 1, doi. 10.1186/s12933-016-0490-6

By:

Lorenz, Martin;
Lawson, Francesca;
Owens, David;
Raccah, Denis;
Roy-Duval, Christine;
Lehmann, Anne;
Perfetti, Riccardo;
Blonde, Lawrence

Publication type:

Article

Aldose reductase inhibition alleviates diabetic cardiomyopathy and is associated with a decrease in myocardial fatty acid oxidation.

Published in:

Cardiovascular Diabetology, 2023, v. 22, n. 1, p. 1, doi. 10.1186/s12933-023-01811-w

By:

Gopal, Keshav;
Karwi, Qutuba G.;
Tabatabaei Dakhili, Seyed Amirhossein;
Wagg, Cory S.;
Zhang, Liyan;
Sun, Qiuyu;
Saed, Christina T.;
Panidarapu, Sai;
Perfetti, Riccardo;
Ramasamy, Ravichandran;
Ussher, John R.;
Lopaschuk, Gary D.

Publication type:

Article

Insulin, but Not Insulin-like Growth Factor-I, Is Expressed during Early Nervous System Development in Prepancreatic Xenopus Embryos.

Published in:

Annals of the New York Academy of Sciences, 1993, v. 692, n. 1, p. 268, doi. 10.1111/j.1749-6632.1993.tb26230.x

By:

PERFETTI, RICCARDO;
SHULDINER, ALAN R.

Publication type:

Article

Propensity‐score‐matched comparative analyses of simultaneously administered fixed‐ratio insulin glargine 100 U and lixisenatide (iGlarLixi) vs sequential administration of insulin glargine and lixisenatide in uncontrolled type 2 diabetes

Published in:

Diabetes, Obesity & Metabolism, 2018, v. 20, n. 12, p. 2821, doi. 10.1111/dom.13462

By:

Rosenstock, Julio;
Handelsman, Yehuda;
Vidal, Josep;
Ampudia Blasco, F. Javier;
Giorgino, Francesco;
Liu, Minzhi;
Perfetti, Riccardo;
Meier, Juris J.

Publication type:

Article