Works by Perez-Tilve, Diego

Results: 40

Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon.

Published in:

Communications Chemistry, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42004-018-0100-5

By:

Mroz, Piotr A.;
Perez-Tilve, Diego;
Mayer, John P.;
DiMarchi, Richard D.

Publication type:

Article

Glucagon Peptide Family and Adipose Tissue: Not that Intimate, just Acquaintances.

Published in:

Endocrinology, 2020, v. 161, n. 2, p. 1, doi. 10.1210/endocr/bqaa006

By:

Perez-Tilve, Diego

Publication type:

Article

Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.

Published in:

Endocrinology, 2018, v. 159, n. 1, p. 400, doi. 10.1210/en.2017-00486

By:

Ryan, Karen K;
Packard, Amy E B;
Larson, Karlton R;
Stout, Jayna;
Fourman, Sarah M;
Thompson, Abigail M K;
Ludwick, Kristen;
Habegger, Kirk M;
Stemmer, Kerstin;
Itoh, Nobuyuki;
Perez-Tilve, Diego;
Tschöp, Matthias H;
Seeley, Randy J;
Ulrich-Lai, Yvonne M

Publication type:

Article

Desacyl Ghrelin Decreases Anxiety-like Behavior in Male Mice.

Published in:

Endocrinology, 2018, v. 159, n. 1, p. 388, doi. 10.1210/en.2017-00540

By:

Mahbod, Parinaz;
Smith, Eric P;
Fitzgerald, Maureen E;
Morano, Rachel L;
Packard, Benjamin A;
Ghosal, Sriparna;
Scheimann, Jessie R;
Perez-Tilve, Diego;
Herman, James P;
Tong, Jenny

Publication type:

Article

Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.

Published in:

Journal of Peptide Science, 2012, v. 18, n. 6, p. 383, doi. 10.1002/psc.2408

By:

Müller, Timo D.;
Sullivan, Lorraine M.;
Habegger, Kirk;
Yi, Chun-Xia;
Kabra, Dhiraj;
Grant, Erin;
Ottaway, Nickki;
Krishna, Radha;
Holland, Jenna;
Hembree, Jazzminn;
Perez-Tilve, Diego;
Pfluger, Paul T.;
DeGuzman, Michael J.;
Siladi, Marc E.;
Kraynov, Vadim S.;
Axelrod, Douglas W.;
DiMarchi, Richard;
Pinkstaff, Jason K.;
Tschöp, Matthias H.

Publication type:

Article

The central melanocortin system directly controls peripheral lipid metabolism.

Published in:

2007

By:

Nogueiras, Ruben;
Wiedmer, Petra;
Perez-Tilve, Diego;
Veyrat-Durebex, Christelle;
Keogh, Julia M.;
Sutton, Gregory M.;
Pfluger, Paul T.;
Castaneda, Tamara R.;
Neschen, Susanne;
Hofmann, Susanna M.;
Howles, Philip N.;
Morgan, Donald A.;
Benoit, Stephen C.;
Szanto, Ildiko;
Schrott, Brigitte;
Schürmann, Annette;
Joost, Hans-Georg;
Hammond, Craig;
Hui, David Y.;
Woods, Stephen C.

Publication type:

journal article

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.

Published in:

2007

By:

Hofmann, Susanna M.;
Li Zhou;
Perez-Tilve, Diego;
Greer, Todd;
Grant, Erin;
Wancata, Lauren;
Thomas, Andrew;
Pfluger, Paul T.;
Basford, Joshua E.;
Gilham, Dean;
Herz, Joachim;
Tschöp, Matthias H.;
Hui, David Y.;
Zhou, Li;
Tschöp, Matthias H

Publication type:

journal article

Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice.

Published in:

2007

By:

Nomiyama, Takashi;
Perez-Tilve, Diego;
Ogawa, Daisuke;
Gizard, Florence;
Yue Zhao;
Heywood, Elizabeth B.;
Jones, Karrie L.;
Kawamori, Ryuzo;
Cassis, Lisa A.;
Tschöp, Matthias H.;
Bruemmer, Dennis;
Zhao, Yue;
Tschöp, Matthias H

Publication type:

journal article

Ghrelin action in the brain controls adipocyte metabolism.

Published in:

Journal of Clinical Investigation, 2006, v. 116, n. 7, p. 1983, doi. 10.1172/JCI25811

By:

Theander-Carrillo, Claudia;
Wiedmer, Petra;
Cettour-Rose, Philippe;
Nogueiras, Ruben;
Perez-Tilve, Diego;
Pfluger, Paul;
Castaneda, Tamara R.;
Muzzin, Patrick;
Schürmann, Annette;
Szanto, Ildiko;
Tschöp, Matthias H.;
Rohner-Jeanrenaud, Françoise

Publication type:

Article

Action Profile of the Antiobesity Drug Candidate Oleoyl-Estrone in Rats.

Published in:

Obesity (19307381), 2010, v. 18, n. 12, p. 2260, doi. 10.1038/oby.2010.53

By:

Strassburg, Sabine;
Pfluger, Paul T.;
Chaudhary, Nilika;
Tso, Patrick;
Tschöp, Matthias H.;
Anker, Stefan D.;
Nogueiras, Ruben;
Perez-Tilve, Diego

Publication type:

Article

Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2010, v. 1, n. 2, p. 159, doi. 10.1007/s13539-010-0012-4

By:

Müller, Timo;
Perez-Tilve, Diego;
Tong, Jenny;
Pfluger, Paul;
Tschöp, Matthias

Publication type:

Article

Influence of Nutritional Status and Leptin Action on Agrp and Pomc Co-Expression in Hypothalamic Melanocortin System Neurons.

Published in:

Neuroendocrinology, 2022, v. 112, n. 3, p. 287, doi. 10.1159/000516834

By:

Morano, Rachel;
Yates, Emily;
Barnes, Rachel;
Wohleb, Eric S.;
Perez-Tilve, Diego

Publication type:

Article

Hormones and diet, but not body weight, control hypothalamic microglial activity.

Published in:

Glia (0894-1491), 2014, v. 62, n. 1, p. 17, doi. 10.1002/glia.22580

By:

Gao, Yuanqing;
Ottaway, Nickki;
Schriever, Sonja C.;
Legutko, Beata;
García‐Cáceres, Cristina;
Fuente, Esther;
Mergen, Clarita;
Bour, Susanne;
Thaler, Joshua P.;
Seeley, Randy J.;
Filosa, Jessica;
Stern, Javier E.;
Perez‐Tilve, Diego;
Schwartz, Michael W.;
Tschöp, Matthias H.;
Yi, Chun‐Xia

Publication type:

Article

Brown adipose tissue thermogenesis in the resistance to and reversal of obesity.

Published in:

Adipocyte, 2013, v. 2, n. 4, p. 196, doi. 10.4161/adip.25417

By:

Lockie, Sarah H;
Stefanidis, Aneta;
Oldfield, Brian J;
Perez-Tilve, Diego

Publication type:

Article

Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance.

Published in:

Adipocyte, 2012, v. 1, n. 4, p. 203, doi. 10.4161/adip.20891

By:

Habegger, Kirk M.;
Matzke, Daniela;
Ottaway, Nickki;
Hembree, Jazzminn;
Holland, Jenna;
Raver, Christine;
Mansfeld, Johannes;
Müller, Timo D.;
Perez-Tilve, Diego;
Pfluger, Paul T.;
Lee, Sang Jun;
Diaz-Meco, Maria;
Moscat, Jorge;
Leitges, Michael;
Tschöp, Matthias H.;
Hofmann, Susanna M.

Publication type:

Article

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans.

Published in:

Science Translational Medicine, 2013, v. 5, n. 209, p. 1, doi. 10.1126/scitranslmed.3007218

By:

Finan, Brian;
Tao Ma;
Ottaway, Nickki;
Müller, Timo D.;
Habegger, Kirk M.;
Heppner, Kristy M.;
Kirchner, Henriette;
Holland, Jenna;
Hembree, Jazzminn;
Raver, Christine;
Lockie, Sarah H.;
Smiley, David L.;
Gelfanov, Vasily;
Bin Yang;
Hofmann, Susanna;
Bruemmer, Dennis;
Drucker, Daniel J.;
Pfluger, Paul T.;
Perez-Tilve, Diego;
Gidda, Jaswant

Publication type:

Article

CNS Leptin Action Modulates Immune Response and Survival in Sepsis.

Published in:

Journal of Neuroscience, 2010, v. 30, n. 17, p. 6036, doi. 10.1523/JNEUROSCI.4875-09.2010

By:

Tschöp, Johannes;
Nogueiras, Ruben;
Haas-Lockie, Sarah;
Kasten, Kevin R.;
Castañeda, Tamara R.;
Huber, Nadine;
Guanciale, Kelsey;
Perez-Tilve, Diego;
Habegger, Kirk;
Ottaway, Nickki;
Woods, Stephen C.;
Oldfield, Brian;
Clarke, Iain;
Chua Jr., Streamson;
Sadaf Farooqi, I.;
O'Rahilly, Stephen;
Caldwell, Charles C.;
Tschöp, Matthias H.

Publication type:

Article

Direct Control of Peripheral Lipid Deposition by CNS GLP-1 Receptor Signaling Is Mediated by the Sympathetic Nervous System and Blunted in Diet-Induced Obesity.

Published in:

Journal of Neuroscience, 2009, v. 29, n. 18, p. 5916, doi. 10.1523/JNEUROSCI.5977-08.2009

By:

Nogueiras, Ruben;
Pérez-Tilve, Diego;
Veyrat-Durebex, Christelle;
Morgan, Donald A.;
Varela, Luis;
Haynes, William G.;
Patterson, James T.;
Disse, Emmanuel;
Pfluger, Paul T.;
López, Miguel;
Woods, Stephen C.;
DiMarchi, Richard;
Diéguez, Carlos;
Rahmouni, Kamal;
Rohner-Jeanrenaud, Françoise;
Tschöp, Matthias H.

Publication type:

Article

The Melanocortin-3 Receptor Is Required for Entrainment to Meal Intake.

Published in:

Journal of Neuroscience, 2008, v. 28, n. 48, p. 12946, doi. 10.1523/JNEUROSCI.3615-08.2008

By:

Sutton, Gregory M.;
Perez-Tilve, Diego;
Nogueiras, Ruben;
Jidong Fang;
Kim, Jason K.;
Cone, Roger D.;
Gimble, Jeffrey M.;
Tschöp, Matthias H.;
Butler, Andrew A.

Publication type:

Article

Prolactin-releasing peptide (PrRP) increases prolactin responses to TRH in vitro and in vivo.

Published in:

Endocrine (1355008X), 2007, v. 31, n. 2, p. 119, doi. 10.1007/s12020-007-0031-x

By:

Carlos Spuch;
Yolanda Diz-Chaves;
Diego Pérez-Tilve;
Mayte Alvarez-Crespo;
Federico Mallo

Publication type:

Article

Melanocortin signaling in the CNS directly regulates circulating cholesterol.

Published in:

Nature Neuroscience, 2010, v. 13, n. 7, p. 877, doi. 10.1038/nn.2569

By:

Perez-Tilve, Diego;
Hofmann, Susanna M.;
Basford, Joshua;
Nogueiras, Ruben;
Pfluger, Paul T.;
Patterson, James T.;
Grant, Erin;
Wilson-Perez, Hilary E.;
Granholm, Norman A.;
Arnold, Myrtha;
Trevaskis, James L.;
Butler, Andrew A.;
Davidson, William S.;
Woods, Stephen C.;
Benoit, Stephen C.;
Sleeman, Mark W.;
DiMarchi, Richard D.;
Hui, David Y.;
Tschöp, Matthias H.

Publication type:

Article

Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice.

Published in:

Diabetologia, 2015, v. 58, n. 9, p. 2124, doi. 10.1007/s00125-015-3651-3

By:

Heppner, Kristy;
Marks, Sarah;
Holland, Jenna;
Ottaway, Nickki;
Smiley, David;
Dimarchi, Richard;
Perez-Tilve, Diego

Publication type:

Article

GLP-1 based therapeutics: simultaneously combating T2DM and obesity.

Published in:

Frontiers in Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnins.2015.00092

By:

Heppner, Kristy M.;
Perez-Tilve, Diego

Publication type:

Article

Ghrelin-induced adiposity is independent of orexigenic effects.

Published in:

FASEB Journal, 2011, v. 25, n. 8, p. 2814, doi. 10.1096/fj.11-183632

By:

Perez-Tilve, Diego;
Heppner, Kristy;
Kirchner, Henriette;
Lockie, Sarah H.;
Woods, Stephen C.;
Smiley, David L.;
Tschöp, Matthias;
Pfluger, Paul

Publication type:

Article

Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle.

Published in:

FASEB Journal, 2010, v. 24, n. 3, p. 862, doi. 10.1096/fj.09-142000

By:

Sutton, Gregory M.;
Begriche, Karima;
Kumar, K. Ganesh;
Gimble, Jeffrey M.;
Perez-Tilve, Diego;
Nogueiras, Ruben;
McMillan, Ryan P.;
Hulver, Matthew W.;
Tschöp, Matthias H.;
Butler, Andrew A.

Publication type:

Article

GLP-1R Responsiveness Predicts Individual Gastric Bypass Efficacy on Glucose Tolerance in Rats.

Published in:

Diabetes, 2014, v. 63, n. 2, p. 505, doi. 10.2337/db13-0511

By:

Habegger, Kirk M.;
Heppner, Kristy M.;
Amburgy, Sarah E.;
Ottaway, Nickki;
Holland, Jenna;
Raver, Christine;
Bartley, Erin;
Müller, Timo D.;
Pfluger, Paul T.;
Berger, Jose;
Toure, Mouhamadoul;
Benoit, Stephen C.;
DiMarchi, Richard D.;
Perez-Tilve, Diego;
D'Alessio, David A.;
Seeley, Randy J.;
Tschöp, Matthias H.

Publication type:

Article

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors.

Published in:

Diabetes, 2014, v. 63, n. 1, p. 122, doi. 10.2337/db13-0414

By:

Heppner, Kristy M.;
Piechowski, Carolin L.;
Müller, Anne;
Ottaway, Nickki;
Sisley, Stephanie;
Smiley, David L.;
Habegger, Kirk M.;
Pfluger, Paul T.;
DiMarchi, Richard;
Biebermann, Heike;
Tschöp, Matthias H.;
Sandoval, Darleen A.;
Perez-Tilve, Diego

Publication type:

Article

GLP-1R Agonism Enhances Adjustable Gastric Banding in Diet-Induced Obese Rats.

Published in:

Diabetes, 2013, v. 62, n. 9, p. 3261, doi. 10.2337/db13-0117

By:

Habegger, Kirk M.;
Kirchner, Henriette;
Chun-Xia Yi;
Heppner, Kristy M.;
Sweeney, Dan;
Ottaway, Nickki;
Holland, Jenna;
Amburgy, Sarah;
Raver, Christine;
Krishna, Radhakrishna;
Müller, Timo D.;
Perez-Tilve, Diego;
Pfluger, Paul T.;
Obici, Silvana;
DiMarchi, Richard D.;
D'Alessio, David A.;
Seeley, Randy J.;
Tschöp, Matthias H.

Publication type:

Article

Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency.

Published in:

Diabetes, 2013, v. 62, n. 7, p. 2380, doi. 10.2337/db12-1498

By:

Wilson-Pérez, Hilary E.;
Chambers, Adam P.;
Ryan, Karen K.;
Bailing Li;
Sandoval, Darleen A.;
Stoffers, Doris;
Drucker, Daniel J.;
Pérez-Tilve, Diego;
Seeley, Randy J.

Publication type:

Article

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions.

Published in:

Diabetes, 2013, v. 62, n. 5, p. 1453, doi. 10.2337/db12-1116

By:

Habegger, Kirk M.;
Stemmer, Kerstin;
Cheng, Christine;
Müller, Timo D.;
Heppner, Kristy M.;
Ottaway, Nickki;
Holland, Jenna;
Hembree, Jazzminn L.;
Smiley, David;
Gelfanov, Vasily;
Krishna, Radha;
Arafat, Ayman M.;
Konkar, Anish;
Belli, Sara;
Kapps, Martin;
Woods, Stephen C.;
Hofmann, Susanna M.;
D'Alessio, David;
Pfluger, Paul T.;
Perez-Tilve, Diego

Publication type:

Article

Direct Control of Brown Adipose Tissue Thermogenesis by Central Nervous System Glucagon-Like Peptide-1 Receptor Signaling.

Published in:

Diabetes, 2012, v. 61, n. 11, p. 2753, doi. 10.2337/db11-1556

By:

Lockie, Sarah H.;
Heppner, Kristy M.;
Chaudhary, Nilika;
Chabenne, Joseph R.;
Morgan, Donald A.;
Veyrat-Durebex, Christelle;
Ananthakrishnan, Gayathri;
Rohner-Jeanrenaud, Françoise;
Drucker, Daniel J.;
DiMarchi, Richard;
Rahmouni, Kamal;
Oldfield, Brian J.;
Tschöp, Matthias H.;
Perez-Tilve, Diego

Publication type:

Article

Caloric Restriction Chronically Impairs Metabolic Programming in Mice.

Published in:

Diabetes, 2012, v. 61, n. 11, p. 2734, doi. 10.2337/db11-1621

By:

Kirchner, Henriette;
Hofmann, Susanna M.;
Fischer-Rosinský, Antje;
Hembree, Jazzminn;
Abplanalp, William;
Ottaway, Nickki;
Donelan, Elizabeth;
Krishna, Radha;
Woods, Stephen C.;
Müller, Timo D.;
Spranger, Joachim;
Perez-Tilve, Diego;
Pfluger, Paul T.;
Tschöp, Matthias H.;
Habegger, Kirk M.

Publication type:

Article

Defective Lipid Delivery Modulates Glucose Tolerance and Metabolic Response to Diet in Apolipoprotein E-Deficient Mice.

Published in:

Diabetes, 2008, v. 57, n. 1, p. 5, doi. 10.2337/db07-0403

By:

Hofmann, Susanna M.;
Perez-Tilve, Diego;
Greer, Todd M.;
Coburn, Beth A.;
Grant, Erin;
Basford, Joshua E.;
Tschöp, Matthias H.;
Hui, David Y.

Publication type:

Article

Exendin-4 Potently Decreases Ghrelin Levels in Fasting Rats.

Published in:

Diabetes, 2007, v. 56, n. 1, p. 143, doi. 10.2337/db05-0996

By:

Pérez-Tilve, Diego;
González-Matias, Lucas;
Alvarez-Crespo, Mayte;
Leiras, Roberto;
Tovar, Sulay;
Diéguez, Carlos;
Mallo, Federico

Publication type:

Article

The GOAT-Ghrelin System Is Not Essential for Hypoglycemia Prevention during Prolonged Calorie Restriction.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0032100

By:

Chun-Xia Yi;
Heppner, Kristy M.;
Kirchner, Henriette;
Jenny Tong;
Bielohuby, Maximillian;
Gaylinn, Bruce D.;
Müller, Timo D.;
Bartley, Erin;
Davis, Harold W.;
Yongmei Zhao;
Joseph, Anupama;
Kruthaupt, Traci;
Ottaway, Nickki;
Kabra, Dhiraj;
Habegger, Kirk M.;
Benoit, Stephen C.;
Bidlingmaier, Martin;
Thorner, Michael O.;
Perez-Tilve, Diego;
Tschöp, Matthias H.

Publication type:

Article

CB1 and GLP-1 Receptors Cross Talk Provides New Therapies for Obesity.

Published in:

2021

By:

Zizzari, Philippe;
He, Rongjun;
Falk, Sarah;
Bellocchio, Luigi;
Allard, Camille;
Clark, Samantha;
Lesté-Lasserre, Thierry;
Marsicano, Giovanni;
Clemmensen, Christoffer;
Perez-Tilve, Diego;
Finan, Brian;
Cota, Daniela;
Quarta, Carmelo

Publication type:

journal article

296-LB: Novel Analogs of the Mitochondrially Encoded Peptide CB5064 Improve Body Weight and Glucose Tolerance in Dio Mice, and Demonstrate Selective Agonism at the Apelin Receptor.

Published in:

Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-296-LB

By:

GRINDSTAFF, KENT;
STENGER, EMILY;
SHANG, ROBIN;
YU, TRACY;
LUO, WENDY C.;
KIM, VIRNA V.;
PEREZ-TILVE, DIEGO;
CUNDY, KENNETH C.

Publication type:

Article

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.

Published in:

2018

By:

Teayoun Kim;
Holleman, Cassie L.;
Nason, Shelly;
Arble, Deanna M.;
Ottaway, Nickki;
Chabenne, Joseph;
Loyd, Christine;
Jeong-a Kim;
Sandoval, Darleen;
Drucker, Daniel J.;
DiMarchi, Richard;
Perez-Tilve, Diego;
Habegger, Kirk M.;
Kim, Teayoun;
Kim, Jeong-A

Publication type:

journal article

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.

Published in:

2018

By:

Teayoun Kim;
Nason, Shelly;
Holleman, Cassie;
Pepin, Mark;
Wilson, Landon;
Berryhill, Taylor F.;
Wende, Adam R.;
Steele, Chad;
Young, Martin E.;
Barnes, Stephen;
Drucker, Daniel J.;
Finan, Brian;
DiMarchi, Richard;
Perez-Tilve, Diego;
Tschöp, Matthias;
Habegger, Kirk M.;
Kim, Teayoun;
Tschoep, Matthias

Publication type:

journal article

CNS regulation of plasma cholesterol.

Published in:

Annals of Medicine, 2012, v. 44, n. 7, p. 656, doi. 10.3109/07853890.2011.590819

By:

Perez-Tilve, Diego;
Davidson, W. Sean;
Tschöp, Matthias;
Hofmann, Susanna M.

Publication type:

Article