Works by Pera, Marta

Results: 16

Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS).

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-024-51578-1

By:

Larrea, Delfina;
Tamucci, Kirstin A.;
Kabra, Khushbu;
Velasco, Kevin R.;
Yun, Taekyung D.;
Pera, Marta;
Montesinos, Jorge;
Agrawal, Rishi R.;
Paradas, Carmen;
Smerdon, John W.;
Lowry, Emily R.;
Stepanova, Anna;
Yoval-Sanchez, Belem;
Galkin, Alexander;
Wichterle, Hynek;
Area-Gomez, Estela

Publication type:

Article

Expanding the Multipotent Profile of Huprine-Tacrine Heterodimers as Disease-Modifying Anti-Alzheimer Agents.

Published in:

Neurodegenerative Diseases, 2012, v. 10, n. 1-4, p. 96, doi. 10.1159/000333225

By:

Muñoz-Torrero, Diego;
Pera, Marta;
Relat, Júlia;
Ratia, Míriam;
Galdeano, Carles;
Viayna, Elisabet;
Sola, Irene;
Formosa, Xavier;
Camps, Pelayo;
Badia, Albert;
Clos, M. Victòria

Publication type:

Article

The Alzheimer's disease‐associated C99 fragment of APP regulates cellular cholesterol trafficking.

Published in:

EMBO Journal, 2020, v. 39, n. 20, p. 1, doi. 10.15252/embj.2019103791

By:

Montesinos, Jorge;
Pera, Marta;
Larrea, Delfina;
Guardia‐Laguarta, Cristina;
Agrawal, Rishi R;
Velasco, Kevin R;
Yun, Taekyung D;
Stavrovskaya, Irina G;
Xu, Yimeng;
Koo, So Yeon;
Snead, Amanda M;
Sproul, Andrew A;
Area‐Gomez, Estela

Publication type:

Article

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.

Published in:

EMBO Journal, 2017, v. 36, n. 22, p. 3356, doi. 10.15252/embj.201796797

By:

Pera, Marta;
Larrea, Delfina;
Guardia‐Laguarta, Cristina;
Montesinos, Jorge;
Velasco, Kevin R;
Agrawal, Rishi R;
Xu, Yimeng;
Chan, Robin B;
Di Paolo, Gilbert;
Mehler, Mark F;
Perumal, Geoffrey S;
Macaluso, Frank P;
Freyberg, Zachary Z;
Acin‐Perez, Rebeca;
Enriquez, Jose Antonio;
Schon, Eric A;
Area‐Gomez, Estela

Publication type:

Article

APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61142-8

By:

Area-Gomez, Estela;
Larrea, Delfina;
Pera, Marta;
Agrawal, Rishi R.;
Guilfoyle, David N.;
Pirhaji, Leila;
Shannon, Kathleen;
Arain, Hirra A.;
Ashok, Archana;
Chen, Qiuying;
Dillman, Allissa A.;
Figueroa, Helen Y.;
Cookson, Mark R.;
Gross, Steven S.;
Fraenkel, Ernest;
Duff, Karen E.;
Nuriel, Tal

Publication type:

Article

Distinct patterns of APP processing in the CNS in autosomal-dominant and sporadic Alzheimer disease.

Published in:

Acta Neuropathologica, 2013, v. 125, n. 2, p. 201, doi. 10.1007/s00401-012-1062-9

By:

Pera, Marta;
Alcolea, Daniel;
Sánchez-Valle, Raquel;
Guardia-Laguarta, Cristina;
Colom-Cadena, Martí;
Badiola, Nahuai;
Suárez-Calvet, Marc;
Lladó, Albert;
Barrera-Ocampo, Alvaro;
Sepulveda-Falla, Diego;
Blesa, Rafael;
Molinuevo, José;
Clarimón, Jordi;
Ferrer, Isidre;
Gelpi, Ellen;
Lleó, Alberto

Publication type:

Article

Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production.

Published in:

Journal of Neurochemistry, 2014, v. 128, n. 2, p. 330, doi. 10.1111/jnc.12466

By:

Suárez‐Calvet, Marc;
Belbin, Olivia;
Pera, Marta;
Badiola, Nahuai;
Magrané, Jordi;
Guardia‐Laguarta, Cristina;
Muñoz, Laia;
Colom‐Cadena, Martí;
Clarimón, Jordi;
Lleó, Alberto

Publication type:

Article

Mild cholesterol depletion reduces amyloid-β production by impairing APP trafficking to the cell surface.

Published in:

Journal of Neurochemistry, 2009, v. 110, n. 1, p. 220, doi. 10.1111/j.1471-4159.2009.06126.x

By:

Guardia-Laguarta, Cristina;
Coma, Mireia;
Pera, Marta;
Clarimón, Jordi;
Sereno, Lidia;
Agulló, José M.;
Molina-Porcel, Laura;
Gallardo, Eduard;
Deng, Amy;
Berezovska, Oksana;
Hyman, Bradley T.;
Blesa, Rafael;
Gómez-Isla, Teresa;
Lleó, Alberto

Publication type:

Article

Undifferentiated and Differentiated PC12 Cells Protected by Huprines Against Injury Induced by Hydrogen Peroxide.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0074344

By:

Pera, Marta;
Camps, Pelayo;
Muñoz-Torrero, Diego;
Perez, Belen;
Badia, Albert;
Clos Guillen, M Victoria

Publication type:

Article

Rare Variants in Calcium Homeostasis Modulator <i>1</i> (CALHM1) Found in Early Onset Alzheimer’s Disease Patients Alter Calcium Homeostasis.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0074203

By:

Rubio-Moscardo, Fanny;
Setó-Salvia, Núria;
Pera, Marta;
Bosch-Morató, Mònica;
Plata, Cristina;
Belbin, Olivia;
Gené, Gemma;
Dols-Icardo, Oriol;
Ingelsson, Martin;
Helisalmi, Seppo;
Soininen, Hilkka;
Hiltunen, Mikko;
Giedraitis, Vilmantas;
Lannfelt, Lars;
Frank, Ana;
Bullido, MªJesús;
Combarros, Onofre;
Sánchez-Juan, Pascual;
Boada, Mercè;
Tárraga, Lluís

Publication type:

Article

Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy.

Published in:

PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026609

By:

Badiola, Nahuai;
de Oliveira, Rita Machado;
Herrera, Federico;
Guardia-Laguarta, Cristina;
Gonçalves, Susana A.;
Pera, Marta;
Suárez-Calvet, Marc;
Clarimon, Jordi;
Outeiro, Tiago Fleming;
Lleó, Alberto

Publication type:

Article

The C99 fragment of APP regulates cholesterol trafficking: Molecular and cell biology/APP/Abeta/amyloid.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.038479

By:

Montesinos, Jorge;
Pera, Marta;
Larrea, Delfina;
Guardia‐Laguarta, Cristina;
Area‐Gomez, Estela

Publication type:

Article

Mutations in CODON 716 of the amyloid precursor protein differentially affect APP processing

Published in:

2011

By:

Suarez-Calvet, Marc;
Guardia-Laguarta, Cristina;
Pera, Marta;
Badiola, Nahuai;
Alcolea, Daniel;
Setó-Salvia, Núria;
Dols, Oriol;
Magrané, Jordi;
Clarimón, Jordi;
Blesa, Rafael;
Lleó, Alberto

Publication type:

Abstract

The pathogenic I716F amyloid precursor protein (APP) mutation leads to a reduced protein processing and a very aggressive early-onset Alzheimer's disease

Published in:

2009

By:

Guardia-Laguarta, Cristina;
Pera, Marta;
Clarimon, Jordi;
Llado, Albert;
Sánchez-Valle, Raquel;
Molinuevo, Jose Luis;
Gómez-Isla, Teresa;
Blesa, Rafael;
Ferrer, Isidre;
Lleo, Alberto

Publication type:

Abstract

ApoE4 upregulates the activity of mitochondria-associated ER membranes.

Published in:

EMBO Reports, 2016, v. 17, n. 1, p. 27, doi. 10.15252/embr.201540614

By:

Tambini, Marc D;
Pera, Marta;
Kanter, Ellen;
Yang, Hua;
Guardia‐Laguarta, Cristina;
Holtzman, David;
Sulzer, David;
Area‐Gomez, Estela;
Schon, Eric A

Publication type:

Article

MFN2 mutations in Charcot–Marie–Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics.

Published in:

Human Molecular Genetics, 2019, v. 28, n. 11, p. 1782, doi. 10.1093/hmg/ddz008

By:

Larrea, Delfina;
Pera, Marta;
Gonnelli, Adriano;
Quintana–Cabrera, Rubén;
Akman, H Orhan;
Guardia-Laguarta, Cristina;
Velasco, Kevin R;
Area-Gomez, Estela;
Bello, Federica Dal;
Stefani, Diego De;
Horvath, Rita;
Shy, Michael E;
Schon, Eric A;
Giacomello, Marta

Publication type:

Article