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Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37630-6
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- Publication type:
- Article
APP antisense oligonucleotides reduce amyloid-β aggregation and rescue endolysosomal dysfunction in Alzheimer's disease.
- Published in:
- Brain: A Journal of Neurology, 2024, v. 147, n. 7, p. 2325, doi. 10.1093/brain/awae092
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- Publication type:
- Article
Elevated 4R tau contributes to endolysosomal dysfunction and neurodegeneration in VCP-related frontotemporal dementia.
- Published in:
- Brain: A Journal of Neurology, 2024, v. 147, n. 3, p. 970, doi. 10.1093/brain/awad370
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- Publication type:
- Article
Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis.
- Published in:
- 2022
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- Publication type:
- journal article
The role of astrocytes in prion-like mechanisms of neurodegeneration.
- Published in:
- 2022
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- Publication type:
- journal article
Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis.
- Published in:
- 2021
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- Publication type:
- journal article
FUS is lost from nuclei and gained in neurites of motor neurons in a human stem cell model of VCP-related ALS.
- Published in:
- 2020
- By:
- Publication type:
- Letter
The microglial component of amyotrophic lateral sclerosis.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Human stem cell-derived astrocytes exhibit region-specific heterogeneity in their secretory profiles.
- Published in:
- 2020
- By:
- Publication type:
- Letter
The FUS about SFPQ in FTLD spectrum disorders.
- Published in:
- 2020
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- Publication type:
- journal article
Paraspeckle components NONO and PSPC1 are not mislocalized from motor neuron nuclei in sporadic ALS.
- Published in:
- 2020
- By:
- Publication type:
- Letter
Decoding the relationship between ageing and amyotrophic lateral sclerosis: a cellular perspective.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Distinct responses of neurons and astrocytes to TDP-43 proteinopathy in amyotrophic lateral sclerosis.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.
- Published in:
- Brain: A Journal of Neurology, 2019, v. 142, n. 9, p. 2572, doi. 10.1093/brain/awz217
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- Publication type:
- Article
Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis.
- Published in:
- 2019
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- Publication type:
- journal article
Stress-Specific Spatiotemporal Responses of RNA-Binding Proteins in Human Stem Cell-Derived Motor Neurons.
- Published in:
- International Journal of Molecular Sciences, 2020, v. 21, n. 21, p. 8346, doi. 10.3390/ijms21218346
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- Publication type:
- Article
Experimental and Therapeutic Opportunities for Stem Cells in Multiple Sclerosis.
- Published in:
- International Journal of Molecular Sciences, 2012, v. 13, n. 11, p. 14470, doi. 10.3390/ijms131114470
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- Publication type:
- Article
Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.
- Published in:
- eLife, 2016, p. 1, doi. 10.7554/eLife.20337
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- Publication type:
- Article
Generating Diverse Spinal Motor Neuron Subtypes from Human Pluripotent Stem Cells.
- Published in:
- Thrombosis, 2015, p. 1, doi. 10.1155/2016/1036974
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- Publication type:
- Article
Human stem cell-derived neurones as a model to study tau function and dysfunction
- Published in:
- 2011
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- Publication type:
- Abstract
Cellular infiltration in traumatic brain injury.
- Published in:
- 2020
- By:
- Publication type:
- journal article
The ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43872-1
- By:
- Publication type:
- Article
Human Stem Cell-Derived Neurons: A System to Study Human Tau Function and Dysfunction.
- Published in:
- PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0013947
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- Publication type:
- Article
Activin/Nodal Inhibition Alone Accelerates Highly Efficient Neural Conversion from Human Embryonic Stem Cells and Imposes a Caudal Positional Identity.
- Published in:
- PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007327
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- Publication type:
- Article
Flexor hallucis brevis spasm.
- Published in:
- Muscle & Nerve, 2013, v. 47, n. 6, p. 939, doi. 10.1002/mus.23796
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- Publication type:
- Article
The FUS gene is dual‐coding with both proteins contributing to FUS‐mediated toxicity.
- Published in:
- EMBO Reports, 2021, v. 22, n. 1, p. 1, doi. 10.15252/embr.202050640
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- Publication type:
- Article
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides.
- Published in:
- Life Science Alliance, 2023, v. 6, n. 9, p. 1, doi. 10.26508/lsa.202201824
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- Publication type:
- Article
Image‐based deep learning reveals the responses of human motor neurons to stress and VCP‐related ALS.
- Published in:
- Neuropathology & Applied Neurobiology, 2022, v. 48, n. 2, p. 1, doi. 10.1111/nan.12770
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- Publication type:
- Article
Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation.
- Published in:
- Journal of Cellular & Molecular Medicine, 2022, v. 26, n. 4, p. 1327, doi. 10.1111/jcmm.17136
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- Publication type:
- Article
Front Cover Image, Volume 43, Issue 4.
- Published in:
- Medicinal Research Reviews, 2023, v. 43, n. 4, p. i, doi. 10.1002/med.21983
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- Publication type:
- Article
Molecular mechanisms of amyotrophic lateral sclerosis as broad therapeutic targets for gene therapy applications utilizing adeno‐associated viral vectors.
- Published in:
- Medicinal Research Reviews, 2023, v. 43, n. 4, p. 829, doi. 10.1002/med.21937
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- Publication type:
- Article
Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis.
- Published in:
- 2009
- By:
- Publication type:
- Report
Unsupervised Cell Segmentation and Labelling in Neural Tissue Images.
- Published in:
- Applied Sciences (2076-3417), 2021, v. 11, n. 9, p. 3733, doi. 10.3390/app11093733
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- Publication type:
- Article
Automated and unbiased discrimination of ALS from control tissue at single cell resolution.
- Published in:
- Brain Pathology, 2021, v. 31, n. 4, p. 1, doi. 10.1111/bpa.12937
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- Publication type:
- Article
Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis.
- Published in:
- Journal of Neurochemistry, 2012, v. 122, n. 4, p. 738, doi. 10.1111/j.1471-4159.2012.07825.x
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- Publication type:
- Article
The translational potential of human induced pluripotent stem cells for clinical neurology.
- Published in:
- Cell Biology & Toxicology, 2017, v. 33, n. 2, p. 129, doi. 10.1007/s10565-016-9372-7
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- Publication type:
- Article
TDP-43 and FUS mislocalization in VCP mutant motor neurons is reversed by pharmacological inhibition of the VCP D2 ATPase domain.
- Published in:
- Brain Communications, 2021, v. 3, n. 3, p. 1, doi. 10.1093/braincomms/fcab166
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- Publication type:
- Article
The Interplay of RNA Binding Proteins, Oxidative Stress and Mitochondrial Dysfunction in ALS.
- Published in:
- Antioxidants, 2021, v. 10, n. 4, p. 552, doi. 10.3390/antiox10040552
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- Publication type:
- Article
Chloroquine, the Coronavirus Crisis, and Neurodegeneration: A Perspective.
- Published in:
- Frontiers in Neurology, 2020, v. 11, p. N.PAG, doi. 10.3389/fneur.2020.596528
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- Publication type:
- Article
The mesenchymal stem cells in multiple sclerosis (MSCIMS) trial protocol and baseline cohort characteristics: an open-label pre-test: post-test study with blinded outcome assessments.
- Published in:
- Trials, 2011, v. 12, n. 1, p. 62, doi. 10.1186/1745-6215-12-62
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- Publication type:
- Article
Abnormal tau phosphorylation in primary progressive multiple sclerosis.
- Published in:
- Acta Neuropathologica, 2010, v. 119, n. 5, p. 591, doi. 10.1007/s00401-010-0671-4
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- Publication type:
- Article
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform (Adv. Healthcare Mater. 10/2022).
- Published in:
- Advanced Healthcare Materials, 2022, v. 11, n. 10, p. 1, doi. 10.1002/adhm.202270047
- By:
- Publication type:
- Article
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform.
- Published in:
- Advanced Healthcare Materials, 2022, v. 11, n. 10, p. 1, doi. 10.1002/adhm.202101817
- By:
- Publication type:
- Article
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform (Adv. Healthcare Mater. 10/2022).
- Published in:
- Advanced Healthcare Materials, 2022, v. 11, n. 10, p. 1, doi. 10.1002/adhm.202270047
- By:
- Publication type:
- Article
Axonal Length Determines Distinct Homeostatic Phenotypes in Human iPSC Derived Motor Neurons on a Bioengineered Platform.
- Published in:
- Advanced Healthcare Materials, 2022, v. 11, n. 10, p. 1, doi. 10.1002/adhm.202101817
- By:
- Publication type:
- Article
Characterizing the RNA targets and position-dependent splicing regulation by TDP-43.
- Published in:
- Nature Neuroscience, 2011, v. 14, n. 4, p. 452, doi. 10.1038/nn.2778
- By:
- Publication type:
- Article
Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers.
- Published in:
- Nucleic Acids Research, 2023, v. 51, n. 16, p. 8774, doi. 10.1093/nar/gkad534
- By:
- Publication type:
- Article
Reactive astrocytes in ALS display diminished intron retention.
- Published in:
- Nucleic Acids Research, 2021, v. 49, n. 6, p. 3168, doi. 10.1093/nar/gkab115
- By:
- Publication type:
- Article
Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04373-8
- By:
- Publication type:
- Article
A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01283-z
- By:
- Publication type:
- Article