Works by Pasinelli, Piera

Results: 22

EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS.

Published in:

eLife, 2024, p. 1, doi. 10.7554/eLife.89298

By:

Urban, Mark W.;
Charsar, Brittany A.;
Heinsinger, Nicolette M.;
Markandaiah, Shashirekha S.;
Sprimont, Lindsay;
Wei Zhou;
Brown, Eric V.;
Henderson, Nathan T.;
Thomas, Samantha J.;
Ghosh, Biswarup;
Cain, Rachel E.;
Trotti, Davide;
Pasinelli, Piera;
Wright, Megan C.;
Dalva, Matthew B.;
Lepore, Angelo C.

Publication type:

Article

Astrocytes expressing ALS‐linked mutant FUS induce motor neuron death through release of tumor necrosis factor‐alpha.

Published in:

Glia (0894-1491), 2018, v. 66, n. 5, p. 1016, doi. 10.1002/glia.23298

By:

Kia, Azadeh;
McAvoy, Kevin;
Krishnamurthy, Karthik;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis.

Published in:

Glia (0894-1491), 2016, v. 64, n. 8, p. 1298, doi. 10.1002/glia.23003

By:

Qosa, Hisham;
Lichter, Jessica;
Sarlo, Mark;
Markandaiah, Shashirekha S.;
McAvoy, Kevin;
Richard, Jean‐Philippe;
Jablonski, Michael R.;
Maragakis, Nicholas J.;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.

Published in:

Glia (0894-1491), 2011, v. 59, n. 11, p. 1719, doi. 10.1002/glia.21218

By:

Foran, Emily;
Bogush, Alexey;
Goffredo, Michael;
Roncaglia, Paola;
Gustincich, Stefano;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Repeat‐associated non‐AUG translation in C9orf72‐ALS/FTD is driven by neuronal excitation and stress.

Published in:

EMBO Molecular Medicine, 2019, v. 11, n. 2, p. 1, doi. 10.15252/emmm.201809423

By:

Westergard, Thomas;
McAvoy, Kevin;
Russell, Katelyn;
Wen, Xinmei;
Pang, Yu;
Morris, Brandie;
Pasinelli, Piera;
Trotti, Davide;
Haeusler, Aaron

Publication type:

Article

Prophylactic Creatine Administration Mediates Neuroprotection in Cerebral Ischemia in Mice.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 26, p. 5909, doi. 10.1523/JNEUROSCI.1278-04.2004

By:

Shan Zhu;
Mingwei Li;
Figueroa, Bryan E.;
Aijian Liu;
Stavrovskaya, Irina G.;
Pasinelli, Piera;
Beal, M. Flint;
Brown Jr., Robert H.;
Kristal, Bruce S.;
Ferrante, Robert J.;
Friedlander, Robert M.

Publication type:

Article

Defects in Synapse Structure and Function Precede Motor Neuron Degeneration in Drosophila Models of FUS-Related ALS.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 50, p. 19590, doi. 10.1523/JNEUROSCI.3396-13.2013

By:

Shahidullah, Mohammad;
Le Marchand, Sylvain J.;
Hong Fei;
Jiaming Zhang;
Pandey, Udai Bhan;
Dalva, Matthew B.;
Pasinelli, Piera;
Levitan, Irwin B.

Publication type:

Article

Small Peptides against the Mutant SOD1/Bcl-2 Toxic Mitochondrial Complex Restore Mitochondrial Function and Cell Viability in Mutant SOD1-Mediated ALS.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 28, p. 11588, doi. 10.1523/JNEUROSCI.5385-12.2013

By:

Wenzhi Tan;
Naniche, Nicole;
Bogush, Alexey;
Pedrini, Steve;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Glucose hypometabolism prompts RAN translation and exacerbates C9orf72-related ALS/FTD phenotypes.

Published in:

EMBO Reports, 2024, v. 25, n. 5, p. 2479, doi. 10.1038/s44319-024-00140-7

By:

Nelson, Andrew T;
Cicardi, Maria Elena;
Markandaiah, Shashirekha S;
Han, John YS;
Philp, Nancy J;
Welebob, Emily;
Haeusler, Aaron R;
Pasinelli, Piera;
Manfredi, Giovanni;
Kawamata, Hibiki;
Trotti, Davide

Publication type:

Article

Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization.

Published in:

Nature Communications, 2019, p. 1, doi. 10.1038/s41467-019-13383-z

By:

Casci, Ian;
Krishnamurthy, Karthik;
Kour, Sukhleen;
Tripathy, Vadreenath;
Ramesh, Nandini;
Anderson, Eric N.;
Marrone, Lara;
Grant, Rogan A.;
Oliver`, Stacie;
Gochenaur, Lauren;
Patel, Krishani;
Sterneckert, Jared;
Gleixner, Amanda M.;
Donnelly, Christopher J.;
Ruepp, Marc-David;
Sini, Antonella M.;
Zuccaro, Emanuela;
Pennuto, Maria;
Pasinelli, Piera;
Pandey, Udai Bhan

Publication type:

Article

Cover.

Published in:

Journal of Neuroscience Research, 2021, v. 99, n. 6, p. i, doi. 10.1002/jnr.24847

By:

Krishnamurthy, Karthik;
Pasinelli, Piera

Publication type:

Article

Synaptic dysfunction in amyotrophic lateral sclerosis/frontotemporal dementia: Therapeutic strategies and novel biomarkers.

Published in:

Journal of Neuroscience Research, 2021, v. 99, n. 6, p. 1499, doi. 10.1002/jnr.24824

By:

Krishnamurthy, Karthik;
Pasinelli, Piera

Publication type:

Article

Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity.

Published in:

Acta Neuropathologica, 2016, v. 131, n. 4, p. 605, doi. 10.1007/s00401-015-1530-0

By:

Daigle, J.;
Krishnamurthy, Karthik;
Ramesh, Nandini;
Casci, Ian;
Monaghan, John;
McAvoy, Kevin;
Godfrey, Earl;
Daniel, Dianne;
Johnson, Edward;
Monahan, Zachary;
Shewmaker, Frank;
Pasinelli, Piera;
Pandey, Udai

Publication type:

Article

Inhibiting drug efflux transporters improves efficacy of ALS therapeutics.

Published in:

Annals of Clinical & Translational Neurology, 2014, v. 1, n. 12, p. 996, doi. 10.1002/acn3.141

By:

Jablonski, Michael R.;
Markandaiah, Shashirekha S.;
Jacob, Dena;
Meng, Ni J.;
Li, Ke;
Gennaro, Victoria;
Lepore, Angelo C.;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-09593-z

By:

Verdone, Brandie Morris;
Cicardi, Maria Elena;
Wen, Xinmei;
Sriramoji, Sindhu;
Russell, Katelyn;
Markandaiah, Shashirekha S.;
Jensen, Brigid K.;
Krishnamurthy, Karthik;
Haeusler, Aaron R.;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS.

Published in:

Nature Neuroscience, 2010, v. 13, n. 11, p. 1396, doi. 10.1038/nn.2660

By:

Bosco, Daryl A.;
Morfini, Gerardo;
Karabacak, N. Murat;
Yuyu Song;
Gros-Louis, Francois;
Pasinelli, Piera;
Goolsby, Holly;
Fontaine, Benjamin A.;
Lemay, Nathan;
McKenna-Yasek, Diane;
Frosch, Matthew P.;
Agar, Jeffrey N.;
Julien, Jean-Pierre;
Brady, Scott T.;
Brown, Robert H.

Publication type:

Article

Molecular biology of amyotrophic lateral sclerosis: insights from genetics.

Published in:

2006

By:

Pasinelli, Piera;
Brown, Robert H.

Publication type:

journal article

ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.

Published in:

Human Molecular Genetics, 2010, v. 19, n. 15, p. 2974, doi. 10.1093/hmg/ddq202

By:

Pedrini, Steve;
Sau, Daniela;
Guareschi, Stefania;
Bogush, Marina;
Brown, Robert H.;
Naniche, Nicole;
Kia, Azadeh;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

Synaptic dysfunction induced by glycine‐alanine dipeptides in C9orf72‐ALS/FTD is rescued by SV2 replenishment.

Published in:

EMBO Molecular Medicine, 2020, v. 12, n. 5, p. 1, doi. 10.15252/emmm.201910722

By:

Jensen, Brigid K;
Schuldi, Martin H;
McAvoy, Kevin;
Russell, Katelyn A;
Boehringer, Ashley;
Curran, Bridget M;
Krishnamurthy, Karthik;
Wen, Xinmei;
Westergard, Thomas;
Ma, Le;
Haeusler, Aaron R;
Edbauer, Dieter;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies.

Published in:

AAPS Journal, 2017, v. 19, n. 6, p. 1600, doi. 10.1208/s12248-017-0120-6

By:

Mohamed, Loqman;
Markandaiah, Shashirekha;
Bonanno, Silvia;
Pasinelli, Piera;
Trotti, Davide

Publication type:

Article

Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis‐linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice.

Published in:

Glia (0894-1491), 2022, v. 70, n. 7, p. 1426, doi. 10.1002/glia.24183

By:

Jensen, Brigid K.;
McAvoy, Kevin J.;
Heinsinger, Nicolette M.;
Lepore, Angelo C.;
Ilieva, Hristelina;
Haeusler, Aaron R.;
Trotti, Davide;
Pasinelli, Piera

Publication type:

Article

AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury.

Published in:

FASEB Journal, 2019, v. 33, n. 12, p. 13775, doi. 10.1096/fj.201901730R

By:

Charsar, Brittany A.;
Brinton, Michael A.;
Locke, Katherine;
Chen, Anna Y.;
Ghosh, Biswarup;
Urban, Mark W.;
Komaravolu, Sreeya;
Krishnamurthy, Karthik;
Smit, Rupert;
Pasinelli, Piera;
Wright, Megan C.;
Smith, George M.;
Lepore, Angelo C.

Publication type:

Article