Works by Parra‐Guillen, Zinnia P.

Results: 21

Disease pharmacokinetic-pharmacodynamic modelling in acute intermittent porphyria to support the development of mRNA-based therapies.

Published in:

2020

By:

Parra‐Guillen, Zinnia P.;
Fontanellas, Antonio;
Jiang, Lei;
Jericó, Daniel;
Martini, Paolo;
Vera‐Yunca, Diego;
Hard, Marjie;
Guey, Lin T.;
Troconiz, Iñaki F.;
Parra-Guillen, Zinnia P;
Vera-Yunca, Diego

Publication type:

journal article

Disentangling Anti‐Tumor Response of Immunotherapy Combinations: A Physiologically Based Framework for V937 Oncolytic Virus and Pembrolizumab.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 5, p. 1304, doi. 10.1002/cpt.3379

By:

Sancho‐Araiz, Aymara;
Parra‐Guillen, Zinnia P.;
Troconiz, Iñaki F.;
Freshwater, Tomoko

Publication type:

Article

Assessment of Clinical Response to V937 Oncolytic Virus After Intravenous or Intratumoral Administration Using Physiologically‐Based Modeling.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 623, doi. 10.1002/cpt.2937

By:

Parra‐Guillen, Zinnia P.;
Sancho‐Araiz, Aymara;
Mayawala, Kapil;
Zalba, Sara;
Garrido, Maria J.;
de Alwis, Dinesh;
Troconiz, Iñaki F.;
Freshwater, Tomoko

Publication type:

Article

Model‐Informed Dose Selection for Xentuzumab, a Dual Insulin‐Like Growth Factor‐I/II—Neutralizing Antibody.

Published in:

Clinical Pharmacology & Therapeutics, 2020, v. 107, n. 3, p. 597, doi. 10.1002/cpt.1648

By:

Parra‐Guillen, Zinnia P.;
Schmid, Ulrike;
Janda, Alvaro;
Freiwald, Matthias;
Troconiz, Iñaki F.

Publication type:

Article

Pharmacodynamic Model of the Hemodynamic Effects of Propofol and Remifentanil and Their Interaction with Noxious Stimulation †.

Published in:

Pharmaceutics, 2024, v. 16, n. 12, p. 1615, doi. 10.3390/pharmaceutics16121615

By:

Garraza-Obaldia, Maite;
Jaramillo, Sebastian;
Parra-Guillen, Zinnia P.;
Valencia, José F.;
Gambús, Pedro L.;
Trocóniz, Iñaki F.

Publication type:

Article

The circadian rhythm of corticosteroid‐binding globulin has little impact on cortisol exposure after hydrocortisone dosing.

Published in:

Clinical Endocrinology, 2019, v. 91, n. 1, p. 33, doi. 10.1111/cen.13969

By:

Melin, Johanna;
Hartung, Niklas;
Parra‐Guillen, Zinnia P.;
Whitaker, Martin J.;
Ross, Richard J.;
Kloft, Charlotte

Publication type:

Article

Population pharmacokinetics of sublingually administered tacrolimus in infants and young children with liver transplantation.

Published in:

British Journal of Clinical Pharmacology, 2023, v. 89, n. 3, p. 1115, doi. 10.1111/bcp.15563

By:

Riva, Natalia;
Ibarra, Manuel;
Parra‐Guillen, Zinnia P.;
Galván, Maria Eugenia;
Pérez, Erika;
Trezeguet Renatti, Guido;
Cáceres Guido, Paulo;
Lopez, Clarisa;
Licciardone, Nieves;
Halac, Esteban;
Dip, Marcelo;
Cruz, Alejandro;
Imventarza, Oscar;
Buamscha, Daniel;
Troconiz, Iñaki F.;
Schaiquevich, Paula

Publication type:

Article

Relevance of primary lesion location, tumour heterogeneity and genetic mutation demonstrated through tumour growth inhibition and overall survival modelling in metastatic colorectal cancer.

Published in:

British Journal of Clinical Pharmacology, 2022, v. 88, n. 1, p. 166, doi. 10.1111/bcp.14937

By:

Vera‐Yunca, Diego;
Parra‐Guillen, Zinnia P.;
Girard, Pascal;
Trocóniz, Iñaki F.;
Terranova, Nadia

Publication type:

Article

Mechanistic modelling of enzyme‐restoration effects of new recombinant liver‐targeted proteins in acute intermittent porphyria.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 14, p. 3815, doi. 10.1111/bph.15821

By:

Vera‐Yunca, Diego;
Córdoba, Karol M.;
Parra‐Guillen, Zinnia P.;
Jericó, Daniel;
Fontanellas, Antonio;
Trocóniz, Iñaki F.

Publication type:

Article

Machine Learning Analysis of Individual Tumor Lesions in Four Metastatic Colorectal Cancer Clinical Studies: Linking Tumor Heterogeneity to Overall Survival.

Published in:

AAPS Journal, 2020, v. 22, n. 3, p. 1, doi. 10.1208/s12248-020-0434-7

By:

Vera-Yunca, Diego;
Girard, Pascal;
Parra-Guillen, Zinnia P.;
Munafo, Alain;
Trocóniz, Iñaki F.;
Terranova, Nadia

Publication type:

Article

Gene Therapy: A Pharmacokinetic/Pharmacodynamic Modelling Overview.

Published in:

Pharmaceutical Research, 2010, v. 27, n. 8, p. 1487, doi. 10.1007/s11095-010-0136-4

By:

Parra-Guillén, Zinnia P.;
González-Aseguinolaza, Gloria;
Berraondo, Pedro;
Trocóniz, Iñaki F.

Publication type:

Article

Mechanistic Modeling of a Novel Oncolytic Virus, V937, to Describe Viral Kinetic and Dynamic Processes Following Intratumoral and Intravenous Administration.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.705443

By:

Parra-Guillen, Zinnia P.;
Freshwater, Tomoko;
Cao, Youfang;
Mayawala, Kapil;
Zalba, Sara;
Garrido, Maria J.;
de Alwis, Dinesh;
Troconiz, Iñaki F.

Publication type:

Article

Predicting Cortisol Exposure from Paediatric Hydrocortisone Formulation Using a Semi-Mechanistic Pharmacokinetic Model Established in Healthy Adults.

Published in:

2018

By:

Melin, Johanna;
Parra-Guillen, Zinnia P.;
Hartung, Niklas;
Huisinga, Wilhelm;
Ross, Richard J.;
Whitaker, Martin J.;
Kloft, Charlotte

Publication type:

journal article

Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients.

Published in:

2018

By:

Klopp-Schulze, Lena;
Joerger, Markus;
Wicha, Sebastian;
Heine, Rob;
Csajka, Chantal;
Parra-Guillen, Zinnia;
Kloft, Charlotte;
Wicha, Sebastian G;
Ter Heine, Rob;
Parra-Guillen, Zinnia P

Publication type:

journal article

Mechanistic PKPD modeling to describe cytokine release associated with CD3 T-cell engager therapies.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2024.1463915

By:

Lefèvre, Apolline;
Parra-Guillen, Zinnia P.;
Trocóniz, Iñaki F.;
Boetsch, Christophe;
Frances, Nicolas

Publication type:

Article

Semi-Mechanistic Model for the Antitumor Response of a Combination Cocktail of Immuno-Modulators in Non-Inflamed (Cold) Tumors.

Published in:

Cancers, 2021, v. 13, n. 20, p. 5049, doi. 10.3390/cancers13205049

By:

Sancho-Araiz, Aymara;
Zalba, Sara;
Garrido, María J.;
Berraondo, Pedro;
Topp, Brian;
de Alwis, Dinesh;
Parra-Guillen, Zinnia P.;
Mangas-Sanjuan, Víctor;
Trocóniz, Iñaki F.

Publication type:

Article

Editorial: Innovative pharmacometric approaches to inform drug development and clinical use.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1274139

By:

Garcia-Cremades, Maria;
Parra-Guillen, Zinnia P.;
Mangas-Sanjuan, Victor;
Geerts, Hugo

Publication type:

Article

A physiologically based pharmacokinetic model for V937 oncolytic virus in mice.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1211452

By:

Peribañez-Dominguez, Sara;
Parra-Guillen, Zinnia P.;
Freshwater, Tomoko;
Troconiz, Iñaki F.

Publication type:

Article

Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.

Published in:

Basic & Clinical Pharmacology & Toxicology, 2017, v. 121, n. 4, p. 309, doi. 10.1111/bcpt.12801

By:

Parra‐Guillen, Zinnia P.;
Berger, Peter B.;
Haschke, Manuel;
Donzelli, Massimiliano;
Winogradova, Daria;
Pfister, Bogumila;
Früh, Martin;
Gillessen, Silke;
Krähenbühl, Stephan;
Kloft, Charlotte;
Joerger, Markus

Publication type:

Article

Pharmacokinetic/Pharmacodynamic Evaluation of Hydrocortisone Therapy in Pediatric Patients with Congenital Adrenal Hyperplasia.

Published in:

2020

By:

Melin, Johanna;
Parra-Guillen, Zinnia P;
Michelet, Robin;
Truong, Thi;
Huisinga, Wilhelm;
Hartung, Niklas;
Hindmarsh, Peter;
Kloft, Charlotte

Publication type:

journal article

Mechanistic characterization of oscillatory patterns in unperturbed tumor growth dynamics: The interplay between cancer cells and components of tumor microenvironment.

Published in:

PLoS Computational Biology, 2023, v. 19, n. 10, p. 1, doi. 10.1371/journal.pcbi.1011507

By:

Sancho-Araiz, Aymara;
Parra-Guillen, Zinnia P.;
Bragard, Jean;
Ardanza, Sergio;
Mangas-Sanjuan, Victor;
Trocóniz, Iñaki F.

Publication type:

Article