Works by Park, Keunwan

Results: 42

Identification of new small molecules for selective inhibition of SERCA 1 in patient‐derived metastatic papillary thyroid cancer.

Published in:

British Journal of Pharmacology, 2025, v. 182, n. 11, p. 2392, doi. 10.1111/bph.17442

By:

Kim, Seok‐Mo;
Park, Keunwan;
Yun, Hyeok Jun;
Kim, Jung Min;
Choi, Kyung Hwa;
Park, Ki Cheong

Publication type:

Article

Localized network centrality and essentiality in the yeast-protein interaction network.

Published in:

Proteomics, 2009, v. 9, n. 22, p. 5143, doi. 10.1002/pmic.200900357

By:

Park, Keunwan;
Kim, Dongsup

Publication type:

Article

Rhizolutin, a Novel 7/10/6‐Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease.

Published in:

Angewandte Chemie, 2020, v. 132, n. 51, p. 23194, doi. 10.1002/ange.202009294

By:

Kwon, Yun;
Shin, Jisu;
Nam, Kwangho;
An, Joon Soo;
Yang, Seung‐Hoon;
Hong, Seong‐Heon;
Bae, Munhyung;
Moon, Kyuho;
Cho, Yakdol;
Woo, Jiwan;
Park, Keunwan;
Kim, Kyeonghwan;
Shin, Jongheon;
Kim, Byung‐Yong;
Kim, YoungSoo;
Oh, Dong‐Chan

Publication type:

Article

Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory‐Impairing Anti‐Parallel Aβ Dimers.

Published in:

Angewandte Chemie, 2020, v. 132, n. 28, p. 11588, doi. 10.1002/ange.202002574

By:

Lee, Jinny Claire;
Kim, Hye Yun;
Lee, Sejin;
Shin, Jisu;
Kim, Hyunjin Vincent;
Kim, Kyeonghwan;
Baek, Seungyeop;
Lee, Donghee;
Jeon, Hanna;
Kim, DaWon;
Yang, Seung‐Hoon;
Han, Gyoonhee;
Park, Keunwan;
Choi, Jaeho;
Park, Jinwoo;
Moss, Jason A.;
Janda, Kim D.;
Kim, YoungSoo

Publication type:

Article

A Novel Competitive Binding Screening Assay Reveals Sennoside B as a Potent Natural Product Inhibitor of TNF-α.

Published in:

Biomedicines, 2021, v. 9, n. 9, p. 1250, doi. 10.3390/biomedicines9091250

By:

Peng, Lei;
Durai, Prasannavenkatesh;
Park, Keunwan;
Pyo, Jeong Joo;
Choi, Yongsoo

Publication type:

Article

Multiple tachykinins and their receptors characterized in the gastropod mollusk Pacific abalone: Expression, signaling cascades, and potential role in regulating lipid metabolism.

Published in:

Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.994863

By:

Seungheon Lee;
Mi Ae Kim;
Jong-Moon Park;
Keunwan Park;
Young Chang Sohn

Publication type:

Article

Potent and Selective Inhibition of CYP1A2 Enzyme by Obtusifolin and Its Chemopreventive Effects.

Published in:

Pharmaceutics, 2022, v. 14, n. 12, p. 2683, doi. 10.3390/pharmaceutics14122683

By:

Park, Eun-Ji;
Park, Keunwan;
Durai, Prasannavenkatesh;
Kim, Ki-Young;
Park, So-Young;
Kwon, Jaeyoung;
Lee, Hee Ju;
Pan, Cheol-Ho;
Liu, Kwang-Hyeon

Publication type:

Article

Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors.

Published in:

Journal of Cheminformatics, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13321-023-00760-6

By:

Durai, Prasannavenkatesh;
Lee, Sue Jung;
Lee, Jae Wook;
Pan, Cheol-Ho;
Park, Keunwan

Publication type:

Article

Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2022, v. 13, n. 6, p. 3149, doi. 10.1002/jcsm.13084

By:

Wijaya, Yoseph Toni;
Setiawan, Tania;
Sari, Ita Novita;
Park, Keunwan;
Lee, Chan Hee;
Cho, Kae Won;
Lee, Yun Kyung;
Lim, Jae‐Young;
Yoon, Jeong Kyo;
Lee, Sae Hwan;
Kwon, Hyog Young

Publication type:

Article

Functional Characterization of Gonadotropin-Releasing Hormone and Corazonin Signaling Systems in Pacific Abalone: Toward Reclassification of Invertebrate Neuropeptides.

Published in:

Neuroendocrinology, 2024, v. 114, n. 1, p. 64, doi. 10.1159/000533662

By:

Kim, Mi Ae;
Kim, Tae Ha;
Kannan, Priyadharshini;
Kho, Kang Hee;
Park, Keunwan;
Sohn, Young Chang

Publication type:

Article

Potential Therapeutic Agents against Paclitaxel—And Sorafenib-Resistant Papillary Thyroid Carcinoma.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 18, p. N.PAG, doi. 10.3390/ijms231810378

By:

Kim, Seok-Mo;
Park, Keunwan;
Lim, Jin Hong;
Yun, Hyeok Jun;
Kim, Sang Yong;
Choi, Kyung Hwa;
Kim, Chan Wung;
Lee, Jae Ha;
Weicker, Raymond;
Pan, Cheol-Ho;
Park, Ki Cheong

Publication type:

Article

Drug Discovery Using Evolutionary Similarities in Chemical Binding to Inhibit Patient-Derived Hepatocellular Carcinoma.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 14, p. 7971, doi. 10.3390/ijms23147971

By:

Lim, Jin Hong;
Park, Keunwan;
Choi, Kyung Hwa;
Kim, Chan Wung;
Lee, Jae Ha;
Weicker, Raymond;
Pan, Cheol-Ho;
Kim, Seok-Mo;
Park, Ki Cheong

Publication type:

Article

Mass spectrometry-guided isolation of thiodiketopiperazines from an EtOAc-extract of Setosphaeria rostrata culture medium and their anti-skin aging effects on TNF-α-induced human dermal fibroblasts.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 4, p. 257, doi. 10.1038/s41429-023-00702-2

By:

Kwon, Haeun;
Ann, Hee Woon;
Park, Sojung;
Kwon, Jaeyoung;
Park, Keunwan;
Ryu, Seung Mok;
Guo, Yuanqiang;
Kim, Jae-Jin;
Yim, Joung Han;
Kim, Il-Chan;
Shim, Sang Hee;
Lee, Sullim;
Lee, Dongho

Publication type:

Article

Morphogenesis of Cell‐Shaped Assemblies via Heterotypic Assembly of Cyclic Triblock Peptides.

Published in:

Macromolecular Chemistry & Physics, 2022, v. 223, n. 16, p. 1, doi. 10.1002/macp.202200103

By:

Kim, Hyoseok;
Ko, Sooho;
Park, Keunwan;
Lim, Yong‐beom

Publication type:

Article

Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models.

Published in:

Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-01112-6

By:

Lee, Hee Yang;
Yoon, Soljee;
Lee, Jeong Hwa;
Park, Keunwan;
Jung, Youngeun;
Cho, Illhwan;
Lee, Donghee;
Shin, Jisu;
Kim, Kyeonghwan;
Kim, Sunmi;
Kim, Jimin;
Kim, Koeun;
Han, Seung Hoon;
Kim, Seong Muk;
Kim, Hye Ju;
Kim, Hye Yun;
Kim, Ikyon;
Kim, Young Soo

Publication type:

Article

Rhizolutin, a Novel 7/10/6‐Tricyclic Dilactone, Dissociates Misfolded Protein Aggregates and Reduces Apoptosis/Inflammation Associated with Alzheimer's Disease.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 51, p. 22994, doi. 10.1002/anie.202009294

By:

Kwon, Yun;
Shin, Jisu;
Nam, Kwangho;
An, Joon Soo;
Yang, Seung‐Hoon;
Hong, Seong‐Heon;
Bae, Munhyung;
Moon, Kyuho;
Cho, Yakdol;
Woo, Jiwan;
Park, Keunwan;
Kim, Kyeonghwan;
Shin, Jongheon;
Kim, Byung‐Yong;
Kim, YoungSoo;
Oh, Dong‐Chan

Publication type:

Article

Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory‐Impairing Anti‐Parallel Aβ Dimers.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 28, p. 11491, doi. 10.1002/anie.202002574

By:

Lee, Jinny Claire;
Kim, Hye Yun;
Lee, Sejin;
Shin, Jisu;
Kim, Hyunjin Vincent;
Kim, Kyeonghwan;
Baek, Seungyeop;
Lee, Donghee;
Jeon, Hanna;
Kim, DaWon;
Yang, Seung‐Hoon;
Han, Gyoonhee;
Park, Keunwan;
Choi, Jaeho;
Park, Jinwoo;
Moss, Jason A.;
Janda, Kim D.;
Kim, YoungSoo

Publication type:

Article

Stable and reusable calcium‐responsive biopolymer for affinity precipitation of therapeutic antibodies.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 8, p. 1, doi. 10.1002/pro.5066

By:

Park, Heesun;
Oh, Jeong‐Seok;
Lee, Jonghwan;
Bang, Jinho;
Park, Keunwan;
Jeong, Suhyeon;
Park, Seho;
Woo, Jae‐Sung;
Kim, Sunghyun

Publication type:

Article

Glycolipids Derived from the Korean Endemic Plant Aruncus aethusifolius Inducing Glucose Uptake in Mouse Skeletal Muscle C2C12 Cells.

Published in:

Plants (2223-7747), 2024, v. 13, n. 5, p. 608, doi. 10.3390/plants13050608

By:

Baek, Jong Gwon;
Park, Do Hwi;
Vu, Ngoc Khanh;
Muvva, Charuvaka;
Hwang, Hoseong;
Song, Sungmin;
Lee, Hyeon-Seong;
Kim, Tack-Joong;
Kwon, Hak Cheol;
Park, Keunwan;
Kang, Ki Sung;
Kwon, Jaeyoung

Publication type:

Article

A small molecule Nec-1 directly induces amyloid clearance in the brains of aged APP/PS1 mice.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-40205-5

By:

Yang, Seung-Hoon;
Shin, Jisu;
Shin, Naewoo Neo;
Hwang, Ji-Hyun;
Hong, Sung-Chul;
Park, Keunwan;
Lee, Jae Wook;
Lee, Sejin;
Baek, Seungyeop;
Kim, Kyeonghwan;
Cho, Illhwan;
Kim, YoungSoo

Publication type:

Article

Interaction network among functional drug groups.

Published in:

BMC Systems Biology, 2013, v. 7, p. 1, doi. 10.1186/1752-0509-7-S3-S4

By:

Minho Lee;
Keunwan Park;
Dongsup Kim

Publication type:

Article

Drug-drug relationship based on target information: application to drug target identification.

Published in:

BMC Systems Biology, 2011, v. 5, n. Suppl 2, p. 1, doi. 10.1186/1752-0509-5-S2-S12

By:

Park, Keunwan;
Dongsup Kim

Publication type:

Article

Computational identification of key residues regulating fluorescence emission in a red/green cyanobacteriochrome.

Published in:

Proteins, 2024, v. 92, n. 1, p. 106, doi. 10.1002/prot.26586

By:

Kannan, Priyadharshini;
Oh, Jisung;
Yeon, Young Joo;
Park, Youn‐Il;
Seo, Moon‐Hyeong;
Park, Keunwan

Publication type:

Article

Analysis of the residue-residue coevolution network and the functionally important residues in proteins.

Published in:

Proteins, 2008, v. 72, n. 3, p. 863, doi. 10.1002/prot.21972

By:

Lee, Byung-Chul;
Park, Keunwan;
Kim, Dongsup

Publication type:

Article

Binding similarity network of ligand.

Published in:

Proteins, 2008, v. 71, n. 2, p. 960, doi. 10.1002/prot.21780

By:

Park, Keunwan;
Kim, Dongsup

Publication type:

Article

A High-Affinity Protein Binder that Blocks the IL-6/STAT3 Signaling Pathway Effectively Suppresses Non-Small Cell Lung Cancer.

Published in:

Molecular Therapy, 2014, v. 22, n. 7, p. 1254, doi. 10.1038/mt.2014.59

By:

Lee, Joong-jae;
Kim, Hyun Jung;
Yang, Chul-Su;
Kyeong, Hyun-Ho;
Choi, Jung-Min;
Hwang, Da-Eun;
Yuk, Jae-Min;
Park, Keunwan;
Kim, Yu Jung;
Lee, Seung-Goo;
Kim, Dongsup;
Jo, Eun-Kyeong;
Cheong, Hae-Kap;
Kim, Hak-Sung

Publication type:

Article

New Monocyclic Terpenoid Lactones from a Brown Algae Sargassum macrocarpum as Monoamine Oxidase Inhibitors.

Published in:

Plants (2223-7747), 2022, v. 11, n. 15, p. 1998, doi. 10.3390/plants11151998

By:

Kwon, Jaeyoung;
Lee, Kyerim;
Hwang, Hoseong;
Kim, Seong-Hwan;
Park, Se Eun;
Durai, Prasannavenkatesh;
Park, Keunwan;
Kim, Hyung-Seop;
Jang, Dae Sik;
Choi, Jae Sue;
Kwon, Hak Cheol

Publication type:

Article

Modeling allosteric signal propagation using protein structure networks.

Published in:

BMC Bioinformatics, 2011, v. 12, n. Suppl 1, p. 1, doi. 10.1186/1471-2105-12-S1-S23

By:

Park, Keunwan;
Kim, Dongsup

Publication type:

Article

Selection and Characterization of Monoclonal Antibodies Targeting Middle East Respiratory Syndrome Coronavirus through a Human Synthetic Fab Phage Display Library Panning.

Published in:

Antibodies (2073-4468), 2019, v. 8, n. 3, p. 42, doi. 10.3390/antib8030042

By:

Kim, Yoonji;
Lee, Hansaem;
Park, Keunwan;
Park, Sora;
Lim, Ju-Hyeon;
So, Min Kyung;
Woo, Hye-Min;
Ko, Hyemin;
Lee, Jeong-Min;
Lim, Sun Hee;
Ko, Byoung Joon;
Park, Yeon-Su;
Choi, So-Young;
Song, Du Hyun;
Lee, Joo-Yeon;
Kim, Sung Soon;
Kim, Dae Young

Publication type:

Article

Machine learning-based chemical binding similarity using evolutionary relationships of target genes.

Published in:

Nucleic Acids Research, 2019, v. 47, n. 20, p. e128, doi. 10.1093/nar/gkz743

By:

Park, Keunwan;
Ko, Young-Joon;
Durai, Prasannavenkatesh;
Pan, Cheol-Ho

Publication type:

Article

Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides.

Published in:

Advanced Science, 2025, v. 12, n. 1, p. 1, doi. 10.1002/advs.202406018

By:

Lim, Yun;
Kang, Tae Kyeom;
Kim, Meong Il;
Kim, Dohyeon;
Kim, Ji Yul;
Jung, Sang Hoon;
Park, Keunwan;
Lee, Wook‐Bin;
Seo, Moon‐Hyeong

Publication type:

Article

Massively Parallel Screening of Toll/Interleukin‐1 Receptor (TIR)‐Derived Peptides Reveals Multiple Toll‐Like Receptors (TLRs)‐Targeting Immunomodulatory Peptides (Adv. Sci. 1/2025).

Published in:

Advanced Science, 2025, v. 12, n. 1, p. 1, doi. 10.1002/advs.202570003

By:

Lim, Yun;
Kang, Tae Kyeom;
Kim, Meong Il;
Kim, Dohyeon;
Kim, Ji Yul;
Jung, Sang Hoon;
Park, Keunwan;
Lee, Wook‐Bin;
Seo, Moon‐Hyeong

Publication type:

Article

Dissecting the Critical Factors for Thermodynamic Stability of Modular Proteins Using Molecular Modeling Approach.

Published in:

PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0098243

By:

Lee, Yuno;
Lee, Joong-jae;
Kim, Songmi;
Lee, Sang-Chul;
Han, Jieun;
Heu, Woosung;
Park, Keunwan;
Kim, Hyun Jung;
Cheong, Hae-Kap;
Kim, Dongsup;
Kim, Hak-Sung;
Lee, Keun Woo

Publication type:

Article

tructure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein.

Published in:

PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0030929

By:

Jieun Han;
Hyun Jung Kim;
Sang-Chul Lee;
Seungpyo Hong;
Park, Keunwan;
Jeon, Young Ho;
Dongsup Kim;
Cheong, Hae-Kap;
Hak-Sung Kim

Publication type:

Article

Control of repeat-protein curvature by computational protein design.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 2, p. 167, doi. 10.1038/nsmb.2938

By:

Park, Keunwan;
Shen, Betty W;
Parmeggiani, Fabio;
Huang, Po-Ssu;
Stoddard, Barry L;
Baker, David

Publication type:

Article

NPF activates a specific NPF receptor and regulates food intake in Pacific abalone Haliotis discus hannai.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-00238-1

By:

Kim, Kyeong Seop;
Kim, Mi Ae;
Park, Keunwan;
Sohn, Young Chang

Publication type:

Article

Rhizolutin directly dissociates Aβ and tau aggregates and reduces apoptosis/inflammation related to Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.049661

By:

Shin, Jisu;
Kwon, Yun;
Nam, Kwangho;
An, Joon Soo;
Yang, Seung‐Hoon;
Hong, Seong‐Heon;
Bae, Munhyung;
Moon, Kyuho;
Cho, Yakdol;
Woo, Jiwan;
Park, Keunwan;
Kim, Kyeonghwan;
Shin, Jongheon;
Kim, Byung‐Yong;
Kim, YoungSoo;
Oh, Dong‐Chan

Publication type:

Article

Glycosylated and Succinylated Macrocyclic Lactones with Amyloid-β-Aggregation-Regulating Activity from a Marine Bacillus sp.

Published in:

Marine Drugs, 2023, v. 21, n. 2, p. 67, doi. 10.3390/md21020067

By:

Cui, Jinsheng;
Ye, Suhyun;
Shin, Daniel;
Cho, Illhwan;
Kim, Hye Yun;
Kwon, Yun;
Park, Keunwan;
Nam, Sang-Jip;
Kim, YoungSoo;
Oh, Dong-Chan

Publication type:

Article

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods.

Published in:

Molecules, 2021, v. 26, n. 3, p. 566, doi. 10.3390/molecules26030566

By:

Durai, Prasannavenkatesh;
Ko, Young-Joon;
Kim, Jin-Chul;
Pan, Cheol-Ho;
Park, Keunwan;
Toropova, Alla P.

Publication type:

Article

Janus Nanosheets with Face‐Selective Molecular Recognition Properties from DNA–Peptide Conjugates.

Published in:

Small, 2021, v. 17, n. 12, p. 1, doi. 10.1002/smll.202006110

By:

Albert, Shine K.;
Lee, Sunghee;
Durai, Prasannavenkatesh;
Hu, Xiaole;
Jeong, Byeongmoon;
Park, Keunwan;
Park, So‐Jung

Publication type:

Article

Multi-input chemical control of protein dimerization for programming graded cellular responses.

Published in:

Nature Biotechnology, 2019, v. 37, n. 10, p. 1209, doi. 10.1038/s41587-019-0242-8

By:

Foight, Glenna Wink;
Wang, Zhizhi;
Wei, Cindy T.;
Jr Greisen, Per;
Warner, Katrina M.;
Cunningham-Bryant, Daniel;
Park, Keunwan;
Brunette, T. J.;
Sheffler, William;
Baker, David;
Maly, Dustin J.

Publication type:

Article

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening.

Published in:

BMC Bioinformatics, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s12859-020-03643-x

By:

Durai, Prasannavenkatesh;
Ko, Young-Joon;
Pan, Cheol-Ho;
Park, Keunwan

Publication type:

Article