Works by Park, Hwangseo

Results: 43

Targeting CD155 in lung adenocarcinoma: A5 nanobody-based therapeutics for precision treatment and enhanced drug delivery.

Published in:

Signal Transduction & Targeted Therapy, 2025, v. 10, n. 1, p. 1, doi. 10.1038/s41392-025-02301-z

By:

Noh, Kyunghee;
Yi, Soyeon;
Kim, Hyeran;
Lee, Jieun;
Kim, Suhyeon;
Yoo, Wonbeak;
Jung, Eunkyeong;
Choi, Jinsol;
Park, Hwangseo;
Hwang, Seungha;
Kang, Jin Young;
Park, Kwang-Hyun;
Park, Heewon;
Lee, Yong-kyu;
Lim, Eun-Kyung;
Kang, Taejoon;
Jung, Juyeon

Publication type:

Article

Accuracy enhancement in the estimation of molecular hydration free energies by implementing the intramolecular hydrogen bond effects.

Published in:

Journal of Cheminformatics, 2015, v. 7, p. 1, doi. 10.1186/s13321-015-0106-2

By:

Kee-Choo Chung;
Hwangseo Park

Publication type:

Article

New solvation free energy function comprising intermolecular solvation and intramolecular self-solvation terms.

Published in:

Journal of Cheminformatics, 2013, v. 5, n. 1, p. 1, doi. 10.1186/1758-2946-5-8

By:

Hwanho Choi;
Hongsuk Kang;
Hwangseo Park

Publication type:

Article

Derivation of Highly Predictive 3D-QSAR Models for hERG Channel Blockers Based on the Quantum Artificial Neural Network Algorithm.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 11, p. 1509, doi. 10.3390/ph16111509

By:

Kim, Taeho;
Chung, Kee-Choo;
Park, Hwangseo

Publication type:

Article

Structure-Based Virtual Screening and De Novo Design of PIM1 Inhibitors with Anticancer Activity from Natural Products.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 3, p. 275, doi. 10.3390/ph14030275

By:

Park, Hwangseo;
Jeon, Jinwon;
Kim, Kewon;
Choi, Soyeon;
Hong, Sungwoo;
Santos, Paulo

Publication type:

Article

Toward the virtual screening of Cdc25A phosphatase inhibitors with the homology modeled protein structure.

Published in:

Journal of Molecular Modeling, 2008, v. 14, n. 9, p. 833, doi. 10.1007/s00894-008-0311-2

By:

Hwangseo Park;
Young Jeon

Publication type:

Article

Critical assessment of the automated AutoDock as a new docking tool for virtual screening.

Published in:

Proteins, 2006, v. 65, n. 3, p. 549, doi. 10.1002/prot.21183

By:

Park, Hwangseo;
Lee, Jinuk;
Lee, Sangyoub

Publication type:

Article

Anticancer activity of a novel small molecule tubulin inhibitor STK899704.

Published in:

PLoS ONE, 2017, v. 12, n. 3, p. 1, doi. 10.1371/journal.pone.0173311

By:

Sakchaisri, Krisada;
Kim, Sun-Ok;
Hwang, Joonsung;
Soung, Nak Kyun;
Lee, Kyung Ho;
Choi, Tae Woong;
Lee, Yongjun;
Park, Chan-Mi;
Thimmegowda, Naraganahalli R.;
Lee, Phil Young;
Shwetha, Bettaswamigowda;
Srinivasrao, Ganipisetti;
Pham, Thi Thu Huong;
Jang, Jae-Hyuk;
Yum, Hye-Won;
Surh, Young-Joon;
Lee, Kyung S.;
Park, Hwangseo;
Kim, Seung Jun;
Kwon, Yong Tae

Publication type:

Article

Molecular Characterization of Two Monoclonal Antibodies against the Same Epitope on B-Cell Receptor Associated Protein 31.

Published in:

PLoS ONE, 2016, v. 11, n. 12, p. 1, doi. 10.1371/journal.pone.0167527

By:

Kim, Won-Tae;
Shin, Saemina;
Hwang, Hyo Jeong;
Kim, Min Kyu;
Jung, Han-Sung;
Park, Hwangseo;
Ryu, Chun Jeih

Publication type:

Article

Structure-Based De Novo Design for the Discovery of Miniprotein Inhibitors Targeting Oncogenic Mutant BRAF.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 10, p. 5535, doi. 10.3390/ijms25105535

By:

Ham, Jae Min;
Kim, Myeongbin;
Kim, Taeho;
Ryu, Seong Eon;
Park, Hwangseo

Publication type:

Article

Structure-Based Virtual Screening and De Novo Design to Identify Submicromolar Inhibitors of G2019S Mutant of Leucine-Rich Repeat Kinase 2.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12825, doi. 10.3390/ijms232112825

By:

Park, Hwangseo;
Kim, Taeho;
Kim, Kewon;
Jang, Ahyoung;
Hong, Sungwoo

Publication type:

Article

Quantum Artificial Neural Network Approach to Derive a Highly Predictive 3D-QSAR Model for Blood–Brain Barrier Passage.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 20, p. 10995, doi. 10.3390/ijms222010995

By:

Kim, Taeho;
You, Byoung Hoon;
Han, Songhee;
Shin, Ho Chul;
Chung, Kee-Choo;
Park, Hwangseo

Publication type:

Article

Rational Computational Design of Fourth-Generation EGFR Inhibitors to Combat Drug-Resistant Non-Small Cell Lung Cancer.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 23, p. 9323, doi. 10.3390/ijms21239323

By:

Park, Hwangseo;
Jung, Hoi-Yun;
Kim, Kewon;
Kim, Myojeong;
Hong, Sungwoo

Publication type:

Article

Blockade of the vaspin–AP-1 axis inhibits arthritis development.

Published in:

Experimental & Molecular Medicine EMM, 2025, v. 57, n. 3, p. 628, doi. 10.1038/s12276-025-01418-z

By:

Jeon, Jimin;
Cho, Chanmi;
Kim, Seoyeong;
Kim, Hyeran;
Lee, Hyemi;
Kim, Seok Jung;
Park, Hwangseo;
Yu, Ji Hoon;
Lee, Sangho;
Lee, Kyu-Sun;
Jung, Juyeon;
Yang, Siyoung

Publication type:

Article

Structural basis for recognition of the tumor suppressor protein PTPN14 by the oncoprotein E7 of human papillomavirus.

Published in:

PLoS Biology, 2019, v. 17, n. 7, p. 1, doi. 10.1371/journal.pbio.3000367

By:

Yun, Hye-Yeoung;
Kim, Min Wook;
Lee, Hye Seon;
Kim, Wantae;
Shin, Ji Hye;
Kim, Hyunmin;
Shin, Ho-Chul;
Park, Hwangseo;
Oh, Byung-Ha;
Kim, Won Kon;
Bae, Kwang-Hee;
Lee, Sang Chul;
Lee, Eun-Woo;
Ku, Bonsu;
Kim, Seung Jun

Publication type:

Article

Two-track virtual screening approach to identify both competitive and allosteric inhibitors of human small C-terminal domain phosphatase 1.

Published in:

Journal of Computer-Aided Molecular Design, 2017, v. 31, n. 8, p. 743, doi. 10.1007/s10822-017-0037-2

By:

Park, Hwangseo;
Lee, Hye;
Ku, Bonsu;
Lee, Sang-Rae;
Kim, Seung

Publication type:

Article

Extended solvent-contact model approach to blind SAMPL5 prediction challenge for the distribution coefficients of drug-like molecules.

Published in:

Journal of Computer-Aided Molecular Design, 2016, v. 30, n. 11, p. 1019, doi. 10.1007/s10822-016-9928-x

By:

Chung, Kee-Choo;
Park, Hwangseo

Publication type:

Article

Extended solvent-contact model approach to SAMPL4 blind prediction challenge for hydration free energies.

Published in:

Journal of Computer-Aided Molecular Design, 2014, v. 28, n. 3, p. 175, doi. 10.1007/s10822-014-9729-z

By:

Park, Hwangseo

Publication type:

Article

Identification of common inhibitors of wild-type and T315I mutant of BCR-ABL through the parallel structure-based virtual screening.

Published in:

Journal of Computer-Aided Molecular Design, 2012, v. 26, n. 8, p. 983, doi. 10.1007/s10822-012-9593-7

By:

Park, Hwangseo;
Hong, Seunghee;
Hong, Sungwoo

Publication type:

Article

Identification of novel inhibitors of mitogen-activated protein kinase phosphatase-1 with structure-based virtual screening.

Published in:

Journal of Computer-Aided Molecular Design, 2011, v. 25, n. 5, p. 469, doi. 10.1007/s10822-011-9432-2

By:

Park, Hwangseo;
Jeon, Jeong-Yi;
Kim, Song;
Jeong, Dae;
Ryu, Seong

Publication type:

Article

Free energy perturbation approach to the critical assessment of selective cyclooxygenase-2 inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2005, v. 19, n. 1, p. 17, doi. 10.1007/s10822-005-0098-5

By:

Hwangseo Park;
Sangyoub Lee

Publication type:

Article

Homology modeling, force field design, and free energy simulation studies to optimize the activities of histone deacetylase inhibitors.

Published in:

Journal of Computer-Aided Molecular Design, 2004, v. 18, n. 6, p. 375, doi. 10.1007/s10822-004-2283-3

By:

Park, Hwangseo;
Lee, Sangyoub

Publication type:

Article

A Tubulin Inhibitor, N-(5-Benzyl-1,3-thiazol-2-yl)-3-(furan-2-yl)prop-2-enamide, Induces Anti-inflammatory Innate Immune Responses to Attenuate LPS-mediated Septic Shock.

Published in:

Bulletin of the Korean Chemical Society, 2014, v. 35, n. 11, p. 3307, doi. 10.5012/bkcs.2014.35.11.3307

By:

Hyun Jung Park;
Sung Won Lee;
Hwangseo Park;
Se-Ho Park;
Seokmann Hong

Publication type:

Article

Discovery of Novel DUSP4 Inhibitors through the Virtual Screening with Docking Simulations.

Published in:

Bulletin of the Korean Chemical Society, 2014, v. 35, n. 9, p. 2655, doi. 10.5012/bkcs.2014.35.9.2655

By:

Hwangseo Park;
Tae Jin Jeon;
Pham Ngoc Chien;
So Ya Park;
Sung Min Oh;
Seung Jun Kim;
Seong Eon Ryu

Publication type:

Article

MetLigDB: a web-based database for the identification of chemical groups to design metalloprotein inhibitors.

Published in:

Journal of Applied Crystallography, 2011, v. 44, n. 4, p. 878, doi. 10.1107/S0021889811022503

By:

Choi, Hwanho;
Kang, Hongsuk;
Park, Hwangseo

Publication type:

Article

New angle-dependent potential energy function for backbone–backbone hydrogen bond in protein–protein interactions.

Published in:

Journal of Computational Chemistry, 2010, v. 31, n. 5, p. 897, doi. 10.1002/jcc.21378

By:

HWANHO CHOI;
HONGSUK KANG;
HWANGSEO PARK

Publication type:

Article

Loop Flexibility and Solvent Dynamics as Determinants for the Selective Inhibition of Cyclin-Dependent Kinase 4: Comparative Molecular Dynamics Simulation Studies of CDK2 and CDK4.

Published in:

ChemBioChem, 2004, v. 5, n. 12, p. 1662, doi. 10.1002/cbic.200400214

By:

Hwangseo Park;
Min Sun Yeom;
Sangyoub Lee

Publication type:

Article

A human protein hydroxylase that accepts D-residues.

Published in:

Communications Chemistry, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s42004-020-0290-5

By:

Choi, Hwanho;
Hardy, Adam P.;
Leissing, Thomas M.;
Chowdhury, Rasheduzzaman;
Nakashima, Yu;
Ge, Wei;
Markoulides, Marios;
Scotti, John S.;
Gerken, Philip A.;
Thorbjornsrud, Helen;
Kang, Dahye;
Hong, Sungwoo;
Lee, Joongoo;
McDonough, Michael A.;
Park, Hwangseo;
Schofield, Christopher J.

Publication type:

Article

Rapid and simple detection of Tamiflu-resistant influenza virus: Development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-31311-x

By:

Hwang, Seul Gee;
Ha, Kab;
Guk, Kyeonghye;
Lee, Do Kyung;
Eom, Gayoung;
Song, Sinae;
Kang, Taejoon;
Park, Hwangseo;
Jung, Juyeon;
Lim, Eun-Kyung

Publication type:

Article

Nocodazole is a High-Affinity Ligand for the Cancer-Related Kinases ABL, c-KIT, BRAF, and MEK.

Published in:

ChemMedChem, 2012, v. 7, n. 1, p. 53, doi. 10.1002/cmdc.201100410

By:

Park, Hwangseo;
Hong, Seunghee;
Hong, Sungwoo

Publication type:

Article

Discovery of VHR Phosphatase Inhibitors with Micromolar Activity based on Structure-Based Virtual Screening.

Published in:

ChemMedChem, 2008, v. 3, n. 6, p. 877, doi. 10.1002/cmdc.200700348

By:

Park, Hwangseo;
Jung, Suk-Kyeong;
Jeong, Dae Gwin;
Ryu, Seong Eon;
Kim, Seung Jun

Publication type:

Article

Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulations.

Published in:

Theoretical Biology & Medical Modelling, 2013, v. 10, n. 1, p. 1, doi. 10.1186/1742-4682-10-49

By:

Hwangseo Park;
Keum Ran Yu;
Bonsu Ku;
Bo Yeon Kim;
Seung Jun Kim

Publication type:

Article

Virtual Screening and Biochemical Evaluation to Identify the Allosteric Inhibitors of Dual Specificity Phosphatase 1.

Published in:

Bulletin of the Korean Chemical Society, 2019, v. 40, n. 3, p. 236, doi. 10.1002/bkcs.11670

By:

Park, Hwangseo;
Kim, Myeongbin;
Park, Tae Hyun;
Jeon, Tae Jin;
Chun, Ha‐Jung;
Eon Ryu, Seong

Publication type:

Article

Discovery of Novel Striatal-enriched Protein Tyrosine Phosphatase Inhibitors Through Structure-based Virtual Screening.

Published in:

Bulletin of the Korean Chemical Society, 2016, v. 37, n. 11, p. 1783, doi. 10.1002/bkcs.10974

By:

Ku, Bonsu;
You, Jin A;
Lee, Hye Seon;
Shin, Ho-Chul;
Park, Hwangseo;
Kim, Seung Jun

Publication type:

Article

Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugation.

Published in:

Molecular Cancer, 2025, v. 24, n. 1, p. 1, doi. 10.1186/s12943-025-02325-7

By:

Yi, Soyeon;
Noh, Kyunghee;
Kim, Hyeran;
Jung, Eunkyeong;
Kim, Suhyeon;
Lee, Jieun;
Guk, Kyeonghye;
Choi, Jinsol;
Lim, Eun-Kyung;
Kim, Seokho;
Park, Hwangseo;
Lim, Jung Hwa;
Jung, Cho-Rok;
Kang, Taejoon;
Jung, Juyeon

Publication type:

Article

Discovery of EGF Receptor Inhibitors That Are Selective for the d746 -750/T790M/C797S Mutant through Structure-Based de Novo Design.

Published in:

Angewandte Chemie, 2017, v. 129, n. 26, p. 7742, doi. 10.1002/ange.201703389

By:

Park, Hwangseo;
Jung, Hoi ‐ Yun;
Mah, Shinmee;
Hong, Sungwoo

Publication type:

Article

Isoxazol-5(4 H)one Derivatives as PTP1B Inhibitors Showing an Anti-Obesity Effect.

Published in:

Chemistry - An Asian Journal, 2011, v. 6, n. 8, p. 2073, doi. 10.1002/asia.201100154

By:

Kafle, Bhooshan;
Aher, Nilkanth G.;
Khadka, Deegendra;
Park, Hwangseo;
Cho, Hyeongjin

Publication type:

Article

Graphite as a Long‐Life Ca<sup>2+</sup>‐Intercalation Anode and its Implementation for Rocking‐Chair Type Calcium‐Ion Batteries.

Published in:

Advanced Science, 2019, v. 6, n. 24, p. N.PAG, doi. 10.1002/advs.201902129

By:

Richard Prabakar, S. J.;
Ikhe, Amol Bhairuba;
Park, Woon Bae;
Chung, Kee‐Choo;
Park, Hwangseo;
Kim, Ki‐Jeong;
Ahn, Docheon;
Kwak, Joon Seop;
Sohn, Kee‐Sun;
Pyo, Myoungho

Publication type:

Article

Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17246-w

By:

Guk, Kyeonghye;
Kim, Hyeran;
Lee, Miyeon;
Choi, Yoon-Aa;
Hwang, Seul Gee;
Han, Gaon;
Kim, Hye-Nan;
Kim, Hongki;
Park, Hwangseo;
Yong, Dongeun;
Kang, Taejoon;
Lim, Eun-Kyung;
Jung, Juyeon

Publication type:

Article

Discovery of EGF Receptor Inhibitors That Are Selective for the d746 -750/T790M/C797S Mutant through Structure-Based de Novo Design.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 26, p. 7634, doi. 10.1002/anie.201703389

By:

Park, Hwangseo;
Jung, Hoi-Yun;
Mah, Shinmee;
Hong, Sungwoo

Publication type:

Article

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.

Published in:

Scientific Reports, 2016, p. 21772, doi. 10.1038/srep21772

By:

Park, Dohyun;
Jeong, Heeyoon;
Lee, Mi Nam;
Koh, Ara;
Kwon, Ohman;
Yang, Yong Ryoul;
Noh, Jungeun;
Suh, Pann-Ghill;
Park, Hwangseo;
Ryu, Sung Ho

Publication type:

Article

NPCARE: database of natural products and fractional extracts for cancer regulation.

Published in:

Journal of Cheminformatics, 2017, v. 9, n. 1, p. 1, doi. 10.1186/s13321-016-0188-5

By:

Choi, Hwanho;
Cho, Sun;
Pak, Ho;
Kim, Youngsoo;
Choi, Jung-yun;
Lee, Yoon;
Gong, Byung;
Kang, Yeon;
Han, Taehoon;
Choi, Geunbae;
Cho, Yeeun;
Lee, Soomin;
Ryoo, Dekwoo;
Park, Hwangseo

Publication type:

Article

Structure-Based Virtual Screening Approach to the Discovery of Novel Inhibitors of Eyes Absent 2 Phosphatase with Various Metal Chelating Moieties.

Published in:

Chemical Biology & Drug Design, 2011, v. 78, n. 4, p. 642, doi. 10.1111/j.1747-0285.2011.01192.x

By:

Hwangseo Park;
Suk-Kyeong Jung;
Yu, Keum R.;
Kim, Ju H.;
Yong-Sam Kim;
Ko, Jeong H.;
Park, Byoung C.;
Kim, Seung J.

Publication type:

Article