Found: 27

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  • Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.

    Published in:
    Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-023-00700-w
    By:
    • Bosch, Megan E.;
    • Dodiya, Hemraj B.;
    • Michalkiewicz, Julia;
    • Lee, Choonghee;
    • Shaik, Shabana M.;
    • Weigle, Ian Q.;
    • Zhang, Can;
    • Osborn, Jack;
    • Nambiar, Aishwarya;
    • Patel, Priyam;
    • Parhizkar, Samira;
    • Zhang, Xiaoqiong;
    • Laury, Marie L.;
    • Mondal, Prasenjit;
    • Gomm, Ashley;
    • Schipma, Matthew John;
    • Mallah, Dania;
    • Butovsky, Oleg;
    • Chang, Eugene B.;
    • Tanzi, Rudolph E.
    Publication type:
    Article

  • Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice.

    Published in:
    Science Translational Medicine, 2023, v. 15, n. 693, p. 1, doi. 10.1126/scitranslmed.ade6285
    By:
    • Parhizkar, Samira;
    • Gent, Grace;
    • Chen, Yun;
    • Rensing, Nicholas;
    • Gratuze, Maud;
    • Strout, Gregory;
    • Sviben, Sanja;
    • Tycksen, Eric;
    • Zhang, Qiang;
    • Gilmore, Petra Erdmann;
    • Sprung, Robert;
    • Malone, Jim;
    • Chen, Wei;
    • Remolina Serrano, Javier;
    • Bao, Xin;
    • Lee, Choonghee;
    • Wang, Chanung;
    • Landsness, Eric;
    • Fitzpatrick, James;
    • Wong, Michael
    Publication type:
    Article

  • Glitter in the darkness? Non‐fibrillar β‐amyloid plaque components significantly impact the β‐amyloid PET signal.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.051983
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz Josef;
    • von Ungern‐Sternberg, Barbara;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • Differential interaction with TREM2 modulates microglial uptake of modified Aβ species.

    Published in:
    Glia, 2021, v. 69, n. 12, p. 2917, doi. 10.1002/glia.24077
    By:
    • Joshi, Pranav;
    • Riffel, Florian;
    • Satoh, Kanayo;
    • Enomoto, Masahiro;
    • Qamar, Seema;
    • Scheiblich, Hannah;
    • Villacampa, Nàdia;
    • Kumar, Sathish;
    • Theil, Sandra;
    • Parhizkar, Samira;
    • Haass, Christian;
    • Heneka, Michael T.;
    • Fraser, Paul E.;
    • St George‐Hyslop, Peter;
    • Walter, Jochen
    Publication type:
    Article

  • Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer’s Disease.

    Published in:
    Journal of Nuclear Medicine, 2021, v. 62, n. 12, p. 1, doi. 10.2967/jnumed.120.261858
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz-Josef;
    • Ungern-Sternberg, Barbara von;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F.;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer’s Disease .

    Published in:
    Journal of Nuclear Medicine, 2021, v. 62, n. 11, p. 1, doi. 10.2967/jnumed.120.261858
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz-Josef;
    • Ungern-Sternberg, Barbara von;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F.;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits.

    Published in:
    Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-021-01263-x
    By:
    • Joshi, Pranav;
    • Riffel, Florian;
    • Kumar, Sathish;
    • Villacampa, Nàdia;
    • Theil, Sandra;
    • Parhizkar, Samira;
    • Haass, Christian;
    • Colonna, Marco;
    • Heneka, Michael T.;
    • Arzberger, Thomas;
    • Herms, Jochen;
    • Walter, Jochen
    Publication type:
    Article

  • Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer’s Disease.

    Published in:
    Journal of Nuclear Medicine, 2021, v. 62, n. 10, p. 1, doi. 10.2967/jnumed.120.261858
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz-Josef;
    • Ungern-Sternberg, Barbara von;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F.;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease.

    Published in:
    Journal of Nuclear Medicine, 2021, v. 62, n. 8, p. 1, doi. 10.2967/jnumed.120.261858
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz-Josef;
    • von Ungern-Sternberg, Barbara;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F.;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease.

    Published in:
    Journal of Nuclear Medicine, 2021, v. 62, n. 7, p. 1, doi. 10.2967/jnumed.120.261858
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz-Josef;
    • von Ungern-Sternberg, Barbara;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F.;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease.

    Published in:
    Journal of Nuclear Medicine, 2021, v. 62, n. 6, p. 1, doi. 10.2967/jnumed.120.261858
    By:
    • Biechele, Gloria;
    • Monasor, Laura Sebastian;
    • Wind, Karin;
    • Blume, Tanja;
    • Parhizkar, Samira;
    • Arzberger, Thomas;
    • Sacher, Christian;
    • Beyer, Leonie;
    • Eckenweber, Florian;
    • Gildehaus, Franz-Josef;
    • von Ungern-Sternberg, Barbara;
    • Willem, Michael;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel;
    • Herms, Jochen;
    • Lichtenthaler, Stefan F.;
    • Haass, Christian;
    • Tahirovic, Sabina;
    • Brendel, Matthias
    Publication type:
    Article

  • Microbiota-derived short chain fatty acids modulate microglia and promote Ab plaque deposition.

    Published in:
    eLife, 2021, p. 1, doi. 10.7554/eLife.59826
    By:
    • Colombo, Alessio Vittorio;
    • Sadler, Rebecca Katie;
    • Llovera, Gemma;
    • Singh, Vikramjeet;
    • Roth, Stefan;
    • Heindl, Steffanie;
    • Monasor, Laura Sebastian;
    • Verhoeven, Aswin;
    • Peters, Finn;
    • Parhizkar, Samira;
    • Kamp, Frits;
    • Gomez de Aguero, Mercedes;
    • MacPherson, Andrew J.;
    • Winkler, Edith;
    • Herms, Jochen;
    • Benakis, Corinne;
    • Dichgans, Martin;
    • Steiner, Harald;
    • Giera, Martin;
    • Haass, Christian
    Publication type:
    Article

  • Asymmetry of plaque burden in amyloid mouse models: Neuroimaging / animal imaging.

    Published in:
    Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.039153
    By:
    • Biechele, Gloria;
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz Josef;
    • von Ungern‐Sternberg, Barbara;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 12, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • von Ungern-Sternberg, Barbara;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 11, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • von Ungern-Sternberg, Barbara;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 10, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • UngernSternberg, Barbara von;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.

    Published in:
    Molecular Neurodegeneration, 2020, v. 15, n. 1, p. N.PAG, doi. 10.1186/s13024-020-00402-7
    By:
    • Takalo, Mari;
    • Wittrahm, Rebekka;
    • Wefers, Benedikt;
    • Parhizkar, Samira;
    • Jokivarsi, Kimmo;
    • Kuulasmaa, Teemu;
    • Mäkinen, Petra;
    • Martiskainen, Henna;
    • Wurst, Wolfgang;
    • Xiang, Xianyuan;
    • Marttinen, Mikael;
    • Poutiainen, Pekka;
    • Haapasalo, Annakaisa;
    • Hiltunen, Mikko;
    • Haass, Christian
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 9, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • Ungern-Sternberg, Barbara von;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 7, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • von Ungern-Sternberg, Barbara;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 6, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • Ungern-Sternberg, Barbara von;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Asymmetry of fibrillar plaque burden in amyloid mouse models.

    Published in:
    Journal of Nuclear Medicine, 2020, v. 61, n. 5, p. 1, doi. 10.2967/jnumed.120.242750
    By:
    • Sacher, Christian;
    • Blume, Tanja;
    • Beyer, Leonie;
    • Biechele, Gloria;
    • Sauerbeck, Julia;
    • Eckenweber, Florian;
    • Deussing, Maximilian;
    • Focke, Carola;
    • Parhizkar, Samira;
    • Lindner, Simon;
    • Gildehaus, Franz-Josef;
    • Ungern-Sternberg, Barbaravon;
    • Baumann, Karlheinz;
    • Tahirovic, Sabina;
    • Kleinberger, Gernot;
    • Willem, Michael;
    • Haass, Christian;
    • Bartenstein, Peter;
    • Cumming, Paul;
    • Rominger, Axel
    Publication type:
    Article

  • Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.

    Published in:
    EMBO Molecular Medicine, 2020, v. 12, n. 4, p. 1, doi. 10.15252/emmm.201911227
    By:
    • Schlepckow, Kai;
    • Monroe, Kathryn M;
    • Kleinberger, Gernot;
    • Cantuti‐Castelvetri, Ludovico;
    • Parhizkar, Samira;
    • Xia, Dan;
    • Willem, Michael;
    • Werner, Georg;
    • Pettkus, Nadine;
    • Brunner, Bettina;
    • Sülzen, Alice;
    • Nuscher, Brigitte;
    • Hampel, Heike;
    • Xiang, Xianyuan;
    • Feederle, Regina;
    • Tahirovic, Sabina;
    • Park, Joshua I;
    • Prorok, Rachel;
    • Mahon, Cathal;
    • Liang, Chun‐Chi
    Publication type:
    Article

  • Active poly‐GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.

    Published in:
    EMBO Molecular Medicine, 2020, v. 12, n. 2, p. N.PAG, doi. 10.15252/emmm.201910919
    By:
    • Zhou, Qihui;
    • Mareljic, Nikola;
    • Michaelsen, Meike;
    • Parhizkar, Samira;
    • Heindl, Steffanie;
    • Nuscher, Brigitte;
    • Farny, Daniel;
    • Czuppa, Mareike;
    • Schludi, Carina;
    • Graf, Alexander;
    • Krebs, Stefan;
    • Blum, Helmut;
    • Feederle, Regina;
    • Roth, Stefan;
    • Haass, Christian;
    • Arzberger, Thomas;
    • Liesz, Arthur;
    • Edbauer, Dieter
    Publication type:
    Article

  • Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.

    Published in:
    EMBO Molecular Medicine, 2019, v. 11, n. 6, p. N.PAG, doi. 10.15252/emmm.201809711
    By:
    • Götzl, Julia K;
    • Brendel, Matthias;
    • Werner, Georg;
    • Parhizkar, Samira;
    • Sebastian Monasor, Laura;
    • Kleinberger, Gernot;
    • Colombo, Alessio‐Vittorio;
    • Deussing, Maximilian;
    • Wagner, Matias;
    • Winkelmann, Juliane;
    • Diehl‐Schmid, Janine;
    • Levin, Johannes;
    • Fellerer, Katrin;
    • Reifschneider, Anika;
    • Bultmann, Sebastian;
    • Bartenstein, Peter;
    • Rominger, Axel;
    • Tahirovic, Sabina;
    • Smith, Scott T;
    • Madore, Charlotte
    Publication type:
    Article

  • The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.

    Published in:
    EMBO Journal, 2017, v. 36, n. 13, p. 1837, doi. 10.15252/embj.201796516
    By:
    • Kleinberger, Gernot;
    • Brendel, Matthias;
    • Mracsko, Eva;
    • Wefers, Benedikt;
    • Groeneweg, Linda;
    • Xiang, Xianyuan;
    • Focke, Carola;
    • Deußing, Maximilian;
    • Suárez‐Calvet, Marc;
    • Mazaheri, Fargol;
    • Parhizkar, Samira;
    • Pettkus, Nadine;
    • Wurst, Wolfgang;
    • Feederle, Regina;
    • Bartenstein, Peter;
    • Mueggler, Thomas;
    • Arzberger, Thomas;
    • Knuesel, Irene;
    • Rominger, Axel;
    • Haass, Christian
    Publication type:
    Article

  • Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models.

    Published in:
    Scientific Reports, 2016, p. 19880, doi. 10.1038/srep19880
    By:
    • Pardon, Marie-Christine;
    • Yanez Lopez, Maria;
    • Yuchun, Ding;
    • Marjańska, Małgorzata;
    • Prior, Malcolm;
    • Brignell, Christopher;
    • Parhizkar, Samira;
    • Agostini, Alessandra;
    • Bai, Li;
    • Auer, Dorothee P.;
    • Faas, Henryk M
    Publication type:
    Article

  • A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.

    Published in:
    Acta Neuropathologica, 2014, v. 127, n. 5, p. 667, doi. 10.1007/s00401-014-1254-6
    By:
    • Ahmed, Zeshan;
    • Cooper, Jane;
    • Murray, Tracey;
    • Garn, Katya;
    • McNaughton, Emily;
    • Clarke, Hannah;
    • Parhizkar, Samira;
    • Ward, Mark;
    • Cavallini, Annalisa;
    • Jackson, Samuel;
    • Bose, Suchira;
    • Clavaguera, Florence;
    • Tolnay, Markus;
    • Lavenir, Isabelle;
    • Goedert, Michel;
    • Hutton, Michael;
    • O'Neill, Michael
    Publication type:
    Article