Works by Papo, Niv

Results: 33

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy.

Published in:

Biochemical Journal, 2021, v. 478, n. 5, p. 1139, doi. 10.1042/BCJ20200628

By:

Yosef, Gal;
Hayun, Hezi;
Papo, Niv

Publication type:

Article

Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method.

Published in:

Biochemical Journal, 2020, v. 477, n. 9, p. 1701, doi. 10.1042/BCJ20200188

By:

Aharon, Lidan;
Aharoni, Shay-Lee;
Radisky, Evette S.;
Papo, Niv

Publication type:

Article

MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.

Published in:

Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0130-4

By:

Shvil, Neta;
Banerjee, Victor;
Zoltsman, Guy;
Shani, Tom;
Kahn, Joy;
Abu-Hamad, Salah;
Papo, Niv;
Engel, Stanislav;
Bernhagen, Jurgen;
Israelson, Adrian

Publication type:

Article

Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs).

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12731-2

By:

Meltzer, M.;
Zvagelsky, T.;
Hadad, U.;
Papo, Niv;
Engel, Stanislav

Publication type:

Article

A KLK4 proteinase substrate capture approach to antagonize PAR1.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95666-4

By:

Rabinovitch, Eitan;
Mihara, Koishiro;
Sananes, Amiram;
Zaretsky, Marianna;
Heyne, Michael;
Shifman, Julia;
Aharoni, Amir;
Hollenberg, Morley D.;
Papo, Niv

Publication type:

Article

Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39076-8

By:

Tzuri, Noam;
Yegodayev, Ksenia M.;
Novoplansky, Ofra;
Elkabets, Moshe;
Aharoni, Amir;
Papo, Niv

Publication type:

Article

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06403-x

By:

Naftaly, Si;
Cohen, Itay;
Shahar, Anat;
Hockla, Alexandra;
Radisky, Evette S.;
Papo, Niv

Publication type:

Article

Correction: Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

Published in:

2017

By:

Dalton, Annamarie C.;
Shlamkovitch, Tomer;
Papo, Niv;
Barton, William A.

Publication type:

Correction Notice

Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.

Published in:

Cancers, 2021, v. 13, n. 16, p. 3969, doi. 10.3390/cancers13163969

By:

Candido, Juliana B.;
Maiques, Oscar;
Boxberg, Melanie;
Kast, Verena;
Peerani, Eleonora;
Tomás-Bort, Elena;
Weichert, Wilko;
Sananes, Amiram;
Papo, Niv;
Magdolen, Viktor;
Sanz-Moreno, Victoria;
Loessner, Daniela

Publication type:

Article

A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and αvβ3 integrin for osteoporosis therapy.

Published in:

PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2002979

By:

Zur, Yuval;
Rosenfeld, Lior;
Keshelman, Chen Anna;
Dalal, Nofar;
Guterman-Ram, Gali;
Orenbuch, Ayelet;
Einav, Yulia;
Levaot, Noam;
Papo, Niv

Publication type:

Article

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies.

Published in:

Molecules, 2020, v. 25, n. 20, p. 4850, doi. 10.3390/molecules25204850

By:

Tilayov, Tal;
Hingaly, Tal;
Greenshpan, Yariv;
Cohen, Shira;
Akabayov, Barak;
Gazit, Roi;
Papo, Niv;
Fantacuzzi, Marialuigia;
Ammazzalorso, Alessandra

Publication type:

Article

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14.

Published in:

FEBS Letters, 2018, v. 592, n. 7, p. 1122, doi. 10.1002/1873-3468.13016

By:

Shirian, Jason;
Arkadash, Valeria;
Cohen, Itay;
Sapir, Tamila;
Radisky, Evette S.;
Papo, Niv;
Shifman, Julia M.

Publication type:

Article

Targeting the Tie2–αvβ3 integrin axis with bi-specific reagents for the inhibition of angiogenesis.

Published in:

BMC Biology, 2018, v. 16, n. 1, p. 1, doi. 10.1186/s12915-018-0557-9

By:

Shlamkovich, Tomer;
Aharon, Lidan;
Koslawsky, Dana;
Einav, Yulia;
Papo, Niv

Publication type:

Article

Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis.

Published in:

Bioengineering & Translational Medicine, 2017, v. 2, n. 1, p. 81, doi. 10.1002/btm2.10051

By:

Kapur, Shiven;
Silverman, Adam P.;
Ye, Anne Z.;
Papo, Niv;
Jindal, Darren;
Blumenkranz, Mark S.;
Cochran, Jennifer R.

Publication type:

Article

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

Published in:

PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0163732

By:

Dalton, Annamarie C.;
Shlamkovitch, Tomer;
Papo, Niv;
Barton, William A.

Publication type:

Article

Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C).

Published in:

PEDS: Protein Engineering, Design & Selection, 2022, v. 35, p. 1, doi. 10.1093/protein/gzab032

By:

Ben-Naim, Lital;
Khalaila, Isam;
Papo, Niv

Publication type:

Article

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-38362-0

By:

Ma, Honghai;
Hockla, Alexandra;
Mehner, Christine;
Coban, Matt;
Papo, Niv;
Radisky, Derek C.;
Radisky, Evette S.

Publication type:

Article

Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13895-8

By:

Heyne, Michael;
Papo, Niv;
Shifman, Julia M.

Publication type:

Article

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability.

Published in:

Biochemical Journal, 2018, v. 475, n. 19, p. 3087, doi. 10.1042/BCJ20180247

By:

Oren, Ofek;
Banerjee, Victor;
Taube, Ran;
Papo, Niv

Publication type:

Article

Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.

Published in:

Biochemical Journal, 2017, v. 474, n. 15, p. 2601, doi. 10.1042/BCJ20170276

By:

Zur, Yuval;
Rosenfeld, Lior;
Bakhman, Anna;
Ilic, Stefan;
Hezi Hayun;
Shahar, Anat;
Akabayov, Barak;
Kosloff, Mickey;
Levaot, Noam;
Papo, Niv

Publication type:

Article

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.

Published in:

Biochemical Journal, 2016, v. 473, n. 10, p. 1329, doi. 10.1042/BJ20151410

By:

Cohen, Itay;
Kayode, Olumide;
Hockla, Alexandra;
Sankaran, Banumathi;
Radisky, Derek C.;
Radisky, Evette S.;
Papo, Niv

Publication type:

Article

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-32019-3

By:

Hayun, Hezi;
Coban, Matt;
Bhagat, Ashok Kumar;
Ozer, Eden;
Alfonta, Lital;
Caulfield, Thomas R.;
Radisky, Evette S.;
Papo, Niv

Publication type:

Article

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site.

Published in:

PLoS ONE, 2021, v. 16, n. 11, p. 1, doi. 10.1371/journal.pone.0249616

By:

Lacham-Hartman, Shiran;
Shmidov, Yulia;
Radisky, Evette S.;
Bitton, Ronit;
Lukatsky, David B.;
Papo, Niv

Publication type:

Article

Mapping the sclerostin–LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin.

Published in:

FEBS Letters, 2025, v. 599, n. 3, p. 316, doi. 10.1002/1873-3468.15033

By:

Katchkovsky, Svetlana;
Meiri, Reut;
Lacham‐Hartman, Shiran;
Orenstein, Yaron;
Levaot, Noam;
Papo, Niv

Publication type:

Article

Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers.

Published in:

Molecular Oncology, 2023, v. 17, n. 11, p. 2337, doi. 10.1002/1878-0261.13513

By:

Sananes, Amiram;
Cohen, Itay;
Allon, Irit;
Ben‐David, Oshrit;
Abu Shareb, Raghda;
Yegodayev, Ksenia M.;
Stepensky, David;
Elkabets, Moshe;
Papo, Niv

Publication type:

Article

In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 6, p. 1, doi. 10.1007/s00018-022-04336-9

By:

Meltzer, May;
Eliash, Noam;
Azoulay, Ziv;
Hadad, Uzi;
Papo, Niv

Publication type:

Article

Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions.

Published in:

Cellular & Molecular Life Sciences, 2022, v. 79, n. 2, p. 1, doi. 10.1007/s00018-022-04127-2

By:

Katchkovsky, Svetlana;
Chatterjee, Biplab;
Abramovitch-Dahan, Chen-Viki;
Papo, Niv;
Levaot, Noam

Publication type:

Article

Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.

Published in:

2021

By:

Oren, Ofek;
Taube, Ran;
Papo, Niv

Publication type:

Literature Review

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils.

Published in:

Cellular & Molecular Life Sciences, 2021, v. 78, n. 5, p. 2145, doi. 10.1007/s00018-020-03623-7

By:

Malishev, Ravit;
Ben-Zichri, Shani;
Oren, Ofek;
Shauloff, Nitzan;
Peretz, Tal;
Taube, Ran;
Papo, Niv;
Jelinek, Raz

Publication type:

Article

Predicting mutant outcome by combining deep mutational scanning and machine learning.

Published in:

Proteins, 2022, v. 90, n. 1, p. 45, doi. 10.1002/prot.26184

By:

Sarfati, Hagit;
Naftaly, Si;
Papo, Niv;
Keasar, Chen

Publication type:

Article

A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers.

Published in:

Proteins, 2019, v. 87, n. 9, p. 738, doi. 10.1002/prot.25700

By:

Dagan, Bar;
Oren, Ofek;
Banerjee, Victor;
Taube, Ran;
Papo, Niv

Publication type:

Article

Cover Image, Volume 87, Issue 3.

Published in:

Proteins, 2019, v. 87, n. 3, p. C1, doi. 10.1002/prot.25664

By:

Bakhman, Anna;
Rabinovich, Eitan;
Shlamkovich, Tomer;
Papo, Niv;
Kosloff, Mickey

Publication type:

Article

Residue‐level determinants of angiopoietin‐2 interactions with its receptor Tie2.

Published in:

Proteins, 2019, v. 87, n. 3, p. 185, doi. 10.1002/prot.25638

By:

Bakhman, Anna;
Rabinovich, Eitan;
Shlamkovich, Tomer;
Papo, Niv;
Kosloff, Mickey

Publication type:

Article

Works by Papo, Niv

Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy.

Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method.

MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.

Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs).

A KLK4 proteinase substrate capture approach to antagonize PAR1.

Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy.

Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.

Correction: Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.

A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and α<sub>v</sub>β<sub>3</sub> integrin for osteoporosis therapy.

Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies.

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14.

Targeting the Tie2–α<sub>v</sub>β<sub>3</sub> integrin axis with bi-specific reagents for the inhibition of angiogenesis.

Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis.

Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.

Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C).

PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.

Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization.

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability.

Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.

Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.

Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14.

Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site.

Mapping the sclerostin–LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin.

Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers.

In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1.

Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions.

Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.

The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils.

Predicting mutant outcome by combining deep mutational scanning and machine learning.

A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers.

Cover Image, Volume 87, Issue 3.

Residue‐level determinants of angiopoietin‐2 interactions with its receptor Tie2.