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Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers.
- Published in:
- Molecular Oncology, 2023, v. 17, n. 11, p. 2337, doi. 10.1002/1878-0261.13513
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- Article
Developing a dual VEGF/PDL1 inhibitor based on high-affinity scFv heterodimers as an anti-cancer therapeutic strategy.
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- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39076-8
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- Article
Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14.
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- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-32019-3
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- Article
In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1.
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- Cellular & Molecular Life Sciences, 2022, v. 79, n. 6, p. 1, doi. 10.1007/s00018-022-04336-9
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- Article
Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs).
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12731-2
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- Article
Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions.
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- Cellular & Molecular Life Sciences, 2022, v. 79, n. 2, p. 1, doi. 10.1007/s00018-022-04127-2
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- Article
Modifying pH-sensitive PCSK9/LDLR interactions as a strategy to enhance hepatic cell uptake of low-density lipoprotein cholesterol (LDL-C).
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- PEDS: Protein Engineering, Design & Selection, 2022, v. 35, p. 1, doi. 10.1093/protein/gzab032
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- Article
Predicting mutant outcome by combining deep mutational scanning and machine learning.
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- Proteins, 2022, v. 90, n. 1, p. 45, doi. 10.1002/prot.26184
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- Article
Amyloid β structural polymorphism, associated toxicity and therapeutic strategies.
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- Cellular & Molecular Life Sciences, 2021, v. 78, n. 23, p. 7185, doi. 10.1007/s00018-021-03954-z
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- Article
Avidity observed between a bivalent inhibitor and an enzyme monomer with a single active site.
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- PLoS ONE, 2021, v. 16, n. 11, p. 1, doi. 10.1371/journal.pone.0249616
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- Article
Kallikrein-Related Peptidase 6 Is Associated with the Tumour Microenvironment of Pancreatic Ductal Adenocarcinoma.
- Published in:
- Cancers, 2021, v. 13, n. 16, p. 3969, doi. 10.3390/cancers13163969
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- Article
A KLK4 proteinase substrate capture approach to antagonize PAR1.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95666-4
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- Article
Simultaneous targeting of CD44 and MMP9 catalytic and hemopexin domains as a therapeutic strategy.
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- Biochemical Journal, 2021, v. 478, n. 5, p. 1139, doi. 10.1042/BCJ20200628
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- Article
The pro-apoptotic domain of BIM protein forms toxic amyloid fibrils.
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- Cellular & Molecular Life Sciences, 2021, v. 78, n. 5, p. 2145, doi. 10.1007/s00018-020-03623-7
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- Article
Engineering Stem Cell Factor Ligands with Different c-Kit Agonistic Potencies.
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- Molecules, 2020, v. 25, n. 20, p. 4850, doi. 10.3390/molecules25204850
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- Article
Quantitative mapping of binding specificity landscapes for homologous targets by using a high-throughput method.
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- Biochemical Journal, 2020, v. 477, n. 9, p. 1701, doi. 10.1042/BCJ20200188
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- Article
Generating quantitative binding landscapes through fractional binding selections combined with deep sequencing and data normalization.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-019-13895-8
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- Article
A hyperthermophilic protein G variant engineered via directed evolution prevents the formation of toxic SOD1 oligomers.
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- Proteins, 2019, v. 87, n. 9, p. 738, doi. 10.1002/prot.25700
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- Article
Cover Image, Volume 87, Issue 3.
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- Proteins, 2019, v. 87, n. 3, p. C1, doi. 10.1002/prot.25664
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- Article
Residue‐level determinants of angiopoietin‐2 interactions with its receptor Tie2.
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- Proteins, 2019, v. 87, n. 3, p. 185, doi. 10.1002/prot.25638
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- Publication type:
- Article
PRSS3/Mesotrypsin and kallikrein-related peptidase 5 are associated with poor prognosis and contribute to tumor cell invasion and growth in lung adenocarcinoma.
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- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-38362-0
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- Article
An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability.
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- Biochemical Journal, 2018, v. 475, n. 19, p. 3087, doi. 10.1042/BCJ20180247
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- Article
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06403-x
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- Article
A dual-specific macrophage colony-stimulating factor antagonist of c-FMS and α<sub>v</sub>β<sub>3</sub> integrin for osteoporosis therapy.
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- PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2002979
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- Article
Targeting the Tie2–α<sub>v</sub>β<sub>3</sub> integrin axis with bi-specific reagents for the inhibition of angiogenesis.
- Published in:
- BMC Biology, 2018, v. 16, n. 1, p. 1, doi. 10.1186/s12915-018-0557-9
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- Article
Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14.
- Published in:
- FEBS Letters, 2018, v. 592, n. 7, p. 1122, doi. 10.1002/1873-3468.13016
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- Article
MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS.
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- Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0130-4
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- Publication type:
- Article
Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor.
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- Biochemical Journal, 2017, v. 474, n. 15, p. 2601, doi. 10.1042/BCJ20170276
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- Article
Correction: Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.
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- 2017
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- Correction Notice
Engineered ligand-based VEGFR antagonists with increased receptor binding affinity more effectively inhibit angiogenesis.
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- Bioengineering & Translational Medicine, 2017, v. 2, n. 1, p. 81, doi. 10.1002/btm2.10051
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- Article
Constitutive Association of Tie1 and Tie2 with Endothelial Integrins is Functionally Modulated by Angiopoietin-1 and Fibronectin.
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- PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0163732
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- Article
Combinatorial protein engineering of proteolytically resistant mesotrypsin inhibitors as candidates for cancer therapy.
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- Biochemical Journal, 2016, v. 473, n. 10, p. 1329, doi. 10.1042/BJ20151410
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- Publication type:
- Article