Works by Panchal, Rekha G.

Results: 33

A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis.

Published in:

Frontiers in Microbiology, 2022, v. 13, p. 1, doi. 10.3389/fmicb.2022.803041

By:

Chiang, Chih-Yuan;
Lane, Douglas J.;
Zou, Yefen;
Hoffman, Tim;
Pan, Jianfeng;
Hampton, Janice;
Maginnis, Jillian;
Nayak, Bishnu P.;
D'Oro, Ugo;
Valiante, Nicholas;
Miller, Andrew T.;
Cooke, Michael;
Wu, Tom;
Bavari, Sina;
Panchal, Rekha G.

Publication type:

Article

Bacterial genome engineering and synthetic biology: combating pathogens.

Published in:

BMC Microbiology, 2016, v. 16, p. 1, doi. 10.1186/s12866-016-0876-3

By:

Krishnamurthy, Malathy;
Moore, Richard T.;
Rajamani, Sathish;
Panchal, Rekha G.

Publication type:

Article

Identification of small molecule inhibitors of anthrax lethal factor.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 1, p. 67, doi. 10.1038/nsmb711

By:

Panchal, Rekha G.;
Hermone, Ann R.;
Tam Luong Nguyen;
Tiang Yian Wong, Ann R.;
Schwarzenbacher, Robert;
Schmidt, James;
Lane, Douglas;
McGrath, Connor;
Turk, Benjamin E.;
Burnett, James;
Aman, M. Javad;
Little, Stephen;
Sausville, Edward A.;
Zaharevitz, Daniel W.;
Cantley, Lewis C.;
Liddington, Robert C.;
Gussio, Rick;
Bavari, Sina

Publication type:

Article

Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug.

Published in:

Infection & Drug Resistance, 2019, v. 12, p. 1393, doi. 10.2147/IDR.S196874

By:

Krishnamurthy, Malathy;
Lemmon, Margaret M;
Falcinelli, Evan M;
Sandy, Reuel A;
Dootz, Jennifer N;
Mott, Tiffany M;
Rajamani, Sathish;
Schaecher, Kurt E;
Duplantier, Allen J;
Panchal, Rekha G

Publication type:

Article

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (IKs) is conferred by hminK.

Published in:

FASEB Journal, 2002, v. 16, n. 12, p. 1662, doi. 10.1096/fj.02-0084fje

By:

Doolan, Gavin K.;
Panchal, Rekha G.;
Fonnes, Eva L.;
Clarke, Alison L.;
Williams, David A.;
Petrou, Steven

Publication type:

Article

Gene transfer: manipulating and monitoring function in cells and tissues.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2001, v. 28, n. 8, p. 687, doi. 10.1046/j.1440-1681.2001.03504.x

By:

Panchal, Rekha G;
Williams, David A;
Kitchener, Peter D;
Reilly, Angela M;
Khan, Jameel;
Bowser, David N;
Petrou, Steven

Publication type:

Article

GENETICALLY TARGETED CALCIUM SENSORS ENHANCE THE STUDY OF ORGANELLE FUNCTION IN LIVING CELLS.

Published in:

Clinical & Experimental Pharmacology & Physiology, 2000, v. 27, n. 9, p. 738, doi. 10.1046/j.1440-1681.2000.03327.x

By:

Petrou, Steven;
Bowser, David N.;
Nicholls, Robert A.;
Panchal, Rekha G.;
Smart, Megan L.;
Reilly, Angela M.;
Williams, David A.

Publication type:

Article

Mutant GABAA receptor γ2-subunit in childhood absence epilepsy and febrile seizures.

Published in:

Nature Genetics, 2001, v. 28, n. 1, p. 49, doi. 10.1038/88259

By:

Wallace, Robyn H.;
Marini, Carla;
Petrou, Steven;
Harkin, Louise A.;
Bowser, David N.;
Panchal, Rekha G.;
Williams, David A.;
Sutherland, Grant R.;
Mulley, John C.;
Scheffer, Ingrid E.;
Berkovic, Samuel F.

Publication type:

Article

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

Published in:

BMC Microbiology, 2015, v. 15, p. 1, doi. 10.1186/s12866-015-0593-3

By:

Chih-Yuan Chiang;
Ulrich, Ricky L.;
Ulrich, Melanie P.;
Eaton, Brett;
Ojeda, Jenifer F.;
Lane, Douglas J.;
Kota, Krishna P.;
Kenny, Tara A.;
Ladner, Jason T.;
Dickson, Samuel P.;
Kuehl, Kathleen;
Raychaudhuri, Rahul;
Mei Sun;
Bavari, Sina;
Wolcott, Mark J.;
Covell, David;
Panchal, Rekha G.

Publication type:

Article

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging.

Published in:

BMC Microbiology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12866-015-0431-7

By:

Cazares, Lisa H.;
Van Tongeren, Sean A.;
Costantino, Julie;
Kenny, Tara;
Garza, Nicole L.;
Donnelly, Ginger;
Lane, Douglas;
Panchal, Rekha G.;
Bavari, Sina

Publication type:

Article

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

Published in:

BMC Microbiology, 2014, v. 14, n. 1, p. 1, doi. 10.1186/1471-2180-14-98

By:

Pegoraro, Gianluca;
Eaton, Brett P.;
Ulrich, Ricky L.;
Lane, Douglas J.;
Ojeda, Jenifer F.;
Bavari, Sina;
DeShazer, David;
Panchal, Rekha G.

Publication type:

Article

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

Published in:

Cancer Gene Therapy, 2003, v. 10, n. 1, p. 14, doi. 10.1038/sj.cgt.7700525

By:

Heltemes, Lynn M;
Hagan, Christy R;
Mitrofanova, Elena E;
Panchal, Rekha G;
Guo, Jun;
Link, Charles J

Publication type:

Article

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Published in:

Nature, 2014, v. 508, n. 7496, p. 402, doi. 10.1038/nature13027

By:

Warren, Travis K.;
Wells, Jay;
Panchal, Rekha G.;
Stuthman, Kelly S.;
Garza, Nicole L.;
Van Tongeren, Sean A.;
Dong, Lian;
Retterer, Cary J.;
Eaton, Brett P.;
Pegoraro, Gianluca;
Honnold, Shelley;
Bantia, Shanta;
Kotian, Pravin;
Chen, Xilin;
Taubenheim, Brian R.;
Welch, Lisa S.;
Minning, Dena M.;
Babu, Yarlagadda S.;
Sheridan, William P.;
Bavari, Sina

Publication type:

Article

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.

Published in:

Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.763950

By:

Sen, Edanur;
Kota, Krishna P.;
Panchal, Rekha G.;
Bavari, Sina;
Kiris, Erkan

Publication type:

Article

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection.

Published in:

Frontiers in Microbiology, 2015, p. 1, doi. 10.3389/fmicb.2015.00683

By:

Chih-Yuan Chiang;
Uzoma, Ijeoma;
Lane, Douglas J.;
Memišević, Vesna;
Alem, Farhang;
Kuan Yao;
Kota, Krishna P.;
Bavari, Sina;
Wallqvist, Anders;
Hakami, Ramin M.;
Panchal, Rekha G.;
Roy, Chad J.;
Li Xu

Publication type:

Article

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

Published in:

Frontiers in Microbiology, 2015, v. 6, p. 1, doi. 10.3389/fmicb.2015.00050

By:

Alem, Farhang;
Yao, Kuan;
Lane, Douglas;
Calvert, Valerie;
Petricoin, Emanuel F.;
Kramer, Liana;
Hale, Martha L.;
Bavari, Sina;
Panchal, Rekha G.;
Hakami, Ramin M.

Publication type:

Article

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 2, p. 408, doi. 10.3390/ijms20020408

By:

Pandya, Unnati M.;
Egbuta, Chinaza;
Abdullah Norman, Trefa M.;
Chiang, Chih-Yuan (Edward);
Wiersma, Valerie R.;
Panchal, Rekha G.;
Bremer, Edwin;
Eggleton, Paul;
Gold, Leslie I

Publication type:

Article

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

Published in:

Membranes, 2016, v. 6, n. 3, p. 36, doi. 10.3390/membranes6030036

By:

Silin, Vitalii;
Kasianowicz, John J.;
Michelman-Ribeiro, Ariel;
Panchal, Rekha G.;
Bavari, Sina;
Robertson, Joseph W. F.

Publication type:

Article

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections.

Published in:

Viruses (1999-4915), 2012, v. 4, n. 11, p. 2806, doi. 10.3390/v4112806

By:

Iversen, Patrick L.;
Warren, Travis K.;
Wells, Jay B.;
Garza, Nicole L.;
Mourich, Dan V.;
Welch, Lisa S.;
Panchal, Rekha G.;
Bavari, Sina

Publication type:

Article

High Content Image Based Analysis Identifies Cell Cycle Inhibitors as Regulators of Ebola Virus Infection.

Published in:

Viruses (1999-4915), 2012, v. 4, n. 10, p. 1865, doi. 10.3390/v4101865

By:

Kota, Krishna P.;
Benko, Jacqueline G.;
Mudhasani, Rajini;
Retterer, Cary;
Tran, Julie P.;
Bavari, Sina;
Panchal, Rekha G.

Publication type:

Article

Shedding Light on Filovirus Infection with High-Content Imaging.

Published in:

Viruses (1999-4915), 2012, v. 4, n. 8, p. 1354, doi. 10.3390/v4081354

By:

Pegoraro, Gianluca;
Bavari, Sina;
Panchal, Rekha G.

Publication type:

Article

A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor.

Published in:

Viruses (1999-4915), 2012, v. 4, n. 8, p. 1279, doi. 10.3390/v4081279

By:

Selaković, Života;
Opsenica, Dejan;
Eaton, Brett;
Retterer, Cary;
Bavari, Sina;
Burnett, James C.;
Šolaja, Bogdan A.;
Panchal, Rekha G.

Publication type:

Article

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Published in:

PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0129264

By:

Kiris, Erkan;
Nuss, Jonathan E.;
Stanford, Stephanie M.;
Wanner, Laura M.;
Cazares, Lisa;
Maestre, Michael F.;
Du, Hao T.;
Gomba, Glenn Y.;
Burnett, James C.;
Gussio, Rick;
Bottini, Nunzio;
Panchal, Rekha G.;
Kane, Christopher D.;
Tessarollo, Lino;
Bavari, Sina

Publication type:

Article

Alveolar Macrophages Infected with Ames or Sterne Strain of Bacillus anthracis Elicit Differential Molecular Expression Patterns.

Published in:

PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0087201

By:

Langel, Felicia D.;
Chiang, Chih-Yuan;
Lane, Douglas;
Kenny, Tara;
Ojeda, Jenifer F.;
Zhong, Yang;
Che, Jianwei;
Zhou, Yingyao;
Ribot, Wilson;
Kota, Krishna P.;
Bavari, Sina;
Panchal, Rekha G.

Publication type:

Article

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0060579

By:

Madrid, Peter B.;
Chopra, Sidharth;
Manger, Ian D.;
Gilfillan, Lynne;
Keepers, Tiffany R.;
Shurtleff, Amy C.;
Green, Carol E.;
Iyer, Lalitha V.;
Dilks, Holli Hutcheson;
Davey, Robert A.;
Kolokoltsov, Andrey A.;
Carrion Jr, Ricardo;
Patterson, Jean L.;
Bavari, Sina;
Panchal, Rekha G.;
Warren, Travis K.;
Wells, Jay B.;
Moos, Walter H.;
Burke, RaeLyn L.;
Tanga, Mary J.

Publication type:

Article

Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection.

Published in:

PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0055167

By:

Kota, Krishna P.;
Eaton, Brett;
Lane, Douglas;
Ulrich, Melanie;
Ulrich, Ricky;
Peyser, Brian D.;
Robinson, Camenzind G.;
Jaissle, James G.;
Pegoraro, Gianluca;
Bavari, Sina;
Panchal, Rekha G.

Publication type:

Article

Development of High Content Imaging Assays for Lethal Viral Pathogens.

Published in:

2010

By:

Panchal, Rekha G.;
Ruthel, Gordon;
Kota, Krishna;
Boltz, Dutch;
Bavari, Sina

Publication type:

Abstract

Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis.

Published in:

Frontiers in Microbiology, 2021, v. 11, p. N.PAG, doi. 10.3389/fmicb.2021.625211

By:

Chiang, Chih-Yuan;
Zhong, Yang;
Ward, Michael D.;
Lane, Douglas J.;
Kenny, Tara;
Rosario-Acevedo, Raysa;
Eaton, Brett P.;
Treviño, Sylvia R.;
Chance, Taylor B.;
Hu, Meghan;
Worsham, Patricia L.;
Waag, David M.;
Moore, Richard T.;
Cazares, Lisa H.;
Cote, Christopher K.;
Zhou, Yingyao;
Panchal, Rekha G.

Publication type:

Article

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison.

Published in:

Clinical Proteomics, 2019, v. 16, n. 1, p. N.PAG, doi. 10.1186/s12014-019-9227-3

By:

Ward, Michael D.;
Brueggemann, Ernst E.;
Kenny, Tara;
Reitstetter, Raven E.;
Mahone, Christopher R.;
Trevino, Sylvia;
Wetzel, Kelly;
Donnelly, Ginger C.;
Retterer, Cary;
Norgren, Robert B.;
Panchal, Rekha G.;
Warren, Travis K.;
Bavari, Sina;
Cazares, Lisa H.

Publication type:

Article

In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens.

Published in:

Journal of Antibiotics, 2021, v. 74, n. 12, p. 884, doi. 10.1038/s41429-021-00472-9

By:

Halasohoris, Stephanie A.;
Scarff, Jennifer M.;
Pysz, Lisa M.;
Lembirik, Sanae;
Lemmon, Margaret M.;
Biek, Donald;
Hannah, Brendan;
Zumbrun, Steven D.;
Panchal, Rekha G.

Publication type:

Article

Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens.

Published in:

Journal of Antibiotics, 2019, v. 72, n. 9, p. 693, doi. 10.1038/s41429-019-0194-8

By:

Scarff, Jennifer M.;
Waidyarachchi, Samanthi L.;
Meyer, Christopher J.;
Lane, Douglas J.;
Chai, Weirui;
Lemmon, Margaret M.;
Liu, Jiuyu;
Butler, Michelle M.;
Bowlin, Terry L.;
Lee, Richard E.;
Panchal, Rekha G.

Publication type:

Article

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 1, p. 47, doi. 10.1038/ja.2012.93

By:

Panchal, Rekha G;
Lane, Douglas;
Boshoff, Helena I;
Butler, Michelle M;
Moir, Donald T;
Bowlin, Terry L;
Bavari, Sina

Publication type:

Article

Oncogene Amplification in Squamous Cell Carcinoma of the Oral Cavity.

Published in:

Cancer Science, 1989, v. 80, n. 5, p. 430, doi. 10.1111/j.1349-7006.1989.tb02332.x

By:

Saranath, Dhananjaya;
Panchal, Rekha G.;
Nair, Rama;
Mehta, Ashok R.;
Sanghavi, Vikram;
Sumegi, Janos;
Klein, George;
Deo, Madhav G.

Publication type:

Article

Works by Panchal, Rekha G.

A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis.

Bacterial genome engineering and synthetic biology: combating pathogens.

Identification of small molecule inhibitors of anthrax lethal factor.

Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug.

Fatty acid augmentation of the cardiac slowly activating delayed rectifier current (I<sub>Ks</sub>) is conferred by hminK.

Gene transfer: manipulating and monitoring function in cells and tissues.

GENETICALLY TARGETED CALCIUM SENSORS ENHANCE THE STUDY OF ORGANELLE FUNCTION IN LIVING CELLS.

Mutant GABA<sub>A</sub> receptor γ2-subunit in childhood absence epilepsy and febrile seizures.

Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.

Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging.

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.

The rat sodium iodide symporter gene permits more effective radioisotope concentration than the human sodium iodide symporter gene in human and rodent cancer cells.

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity.

A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection.

Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.

The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide.

Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections.

High Content Image Based Analysis Identifies Cell Cycle Inhibitors as Regulators of Ebola Virus Infection.

Shedding Light on Filovirus Infection with High-Content Imaging.

A Limited Structural Modification Results in a Significantly More Efficacious Diazachrysene-Based Filovirus Inhibitor.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Alveolar Macrophages Infected with Ames or Sterne Strain of <i>Bacillus anthracis</i> Elicit Differential Molecular Expression Patterns.

A Systematic Screen of FDA-Approved Drugs for Inhibitors of Biological Threat Agents.

Integrating High-Content Imaging and Chemical Genetics to Probe Host Cellular Pathways Critical for Yersinia Pestis Infection.

Development of High Content Imaging Assays for Lethal Viral Pathogens.

Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis.

Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison.

In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens.

Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens.

Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis.

Oncogene Amplification in Squamous Cell Carcinoma of the Oral Cavity.