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Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion.
Published in:
BioMed Research International, 2022, p. 1, doi. 10.1155/2022/9008685
By:
- Bishop, Eleanor;
- Dimitrova, Monika;
- Froggatt, Alexander;
- Estevez-Cebrero, Maria;
- Storer, Lisa C. D.;
- Mussai, Francis;
- Paine, Simon;
- Grundy, Richard G.;
- Dandapani, Madhumita
Publication type:
Article
Disproportionate Expression of ATM in Cerebellar Cortex During Human Neurodevelopment.
Published in:
Cerebellum, 2024, v. 23, n. 2, p. 502, doi. 10.1007/s12311-023-01560-2
By:
- Deacon, Simon;
- Dalleywater, William;
- Peat, Charles;
- Paine, Simon M. L.;
- Dineen, Rob A.
Publication type:
Article
Dominant stop‐loss HNRNPA1 variants in juvenile‐onset myopathy.
Published in:
Muscle & Nerve, 2024, v. 70, n. 4, p. 843, doi. 10.1002/mus.28214
By:
- Turner, Johnnie;
- Bruels, Christine C.;
- Daugherty, Audrey L.;
- Estrella, Elicia A.;
- Stafki, Seth;
- Syeda, Safoora B.;
- Littel, Hannah R.;
- Pais, Lynn;
- Ganesh, Vijay S.;
- Lidov, Hart G. W.;
- Paine, Simon M. L.;
- Maddison, Paul;
- Harrison, Rachel E.;
- Straub, Volker;
- Ghosh, Partha S.;
- Pacak, Christina A.;
- Kunkel, Louis M.;
- Draper, Isabelle;
- Topf, Ana;
- Kang, Peter B.
Publication type:
Article
Improved survival outcomes despite older age at diagnosis: an era‐by‐era analysis of patients with primary central nervous system lymphoma treated at a single referral centre in the United Kingdom.
Published in:
British Journal of Haematology, 2021, v. 195, n. 4, p. 561, doi. 10.1111/bjh.17747
By:
- Kaji, Furqaan A.;
- Martinez‐Calle, Nicolas;
- Bishton, Mark J.;
- Figueroa, Rocio;
- Adlington, Joanne;
- O'Donoghue, Michael;
- Smith, Stuart;
- Byrne, Paul;
- Paine, Simon;
- Sovani, Vishakha;
- Auer, Dorothee;
- James, Eleanor;
- Bessell, Eric M.;
- Grainge, Matthew J.;
- Fox, Christopher P.
Publication type:
Article
Fourth ventricle rosette-forming glioneuronal tumour in children: an unusual presentation in an 8-year-old patient, discussion and review of the literature.
Published in:
Child's Nervous System, 2013, v. 29, n. 5, p. 839, doi. 10.1007/s00381-012-1993-4
By:
- Thurston, Benjamin;
- Gunny, Roxana;
- Anderson, Glenn;
- Paine, Simon;
- Thompson, Dominic;
- Jacques, Thomas;
- Ternier, Jessica
Publication type:
Article
Spatially resolved transcriptomic profiles reveal unique defining molecular features of infiltrative 5ALA-metabolizing cells associated with glioblastoma recurrence.
Published in:
Genome Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13073-023-01207-1
By:
- Andrieux, Geoffroy;
- Das, Tonmoy;
- Griffin, Michaela;
- Straehle, Jakob;
- Paine, Simon M. L.;
- Beck, Jürgen;
- Boerries, Melanie;
- Heiland, Dieter H.;
- Smith, Stuart J.;
- Rahman, Ruman;
- Chakraborty, Sajib
Publication type:
Article
Pale Body-Like Inclusion Formation and Neurodegeneration following Depletion of 26S Proteasomes in Mouse Brain Neurones are Independent of α-Synuclein.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054711
By:
- Paine, Simon M. L.;
- Anderson, Glenn;
- Bedford, Karen;
- Lawler, Karen;
- Mayer, R. John;
- Lowe, James;
- Bedford, Lynn
Publication type:
Article
Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies.
Published in:
Journal of Neuroscience, 2008, v. 28, n. 33, p. 8189, doi. 10.1523/JNEUROSCI.2218-08.2008
By:
- Bedford, Lynn;
- Hay, David;
- Devoy, Anny;
- Paine, Simon;
- Powe, Des G.;
- Seth, Rashmi;
- Gray, Trevor;
- Topham, Ian;
- Fone, Kevin;
- Rezvani, Nooshin;
- Mee, Maureen;
- Soane, Tim;
- Layfield, Robert;
- Sheppard, Paul W.;
- Ebendal, Ted;
- Usoskin, Dmitry;
- Lowe, James;
- Mayer, R. John
Publication type:
Article
Identifying cellular signalling molecules in developmental disorders of the brain: Evidence from focal cortical dysplasia and tuberous sclerosis.
Published in:
Neuropathology & Applied Neurobiology, 2021, v. 47, n. 6, p. 781, doi. 10.1111/nan.12715
By:
- Li, Yao‐Feng;
- Scerif, Fatma;
- Picker, Simon R.;
- Stone, Thomas J.;
- Pickles, Jessica C.;
- Moulding, Dale A.;
- Avery, Aimee;
- Virasami, Alex;
- Fairchild, Amy R.;
- Tisdall, Martin;
- Harkness, William;
- Cross, J Helen;
- Hargrave, Darren;
- Guillemot, Francois;
- Paine, Simon M.;
- Yasin, Shireena A.;
- Jacques, Thomas S.
Publication type:
Article
A case series of Diffuse Glioneuronal Tumours with Oligodendroglioma‐like features and Nuclear Clusters (DGONC).
Published in:
Neuropathology & Applied Neurobiology, 2021, v. 47, n. 3, p. 464, doi. 10.1111/nan.12680
By:
- Pickles, Jessica C;
- Mankad, Kshitij;
- Aizpurua, Miren;
- Paine, Simon ML;
- Bridges, Leslie R;
- Carceller, Fernando;
- Szychot, Elwira;
- Walker, Mark;
- Fairchild, Amy R;
- Mistry, Talisa;
- Ogunbiyi, Olumide;
- Rolland, Alice;
- Stone, Thomas J;
- Dryden, Carryl;
- Addy, Dilys;
- Garimberti, Elisa;
- Chalker, Jane;
- Sahm, Felix;
- Jones, David TW;
- Hargrave, Darren
Publication type:
Article
Brain weight in sudden unexpected death in infancy: experience from a large single-centre cohort.
Published in:
Neuropathology & Applied Neurobiology, 2016, v. 42, n. 4, p. 344, doi. 10.1111/nan.12251
By:
- Bamber, Andrew R.;
- Paine, Simon M. L.;
- Ridout, Deborah A.;
- Pryce, Jeremy W.;
- Jacques, Thomas S.;
- Sebire, Neil J.
Publication type:
Article
Genetic heterogeneity for SMARCB1, H3F3A and BRAF in a malignant childhood brain tumour: genetic-pathological correlation.
Published in:
Neuropathology & Applied Neurobiology, 2015, v. 41, n. 6, p. 832, doi. 10.1111/nan.12257
By:
- Angelini, Paola;
- Chalker, Jane;
- Austin, Nicola;
- Hing, Sandra;
- Paine, Simon M.L.;
- Mankad, Kshitij;
- Hargrave, Darren;
- Jacques, Thomas S.
Publication type:
Article
Tubular aggregates caused by serine active site containing 1 ( SERAC1) mutations in a patient with a mitochondrial encephalopathy.
Published in:
Neuropathology & Applied Neurobiology, 2015, v. 41, n. 3, p. 399, doi. 10.1111/nan.12190
By:
- Wedatilake, Yehani;
- Plagnol, Vincent;
- Anderson, Glenn;
- Paine, Simon M. L.;
- Clayton, Peter T.;
- Jacques, Thomas S.;
- Rahman, Shamima
Publication type:
Article
Characterization of a population of neural progenitor cells in the infant hippocampus.
Published in:
Neuropathology & Applied Neurobiology, 2014, v. 40, n. 5, p. 544, doi. 10.1111/nan.12065
By:
- Paine, Simon M. L.;
- Willsher, Alex R.;
- Nicholson, Sarah L.;
- Sebire, Neil J.;
- Jacques, Thomas S.
Publication type:
Article
Review: Neuropathological features of unexplained sudden unexpected death in infancy: current evidence and controversies.
Published in:
Neuropathology & Applied Neurobiology, 2014, v. 40, n. 4, p. 364, doi. 10.1111/nan.12095
By:
- Paine, Simon ML;
- Jacques, Thomas S;
- Sebire, Neil J
Publication type:
Article
Challenges for the functional diffusion map in pediatric brain tumors.
Published in:
Neuro-Oncology, 2014, v. 16, n. 3, p. 449, doi. 10.1093/neuonc/not197
By:
- Grech-Sollars, Matthew;
- Saunders, Dawn E.;
- Phipps, Kim P.;
- Kaur, Ramneek;
- Paine, Simon M.L.;
- Jacques, Thomas S.;
- Clayden, Jonathan D.;
- Clark, Chris A.
Publication type:
Article
Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients.
Published in:
2015
By:
- Brown, Julianne R.;
- Morfopoulou, Sofia;
- Hubb, Jonathan;
- Emmett, Warren A.;
- Ip, Winnie;
- Shah, Divya;
- Brooks, Tony;
- Paine, Simon M. L.;
- Anderson, Glenn;
- Virasami, Alex;
- Tong, C. Y. William;
- Clark, Duncan A.;
- Plagnol, Vincent;
- Jacques, Thomas S.;
- Qasim, Waseem;
- Hubank, Mike;
- Breuer, Judith
Publication type:
Case Study
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Published in:
Journal of Investigative Dermatology, 2015, v. 135, n. 11, p. 2902, doi. 10.1038/jid.2015.230
By:
- Pawlikowski, Jeffrey S;
- Brock, Claire;
- Chen, Sheau-Chiann;
- Al-Olabi, Lara;
- Nixon, Colin;
- McGregor, Fiona;
- Paine, Simon;
- Chanudet, Estelle;
- Lambie, Wendy;
- Holmes, William M;
- Mullin, James M;
- Richmond, Ann;
- Wu, Hong;
- Blyth, Karen;
- King, Ayala;
- Kinsler, Veronica A;
- Adams, Peter D
Publication type:
Article
Acute Inhibition of MEK Suppresses Congenital Melanocytic Nevus Syndrome in a Murine Model Driven by Activated NRAS and Wnt Signaling.
Published in:
Journal of Investigative Dermatology, 2015, v. 135, n. 8, p. 2093, doi. 10.1038/jid.2015.114
By:
- Pawlikowski, Jeffrey S;
- Brock, Claire;
- Chen, Sheau-Chiann;
- Al-Olabi, Lara;
- Nixon, Colin;
- McGregor, Fiona;
- Paine, Simon;
- Chanudet, Estelle;
- Lambie, Wendy;
- Holmes, William M;
- Mullin, James M;
- Richmond, Ann;
- Wu, Hong;
- Blyth, Karen;
- King, Ayala;
- Kinsler, Veronica A;
- Adams, Peter D
Publication type:
Article
Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.
Published in:
Cell Death & Disease, 2017, v. 8, n. 1, p. e2531, doi. 10.1038/cddis.2016.443
By:
- Ugun-Klusek, Aslihan;
- Tatham, Michael H;
- Elkharaz, Jamal;
- Constantin-Teodosiu, Dumitru;
- Lawler, Karen;
- Mohamed, Hala;
- Paine, Simon M L;
- Anderson, Glen;
- John Mayer, R;
- Lowe, James;
- Ellen Billett, E;
- Bedford, Lynn
Publication type:
Article
A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups.
Published in:
2020
By:
- Ritzmann, Timothy A.;
- Rogers, Hazel A.;
- Paine, Simon M.L.;
- Storer, Lisa C.D.;
- Jacques, Thomas S.;
- Chapman, Rebecca J.;
- Ellison, David;
- Donson, Andrew M.;
- Foreman, Nicholas K.;
- Grundy, Richard G.
Publication type:
journal article
Alzheimer's disease neuropathological change three decades after iatrogenic amyloid-β transmission.
Published in:
Acta Neuropathologica, 2021, v. 142, n. 1, p. 211, doi. 10.1007/s00401-021-02326-y
By:
- Jaunmuktane, Zane;
- Banerjee, Gargi;
- Paine, Simon;
- Parry-Jones, Adrian;
- Rudge, Peter;
- Grieve, Joan;
- Toma, Ahmed K.;
- Farmer, Simon F.;
- Mead, Simon;
- Houlden, Henry;
- Werring, David J.;
- Brandner, Sebastian
Publication type:
Article
Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.
Published in:
Acta Neuropathologica, 2017, v. 133, n. 1, p. 139, doi. 10.1007/s00401-016-1629-y
By:
- Morfopoulou, Sofia;
- Mee, Edward;
- Connaughton, Sarah;
- Brown, Julianne;
- Gilmour, Kimberly;
- Chong, WK;
- Duprex, W.;
- Ferguson, Deborah;
- Hubank, Mike;
- Hutchinson, Ciaran;
- Kaliakatsos, Marios;
- McQuaid, Stephen;
- Paine, Simon;
- Plagnol, Vincent;
- Ruis, Christopher;
- Virasami, Alex;
- Zhan, Hong;
- Jacques, Thomas;
- Schepelmann, Silke;
- Qasim, Waseem
Publication type:
Article
mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis.
Published in:
Acta Neuropathologica, 2013, v. 126, n. 2, p. 207, doi. 10.1007/s00401-013-1135-4
By:
- Yasin, Shireena;
- Ali, Abu;
- Tata, Mathew;
- Picker, Simon;
- Anderson, Glenn;
- Latimer-Bowman, Elizabeth;
- Nicholson, Sarah;
- Harkness, William;
- Cross, J.;
- Paine, Simon;
- Jacques, Thomas
Publication type:
Article
Neuropathology of neurocutaneous melanosis: histological foci of melanotic neurones and glia may be undetectable on MRI.
Published in:
2012
By:
- Kinsler, Veronica;
- Paine, Simon;
- Anderson, Glenn;
- Wijesekara, D.;
- Sebire, Neil;
- Chong, Wui;
- Harkness, William;
- Aylett, Sarah;
- Jacques, Thomas
Publication type:
Letter
Glioblastoma in Beckwith-Wiedemann syndrome: first case report and review of potential pathomechanisms.
Published in:
Acta Neurochirurgica, 2022, v. 164, n. 2, p. 419, doi. 10.1007/s00701-021-05105-6
By:
- Weir, Peter;
- Kumaria, Ashwin;
- Mohmed, Alhassan;
- Javed, Shazia;
- Paine, Simon;
- Byrne, Paul
Publication type:
Article
Tissue metabolite profiles for the characterisation of paediatric cerebellar tumours.
Published in:
Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-30342-8
By:
- Bennett, Christopher D.;
- Kohe, Sarah E.;
- Gill, Simrandip K.;
- Davies, Nigel P.;
- Wilson, Martin;
- Storer, Lisa C. D.;
- Ritzmann, Timothy;
- Paine, Simon M. L.;
- Scott, Ian S.;
- Nicklaus-Wollenteit, Ina;
- Tennant, Daniel A.;
- Grundy, Richard G.;
- Peet, Andrew C.
Publication type:
Article
Optimizing biomarkers for accurate ependymoma diagnosis, prognostication, and stratification within International Clinical Trials: A BIOMECA study.
Published in:
Neuro-Oncology, 2023, v. 25, n. 10, p. 1871, doi. 10.1093/neuonc/noad055
By:
- Chapman, Rebecca J;
- Ghasemi, David R;
- Andreiuolo, Felipe;
- Zschernack, Valentina;
- Espariat, Arnault Tauziede;
- Buttarelli, Francesca R;
- Giangaspero, Felice;
- Grill, Jacques;
- Haberler, Christine;
- Paine, Simon M L;
- Scott, Ian;
- Jacques, Thomas S;
- Sill, Martin;
- Pfister, Stefan;
- Kilday, John-Paul;
- Leblond, Pierre;
- Massimino, Maura;
- Witt, Hendrik;
- Modena, Piergiorgio;
- Varlet, Pascale
Publication type:
Article
SIOP Ependymoma I: Final results, long-term follow-up, and molecular analysis of the trial cohort—A BIOMECA Consortium Study.
Published in:
Neuro-Oncology, 2022, v. 24, n. 6, p. 936, doi. 10.1093/neuonc/noac012
By:
- Ritzmann, Timothy A;
- Chapman, Rebecca J;
- Kilday, John-Paul;
- Thorp, Nicola;
- Modena, Piergiorgio;
- Dineen, Robert A;
- Macarthur, Donald;
- Mallucci, Conor;
- Jaspan, Timothy;
- Pajtler, Kristian W;
- Giagnacovo, Marzia;
- Jacques, Thomas S;
- Paine, Simon M L;
- Ellison, David W;
- Bouffet, Eric;
- Grundy, Richard G
Publication type:
Article
Thioredoxin System Protein Expression Is Associated with Poor Clinical Outcome in Adult and Paediatric Gliomas and Medulloblastomas.
Published in:
Molecular Neurobiology, 2020, v. 57, n. 7, p. 2889, doi. 10.1007/s12035-020-01928-z
By:
- Yao, Anqi;
- Storr, Sarah J.;
- Al-hadyan, Khaled;
- Rahman, Ruman;
- Smith, Stuart;
- Grundy, Richard;
- Paine, Simon;
- Martin, Stewart G.
Publication type:
Article

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