Works by Paine, Mary F.

Results: 45

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism.

Published in:

Drug Metabolism Reviews, 2001, v. 33, n. 3/4, p. 273, doi. 10.1081/DMR-120000653

By:

Fisher, Michael B.;
Paine, Mary F.;
Strelevitz, Timothy J.;
Wrighton, Steven A.

Publication type:

Article

Application of physiologically‐based pharmacokinetic modeling to inform dosing decisions for geriatric patients.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2024, v. 13, n. 12, p. 2031, doi. 10.1002/psp4.13241

By:

Qian, Lixuan;
Wang, Ziteng;
Paine, Mary F.;
Chan, Eric Chun Yong;
Zhou, Zhu

Publication type:

Article

Potential pharmacokinetic interactions with concurrent use of herbal medicines and a ritonavir-boosted COVID-19 protease inhibitor in low and middle-income countries.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1210579

By:

Smith, Dallas J.;
Huichang Bi;
Hamman, Josias;
Xiaochao Ma;
Mitchell, Constance;
Nyirenda, Kumbukani;
Monera-Penduka, Tsitsi;
Oketch-Rabah, Hellen;
Paine, Mary F.;
Pettit, Syril;
Pheiffer, Wihan;
Van Breemen, Richard B.;
Embry, Michelle

Publication type:

Article

Assessing drug interaction risk of the grapefruit juice component and dietary supplement 6′,7′‐dihydroxybergamottin via physiologically‐based pharmacokinetic modeling and simulation.

Published in:

FASEB Journal, 2013, v. 27, p. 1103.4, doi. 10.1096/fasebj.27.1_supplement.1103.4

By:

Ainslie, Garrett Robert;
Gufford, Brandon T;
Won, Christina S;
Wolf, Kristina K;
Paine, Mary F

Publication type:

Article

Rapid Quantitation of Furanocoumarins and Flavonoids in Grapefruit Juice using Ultra-Performance Liquid Chromatography.

Published in:

Phytochemical Analysis, 2013, v. 24, n. 6, p. 654, doi. 10.1002/pca.2449

By:

VanderMolen, Karen M.;
Cech, Nadja B.;
Paine, Mary F.;
Oberlies, Nicholas H.

Publication type:

Article

A Modified Grapefruit Juice Eliminates Two Compound Classes as Major Mediators of the Grapefruit Juice-Fexofenadine Interaction: An In Vitro-In Vivo 'Connect'.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 9, p. 982, doi. 10.1002/jcph.136

By:

Won, Christina S.;
Lan, Tian;
VanderMolen, Karen M.;
Dawson, Paul A.;
Oberlies, Nicholas H.;
Widmer, Wilbur W.;
Scarlett, Yolanda V.;
Paine, Mary F.

Publication type:

Article

Assessment of Orally Administered Δ9-Tetrahydrocannabinol When Coadministered With Cannabidiol on Δ9-Tetrahydrocannabinol Pharmacokinetics and Pharmacodynamics in Healthy Adults: A Randomized Clinical Trial.

Published in:

JAMA Network Open, 2023, v. 6, n. 2, p. e2254752, doi. 10.1001/jamanetworkopen.2022.54752

By:

Zamarripa, C. Austin;
Spindle, Tory R.;
Surujunarain, Renuka;
Weerts, Elise M.;
Bansal, Sumit;
Unadkat, Jashvant D.;
Paine, Mary F.;
Vandrey, Ryan

Publication type:

Article

Assessing Transporter‐Mediated Natural Product‐Drug Interactions Via In vitro‐In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 5, p. 1342, doi. 10.1002/cpt.2107

By:

Nguyen, James T.;
Tian, Dan‐Dan;
Tanna, Rakshit S.;
Hadi, Deena L.;
Bansal, Sumit;
Calamia, Justina C.;
Arian, Christopher M.;
Shireman, Laura M.;
Molnár, Bálint;
Horváth, Miklós;
Kellogg, Joshua J.;
Layton, Matthew E.;
White, John R.;
Cech, Nadja B.;
Boyce, Richard D.;
Unadkat, Jashvant D.;
Thummel, Kenneth E.;
Paine, Mary F.

Publication type:

Article

Intestinal P‐gp and Putative Hepatic OATP1B Induction: International Transporter Consortium Perspective on Drug Development Implications.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 55, doi. 10.1002/cpt.1916

By:

Zamek‐Gliszczynski, Maciej J.;
Patel, Mitesh;
Yang, Xinning;
Lutz, Justin D.;
Chu, Xiaoyan;
Brouwer, Kim L. R.;
Lai, Yurong;
Lee, Caroline A.;
Neuhoff, Sibylle;
Paine, Mary F.;
Sugiyama, Yuichi;
Taskar, Kunal S.;
Galetin, Aleksandra

Publication type:

Article

The Age of Omics‐Driven Precision Medicine.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 3, p. 477, doi. 10.1002/cpt.1532

By:

McColl, Eliza R.;
Asthana, Rashi;
Paine, Mary F.;
Piquette‐Miller, Micheline

Publication type:

Article

ITC Commentary on Metformin Clinical Drug–Drug Interaction Study Design That Enables an Efficacy‐ and Safety‐Based Dose Adjustment Decision.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 5, p. 781, doi. 10.1002/cpt.1082

By:

Zamek‐Gliszczynski, Maciej J.;
Ware, Joseph A.;
Wittwer, Matthias B.;
Zhang, Lei;
Chu, Xiaoyan;
Cook, Jack A.;
Custodio, Joseph M.;
Galetin, Aleksandra;
Giacomini, Kathleen M.;
Lee, Caroline A.;
Paine, Mary F.;
Ray, Adrian S.

Publication type:

Article

“Green Medicine”: The Past, Present, and Future of Botanicals.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 104, n. 3, p. 410, doi. 10.1002/cpt.1168

By:

Paine, Mary F.;
Roe, Amy L.

Publication type:

Article

Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5

Published in:

Clinical Pharmacology & Therapeutics, 2005, v. 78, n. 6, p. 605, doi. 10.1016/j.clpt.2005.08.014

By:

Mouly, Stéphane J.;
Matheny, Chris;
Paine, Mary F.;
Smith, Glenn;
Lamba, Jatinder;
Lamba, Vishal;
Pusek, Susan N.;
Schuetz, Erin G.;
Stewart, Paul W.;
Watkins, Paul B.

Publication type:

Article

6′7′-Dihydroxybergamottin Contributes to the Grapefruit Juice Effect*.

Published in:

Clinical Pharmacology & Therapeutics, 2004, v. 75, n. 6, p. 569, doi. 10.1016/j.clpt.2004.02.007

By:

Kakar, Shefali M.;
Paine, Mary F.;
Stewart, Paul W.;
Watkins, Paul B.

Publication type:

Article

Cytochrome P450 3A4 and P-glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin*.

Published in:

Clinical Pharmacology & Therapeutics, 2002, v. 72, n. 5, p. 524, doi. 10.1067/mcp.2002.128387

By:

Paine, Mary F.;
Wagner, David A.;
Hoffmaster, Keith A.;
Watkins, Paul B.

Publication type:

Article

Seville orange juice-felodipine interaction: Comparison with dilute grapefruit juice and involvement of furocoumarins*.

Published in:

Clinical Pharmacology & Therapeutics, 2001, v. 69, n. 1, p. 14, doi. 10.1067/mcp.2001.113185

By:

Malhotra, Shefali;
Bailey, David G.;
Paine, Mary F.;
Watkins, Paul B.

Publication type:

Article

Part 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the FDA Adverse Event Reporting System.

Published in:

Pharmacology Research & Perspectives, 2025, v. 13, n. 1, p. 1, doi. 10.1002/prp2.70047

By:

Chapin, Maryann R.;
Kane‐Gill, Sandra L.;
Li, Xiaotong;
Abanyie, Kojo;
Taneja, Sanya B.;
Egbert, Susan;
Paine, Mary F.;
Boyce, Richard D.

Publication type:

Article

Part 1: Evaluation of Pediatric Cannabis–Drug Interaction Reports.

Published in:

Pharmacology Research & Perspectives, 2025, v. 13, n. 1, p. 1, doi. 10.1002/prp2.70046

By:

Chapin, Maryann R.;
Kane‐Gill, Sandra L.;
Li, Xiaotong;
Abanyie, Kojo;
Taneja, Sanya B.;
Egbert, Susan;
Paine, Mary F.;
Boyce, Richard D.

Publication type:

Article

Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4?

Published in:

British Journal of Clinical Pharmacology, 2002, v. 54, n. 6, p. 643, doi. 10.1046/j.1365-2125.2002.01687.x

By:

Wanwimolruk, Sompon;
Paine, Mary F.;
Pusek, Susan N.;
Watkins, Paul B.

Publication type:

Article

Effect of grapefruit juice on the disposition of omeprazole.

Published in:

British Journal of Clinical Pharmacology, 2001, v. 52, n. 2, p. 213, doi. 10.1111/j.1365-2125.1978.00999.pp.x

By:

Mouly, Stephane;
Paine, Mary F.

Publication type:

Article

A gel-free MS-based quantitative proteomic approach accurately measures cytochrome P450 protein concentrations in human liver microsomes.

Published in:

Proteomics, 2008, v. 8, n. 20, p. 4186, doi. 10.1002/pmic.200800144

By:

Wang, Michael Zhuo;
Wu, Judy Qiju;
Dennison, Jennifer B.;
Bridges, Arlene S.;
Hall, Stephen D.;
Kornbluth, Sally;
Tidwell, Richard R.;
Smith, Philip C.;
Voyksner, Robert D.;
Paine, Mary F.;
Hall, James Edwin

Publication type:

Article

The warfarin--cranberry juice interaction revisited: A systematic in vitro--in vivo evaluation.

Published in:

Journal of Experimental Pharmacology, 2010, v. 2, p. 83

By:

Ngo, Ngoc;
Brantley, Scott J.;
Carrizosa, Daniel R.;
Kashuba, Angela D. M.;
Dees, E. Claire;
Kroll, David J.;
Oberlies, Nicholas H.;
Paine, Mary F.

Publication type:

Article

First-pass metabolism of midazolam by the human intestine*.

Published in:

Clinical Pharmacology & Therapeutics, 1996, v. 60, n. 1, p. 14, doi. 10.1016/S0009-9236(96)90162-9

By:

Paine, Mary F.;
Shen, Danny D.;
Kunze, Kent L.;
Perkins, James D.;
Marsh, Christopher L.;
McVicar, John P.;
Barr, Darlene M.;
Gillies, Bruce S.;
Thummel, Kenneth E.

Publication type:

Article

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*.

Published in:

Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 5, p. 491, doi. 10.1016/S0009-9236(96)90177-0

By:

Thummel, Kenneth E.;
O'Shea, Diarmuid;
Paine, Mary F.;
Shen, Danny D.;
Kunze, Kent L.;
Perkins, James D.;
Wilkinson, Grant R.

Publication type:

Article

Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 2, p. 1, doi. 10.1371/journal.pntd.0003409

By:

Thuita, John K.;
Wolf, Kristina K.;
Murilla, Grace A.;
Bridges, Arlene S.;
Boykin, David W.;
Mutuku, James N.;
Liu, Qiang;
Jones, Susan K.;
Gem, Charles O.;
Ching, Shelley;
Tidwell, Richard R.;
Wang, Michael Z.;
Paine, Mary F.;
Brun, Reto

Publication type:

Article

Chemotherapy of Second Stage Human African Trypanosomiasis: Comparison between the Parenteral Diamidine DB829 and Its Oral Prodrug DB868 in Vervet Monkeys.

Published in:

PLoS Neglected Tropical Diseases, 2015, v. 9, n. 2, p. 1, doi. 10.1371/journal.pntd.0003409

By:

Thuita, John K.;
Wolf, Kristina K.;
Murilla, Grace A.;
Bridges, Arlene S.;
Boykin, David W.;
Mutuku, James N.;
Liu, Qiang;
Jones, Susan K.;
Gem, Charles O.;
Ching, Shelley;
Tidwell, Richard R.;
Wang, Michael Z.;
Paine, Mary F.;
Brun, Reto

Publication type:

Article

Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 6, p. 1, doi. 10.1371/journal.pntd.0002230

By:

Thuita, John K.;
Wolf, Kristina K.;
Murilla, Grace A.;
Liu, Qiang;
Mutuku, James N.;
Chen, Yao;
Bridges, Arlene S.;
Mdachi, Raymond E.;
Ismail, Mohamed A.;
Ching, Shelley;
Boykin, David W.;
Hall, James Edwin;
Tidwell, Richard R.;
Paine, Mary F.;
Brun, Reto;
Wang, Michael Zhuo

Publication type:

Article

Safety, Pharmacokinetic, and Efficacy Studies of Oral DB868 in a First Stage Vervet Monkey Model of Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 6, p. 1, doi. 10.1371/journal.pntd.0002230

By:

Thuita, John K.;
Wolf, Kristina K.;
Murilla, Grace A.;
Liu, Qiang;
Mutuku, James N.;
Chen, Yao;
Bridges, Arlene S.;
Mdachi, Raymond E.;
Ismail, Mohamed A.;
Ching, Shelley;
Boykin, David W.;
Hall, James Edwin;
Tidwell, Richard R.;
Paine, Mary F.;
Brun, Reto;
Wang, Michael Zhuo

Publication type:

Article

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001734

By:

Thuita, John K.;
Wang, Michael Z.;
Kagira, John M.;
Denton, Cathrine L.;
Paine, Mary F.;
Mdachi, Raymond E.;
Murilla, Grace A.;
Ching, Shelley;
Boykin, David W.;
Tidwell, Richard R.;
Hall, James E.;
Brun, Reto

Publication type:

Article

Pharmacology of DB844, an Orally Active aza Analogue of Pafuramidine, in a Monkey Model of Second Stage Human African Trypanosomiasis.

Published in:

PLoS Neglected Tropical Diseases, 2012, v. 6, n. 7, p. 1, doi. 10.1371/journal.pntd.0001734

By:

Thuita, John K.;
Wang, Michael Z.;
Kagira, John M.;
Denton, Cathrine L.;
Paine, Mary F.;
Mdachi, Raymond E.;
Murilla, Grace A.;
Ching, Shelley;
Boykin, David W.;
Tidwell, Richard R.;
Hall, James E.;
Brun, Reto

Publication type:

Article

The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose‐Dependent: A Three‐Arm Crossover Study in Adults With Type 2 Diabetes.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 2, p. 1, doi. 10.1111/cts.70120

By:

Nguyen, James T.;
Arian, Christopher M.;
Tanna, Rakshit S.;
Cherel, Maxey G.;
Layton, Matthew E.;
White, John R.;
Thummel, Kenneth E.;
Paine, Mary F.

Publication type:

Article

Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta‐9‐Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 1, p. 1, doi. 10.1111/cts.70119

By:

Qian, Lixuan;
Zhang, Tao;
Dinh, Jean;
Paine, Mary F.;
Zhou, Zhu

Publication type:

Article

Co‐consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 10, p. 1779, doi. 10.1111/cts.13578

By:

Clarke, John D.;
Judson, Sabrina M.;
Tian, Dan‐Dan;
Kirby, Trevor O.;
Tanna, Rakshit S.;
Matula‐Péntek, Adrienn;
Horváth, Miklós;
Layton, Matthew E.;
White, John R.;
Cech, Nadja B.;
Thummel, Kenneth E.;
McCune, Jeannine S.;
Shen, Danny D.;
Paine, Mary F.

Publication type:

Article

An evaluation of adverse drug reactions and outcomes attributed to kratom in the US Food and Drug Administration Adverse Event Reporting System from January 2004 through September 2021.

Published in:

CTS: Clinical & Translational Science, 2023, v. 16, n. 6, p. 1002, doi. 10.1111/cts.13505

By:

Li, Xiaotong;
Ndungu, Patrick;
Taneja, Sanya B.;
Chapin, Maryann R.;
Egbert, Susan B.;
Akenapalli, Krishi;
Paine, Mary F.;
Kane‐Gill, Sandra L.;
Boyce, Richard D.

Publication type:

Article

Adapting regulatory drug‐drug interaction guidance to design clinical pharmacokinetic natural product‐drug interaction studies: A NaPDI Center recommended approach.

Published in:

CTS: Clinical & Translational Science, 2022, v. 15, n. 2, p. 322, doi. 10.1111/cts.13172

By:

Cox, Emily J.;
Rettie, Allan E.;
Unadkat, Jashvant D.;
Thummel, Kenneth E.;
McCune, Jeannine S.;
Paine, Mary F.

Publication type:

Article

Effects of Common CYP1A2 Genotypes and Other Key Factors on Intraindividual Variation in the Caffeine Metabolic Ratio: An Exploratory Analysis.

Published in:

CTS: Clinical & Translational Science, 2019, v. 12, n. 1, p. 39, doi. 10.1111/cts.12598

By:

Tian, Dan‐Dan;
Natesan, Senthil;
Paine, Mary F.;
White, John R.

Publication type:

Article

Impact of Drug-Mediated Inhibition of Intestinal Transporters on Nutrient and Endogenous Substrate Disposition...an Afterthought?

Published in:

Pharmaceutics, 2024, v. 16, n. 4, p. 447, doi. 10.3390/pharmaceutics16040447

By:

Kharve, Kshitee;
Engley, Andrew S.;
Paine, Mary F.;
Sprowl, Jason A.

Publication type:

Article

Clinical Pharmacokinetic Assessment of Kratom (Mitragyna speciosa), a Botanical Product with Opioid-like Effects, in Healthy Adult Participants.

Published in:

Pharmaceutics, 2022, v. 14, n. 3, p. 620, doi. 10.3390/pharmaceutics14030620

By:

Tanna, Rakshit S.;
Nguyen, James T.;
Hadi, Deena L.;
Manwill, Preston K.;
Flores-Bocanegra, Laura;
Layton, Matthew E.;
White, John R.;
Cech, Nadja B.;
Oberlies, Nicholas H.;
Rettie, Allan E.;
Thummel, Kenneth E.;
Paine, Mary F.

Publication type:

Article

Evaluation of Cytochrome P450‐Mediated Cannabinoid‐Drug Interactions in Healthy Adult Participants.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 114, n. 3, p. 693, doi. 10.1002/cpt.2973

By:

Bansal, Sumit;
Zamarripa, C. Austin;
Spindle, Tory R.;
Weerts, Elise M.;
Thummel, Kenneth E.;
Vandrey, Ryan;
Paine, Mary F.;
Unadkat, Jashvant D.

Publication type:

Article

Clinical Assessment of the Drug Interaction Potential of the Psychotropic Natural Product Kratom.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 6, p. 1315, doi. 10.1002/cpt.2891

By:

Tanna, Rakshit S.;
Nguyen, James T.;
Hadi, Deena L.;
Layton, Matthew E.;
White, John R.;
Cech, Nadja B.;
Oberlies, Nicholas H.;
Rettie, Allan E.;
Thummel, Kenneth E.;
Paine, Mary F.

Publication type:

Article

Clinical Relevance of Hepatic and Renal P‐gp/BCRP Inhibition of Drugs: An International Transporter Consortium Perspective.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 3, p. 573, doi. 10.1002/cpt.2670

By:

Taskar, Kunal S.;
Yang, Xinning;
Neuhoff, Sibylle;
Patel, Mitesh;
Yoshida, Kenta;
Paine, Mary F.;
Brouwer, Kim L.R.;
Chu, Xiaoyan;
Sugiyama, Yuichi;
Cook, Jack;
Polli, Joseph W.;
Hanna, Imad;
Lai, Yurong;
Zamek‐Gliszczynski, Maciej

Publication type:

Article

Cannabis for Medical Use: Clinical Pharmacology Perspectives on Scientific and Regulatory Challenges.

Published in:

Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 732, doi. 10.1002/cpt.2470

By:

Zhou, Zhu;
Paine, Mary F.;
Spindle, Tory R.;
Huang, Shiew‐Mei;
Zhang, Lei

Publication type:

Article

Hepatic organic anion transporting polypeptides mediate disposition of milk thistle flavonolignans and pharmacokinetic silymarin‐drug interactions.

Published in:

Phytotherapy Research, 2021, v. 35, n. 6, p. 3286, doi. 10.1002/ptr.7049

By:

Lynch, Katherine D.;
Montonye, Michelle L.;
Tian, Dan‐Dan;
Arman, Tarana;
Oyanna, Victoria O.;
Bechtold, Baron J.;
Graf, Tyler N.;
Oberlies, Nicholas H.;
Paine, Mary F.;
Clarke, John D.

Publication type:

Article

Prioritizing pharmacokinetic drug interaction precipitants in natural products: application to OATP inhibitors in grapefruit juice.

Published in:

Biopharmaceutics & Drug Disposition, 2017, v. 38, n. 3, p. 251, doi. 10.1002/bdd.2061

By:

Johnson, Emily J.;
Won, Christina S.;
Köck, Kathleen;
Paine, Mary F.

Publication type:

Article

A Mouse Diversity Panel Approach Reveals the Potential for Clinical Kidney Injury Due to DB289 Not Predicted by Classical Rodent Models.

Published in:

Toxicological Sciences, 2012, v. 130, n. 2, p. 416, doi. 10.1093/toxsci/kfs238

By:

Harrill, Alison H.;
DeSmet, Kristina D.;
Wolf, Kristina K.;
Bridges, Arlene S.;
Eaddy, J. Scott;
Kurtz, C. Lisa;
Hall, J. Ed.;
Paine, Mary F.;
Tidwell, Richard R.;
Watkins, Paul B.

Publication type:

Article