Works by Paglialunga, Sabina

Results: 34

Tracking the Sugar Rush: Incorporating Continuous Glucose Monitoring Into Multisite Early Clinical Research With Type 2 Diabetes Subjects.

Published in:

Clinical Pharmacology in Drug Development, 2018, v. 7, n. 7, p. 676, doi. 10.1002/cpdd.437

By:

Paglialunga, Sabina;
Morimoto, Bruce H.;
de la Peña, Amparo;
Fortier, Caroline

Publication type:

Article

Should You Run a Dedicated TQT Study? Sponsor and Regulatory Considerations on Substitution Pathways to Assess QT Liability.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 116, n. 1, p. 42, doi. 10.1002/cpt.3284

By:

Lester, Robert M.;
Engel, Caroline;
van Haarst, Aernout D.;
Paglialunga, Sabina

Publication type:

Article

Rifampin Drug–Drug–Interaction Studies: Reflections on the Nitrosamine Impurities Issue.

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 4, p. 816, doi. 10.1002/cpt.2652

By:

van Haarst, Aernout;
Smith, Stephen;
Garvin, Clare;
Benrimoh, Natacha;
Paglialunga, Sabina

Publication type:

Article

Review of Drug Development Guidance to Treat Chronic Obstructive Pulmonary Disease: US and EU Perspectives.

Published in:

Clinical Pharmacology & Therapeutics, 2019, v. 106, n. 6, p. 1222, doi. 10.1002/cpt.1540

By:

Haarst, Aernout;
McGarvey, Lorcan;
Paglialunga, Sabina

Publication type:

Article

The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet–Induced Diabetes.

Published in:

Endocrinology, 2019, v. 160, n. 12, p. 2825, doi. 10.1210/en.2018-00936

By:

Hoang, Monica;
Paglialunga, Sabina;
Bombardier, Eric;
Tupling, A Russell;
Joseph, Jamie W

Publication type:

Article

Innovative Approaches to Optimize Clinical Transporter Drug–Drug Interaction Studies.

Published in:

Pharmaceutics, 2024, v. 16, n. 8, p. 992, doi. 10.3390/pharmaceutics16080992

By:

Paglialunga, Sabina;
Benrimoh, Natacha;
van Haarst, Aernout

Publication type:

Article

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.

Published in:

Journal of Clinical Investigation, 2007, v. 117, n. 2, p. 387, doi. 10.1172/JCI29528

By:

Le Bacquer, Olivier;
Petroulakis, Emmanuel;
Paglialunga, Sabina;
Poulin, Francis;
Richard, Denis;
Cianflone, Katherine;
Sonenberg, Nahum

Publication type:

Article

Effects of high-fat feeding on ectopic fat storage and postprandial lipid metabolism in mouse offspring.

Published in:

2015

By:

van Ewijk, Petronella A.;
Paglialunga, Sabina;
Kooi, M. Eline;
Nunes, Patricia M.;
Gemmink, Anne;
Slenter, Jos;
Kornips, Esther;
Jörgensen, Johanna A.;
Hoeks, Joris;
Wildberger, Joachim E.;
Hesselink, Matthijs K.C.;
Glatz, Jan F.C.;
Heerschap, Arend;
Kersten, Sander;
Schrauwen, Patrick;
Schrauwen‐Hinderling, Vera B.

Publication type:

journal article

QT Assessment in Early Drug Development: The Long and the Short of It.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 6, p. 1324, doi. 10.3390/ijms20061324

By:

Lester, Robert M.;
Johnson, Ian A.;
Paglialunga, Sabina

Publication type:

Article

Evaluation of chylomicron effect on ASP production in 3T3-L1 adipocytes.

Published in:

Acta Biochimica et Biophysica Sinica, 2011, v. 43, n. 2, p. 154, doi. 10.1093/abbs/gmq124

By:

Gao, Ying;
Gauvreau, Danny;
Cui, Wei;
Lapointe, Marc;
Paglialunga, Sabina;
Cianflone, Katherine

Publication type:

Article

Evaluating cardiac risk: exposure response analysis in early clinical drug development.

Published in:

Drug, Healthcare & Patient Safety, 2018, v. 10, p. 27, doi. 10.2147/DHPS.S133286

By:

Grenier, Julie;
Paglialunga, Sabina;
Morimoto, Bruce H;
Lester, Robert M

Publication type:

Article

Evaluation of HbA1c screening during outreach events for prediabetes subject recruitment for clinical research.

Published in:

2018

By:

Paglialunga, Sabina;
Bond, Ryan;
Jaycox, Sharon H.

Publication type:

journal article

The effects of acylation stimulating protein supplementation VS antibody neutralization on energy expenditure in wildtype mice.

Published in:

BMC Physiology, 2010, v. 10, p. 4, doi. 10.1186/1472-6793-10-4

By:

Paglialunga, Sabina;
Fisette, Alexandre;
Munkonda, Mercedes;
Ying Gao;
Richard, Denis;
Cianflone, Katherine

Publication type:

Article

Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice.

Published in:

Molecular & Cellular Biology, 2015, v. 35, n. 15, p. 2641, doi. 10.1128/MCB.00380-15

By:

Basu, Poulami;
Alibhai, Faisal J.;
Tsimakouridze, Elena V.;
Singh, Ratnesh K.;
Paglialunga, Sabina;
Holloway, Graham P.;
Martino, Tami A.;
Bakovic, Marica

Publication type:

Article

Deletion of ARNT/HIF1β in pancreatic beta cells does not impair glucose homeostasis in mice, but is associated with defective glucose sensing ex vivo.

Published in:

Diabetologia, 2015, v. 58, n. 12, p. 2832, doi. 10.1007/s00125-015-3768-4

By:

Pillai, Renjitha;
Paglialunga, Sabina;
Hoang, Monica;
Cousteils, Katelyn;
Prentice, Kacey;
Bombardier, Eric;
Huang, Mei;
Gonzalez, Frank;
Tupling, A.;
Wheeler, Michael;
Joseph, Jamie

Publication type:

Article

Extremely rapid increase in fatty acid transport and intramyocellular lipid accumulation but markedly delayed insulin resistance after high fat feeding in rats.

Published in:

Diabetologia, 2015, v. 58, n. 10, p. 2381, doi. 10.1007/s00125-015-3691-8

By:

Bonen, Arend;
Jain, Swati;
Snook, Laelie;
Han, Xiao-Xia;
Yoshida, Yuko;
Buddo, Kathryn;
Lally, James;
Pask, Elizabeth;
Paglialunga, Sabina;
Beaudoin, Marie-Soleil;
Glatz, Jan;
Luiken, Joost;
Harasim, Ewa;
Wright, David;
Chabowski, Adrian;
Holloway, Graham

Publication type:

Article

In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice.

Published in:

Diabetologia, 2015, v. 58, n. 5, p. 1071, doi. 10.1007/s00125-015-3531-x

By:

Paglialunga, Sabina;
Ludzki, Alison;
Root-McCaig, Jared;
Holloway, Graham

Publication type:

Article

Ablating the Rab‐GTPase activating protein TBC1D1 predisposes rats to high‐fat diet‐induced cardiomyopathy.

Published in:

Journal of Physiology, 2020, v. 598, n. 4, p. 683, doi. 10.1113/JP279042

By:

Barbeau, Pierre‐Andre;
Houad, Jacy M.;
Huber, Jason S.;
Paglialunga, Sabina;
Snook, Laelie A.;
Herbst, Eric A. F.;
Dennis, Kaitlyn M. J. H.;
Simpson, Jeremy A.;
Holloway, Graham P.

Publication type:

Article

Evaluation of the safety, tolerability, pharmacokinetics and pharmacodynamics of SM17 in healthy volunteers: results from pre-clinical models and a first-in-human, randomized, double blinded clinical trial.

Published in:

Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1495540

By:

Xu, Guolin;
Paglialunga, Sabina;
Qian, Xuchen;
Ding, Ru;
Webster, Kenneth;
van Haarst, Aernout;
Engel, Caroline;
Hui, Chin Wai;
Lam, Lik Hang;
Li, Weimin;
Wu, Wai Chung;
Rasmussen, Scott;
Hunt, Allen;
Leung, Shui-on

Publication type:

Article

Assay validation and clinical performance of chronic inflammatory and chemokine biomarkers of NASH fibrosis.

Published in:

PLoS ONE, 2019, v. 14, n. 7, p. 1, doi. 10.1371/journal.pone.0217263

By:

Kar, Sumit;
Paglialunga, Sabina;
Jaycox, Sharon H.;
Islam, Rafiqul;
Paredes, Angelo H.

Publication type:

Article

Surfing the T Wave: A Primer on ECG T Wave Morphologies Encountered in Clinical Trials and Impact on the QT Interval and Patient Safety.

Published in:

CTS: Clinical & Translational Science, 2025, v. 18, n. 3, p. 1, doi. 10.1111/cts.70145

By:

Lester, Robert M.;
Paglialunga, Sabina

Publication type:

Article

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling.

Published in:

Diabetes, 2015, v. 64, n. 8, p. 2769, doi. 10.2337/db14-1838

By:

Ludzki, Alison;
Paglialunga, Sabina;
Smith, Brennan K.;
Herbst, Eric A. F.;
Allison, Mary K.;
Heigenhauser, George J.;
Neufer, P. Darrell;
Holloway, Graham P.

Publication type:

Article

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Published in:

2015

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G;
Ropelle, Eduardo R;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Hwang, Jong-Hee;
Schrauwen-Hinderling, Vera B;
Hesselink, Matthijs K C;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

journal article

Evidence for a Direct Effect of the NAD<sup>+</sup> Precursor Acipimox on Muscle Mitochondrial Function in Humans.

Published in:

Diabetes, 2015, v. 64, n. 4, p. 1193, doi. 10.2337/db14-0667

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G.;
Ropelle, Eduardo R.;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M.;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Jong-Hee Hwang;
Schrauwen-Hinderling, Vera B.;
Hesselink, Matthijs K. C.;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

Article

High-Fat Diet-Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII.

Published in:

2014

By:

Jain, Swati S;
Paglialunga, Sabina;
Vigna, Chris;
Ludzki, Alison;
Herbst, Eric A;
Lally, James S;
Schrauwen, Patrick;
Hoeks, Joris;
Tupling, A Russ;
Bonen, Arend;
Holloway, Graham P

Publication type:

Journal Article

High-Fat Diet–Induced Mitochondrial Biogenesis Is Regulated by Mitochondrial-Derived Reactive Oxygen Species Activation of CaMKII.

Published in:

Diabetes, 2014, v. 63, n. 6, p. 1907, doi. 10.2337/db13-0816

By:

Jain, Swati S.;
Paglialunga, Sabina;
Vigna, Chris;
Ludzki, Alison;
Herbst, Eric A.;
Lally, James S.;
Schrauwen, Patrick;
Hoeks, Joris;
Tupling, A. Russ;
Bonen, Arend;
Holloway, Graham P.

Publication type:

Article

Update and trends on pharmacokinetic studies in patients with impaired renal function: practical insight into application of the FDA and EMA guidelines.

Published in:

Expert Review of Clinical Pharmacology, 2017, v. 10, n. 3, p. 273, doi. 10.1080/17512433.2017.1274651

By:

Paglialunga, Sabina;
Offman, Elliot;
Ichhpurani, Nita;
Marbury, Thomas C.;
Morimoto, Bruce H.

Publication type:

Article

Relationship of C5L2 Receptor to Skeletal Muscle Substrate Utilization.

Published in:

PLoS ONE, 2013, v. 8, n. 2, p. 1, doi. 10.1371/journal.pone.0057494

By:

Roy, Christian;
Paglialunga, Sabina;
Schaart, Gert;
Moonen-Kornips, Esther;
Meex, Ruth C.;
Phielix, Esther;
Hoeks, Joris;
Hesselink, Matthijs K. C.;
Cianflone, Katherine;
Schrauwen, Patrick

Publication type:

Article

The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.

Published in:

Applied Physiology, Nutrition & Metabolism, 2017, v. 42, n. 6, p. 647, doi. 10.1139/apnm-2016-0585

By:

Paglialunga, Sabina;
Simnett, Genevieve;
Robson, Holly;
Hoang, Monica;
Pillai, Renjitha;
Arkell, Alicia M.;
Simpson, Jeremy A.;
Bonen, Arend;
Huising, Mark;
Joseph, Jamie W.;
Holloway, Graham P.

Publication type:

Article

Regulation of postprandial lipemia: an update on current trends.

Published in:

Applied Physiology, Nutrition & Metabolism, 2007, v. 32, n. 1, p. 61, doi. 10.1139/H06-100

By:

Paglialunga, Sabina;
Cianflone, Katherine

Publication type:

Article

Role of prolyl hydroxylase domain proteins in the regulation of insulin secretion.

Published in:

Physiological Reports, 2016, v. 4, n. 5, p. 1, doi. 10.14814/phy2.12722

By:

Huang, Mei;
Paglialunga, Sabina;
Wong, Julia M.‐K.;
Hoang, Monica;
Pillai, Renjitha;
Joseph, Jamie W.

Publication type:

Article

Prevalence of Baseline Cardiac Arrhythmias in Participants with Overweight or Obesity in Phase 1 Clinical Trials: Analysis of 24‐Hour Holter Electrocardiogram Recordings.

Published in:

Journal of Clinical Pharmacology, 2023, v. 63, n. 5, p. 539, doi. 10.1002/jcph.2193

By:

Skovgaard, Dorthe;
Haahr, Poul‐Martin;
Lester, Robert;
Clark, Katherine;
Paglialunga, Sabina;
Finer, Nick;
Friedrichsen, Martin H.;
Hjerpsted, Julie B.;
Engelmann, Mads D.M.

Publication type:

Article

Cystatin C Is a More Reliable Biomarker for Determining eGFR to Support Drug Development Studies.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 10, p. 1239, doi. 10.1002/jcph.1132

By:

Kar, Sumit;
Paglialunga, Sabina;
Islam, Rafiqul

Publication type:

Article

Clinical assessment of hepatic de novo lipogenesis in non-alcoholic fatty liver disease.

Published in:

Lipids in Health & Disease, 2016, v. 15, p. 1, doi. 10.1186/s12944-016-0321-5

By:

Paglialunga, Sabina;
Dehn, Clayton A.

Publication type:

Article