Works by PAULE, MERLE G.

Results: 45

Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles.
Published in:
Drug Metabolism Reviews, 2014, v. 46, n. 2, p. 224, doi. 10.3109/03602532.2013.873450
By:
- Trickler, William J.;
- Lantz-McPeak, Susan M.;
- Robinson, Bonnie L.;
- Paule, Merle G.;
- Slikker, William;
- Biris, Alexandru S.;
- Schlager, John J.;
- Hussain, Saber M.;
- Kanungo, Jyotshna;
- Gonzalez, Carmen;
- Ali, Syed F.
Publication type:
Article
Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward.
Published in:
Toxicological Sciences, 2015, v. 148, n. 2, p. 332, doi. 10.1093/toxsci/kfv188
By:
- Roberts, Ruth A.;
- Aschner, Michael;
- Calligaro, David;
- Guilarte, Tomas R.;
- Hanig, Joseph P.;
- Herr, David W.;
- Hudzik, Thomas J.;
- Jeromin, Andreas;
- Kallman, Mary J.;
- Liachenko, Serguei;
- Lynch III, James J.;
- Miller, Diane B.;
- Moser, Virginia C.;
- O'Callaghan, James P.;
- Slikker Jr, William;
- Paule, Merle G.
Publication type:
Article
Potential Adverse Effects of Prolonged Sevoflurane Exposure on Developing Monkey Brain: From Abnormal Lipid Metabolism to Neuronal Damage.
Published in:
Toxicological Sciences, 2015, v. 147, n. 2, p. 562, doi. 10.1093/toxsci/kfv150
By:
- Fang Liu;
- Rainosek, Shuo W.;
- Frisch-Daiello, Jessica L.;
- Patterson, Tucker A.;
- Paule, Merle G.;
- Slikker Jr., William;
- Cheng Wang;
- Xianlin Han
Publication type:
Article
Quantitative Assessment of MRI T2 Response to Kainic Acid Neurotoxicity in Rats in vivo.
Published in:
Toxicological Sciences, 2015, v. 146, n. 1, p. 183, doi. 10.1093/toxsci/kfv083
By:
- Liachenko, Serguei;
- Ramu, Jaivijay;
- Konak, Tetyana;
- Paule, Merle G.;
- Hanig, Joseph
Publication type:
Article
Ketamine-Induced Neuronal Damage and Altered N-Methyl-d-Aspartate Receptor Function in Rat Primary Forebrain Culture.
Published in:
Toxicological Sciences, 2013, v. 131, n. 2, p. 548, doi. 10.1093/toxsci/kfs296
By:
- Liu, Fang;
- Patterson, Tucker A.;
- Sadovova, Natalya;
- Zhang, Xuan;
- Liu, Shuliang;
- Zou, Xiaoju;
- Hanig, Joseph P.;
- Paule, Merle G.;
- Slikker, William;
- Wang, Cheng
Publication type:
Article
Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells.
Published in:
Toxicological Sciences, 2010, v. 118, n. 1, p. 160, doi. 10.1093/toxsci/kfq244
By:
- Trickler, William J.;
- Lantz, Susan M.;
- Murdock, Richard C.;
- Schrand, Amanda M.;
- Robinson, Bonnie L.;
- Newport, Glenn D.;
- Schlager, John J.;
- Oldenburg, Steven J.;
- Paule, Merle G.;
- Slikker, William;
- Hussain, Saber M.;
- Ali, Syed F.
Publication type:
Article
A Minimally Invasive, Translational Biomarker of Ketamine-Induced Neuronal Death in Rats: microPET Imaging Using 18F-Annexin V.
Published in:
Toxicological Sciences, 2009, v. 111, n. 2, p. 355, doi. 10.1093/toxsci/kfp167
By:
- Xuan Zhang;
- Paule, Merle G.;
- Newport, Glenn D.;
- Xiaoju Zou;
- Sadovova, Natalya;
- Berridge, Marc S.;
- Apana, Scott M.;
- Hanig, Joseph P.;
- Slikker Jr., William;
- Cheng Wang
Publication type:
Article
MicroPET/CT Imaging of [18F]-FEPPA in the Nonhuman Primate: A Potential Biomarker of Pathogenic Processes Associated with Anesthetic-Induced Neurotoxicity.
Published in:
ISRN Anesthesiology, 2012, p. 1, doi. 10.5402/2012/261640
By:
- Zhang, Xuan;
- Paule, Merle G.;
- Newport, Glenn D.;
- Liu, Fang;
- Callicott, Ralph;
- Liu, Shuliang;
- Berridge, Marc S.;
- Apana, Scott M.;
- Slikker Jr., William;
- Wang, Cheng
Publication type:
Article
Brain microvessel endothelial cells responses to gold nanoparticles: In vitro pro-inflammatory mediators and permeability.
Published in:
Nanotoxicology, 2011, v. 5, n. 4, p. 479, doi. 10.3109/17435390.2010.540356
By:
- Trickler, William J.;
- Lantz, Susan M.;
- Murdock, Richard C.;
- Schrand, Amanda M.;
- Robinson, Bonnie L.;
- Newport, Glenn D.;
- Schlager, John J.;
- Oldenburg, Steven J.;
- Paule, Merle G.;
- Slikker Jr, William;
- Hussain, Saber M.;
- Ali, Syed F.
Publication type:
Article
Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry.
Published in:
Rapid Communications in Mass Spectrometry: RCM, 2000, v. 14, n. 8, p. 619, doi. 10.1002/(SICI)1097-0231(20000430)14:8<619::AID-RCM916>3.0.CO;2-2
By:
- Doerge, Daniel R.;
- Matthew Fogle, C.;
- Paule, Merle G.;
- McCullagh, Michael;
- Bajic, Steve
Publication type:
Article
Chronic Cocaine Exposure throughout Gestation in the Rhesus Monkey.
Published in:
Annals of the New York Academy of Sciences, 1996, v. 801, n. 1, p. 301, doi. 10.1111/j.1749-6632.1996.tb17450.x
By:
- PAULE, MERLE G.;
- GILLAM, MICHAEL P.;
- BINIENDA, ZBIGNIEW;
- MORRIS, PAUL
Publication type:
Article
Disruption of blastomeric F-actin: a potential early biomarker of developmental toxicity in zebrafish.
Published in:
Molecular & Cellular Biochemistry, 2011, v. 353, n. 1/2, p. 283, doi. 10.1007/s11010-011-0797-2
By:
- Kanungo, Jyotshnabala;
- Paule, Merle G.
Publication type:
Article
Positron emission tomography with [18F]FLT revealed sevoflurane-induced inhibition of neural progenitor cell expansion in vivo.
Published in:
Frontiers in Neurology, 2014, v. 5, p. 1, doi. 10.3389/fneur.2014.00234
By:
- Shuliang Liu;
- Paule, Merle G.;
- Xuan Zhang;
- Newport, Glenn D.;
- Patterson, Tucker A.;
- Apana, Scott M.;
- Berridge, Marc S.;
- Maisha, Mackean P.;
- Slikker Jr., William;
- Cheng Wang
Publication type:
Article
The Reinforcing Effects of Nicotine in Humans and Nonhuman Primates: A Review of Intravenous Self-Administration Evidence and Future Directions for Research.
Published in:
2015
By:
- Goodwin, Amy K.;
- Takato Hiranita;
- Paule, Merle G.;
- Hiranita, Takato
Publication type:
journal article
Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children.
Published in:
New Directions for Child & Adolescent Development, 2022, v. 2022, n. 181/182, p. 53, doi. 10.1002/cad.20458
By:
- Merced‐Nieves, Francheska M.;
- Chelonis, John;
- Pantic, Ivan;
- Schnass, Lourdes;
- Téllez‐Rojo, Martha M.;
- Braun, Joseph M.;
- Paule, Merle G.;
- Wright, Rosalind J.;
- Wright, Robert O.;
- Curtin, Paul
Publication type:
Article
Cytotoxicity profile of pristine graphene on brain microvascular endothelial cells.
Published in:
Journal of Applied Toxicology, 2019, v. 39, n. 7, p. 966, doi. 10.1002/jat.3786
By:
- Rosas‐Hernandez, Hector;
- Ramirez‐Lee, Manuel A.;
- Cuevas, Elvis;
- Lantz, Susan M.;
- Imam, Syed Z.;
- Paule, Merle G.;
- Ali, Syed F.;
- Escudero‐Lourdes, Claudia;
- Majeed, Waqar;
- Bourdo, Shawn E.;
- Biris, Alexandru S.
Publication type:
Article
Cyclosporine exacerbates ketamine toxicity in zebrafish: Mechanistic studies on drug-drug interaction.
Published in:
Journal of Applied Toxicology, 2017, v. 37, n. 12, p. 1438, doi. 10.1002/jat.3488
By:
- Robinson, Bonnie L.;
- Dumas, Melanie;
- Ali, Syed F.;
- Paule, Merle G.;
- Gu, Qiang;
- Kanungo, Jyotshna
Publication type:
Article
Acetyl L-carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment.
Published in:
Journal of Applied Toxicology, 2017, v. 37, n. 2, p. 192, doi. 10.1002/jat.3340
By:
- Guo, Xiaoqing;
- Dumas, Melanie;
- Robinson, Bonnie L.;
- Ali, Syed F.;
- Paule, Merle G.;
- Gu, Qiang;
- Kanungo, Jyotshna
Publication type:
Article
Developmental toxicity assay using high content screening of zebrafish embryos.
Published in:
Journal of Applied Toxicology, 2015, v. 35, n. 3, p. 261, doi. 10.1002/jat.3029
By:
- Lantz‐McPeak, Susan;
- Guo, Xiaoqing;
- Cuevas, Elvis;
- Dumas, Melanie;
- Newport, Glenn D.;
- Ali, Syed F.;
- Paule, Merle G.;
- Kanungo, Jyotshna
Publication type:
Article
Ketamine attenuates cytochrome p450 aromatase gene expression and estradiol-17β levels in zebrafish early life stages.
Published in:
Journal of Applied Toxicology, 2014, v. 34, n. 5, p. 480, doi. 10.1002/jat.2888
By:
- Trickler, William J.;
- Guo, Xiaoqing;
- Cuevas, Elvis;
- Ali, Syed F.;
- Paule, Merle G.;
- Kanungo, Jyotshna
Publication type:
Article
Application of microPET imaging approaches in the study of pediatric anesthetic-induced neuronal toxicity.
Published in:
Journal of Applied Toxicology, 2013, v. 33, n. 9, p. 861, doi. 10.1002/jat.2857
By:
- Zhang, Xuan;
- Paule, Merle G.;
- Wang, Cheng;
- Slikker, William
Publication type:
Article
Ketamine induces motor neuron toxicity and alters neurogenic and proneural gene expression in zebrafish.
Published in:
Journal of Applied Toxicology, 2013, v. 33, n. 6, p. 410, doi. 10.1002/jat.1751
By:
- Kanungo, Jyotshna;
- Cuevas, Elvis;
- Ali, Syed F.;
- Paule, Merle G.
Publication type:
Article
Systems biology approaches for toxicology.
Published in:
Journal of Applied Toxicology, 2007, v. 27, n. 3, p. 201, doi. 10.1002/jat.1207
By:
- Slikker, Jr., William;
- Paule, Merle G.;
- Wright, Linnzi K. M.;
- Patterson, Tucker A.;
- Cheng Wang
Publication type:
Article
Preclinical Assessment of Ketamine.
Published in:
CNS Neuroscience & Therapeutics, 2013, v. 19, n. 6, p. 448, doi. 10.1111/cns.12079
By:
- Wang, Cheng;
- Liu, Fang;
- Patterson, Tucker A.;
- Paule, Merle G.;
- Slikker, William
Publication type:
Article
Effects of silver nanoparticles on human and rat embryonic neural stem cells.
Published in:
Frontiers in Neuroscience, 2015, v. 9, p. 1, doi. 10.3389/fnins.2015.00115
By:
- Fang Liu;
- Mahmood, Meena;
- Yang Xu;
- Watanabe, Fumiya;
- Biris, Alexandru S.;
- Hansen, Deborah K.;
- Inselman, Amy;
- Casciano, Daniel;
- Patterson, Tucker A.;
- Paule, Merle G.;
- Slikker Jr., William;
- Cheng Wang
Publication type:
Article
Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain Barrier.
Published in:
Molecular Neurobiology, 2018, v. 55, n. 1, p. 258, doi. 10.1007/s12035-017-0738-5
By:
- Rosas-Hernandez, Hector;
- Cuevas, Elvis;
- Escudero-Lourdes, Claudia;
- Lantz, Susan M.;
- Gomez-Crisostomo, Nancy P.;
- Sturdivant, Nasya M.;
- Balachandran, Kartik;
- Imam, Syed Z.;
- Slikker, William;
- Paule, Merle G.;
- Ali, Syed F.
Publication type:
Article
A Working Module for the Neurovascular Unit in the Sexually Dimorphic Nucleus of the Preoptic Area.
Published in:
Molecular Neurobiology, 2018, v. 55, n. 1, p. 156, doi. 10.1007/s12035-017-0729-6
By:
- He, Zhen;
- Cui, Li;
- Ferguson, Sherry A.;
- Paule, Merle G.
Publication type:
Article
Downregulation of 14-3-3 Proteins in a Kainic Acid-Induced Neurotoxicity Model.
Published in:
Molecular Neurobiology, 2018, v. 55, n. 1, p. 122, doi. 10.1007/s12035-017-0724-y
By:
- Smani, Danyal;
- Sarkar, Sumit;
- Raymick, James;
- Kanungo, Jyotshna;
- Paule, Merle G.;
- Gu, Qiang
Publication type:
Article
Prolonged exposure to ketamine increases neurodegeneration in the developing monkey brain
Published in:
International Journal of Developmental Neuroscience, 2009, v. 27, n. 7, p. 727, doi. 10.1016/j.ijdevneu.2009.06.010
By:
- Zou, Xiaoju;
- Patterson, Tucker A.;
- Divine, Rebecca L.;
- Sadovova, Natalya;
- Zhang, Xuan;
- Hanig, Joseph P.;
- Paule, Merle G.;
- Slikker, William;
- Wang, Cheng
Publication type:
Article
Protein Kinases and Parkinson's Disease.
Published in:
International Journal of Molecular Sciences, 2016, v. 17, n. 9, p. 1585, doi. 10.3390/ijms17091585
By:
- Mehdi, Syed Jafar;
- Rosas-Hernandez, Hector;
- Cuevas, Elvis;
- Lantz, Susan M.;
- Barger, Steven W.;
- Sarkar, Sumit;
- Paule, Merle G.;
- Ali, Syed F.;
- Imam, Syed Z.
Publication type:
Article
Chronic Exposure to NMDA Receptor and Sodium Channel Blockers during Development in Monkeys and Rats.
Published in:
Annals of the New York Academy of Sciences, 2003, v. 993, n. 1, p. 116, doi. 10.1111/j.1749-6632.2003.tb07519.x
By:
- PAULE, MERLE G.;
- FOGLE, C. MATTHEW;
- ALLEN, RICHARD R.;
- PEARSON, EDWIN C.;
- HAMMOND, TIMOTHY G.;
- POPKE, E. JON
Publication type:
Article
Effects of Chronic NMDA Receptor and Fast Sodium Channel Blockade during Development on the Acquisition of Visual Discriminations and Learning Abilities in Rhesus Monkeys.
Published in:
Annals of the New York Academy of Sciences, 2001, v. 939, n. 1, p. 237, doi. 10.1111/j.1749-6632.2001.tb03630.x
By:
- PAULE, MERLE G.;
- POPKE, E. JON;
- ALLEN, RICHARD R.;
- PEARSON, EDWIN;
- HAMMOND, TIM
Publication type:
Article
Effects of Chronic in Utero Exposure to Cocaine on Behavioral Adaptability in Rhesus Monkey Offspring When Examined in Adulthood.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 914, n. 1, p. 412, doi. 10.1111/j.1749-6632.2000.tb05215.x
By:
- PAULE, MERLE G.;
- GILLAM, MICHAEL P.;
- ALLEN, RICHARD R.;
- CHELONIS, JOHN J.
Publication type:
Article
Development of a Nonhuman Primate Model for Studying the Consequences of Long-Term Neuroprotectant Administration on Complex Brain Functions in Developing Animals.
Published in:
Annals of the New York Academy of Sciences, 1999, v. 890, n. 1, p. 470, doi. 10.1111/j.1749-6632.1999.tb08027.x
By:
- PAULE, MERLE G.;
- POPKE, E. JON;
- PEARSON, EDWIN;
- HAMMOND, TIM
Publication type:
Article
The Effects of Cocaine on Nonhuman Primate Brain Function Are Age Dependenta.
Published in:
Annals of the New York Academy of Sciences, 1998, v. 844, n. 1, p. 178, doi. 10.1111/j.1749-6632.1998.tb08232.x
By:
- PAULE, MERLE G.;
- GILLAM, MICHAEL P.;
- MORRIS, PAUL
Publication type:
Article
Acute Effects of Dexfenfluramine (d-FEN) and Methylenedioxymethamphetamine (MDMA) before and after Short-Course, High-Dose Treatment.
Published in:
Annals of the New York Academy of Sciences, 1998, v. 844, n. 1, p. 183, doi. 10.1111/j.1749-6632.1998.tb08233.x
By:
- FREDERICK, DAVID L.;
- ALI, SYED F.;
- GILLAM, MICHAEL P.;
- GOSSETT, JEFF;
- SLIKKER, WILLIAM;
- PAULE, MERLE G.
Publication type:
Article
Potential Neurotoxicity of Ketamine in the Developing Rat Brain.
Published in:
Toxicological Sciences, 2009, v. 108, n. 1, p. 149, doi. 10.1093/toxsci/kfn270
By:
- Xiaoju Zou;
- Tucker A. Patterson;
- Natalya Sadovova;
- Nathan C. Twaddle;
- Daniel R. Doerge;
- Xuan Zhang;
- Xin Fu;
- Joseph P. Hanig;
- Merle G. Paule;
- William Slikker;
- Cheng Wang
Publication type:
Article
Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey.
Published in:
Toxicological Sciences, 2007, v. 98, n. 1, p. 145, doi. 10.1093/toxsci/kfm084
By:
- William Slikker;
- Xiaoju Zou;
- Charlotte E. Hotchkiss;
- Rebecca L. Divine;
- Natalya Sadovova;
- Nathan C. Twaddle;
- Daniel R. Doerge;
- Andrew C. Scallet;
- Tucker A. Patterson;
- Joseph P. Hanig;
- Merle G. Paule;
- Cheng Wang
Publication type:
Article
Blockade of N-Methyl-D-Aspartate Receptors by Ketamine Produces Loss of Postnatal Day 3 Monkey Frontal Cortical Neurons in Culture.
Published in:
Toxicological Sciences, 2006, v. 91, n. 1, p. 192, doi. 10.1093/toxsci/kfj144
By:
- Cheng Wang;
- Sadovova, Natalya;
- Hotchkiss, Charlotte;
- Xin Fu;
- Scallet, Andrew C.;
- Patterson, Tucker A.;
- Hanig, Joseph;
- Paule, Merle G.;
- Slikker Jr., William
Publication type:
Article
Ontogeny of the N-Methyl-D-Aspartate (NMDA) Receptor System and Susceptibility to Neurotoxicity.
Published in:
Toxicological Sciences, 2002, v. 68, n. 1, p. 9, doi. 10.1093/toxsci/68.1.9
By:
- Haberny, Kathleen A.;
- Paule, Merle G.;
- Scallet, Andrew C.;
- Sistare, Frank D.;
- Lester, David S.;
- Hanig, Joseph P.;
- Slikker Jr., William
Publication type:
Article
Cognitive Tests: Interpretation for Neurotoxicity? (Workshop Summary).
Published in:
Toxicological Sciences, 2000, v. 58, n. 2, p. 222, doi. 10.1093/toxsci/58.2.222
By:
- Slikker Jr., William;
- Beck, Barbara D.;
- Cory-Slechta, Deborah A.;
- Paule, Merle G.;
- Anger, W. Kent;
- Bellinger, David
Publication type:
Article
Meal-Induced Increase in Plasma Gastrin Immunoreactivity in the Rhesus Monkey (Macaca mulatta).
Published in:
American Journal of Primatology, 1989, v. 18, n. 4, p. 315, doi. 10.1002/ajp.1350180405
By:
- Scallet, Andrew C.;
- McKay, Daniel;
- Baley, John R.;
- Ali, Syed F.;
- Paule, Merle G.;
- Slikker, Jr., William;
- Rayford, Phillip L.
Publication type:
Article
Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates.
Published in:
PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0106101
By:
- Yang, Xiaoxia;
- Morris, Suzanne M.;
- Gearhart, Jeffery M.;
- Ruark, Christopher D.;
- Paule, Merle G.;
- Slikker Jr, William;
- Mattison, Donald R.;
- Vitiello, Benedetto;
- Twaddle, Nathan C.;
- Doerge, Daniel R.;
- Young, John F.;
- Fisher, Jeffrey W.
Publication type:
Article
Neuroprotective Efficacy of a New Brain-Penetrating C-Abl Inhibitor in a Murine Parkinson’s Disease Model
Published in:
PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0065129
By:
- Imam, Syed Z.;
- Trickler, William;
- Kimura, Shinya;
- Binienda, Zbigniew K.;
- Paule, Merle G.;
- Slikker Jr, William;
- Li, Senlin;
- Clark, Robert A.;
- Ali, Syed F.
Publication type:
Article
Role of Neural Stem Cell Activity in Postweaning Development of the Sexually Dimorphic Nucleus of the Preoptic Area in Rats.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054927
By:
- Zhen He;
- Ferguson, Sherry A.;
- Li Cui;
- Greenfield Jr., L. John;
- Paule, Merle G.
Publication type:
Article