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Xylosyltransferase I mediates the synthesis of proteoglycans with long glycosaminoglycan chains and controls chondrocyte hypertrophy and collagen fibers organization of in the growth plate.
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- Cell Death & Disease, 2023, v. 14, n. 6, p. 1, doi. 10.1038/s41419-023-05875-0
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TMEM165 a new player in proteoglycan synthesis: loss of TMEM165 impairs elongation of chondroitin- and heparan-sulfate glycosaminoglycan chains of proteoglycans and triggers early chondrocyte differentiation and hypertrophy.
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- Cell Death & Disease, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41419-021-04458-1
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Involvement of thapsigargin- and cyclopiazonic acid-sensitive pumps in the rescue of TMEM165-associated glycosylation defects by Mn<sup>2+</sup>.
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- FASEB Journal, 2019, v. 33, n. 2, p. 2669, doi. 10.1096/fj.201800387R
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- Article
Targeting of Proteoglycan Synthesis Pathway: A New Strategy to Counteract Excessive Matrix Proteoglycan Deposition and Transforming Growth Factor-β1-Induced Fibrotic Phenotype in Lung Fibroblasts.
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- PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146499
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- Article
The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.
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- Frontiers in Cellular Neuroscience, 2014, v. 8, p. 1, doi. 10.3389/fncel.2014.00349
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- Article
Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1-Induced Pulmonary Fibrosis.
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- American Journal of Respiratory Cell & Molecular Biology, 2014, v. 50, n. 3, p. 583, doi. 10.1165/rcmb.2012-0226OC
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- Article
Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.
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- Glycobiology, 2012, v. 22, n. 4, p. 561, doi. 10.1093/glycob/cwr172
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- Article
Xylosyltransferase-I Regulates Glycosaminoglycan Synthesis during the Pathogenic Process of Human Osteoarthritis.
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- PLoS ONE, 2012, v. 7, n. 3, p. 1, doi. 10.1371/journal.pone.0034020
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Molecular characterization of β1,4-galactosyltransferase 7 genetic mutations linked to the progeroid form of Ehlers–Danlos syndrome (EDS)
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- FEBS Letters, 2010, v. 584, n. 18, p. 3962, doi. 10.1016/j.febslet.2010.08.001
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- Article
Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.
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- FASEB Journal, 2010, v. 24, n. 2, p. 436, doi. 10.1096/fj.09-136291
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- Article
Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair.
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- FASEB Journal, 2009, v. 23, n. 3, p. 813, doi. 10.1096/fj.08-118166
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- Article
Molecular basis for acceptor substrate specificity of the human {beta}1,3-glucuronosyltransferases GlcAT-I and GlcAT-P involved in glycosaminoglycan and HNK-1 carbohydrate epitope biosynthesis, respectively.
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- Glycobiology, 2007, v. 17, n. 8, p. 857, doi. 10.1093/glycob/cwm055
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Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7.
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- FEBS Journal, 2007, v. 274, n. 5, p. 1256, doi. 10.1111/j.1742-4658.2007.05670.x
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- Article
Evidence of calcium-dependent pathway in the regulation of human β1,3-glucuronosyltransferase-1 (GlcAT-I) gene expression: a key enzyme in proteoglycan synthesis.
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- FASEB Journal, 2006, v. 20, n. 10, p. 1692, doi. 10.1096/fj.05-5073fje
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Phylogenetic and mutational analyses reveal key residues for UDP-glucuronic acid binding and activity of β1,3-glucuronosyltransferase I (GlcAT-I).
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- Protein Science: A Publication of the Protein Society, 2006, v. 15, n. 7, p. 1667, doi. 10.1110/ps.062089106
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The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms.
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- FEBS Journal, 2005, v. 272, n. 4, p. 1063, doi. 10.1111/j.1742-4658.2005.04548.x
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- Article