Works by Ottmann, Christian

Results: 80
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    Stabilizer-Guided Inhibition of Protein–Protein Interactions.

    Published in:
    Angewandte Chemie, 2015, v. 127, n. 52, p. 15946, doi. 10.1002/ange.201507976
    By:
    • Milroy, Lech ‐ Gustav;
    • Bartel, Maria;
    • Henen, Morkos A.;
    • Leysen, Seppe;
    • Adriaans, Joris M. C.;
    • Brunsveld, Luc;
    • Landrieu, Isabelle;
    • Ottmann, Christian
    Publication type:
    Article
    3

    A Natural-Product Switch for a Dynamic Protein Interface.

    Published in:
    Angewandte Chemie, 2014, v. 126, n. 25, p. 6561, doi. 10.1002/ange.201403773
    By:
    • Scheepstra, Marcel;
    • Nieto, Lidia;
    • Hirsch, Anna K. H.;
    • Fuchs, Sascha;
    • Leysen, Seppe;
    • Lam, Chan Vinh;
    • in het Panhuis, Leslie;
    • van Boeckel, Constant A. A.;
    • Wienk, Hans;
    • Boelens, Rolf;
    • Ottmann, Christian;
    • Milroy, Lech-Gustav;
    • Brunsveld, Luc
    Publication type:
    Article
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    Stabilization of protein-protein interactions in drug discovery.

    Published in:
    Expert Opinion on Drug Discovery, 2017, v. 12, n. 9, p. 925, doi. 10.1080/17460441.2017.1346608
    By:
    • Andrei, Sebastian A.;
    • Sijbesma, Eline;
    • Hann, Michael;
    • Davis, Jeremy;
    • O’Mahony, Gavin;
    • Perry, Matthew W. D.;
    • Karawajczyk, Anna;
    • Eickhoff, Jan;
    • Brunsveld, Luc;
    • Doveston, Richard G.;
    • Milroy, Lech-Gustav;
    • Ottmann, Christian
    Publication type:
    Article
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    Allosteric Regulation of Proteases.

    Published in:
    ChemBioChem, 2008, v. 9, n. 18, p. 2920, doi. 10.1002/cbic.200800528
    By:
    • Hauske, Patrick;
    • Ottmann, Christian;
    • Meltzer, Michael;
    • Ehrmann, Michael;
    • Kaiser, Markus
    Publication type:
    Article
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    Intermolecular channels direct crystal orientation in mineralized collagen.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18846-2
    By:
    • Xu, YiFei;
    • Nudelman, Fabio;
    • Eren, E. Deniz;
    • Wirix, Maarten J. M.;
    • Cantaert, Bram;
    • Nijhuis, Wouter H.;
    • Hermida-Merino, Daniel;
    • Portale, Giuseppe;
    • Bomans, Paul H. H.;
    • Ottmann, Christian;
    • Friedrich, Heiner;
    • Bras, Wim;
    • Akiva, Anat;
    • Orgel, Joseph P. R. O.;
    • Meldrum, Fiona C.;
    • Sommerdijk, Nico
    Publication type:
    Article
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    TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics.

    Published in:
    Angewandte Chemie, 2020, v. 132, n. 46, p. 20518, doi. 10.1002/ange.202006280
    By:
    • Kunig, Verena B. K.;
    • Potowski, Marco;
    • Akbarzadeh, Mohammad;
    • Klika Škopić, Mateja;
    • Santos Smith, Denise;
    • Arendt, Lukas;
    • Dormuth, Ina;
    • Adihou, Hélène;
    • Andlovic, Blaž;
    • Karatas, Hacer;
    • Shaabani, Shabnam;
    • Zarganes‐Tzitzikas, Tryfon;
    • Neochoritis, Constantinos G.;
    • Zhang, Ran;
    • Groves, Matthew;
    • Guéret, Stéphanie M.;
    • Ottmann, Christian;
    • Rahnenführer, Jörg;
    • Fried, Roland;
    • Dömling, Alexander
    Publication type:
    Article
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    Designed Spiroketal Protein Modulation.

    Published in:
    Angewandte Chemie, 2017, v. 129, n. 20, p. 5572, doi. 10.1002/ange.201612504
    By:
    • Scheepstra, Marcel;
    • Andrei, Sebastian A.;
    • Unver, M. Yagiz;
    • Hirsch, Anna K. H.;
    • Leysen, Seppe;
    • Ottmann, Christian;
    • Brunsveld, Luc;
    • Milroy, Lech ‐ Gustav
    Publication type:
    Article
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    Identification of an allosteric binding site for RORγt inhibition.

    Published in:
    Nature Communications, 2015, v. 6, n. 12, p. 8833, doi. 10.1038/ncomms9833
    By:
    • Scheepstra, Marcel;
    • Leysen, Seppe;
    • van Almen, Geert C.;
    • Miller, J. Richard;
    • Piesvaux, Jennifer;
    • Kutilek, Victoria;
    • van Eenennaam, Hans;
    • Zhang, Hongjun;
    • Barr, Kenneth;
    • Nagpal, Sunil;
    • Soisson, Stephen M.;
    • Kornienko, Maria;
    • Wiley, Kristen;
    • Elsen, Nathaniel;
    • Sharma, Sujata;
    • Correll, Craig C.;
    • Trotter, B. Wesley;
    • van der Stelt, Mario;
    • Oubrie, Arthur;
    • Ottmann, Christian
    Publication type:
    Article
    41

    In melanoma, Hippo signaling is affected by copy number alterations and YAP1 overexpression impairs patient survival.

    Published in:
    Pigment Cell & Melanoma Research, 2014, v. 27, n. 4, p. 671, doi. 10.1111/pcmr.12249
    By:
    • Menzel, Moritz;
    • Meckbach, Diana;
    • Weide, Benjamin;
    • Toussaint, Nora C.;
    • Schilbach, Karin;
    • Noor, Seema;
    • Eigentler, Thomas;
    • Ikenberg, Kristian;
    • Busch, Christian;
    • Quintanilla ‐ Martinez, Leticia;
    • Kohlhofer, Ursula;
    • Göke, Antonia;
    • Göke, Friederike;
    • Handgretinger, Rupert;
    • Ottmann, Christian;
    • Bastian, Boris C.;
    • Garbe, Claus;
    • Röcken, Martin;
    • Perner, Sven;
    • Kohlbacher, Oliver
    Publication type:
    Article
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    TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics.

    Published in:
    Angewandte Chemie International Edition, 2020, v. 59, n. 46, p. 20338, doi. 10.1002/anie.202006280
    By:
    • Kunig, Verena B. K.;
    • Potowski, Marco;
    • Akbarzadeh, Mohammad;
    • Klika Škopić, Mateja;
    • Santos Smith, Denise;
    • Arendt, Lukas;
    • Dormuth, Ina;
    • Adihou, Hélène;
    • Andlovic, Blaž;
    • Karatas, Hacer;
    • Shaabani, Shabnam;
    • Zarganes‐Tzitzikas, Tryfon;
    • Neochoritis, Constantinos G.;
    • Zhang, Ran;
    • Groves, Matthew;
    • Guéret, Stéphanie M.;
    • Ottmann, Christian;
    • Rahnenführer, Jörg;
    • Fried, Roland;
    • Dömling, Alexander
    Publication type:
    Article
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    Designed Spiroketal Protein Modulation.

    Published in:
    Angewandte Chemie International Edition, 2017, v. 56, n. 20, p. 5480, doi. 10.1002/anie.201612504
    By:
    • Scheepstra, Marcel;
    • Andrei, Sebastian A.;
    • Unver, M. Yagiz;
    • Hirsch, Anna K. H.;
    • Leysen, Seppe;
    • Ottmann, Christian;
    • Brunsveld, Luc;
    • Milroy, Lech‐Gustav
    Publication type:
    Article