Works by Ottenheijm, Coen A C

Results: 40

Pathogenic TNNT1 variants are associated with aberrant thin filament compliance and myofibre hyper‐contractility.

Published in:

Journal of Physiology, 2025, v. 603, n. 12, p. 3533, doi. 10.1113/JP288109

By:

Laitila, Jenni;
Lewis, Christopher T. A.;
Hessel, Anthony L.;
Primiano, Guido;
Hernandez‐Lain, Aurelio;
Fiorillo, Chiara;
Lawlor, Michael W.;
Ottenheijm, Coen A. C.;
Jungbluth, Heinz;
Man, Ka Fu;
Fornili, Arianna;
Ochala, Julien

Publication type:

Article

In vitro and in vivo muscle mass and strength during the first week of critical illness.

Published in:

Intensive Care Medicine Experimental, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40635-025-00755-7

By:

Claassen, Wout J.;
van Ruijven, Isabel M.;
van den Berg, Marloes;
Baelde, Rianne J.;
Fortes Monteiro, Alexcia;
Balesar, Rajvi M. N.;
Hania, Sylvia W.;
van der Peet, Donald L.;
Weijs, Peter J. M.;
Ottenheijm, Coen A. C.;
Stapel, Sandra N.

Publication type:

Article

In vitro and in vivo muscle mass and strength during the first week of critical illness.

Published in:

Intensive Care Medicine Experimental, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40635-025-00755-7

By:

Claassen, Wout J.;
van Ruijven, Isabel M.;
van den Berg, Marloes;
Baelde, Rianne J.;
Fortes Monteiro, Alexcia;
Balesar, Rajvi M. N.;
Hania, Sylvia W.;
van der Peet, Donald L.;
Weijs, Peter J. M.;
Ottenheijm, Coen A. C.;
Stapel, Sandra N.

Publication type:

Article

Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers.

Published in:

2021

By:

Shi, Zhonghua;
de Vries, Heder J.;
Vlaar, Alexander P. J.;
van der Hoeven, Johannes;
Boon, Reinier A.;
Heunks, Leo M. A.;
Ottenheijm, Coen A. C.;
Dutch COVID-19 Diaphragm Investigators

Publication type:

journal article

Nebulin, a major player in muscle health and disease.

Published in:

FASEB Journal, 2011, v. 25, n. 3, p. 822, doi. 10.1096/fj.10-157412

By:

Labeit, Siegfried;
Ottenheijm, Coen A. C.;
Granzier, Henk

Publication type:

Article

Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle.

Published in:

FASEB Journal, 2008, v. 22, n. 8, p. 2912, doi. 10.1096/fj.07-104372

By:

Ottenheijm, Coen A. C.;
Chi Fong;
Vangheluwe, Peter;
Wuytack, Frank;
Babu, Gopal J.;
Periasamy, Muthu;
Witt, Christian C.;
Labeit, Siegfried;
Granzier, Henk

Publication type:

Article

Comprehensive phenotypic characterization of an allelic series of zebrafish models of NEB-related nemaline myopathy.

Published in:

Human Molecular Genetics, 2024, v. 33, n. 12, p. 1036, doi. 10.1093/hmg/ddae033

By:

Fabian, Lacramioara;
Karimi, Esmat;
Farman, Gerrie P;
Gohlke, Jochen;
Ottenheijm, Coen A C;
Granzier, Hendrikus L;
Dowling, James J

Publication type:

Article

Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.

Published in:

Human Molecular Genetics, 2021, v. 30, n. 14, p. 1305, doi. 10.1093/hmg/ddab112

By:

Winter, Josine M de;
Gineste, Charlotte;
Minardi, Elisa;
Brocca, Lorenza;
Rossi, Maira;
Borsboom, Tamara;
Beggs, Alan H;
Bernard, Monique;
Bendahan, David;
Hwee, Darren T;
Malik, Fady I;
Pellegrino, Maria Antonietta;
Bottinelli, Roberto;
Gondin, Julien;
Ottenheijm, Coen A C

Publication type:

Article

Muscle weakness in TPM3-myopathy is due to reduced Ca<sup>2+</sup>-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 22, p. 6278, doi. 10.1093/hmg/ddv334

By:

Yuen, Michaela;
Cooper, Sandra T.;
Marston, Steve B.;
Nowak, Kristen J.;
McNamara, Elyshia;
Mokbel, Nancy;
Ilkovski, Biljana;
Ravenscroft, Gianina;
Rendu, John;
de Winter, Josine M.;
Klinge, Lars;
Beggs, Alan H.;
North, Kathryn N.;
Ottenheijm, Coen A. C.;
Clarke, Nigel F.

Publication type:

Article

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Published in:

Brain: A Journal of Neurology, 2013, v. 136, n. 6, p. 1718, doi. 10.1093/brain/awt113

By:

Ottenheijm, Coen A. C.;
Buck, Danielle;
de Winter, Josine M.;
Ferrara, Claudia;
Piroddi, Nicoletta;
Tesi, Chiara;
Jasper, Jeffrey R.;
Malik, Fady I.;
Meng, Hui;
Stienen, Ger J. M.;
Beggs, Alan H.;
Labeit, Siegfried;
Poggesi, Corrado;
Lawlor, Michael W.;
Granzier, Henk

Publication type:

Article

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Published in:

2018

By:

Joureau, Barbara;
de Winter, Josine Marieke;
Conijn, Stefan;
Bogaards, Sylvia J. P.;
Kovacevic, Igor;
Kalganov, Albert;
Persson, Malin;
Lindqvist, Johan;
Stienen, Ger J. M.;
Irving, Thomas C.;
Ma, Weikang;
Yuen, Michaela;
Clarke, Nigel F.;
Rassier, Dilson E.;
Malfatti, Edoardo;
Romero, Norma B.;
Beggs, Alan H.;
Ottenheijm, Coen A. C.

Publication type:

journal article

Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers.

Published in:

2018

By:

Lindqvist, Johan;
van den Berg, Marloes;
van der Pijl, Robbert;
Hooijman, Pleuni E;
Beishuizen, Albertus;
Elshof, Judith;
de Waard, Monique;
Girbes, Armand;
Spoelstra-de Man, Angelique;
Shi, Zhong-Hua;
van den Brom, Charissa;
Bogaards, Sylvia;
Shen, Shengyi;
Strom, Joshua;
Granzier, Henk;
Kole, Jeroen;
Musters, René J P;
Paul, Marinus A;
Heunks, Leo M A;
Ottenheijm, Coen A C

Publication type:

journal article

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

Published in:

2017

By:

van den Berg, Marloes;
Hooijman, Pleuni E.;
Beishuizen, Albertus;
de Waard, Monique C.;
Paul, Marinus A.;
Hartemink, Koen J.;
van Hees, Hieronymus W. H.;
Lawlor, Michael W.;
Brocca, Lorenza;
Bottinelli, Roberto;
Pellegrino, Maria A.;
Stienen, Ger J. M.;
Heunks, Leo M. A.;
Wüst, Rob C. I.;
Ottenheijm, Coen A. C.

Publication type:

journal article

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

Published in:

2015

By:

Hooijman, Pleuni E;
Beishuizen, Albertus;
Witt, Christian C;
de Waard, Monique C;
Girbes, Armand R J;
Spoelstra-de Man, Angelique M E;
Niessen, Hans W M;
Manders, Emmy;
van Hees, Hieronymus W H;
van den Brom, Charissa E;
Silderhuis, Vera;
Lawlor, Michael W;
Labeit, Siegfried;
Stienen, Ger J M;
Hartemink, Koen J;
Paul, Marinus A;
Heunks, Leo M A;
Ottenheijm, Coen A C

Publication type:

journal article

Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 10, p. 1126, doi. 10.1164/rccm.201412-2214OC

By:

Hooijman, Pleuni E.;
Beishuizen, Albertus;
Witt, Christian C.;
de Waard, Monique C.;
Girbes, Armand R. J.;
Spoelstra-de Man, Angelique M. E.;
Niessen, Hans W. M.;
Manders, Emmy;
van Hees, Hieronymus W. H.;
van den Brom, Charissa E.;
Silderhuis, Vera;
Lawlor, Michael W.;
Labeit, Siegfried;
Stienen, Ger J. M.;
Hartemink, Koen J.;
Paul, Marinus A.;
Heunks, Leo M. A.;
Ottenheijm, Coen A. C.

Publication type:

Article

DIAPHRAGM MUSCLE FIBER WEAKNESS AND UBIQUITIN-PROTEASOME ACTIVATION IN CRITICALLY ILL PATIENTS.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 10, p. E1, doi. 10.1164/rccm.201412-2214oc

By:

Hooijman, Pleuni E.;
Beishuizen, Albertus;
Witt, Christian C.;
de Waard, Monique C.;
Girbes, Armand R. J.;
Spoelstra-de Man, Angelique M. E.;
Niessen, Hans W. M.;
Manders, E.;
van Hees, Hieronymus W. H.;
van den Brom, Charissa E.;
Silderhuis, Vera;
Lawlor, Michael W.;
Labeit, Siegfried;
Stienen, Ger J. M.;
Hartemink, Koen J.;
Paul, Marinus A.;
Heunks, Leo M. A.;
Ottenheijm, Coen A. C.

Publication type:

Article

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

Published in:

2014

By:

Hooijman, Pleuni E;
Beishuizen, Albertus;
de Waard, Monique C;
de Man, Frances S;
Vermeijden, J W;
Steenvoorde, Pascal;
Bouwman, R Arthur;
Lommen, Wies;
van Hees, Hieronymus W H;
Heunks, Leo M A;
Dickhoff, Chris;
van der Peet, Donald L;
Girbes, Armand R J;
Jasper, Jeff R;
Malik, Fady I;
Stienen, Ger J M;
Hartemink, Koen J;
Paul, Marinus A;
Ottenheijm, Coen A C

Publication type:

Letter

Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 7, p. 863, doi. 10.1164/rccm.201312-2260le

By:

Hooijman, Pleuni E.;
Beishuizen, Albertus;
de Waard, Monique C.;
de Man, Frances S.;
Vermeijden, J. W.;
Steenvoorde, Pascal;
Arthur Bouwman, R.;
Lommen, Wies;
van Hees, Hieronymus W. H.;
Heunks, Leo M. A.;
Dickhoff, Chris;
van der Peet, Donald L.;
Girbes, Armand R. J.;
Jasper, Jeff R.;
Malik, Fady I.;
Stienen, Ger J. M.;
Hartemink, Koen J.;
Paul, Marinus A.;
Ottenheijm, Coen A. C.

Publication type:

Article

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2011, v. 183, n. 10, p. 1411, doi. 10.1164/rccm.201003-0354OC

By:

de Man, Frances S.;
van Hees, Hieronymus W. H.;
Handoko, M. Louis;
Niessen, Hans W.;
Schalij, Ingrid;
Humbert, Marc;
Dorfmüller, Peter;
Mercier, Olaf;
Bogaard, Harm-Jan;
Postmus, Piet E.;
Westerhof, Nico;
Stienen, Ger J. M.;
van der Laarse, Willem J.;
Vonk-Noordegraaf, Anton;
Ottenheijm, Coen A. C.

Publication type:

Article

Deleting Titin's C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle.

Published in:

Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00494

By:

van der Pijl, Robbert J.;
Hudson, Brian;
Granzier-Nakajima, Tomotaroh;
Li, Frank;
Knottnerus, Anne M.;
Smith, John;
Chung, Charles S.;
Gotthardt, Michael;
Granzier, Henk L.;
Ottenheijm, Coen A. C.

Publication type:

Article

Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease.

Published in:

2006

By:

Ottenheijm CAC;
Heunks LMA;
Li Y;
Jin B;
Minnaard R;
van Hees HWH;
Dekhuijzen PNR;
Ottenheijm, Coen A C;
Heunks, Leo M A;
Li, Yi-Ping;
Jin, Bingwen;
Minnaard, Ronnie;
van Hees, Hieronymus W H;
Dekhuijzen, P N Richard

Publication type:

journal article

Activation of the Ubiquitin-Proteasome Pathway in the Diaphragm in Chronic Obstructive Pulmonary Disease.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2006, v. 174, n. 9, p. 997, doi. 10.1164/rccm.200605-721OC

By:

Ottenheijm, Coen A. C.;
Heunks, Leo M. A.;
Yi-Ping Li;
Jin, Bingwen;
Minnaard, Ronnie;
van Hees, Hieronymus W. H.;
Richard Dekhuijzen, P. N.

Publication type:

Article

Diaphragm dysfunction in chronic obstructive pulmonary disease.

Published in:

2005

By:

Ottenheijm CAC;
Heunks LMA;
Sieck GC;
Zhan W;
Jansen SM;
Degens H;
de Boo T;
Dekhuijzen PNR;
Ottenheijm, Coen A C;
Heunks, Leo M A;
Sieck, Gary C;
Zhan, Wen-Zhi;
Jansen, Suzanne M;
Degens, Hans;
de Boo, Theo;
Dekhuijzen, P N Richard

Publication type:

journal article

Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2005, v. 172, n. 2, p. 200, doi. 10.1164/rccm.200502-262OC

By:

Ottenheijm, Coen A. C.;
Heunks, Leo M. A.;
Sieck, Gary C.;
Wen-Zhi Zhan;
Jansen, Suzanne M.;
Degens, Hans;
de Boo, Theo;
Dekhuijzen, P. N. Richard

Publication type:

Article

New Insights into the Structural Roles of Nebulin in Skeletal Muscle.

Published in:

Journal of Biomedicine & Biotechnology, 2010, p. 1, doi. 10.1155/2010/968139

By:

Ottenheijm, Coen A. C.;
Granzier, Henk

Publication type:

Article

Intraoperative phrenic nerve stimulation to prevent diaphragm fiber weakness during thoracic surgery.

Published in:

PLoS ONE, 2025, v. 20, n. 4, p. 1, doi. 10.1371/journal.pone.0320936

By:

Bresciani, Guilherme;
Beaver, Thomas;
Martin, A. Daniel;
van der Pijl, Robbert;
Mankowski, Robert;
Leeuwenburgh, Christiaan;
Ottenheijm, Coen A. C.;
Martin, Tomas;
Arnaoutakis, George;
Ahmed, Shakeel;
Mariani, Vinicius M.;
Xue, Wei;
Smith, Barbara K.;
Ferreira, Leonardo F.

Publication type:

Article

Diaphragm adaptations in patients with COPD.

Published in:

Respiratory Research, 2008, v. 9, p. 1, doi. 10.1186/1465-9921-9-12

By:

Ottenheijm, Coen A. C.;
Heunks, Leo M. A.;
Dekhuijzen, Richard P. N.

Publication type:

Article

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

Published in:

BMC Neurology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2377-13-144

By:

Lassche, Saskia;
Ottenheijm, Coen A. C.;
Voermans, Nicol C.;
Westeneng, Henk-Jan;
Janssen, Barbara H.;
van der Maarel, Silvère M.;
Hopman, Maria T.;
Padberg, George W.;
Stienen, Ger J. M.;
van Engelen, Baziel G. M.

Publication type:

Article

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

Published in:

2013

By:

Lassche, Saskia;
Ottenheijm, Coen Ac;
Voermans, Nicol C;
Westeneng, Henk-Jan;
Janssen, Barbara H;
van der Maarel, Silvère M;
Hopman, Maria T;
Padberg, George W;
Stienen, Ger Jm;
van Engelen, Baziel Gm;
Ottenheijm, Coen A C;
Stienen, Ger J M;
van Engelen, Baziel G M

Publication type:

journal article

A bright light on myosin to study skeletal muscle relaxation.

Published in:

Journal of Physiology, 2020, v. 598, n. 22, p. 5001, doi. 10.1113/JP280664

By:

Galli, Ricardo A.;
Ottenheijm, Coen A. C.

Publication type:

Article

End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium.

Published in:

Journal of Physiology, 2019, v. 597, n. 17, p. 4521, doi. 10.1113/JP277985

By:

Najafi, Aref;
de Locht, Martijn;
Schuldt, Maike;
Schönleitner, Patrick;
Willigenburg, Menne;
Bollen, Ilse;
Goebel, Max;
Ottenheijm, Coen A. C.;
der Velden, Jolanda;
Helmes, Michiel;
Kuster, Diederik W. D.

Publication type:

Article

Association of diaphragm thickness and echogenicity with age, sex, and body mass index in healthy subjects.

Published in:

Muscle & Nerve, 2022, v. 66, n. 2, p. 197, doi. 10.1002/mus.27639

By:

van Doorn, Jeroen L. M.;
Wijntjes, Juerd;
Saris, Christiaan G. J.;
Ottenheijm, Coen A. C.;
van Alfen, Nens;
Doorduin, Jonne

Publication type:

Article

Diaphragm Pacing in Early Critical Illness? A Plea for a Super-Relaxed Approach.

Published in:

2025

By:

Heunks, Leo;
Donker, Dirk W.;
Oppersma, Eline;
Ottenheijm, Coen A. C.;
Doorduin, Jonne

Publication type:

Case Study

Replacement Fibrosis in the Diaphragm of Mechanically Ventilated Critically Ill Patients.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2023, v. 207, n. 3, p. 351, doi. 10.1164/rccm.202208-1608LE

By:

Zhonghua Shi;
van den Berg, Marloes;
Beishuizen, Albertus;
Heunks, Leo;
Ottenheijm, Coen A. C.

Publication type:

Article

Training one type of striated muscle to counteract failure of another type.

Published in:

Journal of Physiology, 2012, v. 590, n. 6, p. 1307, doi. 10.1113/jphysiol.2012.228569

By:

Stienen, Ger J. M.;
Ottenheijm, Coen A. C.

Publication type:

Article

Rbm20 ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15689, doi. 10.3390/ijms232415689

By:

van den Berg, Marloes;
Peters, Eva L.;
van der Pijl, Robbert J.;
Shen, Shengyi;
Heunks, Leo M. A.;
Granzier, Henk L.;
Ottenheijm, Coen A. C.

Publication type:

Article

Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 17, p. 9187, doi. 10.3390/ijms22179187

By:

van de Locht, Martijn;
Borsboom, Tamara C.;
Winter, Josine M.;
Ottenheijm, Coen A. C.

Publication type:

Article

Nebulin: big protein with big responsibilities.

Published in:

Journal of Muscle Research & Cell Motility, 2020, v. 41, n. 1, p. 103, doi. 10.1007/s10974-019-09565-3

By:

Yuen, Michaela;
Ottenheijm, Coen A. C.

Publication type:

Article

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

Published in:

Skeletal Muscle, 2015, v. 5, n. 1, p. 1, doi. 10.1186/s13395-015-0037-7

By:

de Winter, Josine M.;
Joureau, Barbara;
Sequeira, Vasco;
Clarke, Nigel F.;
van der Velden, Jolanda;
Stienen, Ger J. M.;
Granzier, Henk;
Beggs, Alan H.;
Ottenheijm, Coen A. C.

Publication type:

Article

Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb.

Published in:

Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-0893-1

By:

Laitila, Jenni M.;
McNamara, Elyshia L.;
Wingate, Catherine D.;
Goullee, Hayley;
Ross, Jacob A.;
Taylor, Rhonda L.;
van der Pijl, Robbert;
Griffiths, Lisa M.;
Harries, Rachel;
Ravenscroft, Gianina;
Clayton, Joshua S.;
Sewry, Caroline;
Lawlor, Michael W.;
Ottenheijm, Coen A. C.;
Bakker, Anthony J.;
Ochala, Julien;
Laing, Nigel G.;
Wallgren-Pettersson, Carina;
Pelin, Katarina;
Nowak, Kristen J.

Publication type:

Article