Works by Ostrov, David A.

Results: 44

Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.

Published in:

Nature Immunology, 2006, v. 7, n. 8, p. 875, doi. 10.1038/ni1359

By:

Prada, José A. Hernández;
Haire, Robert N.;
Allaire, Marc;
Jakoncic, Jean;
Stojanoff, Vivian;
Cannon, John P.;
Litman, Gary W.;
Ostrov, David A.

Publication type:

Article

Epitope Mapping of Pathogenic Autoantigens on Sjögren's Syndrome-Susceptible Human Leukocyte Antigens Using In Silico Techniques.

Published in:

Journal of Clinical Medicine, 2022, v. 11, n. 6, p. 1690, doi. 10.3390/jcm11061690

By:

Gupta, Shivai;
Li, Danmeng;
Ostrov, David A.;
Nguyen, Cuong Q.

Publication type:

Article

The Elusive Coreceptors for the SARS-CoV-2 Spike Protein.

Published in:

Viruses (1999-4915), 2023, v. 15, n. 1, p. 67, doi. 10.3390/v15010067

By:

Berkowitz, Reed L.;
Ostrov, David A.

Publication type:

Article

Ancestral origins are associated with SARS-CoV-2 susceptibility and protection in a Florida patient population.

Published in:

PLoS ONE, 2023, v. 18, n. 1, p. 1, doi. 10.1371/journal.pone.0276700

By:

Shen, Yiran;
Khatri, Bhuwan;
Rananaware, Santosh;
Li, Danmeng;
Ostrov, David A.;
Jain, Piyush K.;
Lessard, Christopher J.;
Nguyen, Cuong Q.

Publication type:

Article

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.

Published in:

Cell Cycle, 2012, v. 11, n. 17, p. 3250, doi. 10.4161/cc.21611

By:

Ucar, Deniz A.;
Kurenova, Elena;
Garrett, Timothy J.;
Cance, William G.;
Nyberg, Carl;
Cox, Audrey;
Massoll, Nicole;
Ostrov, David A.;
Lawrence, Nicholas;
Sebti, Said M.;
Zajac-Kaye, Maria;
Hochwald, Steven N.

Publication type:

Article

A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo.

Published in:

Cells (2073-4409), 2019, v. 8, n. 12, p. 1586, doi. 10.3390/cells8121586

By:

Zhang, Xiaojuan;
Pham, Kien;
Li, Danmeng;
Schutte, Ryan J.;
Gonzalo, David Hernandez;
Zhang, Penghui;
Oshins, Regina;
Tan, Weihong;
Brantly, Mark;
Liu, Chen;
Ostrov, David A.

Publication type:

Article

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC.

Published in:

PLoS ONE, 2020, v. 15, n. 1, p. 1, doi. 10.1371/journal.pone.0226917

By:

Brown, Matthew;
Zhang, Wanbin;
Yan, Deyue;
Kenath, Rajath;
Le, Le;
Wang, He;
Delitto, Daniel;
Ostrov, David;
Robertson, Keith;
Liu, Chen;
Pham, Kien

Publication type:

Article

Targeting the site encoded by SERPINA1*E342K for treating alpha‐1 antitrypsin deficiency‐associated liver diseases.

Published in:

FEBS Letters, 2019, v. 593, n. 14, p. 1849, doi. 10.1002/1873-3468.13452

By:

Zhang, Xiaojuan;
Pham, Kien;
Li, Danmeng;
Schutte, Ryan J.;
Brantly, Mark;
Liu, Chen;
Ostrov, David A.

Publication type:

Article

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.

Published in:

2018

By:

Ostrov, David A.;
Alkanani, Aimon;
McDaniel, Kristen A.;
Case, Stephanie;
Baschal, Erin E.;
Pyle, Laura;
Ellis, Sam;
Pöllinger, Bernadette;
Seidl, Katherine J.;
Shah, Viral N.;
Garg, Satish K.;
Atkinson, Mark A.;
Gottlieb, Peter A.;
Michels, Aaron W.

Publication type:

journal article

Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis.

Published in:

International Journal of Oncology, 2017, v. 51, n. 5, p. 1370, doi. 10.3892/ijo.2017.4131

By:

RATNAYAKE, WISHRAWANA S.;
APOSTOLATOS, ANDRÉ H.;
OSTROV, DAVID A.;
ACEVEDO-DUNCAN, MILDRED

Publication type:

Article

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0147230

By:

Sullivan, Katherine;
Cramer-Morales, Kimberly;
McElroy, Daniel L.;
Ostrov, David A.;
Haas, Kimberly;
Childers, Wayne;
Hromas, Robert;
Skorski, Tomasz

Publication type:

Article

Sigma Receptor Ligands Prevent COVID Mortality In Vivo: Implications for Future Therapeutics.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 21, p. 15718, doi. 10.3390/ijms242115718

By:

Berkowitz, Reed L.;
Bluhm, Andrew P.;
Knox, Glenn W.;
McCurdy, Christopher R.;
Ostrov, David A.;
Norris, Michael H.

Publication type:

Article

Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic Movements.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 1, p. 80, doi. 10.3390/ijms22010080

By:

Tagliamonte, Massimiliano S.;
Abid, Nabil;
Borocci, Stefano;
Sangiovanni, Elisa;
Ostrov, David A.;
Kosakovsky Pond, Sergei L.;
Salemi, Marco;
Chillemi, Giovanni;
Mavian, Carla

Publication type:

Article

Structural Elements Recognized by Abacavir-Induced T Cells.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 7, p. 1464, doi. 10.3390/ijms18071464

By:

Yerly, Daniel;
Pompeu, Yuri Andreiw;
Schutte, Ryan J.;
Eriksson, Klara. K.;
Strhyn, Anette;
Bracey, Austin. W.;
Buus, Soren;
Ostrov, David A.

Publication type:

Article

Molecular docking predictions of fragrance binding to human leukocyte antigen molecules.

Published in:

Contact Dermatitis (01051873), 2019, v. 81, n. 3, p. 174, doi. 10.1111/cod.13283

By:

Schutte, Ryan J.;
Zhang, Xiaojuan;
An, Nan;
Ostrov, David A.;
Vukmanović, Stanislav

Publication type:

Article

Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01.

Published in:

Allergy, 2019, v. 74, n. 8, p. 1533, doi. 10.1111/all.13769

By:

Zhao, Qing;
Alhilali, Khetam;
Alzahrani, Abdulaziz;
Almutairi, Mubarak;
Amjad, Juwaria;
Liu, Hong;
Sun, Yonghu;
Sun, Lele;
Zhang, Huimin;
Meng, Xiaoli;
Gibson, Andrew;
Ogese, Monday O.;
Kevin Park, B.;
Liu, Jianjun;
Ostrov, David A.;
Zhang, Furen;
Naisbitt, Dean J.

Publication type:

Article

Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.

Published in:

Breast Cancer Research & Treatment, 2014, v. 145, n. 1, p. 45, doi. 10.1007/s10549-014-2940-8

By:

Chen, Zhijuan;
Ruan, Qing;
Han, Song;
Xi, Lei;
Jiang, Wenguo;
Jiang, Huabei;
Ostrov, David;
Cai, Jun

Publication type:

Article

Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir.

Published in:

Clinical Infectious Diseases, 2017, v. 64, n. 9, p. 1198, doi. 10.1093/cid/cix096

By:

Thomas, Mark;
Hopkins, Chris;
Duffy, Eamon;
Daniel Lee;
Loulergue, Pierre;
Ripamonti, Diego;
Ostrov, David A.;
Phillips, Elizabeth

Publication type:

Article

A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer.

Published in:

Cell Cycle, 2009, v. 8, n. 15, p. 2435, doi. 10.4161/cc.8.15.9145

By:

Hochwald, Steven N.;
Nyberg, Carl;
Zheng, Min;
Zheng, Donghang;
Wood, Cheng;
Massoll, Nicole A.;
Magis, Andrew;
Ostrov, David;
Cance, William G.;
Golubovskaya, Vita M.

Publication type:

Article

Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors.

Published in:

Cell Adhesion & Migration, 2018, v. 12, n. 5, p. 447, doi. 10.1080/19336918.2018.1471323

By:

Ratnayake, Wishrawana S.;
Apostolatos, Christopher A.;
Apostolatos, André H.;
Schutte, Ryan J.;
Huynh, Monica A.;
Ostrov, David A.;
Acevedo-Duncan, Mildred

Publication type:

Article

Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management.

Published in:

Current Allergy & Asthma Reports, 2018, v. 18, n. 4, p. 1, doi. 10.1007/s11882-018-0778-6

By:

Mustafa, S. Shahzad;
Ostrov, David;
Yerly, Daniel

Publication type:

Article

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

Published in:

Journal of Diabetes Research, 2016, p. 1, doi. 10.1155/2016/6179635

By:

Buschard, Karsten;
Bracey, Austin W.;
McElroy, Daniel L.;
Magis, Andrew T.;
Osterbye, Thomas;
Atkinson, Mark A.;
Bailey, Kate M.;
Posgai, Amanda L.;
Ostrov, David A.

Publication type:

Article

A novel ATG4B antagonist inhibits autophagy and has a negative impact on osteosarcoma tumors.

Published in:

Autophagy, 2014, v. 10, n. 11, p. 2021, doi. 10.4161/auto.32229

By:

Akin, Debra;
Wang, S Keisin;
Habibzadegah-Tari, Pouran;
Law, Brian;
Ostrov, David;
Li, Min;
Yin, Xiao-Ming;
Kim, Jae-Sung;
Horenstein, Nicole;
Dunn, William A

Publication type:

Article

Effects of Type 1 Diabetes-Associated IFIH1 Polymorphisms on MDA5 Function and Expression.

Published in:

Current Diabetes Reports, 2015, v. 15, n. 11, p. 1, doi. 10.1007/s11892-015-0656-8

By:

Looney, Benjamin M.;
Xia, Chang-Qing;
Concannon, Patrick;
Ostrov, David A.;
Clare-Salzler, Michael J.

Publication type:

Article

Low‐frequency variants in mildly symptomatic vaccine breakthrough infections presents a doubled‐edged sword.

Published in:

Journal of Medical Virology, 2022, v. 94, n. 7, p. 3192, doi. 10.1002/jmv.27726

By:

Magalis, Brittany R.;
Mavian, Carla;
Tagliamonte, Massimiliano;
Rich, Shannan N.;
Cash, Melanie;
Riva, Alberto;
Loeb, Julia C.;
Norris, Michael;
Amador, David M.;
Zhang, Yanping;
Shapiro, Jerne;
Starostik, Petr;
Marini, Simone;
Myers, Paul;
Ostrov, David A.;
Lednicky, John A.;
Glenn Morris, J.;
Lauzardo, Michael;
Salemi, Marco

Publication type:

Article

The structural basis of HLA-associated drug hypersensitivity syndromes.

Published in:

Immunological Reviews, 2012, v. 250, n. 1, p. 158, doi. 10.1111/j.1600-065X.2012.01163.x

By:

Pompeu, Yuri A.;
Stewart, Jon D.;
Mallal, Simon;
Phillips, Elizabeth;
Peters, Bjoern;
Ostrov, David A.

Publication type:

Article

Structure-Based Discovery of Angiotensin-Converting Enzyme 2 (ACE2) Activators.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1365, doi. 10.1096/fasebj.21.6.a1365-c

By:

Prada, Jose Antonio Hernandez;
Ostrov, David A.;
Katovich, Michael J.;
Raizada, Mohan K.

Publication type:

Article

Identification and Characterization of a Novel Jak2 Tyrosine Kinase Inhibitor.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A793, doi. 10.1096/fasebj.21.6.a793-c

By:

Sayyah, Jacqueline;
Ostrov, David;
Sayeski, Peter P.

Publication type:

Article

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.

Published in:

BMC Cancer, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2407-13-342

By:

Golubovskaya, Vita M.;
Ho, Baotran;
Min Zheng;
Magis, Andrew;
Ostrov, David;
Morrison, Carl;
Cance, William G.

Publication type:

Article

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.

Published in:

2013

By:

Golubovskaya, Vita M;
Ho, Baotran;
Zheng, Min;
Magis, Andrew;
Ostrov, David;
Morrison, Carl;
Cance, William G

Publication type:

journal article

Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0124878

By:

Metushi, Imir G.;
Wriston, Amanda;
Banerjee, Priyanka;
Gohlke, Bjoern Oliver;
English, A. Michelle;
Lucas, Andrew;
Moore, Carrie;
Sidney, John;
Buus, Soren;
Ostrov, David A.;
Mallal, Simon;
Phillips, Elizabeth;
Shabanowitz, Jeffrey;
Hunt, Donald F.;
Preissner, Robert;
Peters, Bjoern

Publication type:

Article

Abacavir-Reactive Memory T Cells Are Present in Drug Naïve Individuals.

Published in:

PLoS ONE, 2015, v. 10, n. 2, p. 1, doi. 10.1371/journal.pone.0117160

By:

Lucas, Andrew;
Lucas, Michaela;
Strhyn, Anette;
Keane, Niamh M.;
McKinnon, Elizabeth;
Pavlos, Rebecca;
Moran, Ellen M.;
Meyer-Pannwitt, Viola;
Gaudieri, Silvana;
D’Orsogna, Lloyd;
Kalams, Spyros;
Ostrov, David A.;
Buus, Søren;
Peters, Bjoern;
Mallal, Simon;
Phillips, Elizabeth

Publication type:

Article

Functional Expression of Human Adenine Nucleotide Translocase 4 in Saccharomyces Cerevisiae.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019250

By:

Hamazaki, Takashi;
Wai-Yee Leung;
Cain, Brian D.;
Ostrov, David A.;
Thorsness, Peter E.;
Terada, Naohiro

Publication type:

Article

DNA Polymerase β as a Novel Target for Chemotherapeutic Intervention of Colorectal Cancer.

Published in:

PLoS ONE, 2011, v. 6, n. 2, p. 1, doi. 10.1371/journal.pone.0016691

By:

Jaiswal, Aruna S.;
Banerjee, Sanjeev;
Aneja, Ritu;
Sarkar, Fazlul H.;
Ostrov, David A.;
Narayan, Satya

Publication type:

Article

A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts.

Published in:

Molecular Carcinogenesis, 2010, v. 49, n. 2, p. 200, doi. 10.1002/mc.20590

By:

Zheng, Donghang;
Golubovskaya, Vita;
Kurenova, Elena;
Wood, Cheng;
Massoll, Nicole A.;
Ostrov, David;
Cance, William G.;
Hochwald, Steven N.

Publication type:

Article

Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells.

Published in:

Pathogens, 2021, v. 10, n. 11, p. 1514, doi. 10.3390/pathogens10111514

By:

Ostrov, David A.;
Bluhm, Andrew P.;
Li, Danmeng;
Khan, Juveriya Qamar;
Rohamare, Megha;
Rajamanickam, Karthic;
K. Bhanumathy, Kalpana;
Lew, Jocelyne;
Falzarano, Darryl;
Vizeacoumar, Franco J.;
Wilson, Joyce A.;
Mottinelli, Marco;
Kanumuri, Siva Rama Raju;
Sharma, Abhisheak;
McCurdy, Christopher R.;
Norris, Michael H.

Publication type:

Article

Durability of and role of AKT in FGF7p urothelial protection against cyclophosphamide.

Published in:

Physiological Reports, 2022, v. 10, n. 12, p. 1, doi. 10.14814/phy2.15358

By:

Narla, Sridhar Tatarao;
Rice, Lori;
Ostrov, David;
Bushnell, Daniel Scott;
Duara, Joanne Lindsey;
Bates, Carlton Matthew

Publication type:

Article

FGF7 peptide (FGF7p) mimetic mitigates bladder urothelial injury from cyclophosphamide.

Published in:

Physiological Reports, 2022, v. 10, n. 7, p. 1, doi. 10.14814/phy2.15241

By:

Narla, Sridhar Tatarao;
Rice, Lori;
Ostrov, David;
Swarts, Steven G.;
Siemann, Dietmar W.;
Bushnell, Daniel Scott;
Holden, Jacqueline G.;
Duara, Joanne Lindsey;
Bates, Carlton Matthew

Publication type:

Article

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, ...

Published in:

Carcinogenesis, 2012, v. 33, n. 5, p. 1004, doi. 10.1093/carcin/bgs120

By:

Golubovskaya, Vita M.;
Figel, Sheila;
Ho, Baotran T.;
Johnson, Christopher P.;
Yemma, Michael;
Huang, Grace;
Zheng, Min;
Nyberg, Carl;
Magis, Andrew;
Ostrov, David A.;
Gelman, Irwin H.;
Cance, William G.

Publication type:

Article

Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate.

Published in:

Journal of Clinical Pharmacology, 2012, v. 52, n. 6, p. 837, doi. 10.1177/0091270011405664

By:

Shroads, Albert L.;
Langaee, Taimour;
Coats, Bonnie S.;
Kurtz, Tracie L.;
Bullock, John R.;
Weithorn, David;
Gong, Yan;
Wagner, David A.;
Ostrov, David A.;
Johnson, Julie A.;
Stacpoole, Peter W.

Publication type:

Article

Role of Proinsulin Self-Association in Mutant INS Gene–Induced Diabetes of Youth.

Published in:

Diabetes, 2020, v. 69, n. 5, p. 954, doi. 10.2337/db19-1106

By:

Sun, Jinhong;
Xiong, Yi;
Li, Xin;
Haataja, Leena;
Chen, Wei;
Mir, Saiful A.;
Lv, Li;
Madley, Rachel;
Larkin, Dennis;
Anjum, Arfah;
Dhayalan, Balamurugan;
Rege, Nischay;
Wickramasinghe, Nalinda P.;
Weiss, Michael A.;
Itkin-Ansari, Pamela;
Kaufman, Randal J.;
Ostrov, David A.;
Arvan, Peter;
Liu, Ming

Publication type:

Article

Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors.

Published in:

Molecules, 2021, v. 26, n. 4, p. 983, doi. 10.3390/molecules26040983

By:

Neubert, John K.;
Oliferenko, Alexander A.;
Oliferenko, Polina V.;
Emets, Sergey V.;
Ostrov, David A.;
Altschuler, Gary I.;
Calkins, Joe;
Wickersham, Jay;
Hromas, Robert;
Lebedyeva, Iryna O.;
Dembinski, Roman;
Alabugin, Igor

Publication type:

Article

7th drug hypersensitivity meeting: part one.

Published in:

Clinical & Translational Allergy, 2016, v. 6, n. 3, p. 1, doi. 10.1186/s13601-016-0121-z

By:

Carr, Daniel F.;
Chung, Wen‐Hung;
Jenkiins, Rosalind E.;
Chaponda, Mas;
Nwikue, Gospel;
Cornejo Castro, Elena M.;
Antoine, Daniel J.;
Pirmohamed, Munir;
Wuillemin, Natascha;
Dina, Dolores;
Eriksson, Klara K.;
Yerly, Daniel;
Pavlos, Rebecca;
Mckinnin, Elizabeth;
Ostrov, David;
Peters, Bjoern;
Buus, Soren;
Koelle, David;
Chopra, Abha;
Rive, Craig

Publication type:

Article

Identification of drug-specific public TCR driving severe cutaneous adverse reactions.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11396-2

By:

Pan, Ren-You;
Chu, Mu-Tzu;
Wang, Chuang-Wei;
Lee, Yun-Shien;
Lemonnier, Francois;
Michels, Aaron W.;
Schutte, Ryan;
Ostrov, David A.;
Chen, Chun-Bing;
Phillips, Elizabeth Jane;
Mallal, Simon Alexander;
Mockenhaupt, Maja;
Bellón, Teresa;
Tassaneeyakul, Wichittra;
White, Katie D.;
Roujeau, Jean-Claude;
Chung, Wen-Hung;
Hung, Shuen-Iu

Publication type:

Article