Works by Orford, Keith

Results: 11

Relative Bioavailability of Pediatric Oral Solution and Tablet Formulations of Trametinib in Adult Patients With Solid Tumors.

Published in:

Clinical Pharmacology in Drug Development, 2015, v. 4, n. 4, p. 287, doi. 10.1002/cpdd.152

By:

Cox, Donna S.;
Allred, Alicia;
Zhou, YanYan;
Infante, Jeffrey R.;
Gordon, Michael S.;
Bendell, Johanna;
Jones, Suzanne;
Burris, Howard;
Orford, Keith

Publication type:

Article

Phase I study of the MEK inhibitor trametinib in combination with the AKT inhibitor afuresertib in patients with solid tumors and multiple myeloma.

Published in:

Cancer Chemotherapy & Pharmacology, 2015, v. 75, n. 1, p. 183, doi. 10.1007/s00280-014-2615-5

By:

Tolcher, Anthony;
Patnaik, Amita;
Papadopoulos, Kyriakos;
Rasco, Drew;
Becerra, Carlos;
Allred, Alicia;
Orford, Keith;
Aktan, Gursel;
Ferron-Brady, Geraldine;
Ibrahim, Nageatte;
Gauvin, Jennifer;
Motwani, Monica;
Cornfeld, Mark

Publication type:

Article

A single supratherapeutic dose of ridaforolimus does not prolong the QTc interval in patients with advanced cancer.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 4, p. 567, doi. 10.1007/s00280-012-1942-7

By:

Lush, Richard;
Patnaik, Amita;
Sullivan, Daniel;
Papadopoulos, Kyriakos;
Trucksis, Michele;
McCrea, Jacqueline;
Cerchio, Kristine;
Li, Xiaodong;
Stroh, Mark;
Selverian, Diana;
Orford, Keith;
Ebbinghaus, Scot;
Agrawal, Nancy;
Iwamoto, Marian;
Wagner, John;
Tolcher, Anthony

Publication type:

Article

The minimal impact of food on the pharmacokinetics of ridaforolimus.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 70, n. 1, p. 177, doi. 10.1007/s00280-012-1897-8

By:

Stroh, Mark;
Li, Xiaodong;
Marsilio, Sabrina;
Panebianco, Deborah;
Johnson-Levonas, Amy;
Juan, Axel;
Orford, Keith;
Agrawal, Nancy;
Trucksis, Michele;
Wagner, John;
Murphy, Gail;
Iwamoto, Marian

Publication type:

Article

The effect of multiple doses of rifampin and ketoconazole on the single-dose pharmacokinetics of ridaforolimus.

Published in:

Cancer Chemotherapy & Pharmacology, 2012, v. 69, n. 5, p. 1247, doi. 10.1007/s00280-011-1819-1

By:

Stroh, Mark;
Palcza, John;
McCrea, Jacqueline;
Marsilio, Sabrina;
Breidinger, Sheila;
Panebianco, Deborah;
Johnson-Levonas, Amy;
Kraft, Walter;
Orford, Keith;
Murphy, Gail;
Agrawal, Nancy;
Trucksis, Michele;
Wagner, John;
Iwamoto, Marian

Publication type:

Article

Concomitant oral and intravenous pharmacokinetics of trametinib, a MEK inhibitor, in subjects with solid tumours.

Published in:

British Journal of Clinical Pharmacology, 2014, v. 78, n. 3, p. 524, doi. 10.1111/bcp.12373

By:

Leonowens, Cathrine;
Pendry, Carolyn;
Bauman, John;
Young, Graeme C.;
Ho, May;
Henriquez, Frank;
Fang, Lei;
Morrison, Royce A.;
Orford, Keith;
Ouellet, Daniele

Publication type:

Article

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation.

Published in:

Nature Reviews Genetics, 2008, v. 9, n. 2, p. 115, doi. 10.1038/nrg2269

By:

Orford, Keith W.;
Scadden, David T.

Publication type:

Article

Effects of low-fat and high-fat meals on steady-state pharmacokinetics of lapatinib in patients with advanced solid tumours.

Published in:

Investigational New Drugs, 2014, v. 32, n. 3, p. 481, doi. 10.1007/s10637-013-0055-4

By:

Devriese, Lot;
Koch, Kevin;
Mergui-Roelvink, Marja;
Matthys, Gemma;
Ma, Wen;
Robidoux, Andre;
Stephenson, Joe;
Chu, Quincy;
Orford, Keith;
Cartee, Leanne;
Botbyl, Jeff;
Arya, Nikita;
Schellens, Jan

Publication type:

Article

Lack of Meaningful Effect of Ridaforolimus on the Pharmacokinetics of Midazolam in Cancer Patients: Model Prediction and Clinical Confirmation.

Published in:

Journal of Clinical Pharmacology, 2014, v. 54, n. 11, p. 1256, doi. 10.1002/jcph.331

By:

Stroh, Mark;
Talaty, Jennifer;
Sandhu, Punam;
McCrea, Jacqueline;
Patnaik, Amita;
Tolcher, Anthony;
Palcza, John;
Orford, Keith;
Breidinger, Sheila;
Narasimhan, Narayana;
Panebianco, Deborah;
Lush, Richard;
Papadopoulos, Kyriakos P.;
Wagner, John A.;
Trucksis, Michele;
Agrawal, Nancy

Publication type:

Article

Evaluation of the Effects of Food on the Single-Dose Pharmacokinetics of Trametinib, a First-in-Class MEK Inhibitor, in Patients with Cancer.

Published in:

Journal of Clinical Pharmacology, 2013, v. 53, n. 9, p. 946, doi. 10.1002/jcph.115

By:

Cox, Donna S.;
Papadopoulos, Kyri;
Fang, Lei;
Bauman, John;
LoRusso, Patricia;
Tolcher, Anthony;
Patnaik, Amita;
Pendry, Carolyn;
Orford, Keith;
Ouellet, Daniele

Publication type:

Article

Trametinib, a first-in-class oral MEK inhibitor mass balance study with limited enrollment of two male subjects with advanced cancers.

Published in:

Xenobiotica, 2014, v. 44, n. 4, p. 352, doi. 10.3109/00498254.2013.831143

By:

Ho, May Y. K.;
Morris, Michael J.;
Pirhalla, Jill L.;
Bauman, John W.;
Pendry, Carolyn B.;
Orford, Keith W.;
Morrison, Royce A.;
Cox, Donna S.

Publication type:

Article