Works by Orchard, Lindsey

Results: 11

Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.

Published in:

PLoS Pathogens, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.ppat.1010926

By:

Okombo, John;
Mok, Sachel;
Qahash, Tarrick;
Yeo, Tomas;
Bath, Jade;
Orchard, Lindsey M.;
Owens, Edward;
Koo, Imhoi;
Albert, Istvan;
Llinás, Manuel;
Fidock, David A.

Publication type:

Article

Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation.

Published in:

BMC Genomics, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12864-019-6322-9

By:

van Biljon, Riëtte;
van Wyk, Roelof;
Painter, Heather J.;
Orchard, Lindsey;
Reader, Janette;
Niemand, Jandeli;
Llinás, Manuel;
Birkholtz, Lyn-Marie

Publication type:

Article

The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Plasmodium falciparum Gametocyte Development and Transmission.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 5087, doi. 10.3390/ijms20205087

By:

Ngwa, Che Julius;
Kiesow, Meike Jutta;
Orchard, Lindsey Marie;
Farrukh, Afia;
Llinás, Manuel;
Pradel, Gabriele

Publication type:

Article

A seven-helix protein constitutes stress granules crucial for regulating translation during human-to-mosquito transmission of Plasmodium falciparum.

Published in:

PLoS Pathogens, 2018, v. 14, n. 8, p. 1, doi. 10.1371/journal.ppat.1007249

By:

Bennink, Sandra;
von Bohl, Andreas;
Ngwa, Che J.;
Henschel, Leonie;
Kuehn, Andrea;
Pilch, Nicole;
Weißbach, Tim;
Rosinski, Alina N.;
Scheuermayer, Matthias;
Repnik, Urska;
Przyborski, Jude M.;
Minns, Allen M.;
Orchard, Lindsey M.;
Griffiths, Gareth;
Lindner, Scott E.;
Llinás, Manuel;
Pradel, Gabriele

Publication type:

Article

The PfAP2‐G2 transcription factor is a critical regulator of gametocyte maturation.

Published in:

Molecular Microbiology, 2021, v. 115, n. 5, p. 1005, doi. 10.1111/mmi.14676

By:

Singh, Suprita;
Santos, Joana M.;
Orchard, Lindsey M.;
Yamada, Naomi;
Biljon, Riëtte;
Painter, Heather J.;
Mahony, Shaun;
Llinás, Manuel

Publication type:

Article

Transcriptional Profiling Defines Histone Acetylation as a Regulator of Gene Expression during Human-to-Mosquito Transmission of the Malaria Parasite Plasmodium falciparum.

Published in:

Frontiers in Cellular & Infection Microbiology, 2017, v. 7, p. 1, doi. 10.3389/fcimb.2017.00320

By:

Ngwa, Che J.;
Kiesow, Meike J.;
Papst, Olga;
Orchard, Lindsey M.;
Filarsky, Michael;
Rosinski, Alina N.;
Voss, Till S.;
Llinás, Manuel;
Pradel, Gabriele

Publication type:

Article

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast.

Published in:

Cellular Microbiology, 2017, v. 19, n. 1, p. n/a, doi. 10.1111/cmi.12633

By:

Shears, Melanie J.;
MacRae, James I.;
Mollard, Vanessa;
Goodman, Christopher D.;
Sturm, Angelika;
Orchard, Lindsey M.;
Llinás, Manuel;
McConville, Malcolm J.;
Botté, Cyrille Y.;
McFadden, Geoffrey I.

Publication type:

Article

Refining the transcriptome of the human malaria parasite Plasmodium falciparum using amplification-free RNA-seq.

Published in:

BMC Genomics, 2020, v. 21, n. 1, p. 1, doi. 10.1186/s12864-020-06787-5

By:

Chappell, Lia;
Ross, Philipp;
Orchard, Lindsey;
Russell, Timothy J.;
Otto, Thomas D.;
Berriman, Matthew;
Rayner, Julian C.;
Llinás, Manuel

Publication type:

Article

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20629-8

By:

Reader, Janette;
van der Watt, Mariëtte E.;
Taylor, Dale;
Le Manach, Claire;
Mittal, Nimisha;
Ottilie, Sabine;
Theron, Anjo;
Moyo, Phanankosi;
Erlank, Erica;
Nardini, Luisa;
Venter, Nelius;
Lauterbach, Sonja;
Bezuidenhout, Belinda;
Horatscheck, Andre;
van Heerden, Ashleigh;
Spillman, Natalie J.;
Cowell, Anne N.;
Connacher, Jessica;
Opperman, Daniel;
Orchard, Lindsey M.

Publication type:

Article

Dissecting the role of PfAP2-G in malaria gametocytogenesis.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15026-0

By:

Josling, Gabrielle A.;
Russell, Timothy J.;
Venezia, Jarrett;
Orchard, Lindsey;
van Biljon, Riëtte;
Painter, Heather J.;
Llinás, Manuel

Publication type:

Article

H3K36 methylation reprograms gene expression to drive early gametocyte development in Plasmodium falciparum.

Published in:

Epigenetics & Chromatin, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13072-021-00393-9

By:

Connacher, Jessica;
Josling, Gabrielle A.;
Orchard, Lindsey M.;
Reader, Janette;
Llinás, Manuel;
Birkholtz, Lyn-Marié

Publication type:

Article