Works by Opitz, Christiane A.

Results: 27

The therapeutic potential of targeting tryptophan catabolism in cancer.

Published in:

2020

By:

Opitz, Christiane A.;
Somarribas Patterson, Luis F.;
Mohapatra, Soumya R.;
Dewi, Dyah L.;
Sadik, Ahmed;
Platten, Michael;
Trump, Saskia

Publication type:

journal article

Suppression of TDO-mediated tryptophan catabolism in glioblastoma cells by a steroid-responsive FKBP52-dependent pathway.

Published in:

Glia (0894-1491), 2015, v. 63, n. 1, p. 78, doi. 10.1002/glia.22734

By:

Ott, Martina;
Litzenburger, Ulrike M.;
Rauschenbach, Katharina J.;
Bunse, Lukas;
Ochs, Katharina;
Sahm, Felix;
Pusch, Stefan;
Opitz, Christiane A.;
Blaes, Jonas;
von Deimling, Andreas;
Wick, Wolfgang;
Platten, Michael

Publication type:

Article

Making liver cancer cells go ARGh!

Published in:

EMBO Journal, 2022, v. 41, n. 21, p. 1, doi. 10.15252/embj.2022112415

By:

Henneberg, Alessa L;
Opitz, Christiane A

Publication type:

Article

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.

Published in:

Nature, 2011, v. 478, n. 7368, p. 197, doi. 10.1038/nature10491

By:

Opitz, Christiane A.;
Litzenburger, Ulrike M.;
Sahm, Felix;
Ott, Martina;
Tritschler, Isabel;
Trump, Saskia;
Schumacher, Theresa;
Jestaedt, Leonie;
Schrenk, Dieter;
Weller, Michael;
Jugold, Manfred;
Guillemin, Gilles J.;
Miller, Christine L.;
Lutz, Christian;
Radlwimmer, Bernhard;
Lehmann, Irina;
von Deimling, Andreas;
Wick, Wolfgang;
Platten, Michael

Publication type:

Article

Constitutive Expression of the Immunosuppressive Tryptophan Dioxygenase TDO2 in Glioblastoma Is Driven by the Transcription Factor C/EBPβ.

Published in:

Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.00657

By:

Kudo, Takumi;
Prentzell, Mirja T.;
Mohapatra, Soumya R.;
Sahm, Felix;
Zhao, Zhongliang;
Grummt, Ingrid;
Wick, Wolfgang;
Opitz, Christiane A.;
Platten, Michael;
Green, Edward W.

Publication type:

Article

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma.

Published in:

Frontiers in Immunology, 2019, v. 10, p. 1, doi. 10.3389/fimmu.2019.02762

By:

Mohapatra, Soumya R.;
Sadik, Ahmed;
Tykocinski, Lars-Oliver;
Dietze, Jørn;
Poschet, Gernot;
Heiland, Ines;
Opitz, Christiane A.

Publication type:

Article

Toll-Like Receptor Engagement Enhances the Immunosuppressive Properties of Human Bone Marrow-Derived Mesenchymal Stem Cells by Inducing Indoleamine-2,3-dioxygenase-l via Interferon-" and Protein Kinase R.

Published in:

Stem Cells, 2009, v. 27, n. 4, p. 909, doi. 10.1002/stem.7

By:

Opitz, Christiane A.;
Litzenburger, Ulrike M.;
Lutz, Christian;
Lanz, Tobias V.;
Tritschler, Isabel;
Köppel, Alexandra;
Tolosa, Eva;
Hoberg, Maik;
Anderl, Jan;
Aicher, Wilhelm K.;
Weller, Michael;
Wick, Wolfgang;
Platten, Michael

Publication type:

Article

Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis.

Published in:

PLoS Pathogens, 2020, v. 16, n. 10, p. 1, doi. 10.1371/journal.ppat.1008973

By:

Lercher, Alexander;
Popa, Alexandra M.;
Viczenczova, Csilla;
Kosack, Lindsay;
Klavins, Kristaps;
Agerer, Benedikt;
Opitz, Christiane A.;
Lanz, Tobias V.;
Platten, Michael;
Bergthaler, Andreas

Publication type:

Article

From anti-aging drugs to cancer therapy: is there a potential for sirtuin activators in gliomas?

Published in:

Neuro-Oncology, 2021, v. 23, n. 1, p. 3, doi. 10.1093/neuonc/noaa234

By:

Opitz, Christiane A;
Turcan, Sevin

Publication type:

Article

Molecular differences in IDH wildtype glioblastoma according to MGMT promoter methylation.

Published in:

Neuro-Oncology, 2018, v. 20, n. 3, p. 367, doi. 10.1093/neuonc/nox160

By:

Kessler, Tobias;
Sahm, Felix;
Sadik, Ahmed;
Stichel, Damian;
Hertenstein, Anne;
Reifenberger, Guido;
Zacher, Angela;
Sabel, Michael;
Tabatabai, Ghazaleh;
Steinbach, Joachim;
Sure, Ulrich;
Krex, Dietmar;
Grosu, Anca-L.;
Bewerunge-Hudler, Melanie;
Jones, David;
Pfister, Stefan M.;
Weller, Michael;
Opitz, Christiane;
Bendszus, Martin;
von Deimling, Andreas

Publication type:

Article

Dynamics of NAD-metabolism: everything but constant.

Published in:

Biochemical Society Transactions, 2015, v. 43, n. 6, p. 1127, doi. 10.1042/BST20150133

By:

Opitz, Christiane A.;
Heiland, Ines

Publication type:

Article

Methylome analyses of three glioblastoma cohorts reveal chemotherapy sensitivity markers within DDR genes.

Published in:

Cancer Medicine, 2020, v. 9, n. 22, p. 8373, doi. 10.1002/cam4.3447

By:

Kessler, Tobias;
Berberich, Anne;
Sadik, Ahmed;
Sahm, Felix;
Gorlia, Thierry;
Meisner, Christoph;
Hoffmann, Dirk C.;
Wick, Antje;
Kickingereder, Philipp;
Rübmann, Petra;
Bendszus, Martin;
Opitz, Christiane;
Weller, Michael;
Bent, Martin;
Stupp, Roger;
Winkler, Frank;
Brandes, Alba;
Deimling, Andreas;
Platten, Michael;
Wick, Wolfgang

Publication type:

Article

Automated Liquid Handling Extraction and Rapid Quantification of Underivatized Amino Acids and Tryptophan Metabolites from Human Serum and Plasma Using Dual-Column U(H)PLC-MRM-MS and Its Application to Prostate Cancer Study.

Published in:

Metabolites (2218-1989), 2024, v. 14, n. 7, p. 370, doi. 10.3390/metabo14070370

By:

Kipura, Tobias;
Hotze, Madlen;
Hofer, Alexa;
Egger, Anna-Sophia;
Timpen, Lea E.;
Opitz, Christiane A.;
Townsend, Paul A.;
Gethings, Lee A.;
Thedieck, Kathrin;
Kwiatkowski, Marcel

Publication type:

Article

Resistance Exercise Reduces Kynurenine Pathway Metabolites in Breast Cancer Patients Undergoing Radiotherapy.

Published in:

Frontiers in Oncology, 2019, p. 1, doi. 10.3389/fonc.2019.00962

By:

Zimmer, Philipp;
Schmidt, Martina E.;
Prentzell, Mirja Tamara;
Berdel, Bianca;
Wiskemann, Joachim;
Kellner, Karl Heinz;
Debus, Jürgen;
Ulrich, Cornelia;
Opitz, Christiane A.;
Steindorf, Karen

Publication type:

Article

ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.

Published in:

Nucleic Acids Research, 2021, v. 49, n. 20, p. 11666, doi. 10.1093/nar/gkab964

By:

Bakr, Ali;
Hey, Joschka;
Sigismondo, Gianluca;
Liu, Chun-Shan;
Sadik, Ahmed;
Goyal, Ashish;
Cross, Alice;
Iyer, Ramya Lakshmana;
Müller, Patrick;
Trauernicht, Max;
Breuer, Kersten;
Lutsik, Pavlo;
Opitz, Christiane A;
Krijgsveld, Jeroen;
Weichenhan, Dieter;
Plass, Christoph;
Popanda, Odilia;
Schmezer, Peter

Publication type:

Article

Tryptophan-2,3-dioxygenase is regulated by prostaglandin E2 in malignant glioma via a positive signaling loop involving prostaglandin E receptor-4.

Published in:

Journal of Neurochemistry, 2016, v. 136, n. 6, p. 1142, doi. 10.1111/jnc.13503

By:

Ochs, Katharina;
Ott, Martina;
Rauschenbach, Katharina J.;
Deumelandt, Katrin;
Sahm, Felix;
Opitz, Christiane A.;
Deimling, Andreas;
Wick, Wolfgang;
Platten, Michael

Publication type:

Article

Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis.

Published in:

Oncogenesis, 2020, v. 9, n. 11, p. 1, doi. 10.1038/s41389-020-00286-8

By:

Nothdurft, Silke;
Thumser-Henner, Clotilde;
Breitenbücher, Frank;
Okimoto, Ross A.;
Dorsch, Madeleine;
Opitz, Christiane A.;
Sadik, Ahmed;
Esser, Charlotte;
Hölzel, Michael;
Asthana, Saurabh;
Forster, Jan;
Beisser, Daniela;
Kalmbach, Sophie;
Grüner, Barbara M.;
Bivona, Trever G.;
Schramm, Alexander;
Schuler, Martin

Publication type:

Article

Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis.

Published in:

Scientific Reports, 2017, p. 41271, doi. 10.1038/srep41271

By:

Lanz, Tobias V.;
Williams, Sarah K.;
Stojic, Aleksandar;
Iwantscheff, Simeon;
Sonner, Jana K.;
Grabitz, Carl;
Becker, Simon;
Böhler, Laura-Inés;
Mohapatra, Soumya R.;
Sahm, Felix;
Küblbeck, Günter;
Nakamura, Toshikazu;
Funakoshi, Hiroshi;
Opitz, Christiane A.;
Wick, Wolfgang;
Diem, Ricarda;
Platten, Michael

Publication type:

Article

Device-Controlled Microcondensation for Spatially Confined On-Tissue Digests in MALDI Imaging of N -Glycans.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 11, p. 1356, doi. 10.3390/ph15111356

By:

Fülöp, Annabelle;
Marsching, Christian;
Barka, Frederik;
Ucal, Yasemin;
Pfänder, Pauline;
Opitz, Christiane A.;
Barka, Günes;
Hopf, Carsten

Publication type:

Article

The Indoleamine-2,3-Dioxygenase (IDO) Inhibitor 1-Methyl-D-tryptophan Upregulates IDO1 in Human Cancer Cells.

Published in:

PLoS ONE, 2011, v. 6, n. 5, p. 1, doi. 10.1371/journal.pone.0019823

By:

Opitz, Christiane A.;
Litzenburger, Ulrike M.;
Opitz, Uta;
Sahm, Felix;
Ochs, Katharina;
Lutz, Christian;
Wick, Wolfgang;
Platten, Michael

Publication type:

Article

Suppression of Th1 differentiation by tryptophan supplementation in vivo.

Published in:

Amino Acids, 2017, v. 49, n. 7, p. 1169, doi. 10.1007/s00726-017-2415-4

By:

Lanz, Tobias;
Becker, Simon;
Mohapatra, Soumya;
Opitz, Christiane;
Wick, Wolfgang;
Platten, Michael

Publication type:

Article

Hypoxia decreases the T helper cell-suppressive capacity of synovial fibroblasts by downregulating IDO1-mediated tryptophan metabolism.

Published in:

Rheumatology, 2020, v. 59, n. 5, p. 1148, doi. 10.1093/rheumatology/kez587

By:

Kaul, Nathalie-Christin;
Mohapatra, Soumya R;
Adam, Isabell;
Tucher, Christine;
Tretter, Theresa;
Opitz, Christiane A;
Lorenz, Hanns-Martin;
Tykocinski, Lars-Oliver

Publication type:

Article

Spatial probabilistic mapping of metabolite ensembles in mass spectrometry imaging.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37394-z

By:

Abu Sammour, Denis;
Cairns, James L.;
Boskamp, Tobias;
Marsching, Christian;
Kessler, Tobias;
Ramallo Guevara, Carina;
Panitz, Verena;
Sadik, Ahmed;
Cordes, Jonas;
Schmidt, Stefan;
Mohammed, Shad A.;
Rittel, Miriam F.;
Friedrich, Mirco;
Platten, Michael;
Wolf, Ivo;
von Deimling, Andreas;
Opitz, Christiane A.;
Wick, Wolfgang;
Hopf, Carsten

Publication type:

Article

Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells

Published in:

FEBS Letters, 2007, v. 581, n. 25, p. 4927, doi. 10.1016/j.febslet.2007.09.032

By:

Opitz, Christiane A.;
Rimmerman, Neta;
Zhang, Yanmin;
Mead, Laura E.;
Yoder, Mervin C.;
Ingram, David A.;
Walker, J. Michael;
Rehman, Jalees

Publication type:

Article

Hypoxia Routes Tryptophan Homeostasis Towards Increased Tryptamine Production.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.590532

By:

Mohapatra, Soumya R.;
Sadik, Ahmed;
Sharma, Suraj;
Poschet, Gernot;
Gegner, Hagen M.;
Lanz, Tobias V.;
Lucarelli, Philippe;
Klingmüller, Ursula;
Platten, Michael;
Heiland, Ines;
Opitz, Christiane A.

Publication type:

Article

The aryl hydrocarbon receptor as a promoter of malignant glioma.

Published in:

Cell Cycle, 2012, v. 11, n. 4, p. 643, doi. 10.4161/cc.11.4.19357

By:

Platten, Michael;
Opitz, Christiane;
Wick, Wolfgang

Publication type:

Article

Microenvironmental Clues for Glioma Immunotherapy.

Published in:

Current Neurology & Neuroscience Reports, 2014, v. 14, n. 4, p. 1, doi. 10.1007/s11910-014-0440-1

By:

Platten, Michael;
Ochs, Katharina;
Lemke, Dieter;
Opitz, Christiane;
Wick, Wolfgang

Publication type:

Article