Works by Onishi, Hiraku

Results: 47

Efficacy of lactosaminated and intact N-succinyl-chitosan-mitomycin C conjugates against M5076 liver metastatic cancer.

Published in:

Journal of Pharmacy & Pharmacology, 2002, v. 54, n. 4, p. 529, doi. 10.1211/0022357021778646

By:

Kato, Yoshinori;
Onishi, Hiraku;
Machida, Yoshiharu

Publication type:

Article

Evaluation of polyvinyl alcohols as mucoadhesive polymers for mucoadhesive buccal tablets prepared by direct compression.

Published in:

Drug Development & Industrial Pharmacy, 2017, v. 43, n. 9, p. 1489, doi. 10.1080/03639045.2017.1321657

By:

Ikeuchi-Takahashi, Yuri;
Ishihara, Chizuko;
Onishi, Hiraku

Publication type:

Article

In vivo absorption study of ritodrine hydrochloride in the buccal administration to rats.

Published in:

Drug Development & Industrial Pharmacy, 2013, v. 39, n. 9, p. 1414, doi. 10.3109/03639045.2012.704044

By:

Sakata, Osamu;
Onishi, Hiraku

Publication type:

Article

Formulation and evaluation of matrix type mucoadhesive tablets aimed at treating oral aphtha.

Published in:

Drug Development & Industrial Pharmacy, 2013, v. 39, n. 8, p. 1254, doi. 10.3109/03639045.2012.717297

By:

Ikeuchi-Takahashi, Yuri;
Watanabe, Naoko;
Sasatsu, Masanaho;
Onishi, Hiraku

Publication type:

Article

Comparison of simple Eudragit microparticles loaded with prednisolone and Eudragit-coated chitosan-succinyl-prednisolone conjugate microparticles: Part I. Particle characteristics and in vitro evaluation as a colonic delivery system.

Published in:

Drug Development & Industrial Pharmacy, 2012, v. 38, n. 7, p. 800, doi. 10.3109/03639045.2011.628677

By:

Onishi, Hiraku;
Kikuchi, Hisashi;
Machida, Yoshiharu

Publication type:

Article

Semi-solid dosage form of clonazepam for rapid oral mucosal absorption.

Published in:

Drug Development & Industrial Pharmacy, 2011, v. 37, n. 7, p. 809, doi. 10.3109/03639045.2010.545069

By:

Sakata, Osamu;
Machida, Yoshiharu;
Onishi, Hiraku

Publication type:

Article

Preparation of chitosan/alginate/calcium complex microparticles loaded with lactoferrin and their efficacy on carrageenan-induced edema in rats.

Published in:

Drug Development & Industrial Pharmacy, 2010, v. 36, n. 8, p. 879, doi. 10.3109/03639040903567109

By:

Onishi, Hiraku;
Koyama, Kennichi;
Sakata, Osamu;
Machida, Yoshiharu

Publication type:

Article

Preparation of medicinal carbon tablets by modified wet compression method.

Published in:

Drug Development & Industrial Pharmacy, 2009, v. 35, n. 11, p. 1333, doi. 10.3109/03639040902902419

By:

Miyachi, Masakazu;
Onishi, Hiraku;
Yumoto, Tetsuro;
Machida, Yoshiharu

Publication type:

Article

Clonazepam Oral Droplets for the Treatment of Acute Epileptic Seizures.

Published in:

Drug Development & Industrial Pharmacy, 2008, v. 34, n. 12, p. 1376, doi. 10.1080/03639040802122977

By:

Sakata, Osamu;
Onishi, Hiraku;
Machida, Yoshiharu

Publication type:

Article

Eudragit Coating of Chitosan-Prednisolone Conjugate Microspheres and In Vitro Evaluation of Coated Microspheres.

Published in:

Drug Development & Industrial Pharmacy, 2007, v. 33, n. 8, p. 848, doi. 10.1080/03639040701377904

By:

Onishi, Hiraku;
Oosegi, Tomoko;
Machida, Yoshiharu;
McGinity, James W.

Publication type:

Article

Preparation and In Vitro Characteristics of Lactoferrin-loaded Chitosan Microparticles.

Published in:

Drug Development & Industrial Pharmacy, 2007, v. 33, n. 6, p. 641, doi. 10.1080/03639040601085334

By:

Onishi, Hiraku;
Machida, Yoshiharu;
Koyama, Kenichi

Publication type:

Article

Novel Mucoadhesive Oral Patch Containing Diazepam.

Published in:

Drug Development & Industrial Pharmacy, 2005, v. 31, n. 7, p. 607, doi. 10.1080/03639040500216071

By:

Onishi, Hiraku;
Sakata, Osamu;
Masuda, Kosuke;
Machida, Yoshiharu

Publication type:

Article

Preparation and In Vitro Evaluation of Chitosan Microspheres Containing Prednisolone: Comparison of Simple and Conjugate Microspheres.

Published in:

Drug Development & Industrial Pharmacy, 2005, v. 31, n. 7, p. 597, doi. 10.1080/03639040500216063

By:

Onishi, Hiraku;
Oosegi, Tomoko;
Machida, Yoshiharu;
McGinity, James W.

Publication type:

Article

Double Liposomes: Hypoglycemic Effects of Liposomal Insulin on Normal Rats.

Published in:

Drug Development & Industrial Pharmacy, 2003, v. 29, n. 7, p. 725, doi. 10.1081/DDC-120021771

By:

Katayama, Ken;
Kato, Yoshinori;
Onishi, Hiraku;
Nagai, Tsuneji;
Machida, Yoshiharu

Publication type:

Article

Preparation and Characterization of Chitosan Microspheres Containing Doxifluridine.

Published in:

Drug Development & Industrial Pharmacy, 2003, v. 29, n. 4, p. 417, doi. 10.1081/DDC-120018377

By:

Yoshino, Tomoaki;
Machida, Yoshiharu;
Onishi, Hiraku;
Nagai, Tsuneji

Publication type:

Article

Preparation and In Vitro Properties of N-Succinylchitosan– or Carboxymethylchitin–Mitomycin C Conjugate Microparticles with Specified Size.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 7, p. 659, doi. 10.1081/DDC-100107322

By:

Onishi, Hiraku;
Takahashi, Hiroaki;
Yoshiyasu, Miwa;
Machida, Yoshiharu

Publication type:

Article

Bioadhesive Characteristics of Chitosan Microspheres to the Mucosa of Rat Small Intestine.

Published in:

Drug Development & Industrial Pharmacy, 2001, v. 27, n. 6, p. 567, doi. 10.1081/DDC-100105182

By:

Shimoda, Junko;
Onishi, Hiraku;
Machida, Yoshiharu

Publication type:

Article

Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene-silencing effects and siRNA biodistribution in mice.

Published in:

Molecular Medicine Reports, 2020, v. 22, n. 5, p. 4183

By:

Hattori, Yoshiyuki;
Tamaki, Kyoko;
Sakasai, Sho;
Ozaki, Kei-Ichi;
Onishi, Hiraku

Publication type:

Article

Effects of cationic lipids in cationic liposomes and disaccharides in the freeze-drying of siRNA lipoplexes on gene silencing in cells by reverse transfection.

Published in:

Journal of Liposome Research, 2020, v. 30, n. 3, p. 235, doi. 10.1080/08982104.2019.1630643

By:

Hattori, Yoshiyuki;
Hu, Subin;
Onishi, Hiraku

Publication type:

Article

Small interfering RNA delivery into the liver by cationic cholesterol derivative-based liposomes.

Published in:

Journal of Liposome Research, 2017, v. 27, n. 4, p. 264, doi. 10.1080/08982104.2016.1205599

By:

Hattori, Yoshiyuki;
Machida, Yoko;
Honda, Maho;
Takeuchi, Nozomi;
Yoshiike, Yuki;
Ohno, Hiroaki;
Onishi, Hiraku

Publication type:

Article

Gene delivery into hepatic cells with ternary complexes of plasmid DNA, cationic liposomes and apolipoprotein E-derived peptide.

Published in:

Experimental & Therapeutic Medicine, 2019, v. 18, n. 4, p. 2628, doi. 10.3892/etm.2019.7863

By:

Hattori, Yoshiyuki;
Nakagawa, Yuta;
Onishi, Hiraku

Publication type:

Article

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study.

Published in:

Pharmaceutics, 2020, v. 12, n. 7, p. 603, doi. 10.3390/pharmaceutics12070603

By:

Sakurai, Hiroomi;
Ikeuchi-Takahashi, Yuri;
Kobayashi, Ayaka;
Yoshimura, Nobuyoshi;
Ishihara, Chizuko;
Aomori, Tohru;
Onishi, Hiraku

Publication type:

Article

Nanogels of Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Preparation, In Vitro Characteristics and Therapeutic Potential.

Published in:

Pharmaceutics, 2019, v. 11, n. 7, p. 333, doi. 10.3390/pharmaceutics11070333

By:

Zhou, Haiyan;
Ichikawa, Atsuko;
Ikeuchi-Takahashi, Yuri;
Hattori, Yoshiyuki;
Onishi, Hiraku

Publication type:

Article

Effect of Cationic Lipid Type in Folate-PEG-Modified Cationic Liposomes on Folate Receptor-Mediated siRNA Transfection in Tumor Cells.

Published in:

Pharmaceutics, 2019, v. 11, n. 4, p. 181, doi. 10.3390/pharmaceutics11040181

By:

Hattori, Yoshiyuki;
Shimizu, Satono;
Ozaki, Kei-ichi;
Onishi, Hiraku

Publication type:

Article

Comparison of intraperitoneal continuous infusion of floxuridine and bolus administration in a peritoneal gastric cancer xenograft model.

Published in:

Cancer Chemotherapy & Pharmacology, 2004, v. 53, n. 5, p. 415, doi. 10.1007/s00280-003-0748-z

By:

Inoue, Kentaro;
Onishi, Hiraku;
Kato, Yoshinori;
Michiura, Taku;
Nakai, Koji;
Sato, Mutsuya;
Yamamichi, Keigo;
Machida, Yoshiharu;
Nakane, Yasushi

Publication type:

Article

Development of Morin-Loaded Nanoemulsions Containing Various Polymers; Role of Polymers in Formulation Properties and Bioavailability.

Published in:

AAPS PharmSciTech, 2020, v. 21, n. 5, p. 1, doi. 10.1208/s12249-020-01670-8

By:

Ikeuchi-Takahashi, Yuri;
Murata, Shingo;
Murata, Wataru;
Kobayashi, Ayaka;
Ishihara, Chizuko;
Onishi, Hiraku

Publication type:

Article

Nanogels of a Succinylated Glycol Chitosan-Succinyl Prednisolone Conjugate: Release Behavior, Gastrointestinal Distribution, and Systemic Absorption.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 7, p. 2376, doi. 10.3390/ijms21072376

By:

Zhou, Haiyan;
Ikeuchi-Takahashi, Yuri;
Hattori, Yoshiyuki;
Onishi, Hiraku

Publication type:

Article

Preparation and Evaluation of Enteric-Coated Chitosan Derivative-Based Microparticles Loaded with Salmon Calcitonin as an Oral Delivery System.

Published in:

International Journal of Molecular Sciences, 2016, v. 17, n. 9, p. 1546, doi. 10.3390/ijms17091546

By:

Hiraku Onishi;
Ayako Tokuyasu

Publication type:

Article

Comparison of Simple Eudragit Microparticles Loaded with Prednisolone and Eudragit-Coated Chitosan-Succinyl-Prednisolone Conjugate Microparticles: Part II. In Vivo Evaluation of Efficacy, Toxicity, and Biodisposition Characteristics.

Published in:

International Journal of Molecular Sciences, 2015, v. 16, n. 11, p. 26125, doi. 10.3390/ijms161125949

By:

Hiraku Onishi;
Hisashi Kikuchi

Publication type:

Article

Preliminary Investigation of the Usability Characteristics Required for Wound Management Products by Semi-Structural Interview of Medical Staff.

Published in:

Pharmacy, 2020, v. 8, n. 4, p. 152, doi. 10.3390/pharmacy8030152

By:

Hirose, Kaoru;
Kawano, Yayoi;
Shigeno, Nahoko;
Mizutani, Yoshikatsu;
Onishi, Hiraku;
Hanawa, Takehisa

Publication type:

Article

Preliminary Investigation of the Usability Characteristics Required for Wound Management Products by Semi-Structural Interview of Medical Staff.

Published in:

Pharmacy, 2020, v. 8, n. 3, p. 152, doi. 10.3390/pharmacy8030152

By:

Hirose, Kaoru;
Kawano, Yayoi;
Shigeno, Nahoko;
Mizutani, Yoshikatsu;
Onishi, Hiraku;
Hanawa, Takehisa

Publication type:

Article

Preparation of carboxy-PEG-PLA nanoparticles loaded with camptothecin and their body distribution in solid tumor-bearing mice.

Published in:

Drug Development Research, 2009, v. 70, n. 7, p. 512, doi. 10.1002/ddr.20322

By:

Ueki, Kennichi;
Onishi, Hiraku;
Sasatsu, Masanaho;
Machida, Yoshiharu

Publication type:

Article

Preparation and evaluation of glycyrrhetic acid‐containing microparticles as an anti‐hepatotoxic system.

Published in:

Drug Development Research, 2005, v. 66, n. 3, p. 189, doi. 10.1002/ddr.20042

By:

Hiraku Onishi;
Hiroaki Takahashi;
Yoshiharu Machida

Publication type:

Article

Preparation and evaluation of fast-dissolving films of etilefrine hydrochloride for practical buccal dosing.

Published in:

Pharmaceutical Development & Technology, 2021, v. 26, n. 5, p. 610, doi. 10.1080/10837450.2021.1904260

By:

Onishi, Hiraku;
Sakata, Osamu

Publication type:

Article

Preparation of orally fast-dissolving tablets of etilefrine hydrochloride to achieve efficient absorption.

Published in:

Pharmaceutical Development & Technology, 2020, v. 25, n. 9, p. 1162, doi. 10.1080/10837450.2020.1794000

By:

Sakata, Osamu;
Onishi, Hiraku

Publication type:

Article

Development of microparticles coated with poly-γ-glutamic acid to improve oral absorption of a poorly water-soluble drug.

Published in:

Pharmaceutical Development & Technology, 2019, v. 24, n. 8, p. 992, doi. 10.1080/10837450.2019.1621898

By:

Ikeuchi-Takahashi, Yuri;
Shiokawa, Yudai;
Sekita, Kazuki;
Yonemochi, Etsuo;
Onishi, Hiraku

Publication type:

Article

Chitosan-Drug Conjugate Microspheres: Preparation and Drug Release Properties of Microspheres Composed of the Conjugate of 2′- or 3′-(4-Carboxy-butyryl)-5- Fluorouridine with Chitosan.

Published in:

Drug Development & Industrial Pharmacy, 1996, v. 22, n. 5, p. 457, doi. 10.3109/03639049609069355

By:

Onishi, Hiraku;
Shimoda, Junko;
Machida, Yoshiharu

Publication type:

Article

Therapeutic effects of protein kinase N3 small interfering RNA and doxorubicin combination therapy on liver and lung metastases.

Published in:

Oncology Letters, 2017, v. 14, n. 5, p. 5157, doi. 10.3892/ol.2017.6830

By:

YOSHIYUKI HATTORI;
TAKUTO KIKUCHI;
MARI NAKAMURA;
KEI-ICHI OZAKI;
HIRAKU ONISHI

Publication type:

Article

Methyl vinyl ketone impairs spatial memory and activates hippocampal glial cells in mice.

Published in:

PLoS ONE, 2023, v. 18, n. 8, p. 1, doi. 10.1371/journal.pone.0289714

By:

Sato, Ren Y.;
Kotake, Koki;
Zhang, Yumin;
Onishi, Hiraku;
Matsui, Futaba;
Norimoto, Hiroaki;
Zhou, Zhiwen

Publication type:

Article

In vivo efficacy of a novel double liposome as an oral dosage form of salmon calcitonin.

Published in:

Drug Development Research, 2003, v. 58, n. 3, p. 253, doi. 10.1002/ddr.10162

By:

Ebato, Yoshinori;
Kato, Yoshinori;
Onishi, Hiraku;
Nagai, Tsuneji;
Machida, Yoshiharu

Publication type:

Article

Glycyrrhetic acid-loaded microparticles: liver-specific delivery and therapeutic potential against carbon tetrachloride-induced hepatitis.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 4, p. 437

By:

Hiroaki Takahashi;
Hiraku Onishi;
Yoshiharu Machida

Publication type:

Article

Effect of PEG anchor in PEGylation of folate-modified cationic liposomes with PEG-derivatives on systemic siRNA delivery into the Tumor.

Published in:

Journal of Drug Targeting, 2023, v. 31, n. 1, p. 74, doi. 10.1080/1061186X.2022.2104860

By:

Tang, Min;
Sakasai, Sho;
Onishi, Hiraku;
Kawano, Kumi;
Hattori, Yoshiyuki

Publication type:

Article

Targeting potential of alginate-glycyl-prednisolone conjugate nanogel to inflamed joints in rats with adjuvant-induced arthritis.

Published in:

Journal of Drug Targeting, 2021, v. 29, n. 8, p. 892, doi. 10.1080/1061186X.2021.1892116

By:

Onishi, Hiraku;
Mizuno, Kohei;
Ikeuchi-Takahashi, Yuri;
Hattori, Yoshiyuki

Publication type:

Article

Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex.

Published in:

Journal of Drug Targeting, 2019, v. 27, n. 2, p. 217, doi. 10.1080/1061186X.2018.1502775

By:

Hattori, Yoshiyuki;
Nakamura, Mari;
Takeuchi, Nozomi;
Tamaki, Kyoko;
Shimizu, Satono;
Yoshiike, Yuki;
Onishi, Hiraku;
Taguchi, Masamitsu;
Ohno, Hiroaki;
Ozaki, Kei-Ichi

Publication type:

Article

Preparation of chondroitin sulfate-adipic acid dihydrazide-doxorubicin conjugate and its antitumour characteristics against LLC cells.

Published in:

Journal of Drug Targeting, 2017, v. 25, n. 8, p. 747, doi. 10.1080/1061186X.2017.1327593

By:

Onishi, Hiraku;
Fukasawa, Ai;
Miatmoko, Andang;
Kawano, Kumi;
Ikeuchi-Takahashi, Yuri;
Hattori, Yoshiyuki

Publication type:

Article

Preparation and evaluation of conjugate nanogels of glycyl-prednisolone with natural anionic polysaccharides as anti-arthritic delivery systems.

Published in:

Drug Delivery, 2021, v. 28, n. 1, p. 136, doi. 10.1080/10717544.2020.1865478

By:

Kohei Mizuno;
Yuri Ikeuchi-Takahashi;
Yoshiyuki Hattori;
Hiraku Onishi

Publication type:

Article

Particle Characteristics and Biodistribution of Camptothecin-Loaded PLA/(PEG-PPG-PEG) Nanoparticles.

Published in:

Drug Delivery, 2008, v. 15, n. 1, p. 3, doi. 10.1080/10717540701827154

By:

Kunii, Ryotaro;
Onishi, Hiraku;
Ueki, Ken-ichi;
Koyama, Ken-ichi;
Machida, Yoshiharu

Publication type:

Article