Works by Onaka, Hiroyasu

Results: 48

Production of a Novel Amide-Containing Polyene by Activating a Cryptic Biosynthetic Gene Cluster in Streptomyces sp. MSC090213JE08.

Published in:

ChemBioChem, 2016, v. 17, n. 15, p. 1464, doi. 10.1002/cbic.201600167

By:

Du, Danyao;
Katsuyama, Yohei;
Onaka, Hiroyasu;
Fujie, Manabu;
Satoh, Noriyuki;
Shin‐ya, Kazuo;
Ohnishi, Yasuo

Publication type:

Article

Back Cover: Insights into the Biosynthesis of Dehydroalanines in Goadsporin (ChemBioChem 3/2016).

Published in:

ChemBioChem, 2016, v. 17, n. 3, p. 268, doi. 10.1002/cbic.201600046

By:

Ozaki, Taro;
Kurokawa, Yukari;
Hayashi, Shohei;
Oku, Naoya;
Asamizu, Shumpei;
Igarashi, Yasuhiro;
Onaka, Hiroyasu

Publication type:

Article

Insights into the Biosynthesis of Dehydroalanines in Goadsporin.

Published in:

ChemBioChem, 2016, v. 17, n. 3, p. 218, doi. 10.1002/cbic.201500541

By:

Ozaki, Taro;
Kurokawa, Yukari;
Hayashi, Shohei;
Oku, Naoya;
Asamizu, Shumpei;
Igarashi, Yasuhiro;
Onaka, Hiroyasu

Publication type:

Article

Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria.

Published in:

Journal of Industrial Microbiology & Biotechnology, 2019, v. 46, n. 3/4, p. 363, doi. 10.1007/s10295-018-2100-y

By:

Hoshino, Shotaro;
Onaka, Hiroyasu;
Abe, Ikuro

Publication type:

Article

Effects of carbon ion beam-induced mutagenesis for the screening of RED production-deficient mutants of Streptomyces coelicolor JCM4020.

Published in:

PLoS ONE, 2022, v. 17, n. 7, p. 1, doi. 10.1371/journal.pone.0270379

By:

Yanagisawa, Masaomi;
Asamizu, Shumpei;
Satoh, Katsuya;
Oono, Yutaka;
Onaka, Hiroyasu

Publication type:

Article

Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation.

Published in:

Angewandte Chemie, 2019, v. 131, n. 38, p. 13620, doi. 10.1002/ange.201905970

By:

Sugiyama, Ryosuke;
Nakatani, Takahiro;
Nishimura, Shinichi;
Takenaka, Kei;
Ozaki, Taro;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus : identification of a target gene of the A-factor receptor.

Published in:

Molecular Microbiology, 1999, v. 34, n. 1, p. 102, doi. 10.1046/j.1365-2958.1999.01579.x

By:

Ohnishi, Yasuo;
Kameyama, Shogo;
Onaka, Hiroyasu;
Horinouchi, Sueharu

Publication type:

Article

Involvement of two A-factor receptor homologues in Streptomyces coelicolor A3(2) in the regulation of secondary metabolism and morphogenesis.

Published in:

Molecular Microbiology, 1998, v. 28, n. 4, p. 743, doi. 10.1046/j.1365-2958.1998.00832.x

By:

Onaka, Hiroyasu;
Nakagawa, Taishiro;
Horinouchi, Sueharu

Publication type:

Article

DNA-binding activity of the A-factor receptor protein and its recognition DNA sequences.

Published in:

Molecular Microbiology, 1997, v. 24, n. 6, p. 991, doi. 10.1046/j.1365-2958.1997.4081772.x

By:

Onaka, Hiroyasu;
Horinouchi, Sueharu

Publication type:

Article

Unlocking hidden bioactive compounds: from indolocarbazole and RiPP biosynthesis to the activation of cryptic secondary metabolism via microbial interactions.

Published in:

Journal of Antibiotics, 2025, v. 78, n. 7, p. 395, doi. 10.1038/s41429-025-00828-5

By:

Onaka, Hiroyasu

Publication type:

Article

A new pyranonaphthoquinone, actinoquinonal A, and its congeners from the combined-culture of Streptomyces sp. 23–50 and Tsukamurella pulmonis TP-B0596.

Published in:

Journal of Antibiotics, 2025, v. 78, n. 6, p. 350, doi. 10.1038/s41429-025-00821-y

By:

Yanagisawa, Kazuki;
Kaneko, Kensuke;
Ikeda, Hiroaki;
Iwata, Sumika;
Muranaka, Atsuya;
Koshino, Hiroyuki;
Nagao, Noeka;
Watari, Susumu;
Nishimura, Shinichi;
Shinzato, Naoya;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

Amoxetamide A, a new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis.

Published in:

Journal of Antibiotics, 2024, v. 77, n. 1, p. 66, doi. 10.1038/s41429-023-00668-1

By:

Pan, Chengqian;
Ikeda, Hiroaki;
Minote, Mayuri;
Tokuda, Tensei;
Kuranaga, Takefumi;
Taniguchi, Tohru;
Shinzato, Naoya;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

Kimidinomycin, a new antibiotic against Mycobacterium avium complex, produced by Streptomyces sp. KKTA-0263.

Published in:

Journal of Antibiotics, 2022, v. 75, n. 2, p. 72, doi. 10.1038/s41429-021-00494-3

By:

Hikima, Ayumi;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Zhang, Huiping;
Tomoda, Hiroshi;
Koyama, Nobuhiro

Publication type:

Article

Longicatenamides A–D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596.

Published in:

Journal of Antibiotics, 2021, v. 74, n. 5, p. 307, doi. 10.1038/s41429-020-00400-3

By:

Jiang, Yulu;
Matsumoto, Takumi;
Kuranaga, Takefumi;
Lu, Shan;
Wang, Weicheng;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 11, p. 911, doi. 10.1038/s41429-018-0088-1

By:

Hagihara, Ryota;
Katsuyama, Yohei;
Sugai, Yoshinori;
Onaka, Hiroyasu;
Ohnishi, Yasuo

Publication type:

Article

Umezawamides, new bioactive polycyclic tetramate macrolactams isolated from a combined-culture of Umezawaea sp. and mycolic acid-containing bacterium.

Published in:

Journal of Antibiotics, 2018, v. 71, n. 7, p. 653, doi. 10.1038/s41429-018-0040-4

By:

Hoshino, Shotaro;
Wong, Chin Piow;
Ozeki, Masahiro;
Zhang, Huiping;
Hayashi, Fumiaki;
Awakawa, Takayoshi;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Abe, Ikuro

Publication type:

Article

Novel antibiotic screening methods to awaken silent or cryptic secondary metabolic pathways in actinomycetes.

Published in:

Journal of Antibiotics, 2017, v. 70, n. 8, p. 865, doi. 10.1038/ja.2017.51

By:

Onaka, Hiroyasu

Publication type:

Article

Mycolic acid-containing bacteria activate heterologous secondary metabolite expression in Streptomyces lividans.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 9, p. 594, doi. 10.1038/ja.2015.31

By:

Onaka, Hiroyasu;
Ozaki, Taro;
Mori, Yukiko;
Izawa, Masumi;
Hayashi, Shohei;
Asamizu, Shumpei

Publication type:

Article

Arcyriaflavin E, a new cytotoxic indolocarbazole alkaloid isolated by combined-culture of mycolic acid-containing bacteria and Streptomyces cinnamoneus NBRC 13823.

Published in:

Journal of Antibiotics, 2015, v. 68, n. 5, p. 342, doi. 10.1038/ja.2014.147

By:

Hoshino, Shotaro;
Zhang, Lihan;
Awakawa, Takayoshi;
Wakimoto, Toshiyuki;
Onaka, Hiroyasu;
Abe, Ikuro

Publication type:

Article

5-Prenyltryptophol, a new inhibitor of bone morphogenetic protein-induced alkaline phosphatase expression in myoblasts, produced by Streptomyces colinus subsp. albescens HEK608.

Published in:

Journal of Antibiotics, 2014, v. 67, n. 8, p. 589, doi. 10.1038/ja.2014.44

By:

Uchida, Ryuji;
Nakai, Megumi;
Ohte, Satoshi;
Onaka, Hiroyasu;
Katagiri, Takenobu;
Tomoda, Hiroshi

Publication type:

Article

New structural scaffold 14-membered macrocyclic lactone ring for selective inhibitors of cell wall peptidoglycan biosynthesis in Staphylococcus aureus.

Published in:

Journal of Antibiotics, 2013, v. 66, n. 5, p. 303, doi. 10.1038/ja.2012.122

By:

Koyama, Nobuhiro;
Yotsumoto, Makoto;
Onaka, Hiroyasu;
Tomoda, Hiroshi

Publication type:

Article

Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp.

Published in:

Journal of Antibiotics, 2010, v. 63, n. 9, p. 563, doi. 10.1038/ja.2010.70

By:

Igarashi, Yasuhiro;
Shimasaki, Ryoko;
Miyanaga, Satoshi;
Oku, Naoya;
Onaka, Hiroyasu;
Sakurai, Hiroaki;
Saiki, Ikuo;
Kitani, Shigeru;
Nihira, Takuya;
Wimonsiravude, Waurawan;
Panbangred, Watanalai

Publication type:

Article

NMR characterization of streptogramin B and L‐156,587, a non‐synergistic pair of the streptogramin family antibiotic complexes produced inductively by a combined culture of Streptomyces albogriseolus and Tsukamurella pulmonis.

Published in:

Magnetic Resonance in Chemistry, 2022, v. 60, n. 2, p. 261, doi. 10.1002/mrc.5219

By:

Oku, Naoya;
Takemura, Shion;
Onaka, Hiroyasu;
Igarashi, Yasuhiro

Publication type:

Article

Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 38, p. 13486, doi. 10.1002/anie.201905970

By:

Sugiyama, Ryosuke;
Nakatani, Takahiro;
Nishimura, Shinichi;
Takenaka, Kei;
Ozaki, Taro;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

Identification of endophytic Streptomyces sp. R-5 and analysis of its antimicrobial metabolites.

Published in:

Journal of General Plant Pathology, 2004, v. 70, n. 1, p. 66, doi. 10.1007/s10327-003-0082-7

By:

Masafumi Shimizu;
Yasuhiro Igarashi;
Tamotsu Furumai;
Hiroyasu Onaka;
Hitoshi Kunoh

Publication type:

Article

Multiplication of isolate R-5 of Streptomyces galbus on rhododendron leaves and its production of cell wall-degrading enzymes.

Published in:

Journal of General Plant Pathology, 2003, v. 69, n. 1, p. 65, doi. 10.1007/s10327-002-0014-y

By:

Minamiyama, Hidetoshi;
Shimizu, Masafumi;
Kunoh, Hitoshi;
Furumai, Tamotsu;
Igarashi, Yasuhiro;
Onaka, Hiroyasu;
Yoshida, Ryuji

Publication type:

Article

Genetic approaches to generate hyper-producing strains of goadsporin: the relationships between productivity and gene duplication in secondary metabolite biosynthesis.

Published in:

Bioscience, Biotechnology & Biochemistry, 2014, v. 78, n. 3, p. 394, doi. 10.1080/09168451.2014.885824

By:

Kentaro Haginaka;
Shumpei Asamizu;
Taro Ozaki;
Yasuhiro Igarashi;
Tamotsu Furumai;
Hiroyasu Onaka

Publication type:

Article

Characterization and Functional Modification of StaC and RebC, Which Are Involved in the Pyrrole Oxidation of Indolocarbazole Biosynthesis.

Published in:

Bioscience, Biotechnology & Biochemistry, 2011, v. 75, n. 11, p. 2184, doi. 10.1271/bbb.110474

By:

Shumpei Asamizu;
Yoshitsugu Shiro;
Yasuhiro Igarashi;
Shingo Nagano;
Hiroyasu Onaka

Publication type:

Article

Biosynthesis of Indolocarbazole and Goadsporin, Two Different Heterocyclic Antibiotics Produced by Actinomycetes.

Published in:

Bioscience, Biotechnology & Biochemistry, 2009, v. 73, n. 10, p. 2149, doi. 10.1271/bbb.90263

By:

Onaka, Hiroyasu

Publication type:

Article

Coupling Reaction of Indolepyruvic Acid by StaD and Its Product: Implications for Biosynthesis of Indolocarbazole and Violacein.

Published in:

ChemBioChem, 2012, v. 13, n. 17, p. 2495, doi. 10.1002/cbic.201200535

By:

Asamizu, Shumpei;
Hirano, Satoshi;
Onaka, Hiroyasu;
Koshino, Hiroyuki;
Shiro, Yoshitsugu;
Nagano, Shingo

Publication type:

Article

Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo.

Published in:

Nature Communications, 2017, v. 8, n. 2, p. 14207, doi. 10.1038/ncomms14207

By:

Ozaki, Taro;
Yamashita, Kona;
Goto, Yuki;
Shimomura, Morito;
Hayashi, Shohei;
Asamizu, Shumpei;
Sugai, Yoshinori;
Ikeda, Haruo;
Suga, Hiroaki;
Onaka, Hiroyasu

Publication type:

Article

Absolute Configuration and Antitumor Activity of Myxochelin A Produced by Nonomuraea pusilla TP-A0861<sup>†</sup>.

Published in:

Journal of Antibiotics, 2006, v. 59, n. 11, p. 698, doi. 10.1038/ja.2006.93

By:

Miyanaga, Satoshi;
Obata, Takamasa;
Onaka, Hiroyasu;
Fujita, Tsuyoshi;
Saito, Noriko;
Sakurai, Hiroaki;
Saiki, Ikuo;
Furumai, Tamotsu;
Igarashi, Yasuhiro

Publication type:

Article

Absolute Configuration of TPU-0043, a Pentaene Macrolide from Streptomyces sp.

Published in:

Journal of Antibiotics, 2005, v. 58, n. 8, p. 523, doi. 10.1038/ja.2005.71

By:

Igarashi, Yasuhiro;
In, Yasuko;
Ishida, Toshimasa;
Fujita, Tsuyoshi;
Yamakawa, Takashi;
Onaka, Hiroyasu;
Furumai, Tamotsu

Publication type:

Article

Anicemycin, a New Inhibitor of Anchorage-independent Growth of Tumor Cells from Streptomyces sp. TP-A0648.

Published in:

Journal of Antibiotics, 2005, v. 58, n. 5, p. 322, doi. 10.1038/ja.2005.40

By:

Igarashi, Yasuhiro;
Ootsu, Koushirou;
Onaka, Hiroyasu;
Fujita, Tsuyoshi;
Uehara, Yoshimasa;
Furumai, Tamotsu

Publication type:

Article

Revision of the Structure Assigned to the Antibiotic BU-4664L from Micromonopora.

Published in:

Journal of Antibiotics, 2005, v. 58, n. 5, p. 350, doi. 10.1038/ja.2005.44

By:

Igarashi, Yasuhiro;
Miyanaga, Satoshi;
Onaka, Hiroyasu;
Takeshita, Michinori;
Furumai, Tamotsu

Publication type:

Article

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.

Published in:

Angewandte Chemie, 2016, v. 128, n. 35, p. 10434, doi. 10.1002/ange.201604126

By:

Sugiyama, Ryosuke;
Nishimura, Shinichi;
Ozaki, Taro;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

Transcriptionally induced nucleoid-associated protein-like ccr1 in combined-culture serves as a global effector of Streptomyces secondary metabolism.

Published in:

Frontiers in Microbiology, 2024, p. 1, doi. 10.3389/fmicb.2024.1422977

By:

Yukun Lei;
Hiroyasu Onaka;
Shumpei Asamizu

Publication type:

Article

Cloning of the Gene Cluster Responsible for Biosynthesis of KS-505a (Longestin), a Unique Tetraterpenoid.

Published in:

Bioscience, Biotechnology & Biochemistry, 2007, v. 71, n. 12, p. 3072, doi. 10.1271/bbb.70477

By:

Hayashi, Yutaka;
Onaka, Hiroyasu;
Itoh, Nobuya;
Seto, Haruo;
Dairi, Tohru

Publication type:

Article

Cytochrome P450 Homolog Is Responsible for C-N Bond Formation between Aglycone and Deoxysugar in the Straurosporine Biosynthesis of Streptomyces sp. TP-A0274.

Published in:

Bioscience, Biotechnology & Biochemistry, 2005, v. 69, n. 9, p. 1753, doi. 10.1271/bbb.69.1753

By:

Onaka, Hiroyasu;
Asamizu, Shumpei;
Igarashi, Yasuhiro;
Yoshida, Ryuji;
Furumai, Tamotsu

Publication type:

Article

Characterization of the Biosynthetic Gene Cluster of Rebeccamycin from Lechevalieria aerocolonigenes ATCC 39243.

Published in:

Bioscience, Biotechnology & Biochemistry, 2003, v. 67, n. 1, p. 127, doi. 10.1271/bbb.67.127

By:

Onaka, Hiroyasu;
Taniguchi, Shin-ichi;
Igarashi, Yasuhiro;
Furumai, Tamotsu

Publication type:

Article

Minimal lactazole scaffold for in vitro thiopeptide bioengineering.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16145-4

By:

Vinogradov, Alexander A.;
Shimomura, Morito;
Goto, Yuki;
Ozaki, Taro;
Asamizu, Shumpei;
Sugai, Yoshinori;
Suga, Hiroaki;
Onaka, Hiroyasu

Publication type:

Article

Killing of Mycolic Acid-Containing Bacteria Aborted Induction of Antibiotic Production by Streptomyces in Combined-Culture.

Published in:

PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0142372

By:

Asamizu, Shumpei;
Ozaki, Taro;
Teramoto, Kanae;
Satoh, Katsuya;
Onaka, Hiroyasu

Publication type:

Article

Intimate relationships among actinomycetes and mycolic acid-containing bacteria.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-11406-2

By:

Kato, Manami;
Asamizu, Shumpei;
Onaka, Hiroyasu

Publication type:

Article

Phage tail-like nanostructures affect microbial interactions between Streptomyces and fungi.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-99490-8

By:

Nagakubo, Toshiki;
Yamamoto, Tatsuya;
Asamizu, Shumpei;
Toyofuku, Masanori;
Nomura, Nobuhiko;
Onaka, Hiroyasu

Publication type:

Article

Five pimarane diterpenoids from Kaempferia champasakensis and their cytotoxic activities.

Published in:

Journal of Natural Medicines, 2024, v. 78, n. 4, p. 908, doi. 10.1007/s11418-024-01829-8

By:

Do, Kiep Minh;
Hoshino, Shotaro;
Kodama, Takeshi;
Nguyen, Hien Minh;
Ikumi, Naotaka;
Onaka, Hiroyasu;
Morita, Hiroyuki

Publication type:

Article

A new 3,4-seco-isopimarane and three new isopimarane diterpenoids from Kaempferia champasakensis collected from Vietnam and their cytotoxic activities.

Published in:

Journal of Natural Medicines, 2024, v. 78, n. 3, p. 537, doi. 10.1007/s11418-024-01789-z

By:

Do, Kiep Minh;
Hoshino, Shotaro;
Kodama, Takeshi;
Nguyen, Hien Minh;
Van Le, Son;
Ikumi, Naotaka;
Onaka, Hiroyasu;
Morita, Hiroyuki

Publication type:

Article

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 35, p. 10278, doi. 10.1002/anie.201604126

By:

Sugiyama, Ryosuke;
Nishimura, Shinichi;
Ozaki, Taro;
Asamizu, Shumpei;
Onaka, Hiroyasu;
Kakeya, Hideaki

Publication type:

Article

A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis.

Published in:

Nature Chemical Biology, 2010, v. 6, n. 9, p. 641, doi. 10.1038/nchembio.418

By:

Noguchi, Akio;
Kitamura, Takeshi;
Onaka, Hiroyasu;
Horinouchi, Sueharu;
Ohnishi, Yasuo

Publication type:

Article