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Design, Synthesis, and Antisickling Investigation of a Thiazolidine Prodrug of TD-7 That Prolongs the Duration of Action of Antisickling Aromatic Aldehyde.
- Published in:
- Pharmaceutics, 2023, v. 15, n. 11, p. 2547, doi. 10.3390/pharmaceutics15112547
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- Article
Improving the Solubility and Oral Bioavailability of a Novel Aromatic Aldehyde Antisickling Agent (PP10) for the Treatment of Sickle Cell Disease.
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- Pharmaceutics, 2021, v. 13, n. 8, p. 1148, doi. 10.3390/pharmaceutics13081148
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- Article
Clinical Pharmacokinetic Evaluation of Optimized Liquisolid Tablets as a Potential Therapy for Male Sexual Dysfunction.
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- Pharmaceutics, 2020, v. 12, n. 12, p. 1187, doi. 10.3390/pharmaceutics12121187
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- Article
Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity.
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- Pharmaceuticals (14248247), 2020, v. 13, n. 11, p. 393, doi. 10.3390/ph13110393
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- Article
Exploring antiproliferative activities and kinase profile of ortho‐substituted N‐(4‐(2‐(benzylamino)‐2‐oxoethyl)phenyl)benzamides.
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- Chemical Biology & Drug Design, 2024, v. 103, n. 1, p. 1, doi. 10.1111/cbdd.14379
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- Article
Targeted modification of furan‐2‐carboxaldehydes into Michael acceptor analogs yielded long‐acting hemoglobin modulators with dual antisickling activities.
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- Chemical Biology & Drug Design, 2024, v. 103, n. 1, p. 1, doi. 10.1111/cbdd.14371
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- Article
Mangosteen Metabolites as Promising Alpha-Amylase Inhibitor Candidates: In Silico and In Vitro Evaluations.
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- Metabolites (2218-1989), 2022, v. 12, n. 12, p. 1229, doi. 10.3390/metabo12121229
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- Article
A single‐step synthesis of 1,3,4,6‐tetraaryl‐5‐aryliminopiperazin‐2‐one.
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- Journal of Heterocyclic Chemistry, 2021, v. 58, n. 2, p. 442, doi. 10.1002/jhet.4179
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- Article
Protective potential of mokko lactone from Cheilocostus speciosus (J. Koenig) C.D. Specht (Costaceae) rhizomes against fulminant hepatic failure.
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- Turkish Journal of Botany, 2023, v. 47, n. 4, p. 256, doi. 10.55730/1300-008X.2764
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- Article
Insights on Cancer Cell Inhibition, Subcellular Activities, and Kinase Profile of Phenylacetamides Pending 1 H -Imidazol-5-One Variants.
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- Frontiers in Pharmacology, 2022, v. 12, p. 1, doi. 10.3389/fphar.2021.794325
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- Article
Phytoconstituents, In Vitro Anti-Infective Activity of Buddleja indica Lam., and In Silico Evaluation of its SARS-CoV-2 Inhibitory Potential.
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- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.619373
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- Article
An Investigation of Structure-Activity Relationships of Azolylacryloyl Derivatives Yielded Potent and Long-Acting Hemoglobin Modulators for Reversing Erythrocyte Sickling.
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- Biomolecules (2218-273X), 2020, v. 10, n. 11, p. 1508, doi. 10.3390/biom10111508
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- Article
1H-Imidazole-2,5-Dicarboxamides as NS4A Peptidomimetics: Identification of a New Approach to Inhibit HCV-NS3 Protease.
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- Biomolecules (2218-273X), 2020, v. 10, n. 3, p. 479, doi. 10.3390/biom10030479
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- Article
Zein-alpha lipoic acid-loaded nanoparticles to enhance the oral bioavailability of dapoxetine: optimization and clinical pharmacokinetic evaluation.
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- International Journal of Nanomedicine, 2019, v. 14, p. 7461, doi. 10.2147/IJN.S224611
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- Article
Fungal Bergamotane Sesquiterpenoids—Potential Metabolites: Sources, Bioactivities, and Biosynthesis.
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- Marine Drugs, 2022, v. 20, n. 12, p. 771, doi. 10.3390/md20120771
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- Article
Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists.
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- Molecules, 2023, v. 28, n. 4, p. 1761, doi. 10.3390/molecules28041761
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- Article
Unveiling the Efficacy of Sesquiterpenes from Marine Sponge Dactylospongia elegans in Inhibiting Dihydrofolate Reductase Using Docking and Molecular Dynamic Studies.
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- Molecules, 2023, v. 28, n. 3, p. 1292, doi. 10.3390/molecules28031292
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- Article
Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists.
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- Molecules, 2023, v. 28, n. 1, p. 44, doi. 10.3390/molecules28010044
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- Article
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
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- Molecules, 2022, v. 27, n. 20, p. 6835, doi. 10.3390/molecules27206835
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- Article
Advances in Fungal Phenaloenones—Natural Metabolites with Great Promise: Biosynthesis, Bioactivities, and an In Silico Evaluation of Their Potential as Human Glucose Transporter 1 Inhibitors.
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- Molecules, 2022, v. 27, n. 20, p. 6797, doi. 10.3390/molecules27206797
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- Article
Reexamining Povarov Reaction's Scope and Limitation in the Generation of HCV-NS4A Peptidomimetics.
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- Heteroatom Chemistry, 2022, p. 1, doi. 10.1155/2022/8181543
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- Article
Molecular insight into 2‐phosphoglycolate activation of the phosphatase activity of bisphosphoglycerate mutase.
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- Acta Crystallographica: Section D, Structural Biology, 2022, v. 78, n. 4, p. 472, doi. 10.1107/S2059798322001802
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- Article
VZHE-039, a novel antisickling agent that prevents erythrocyte sickling under both hypoxic and anoxic conditions.
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- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-77171-2
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- Article
Molecular Mimics of Classic P-Glycoprotein Inhibitors as Multidrug Resistance Suppressors and Their Synergistic Effect on Paclitaxel.
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- PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0168938
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- Article
Cytotoxic and alpha amylase-inhibitory metabolites from Tagetes minuta: In vitro evaluation and docking studies.
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- Tropical Journal of Pharmaceutical Research, 2023, v. 22, n. 4, p. 795, doi. 10.4314/tjpr.v22i4.12
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- Article
The Relationships of AMPK Allosteric Inhibitors with Their Activities against Breast Cancer in 2D and 3D Models.
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- ChemistrySelect, 2023, v. 8, n. 43, p. 1, doi. 10.1002/slct.202302979
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- Article
Incorporation of Perillyl Alcohol into Lipid-Based Nanocarriers Enhances the Antiproliferative Activity in Malignant Glioma Cells.
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- Biomedicines, 2023, v. 11, n. 10, p. 2771, doi. 10.3390/biomedicines11102771
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- Article
Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor.
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- Molecules, 2017, v. 22, n. 2, p. 188, doi. 10.3390/molecules22020188
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- Article
Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin.
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- Molecules, 2016, v. 21, n. 8, p. 1057, doi. 10.3390/molecules21081057
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- Article
Exploring the Activity of Fungal Phenalenone Derivatives as Potential CK2 Inhibitors Using Computational Methods.
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- Journal of Fungi, 2022, v. 8, n. 5, p. 443, doi. 10.3390/jof8050443
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- Article
Chaetomugilins and Chaetoviridins—Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular Dynamics.
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- Journal of Fungi, 2022, v. 8, n. 2, p. N.PAG, doi. 10.3390/jof8020127
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- Article
Thiophenes—Naturally Occurring Plant Metabolites: Biological Activities and In Silico Evaluation of Their Potential as Cathepsin D Inhibitors.
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- Plants (2223-7747), 2022, v. 11, n. 4, p. 539, doi. 10.3390/plants11040539
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- Article
SAR Probing of KX2-391 Provided Analogues With Juxtaposed Activity Profile Against Major Oncogenic Kinases.
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- Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.879457
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- Article
Enhancing MS‐275 Anticancer Activity: Encapsulation of MS‐275 in TPGS Micelles Demonstrated High Efficiency.
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- Journal of Nanotechnology, 2024, v. 2024, p. 1, doi. 10.1155/2024/8207090
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- Article
Assessments of Alpha-Amylase Inhibitory Potential of Tagetes Flavonoids through In Vitro, Molecular Docking, and Molecular Dynamics Simulation Studies.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 12, p. 10195, doi. 10.3390/ijms241210195
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- Article
Enhancing Ezetimibe Anticancer Activity Through Development of Drug Nano-Micelles Formulations: A Promising Strategy Supported by Molecular Docking.
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- International Journal of Nanomedicine, 2023, v. 18, p. 6689, doi. 10.2147/IJN.S438704
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- Article