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Eicosanoids in Skin Wound Healing.
Published in:
International Journal of Molecular Sciences, 2020, v. 21, n. 22, p. 8435, doi. 10.3390/ijms21228435
By:
- Yasukawa, Ken;
- Okuno, Toshiaki;
- Yokomizo, Takehiko
Publication type:
Article
The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders.
Published in:
International Journal of Molecular Sciences, 2019, v. 20, n. 14, p. 3580, doi. 10.3390/ijms20143580
By:
- Jo-Watanabe, Airi;
- Okuno, Toshiaki;
- Yokomizo, Takehiko
Publication type:
Article
αDβ2 as a novel target of experimental polymicrobial sepsis.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1059996
By:
- Koutsogiannaki, Sophia;
- Lifei Hou;
- Toshiaki Okuno;
- Shibamura-Fujiogi, Miho;
- Luo, Hongbo R.;
- Koichi Yuki
Publication type:
Article
Prostaglandin E2 and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition.
Published in:
Genes to Cells, 2020, v. 25, n. 3, p. 197, doi. 10.1111/gtc.12750
By:
- Ishihara, Erika;
- Nagaoka, Yuya;
- Okuno, Toshiaki;
- Kofuji, Satoshi;
- Ishigami‐Yuasa, Mari;
- Kagechika, Hiroyuki;
- Kamimura, Kenya;
- Terai, Shuji;
- Yokomizo, Takehiko;
- Sugimoto, Yukihiko;
- Fujita, Yasuyuki;
- Suzuki, Akira;
- Nishina, Hiroshi
Publication type:
Article
Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2.
Published in:
Scientific Reports, 2017, v. 7, n. 1, p. 1, doi. 10.1038/s41598-017-13122-8
By:
- Iwamoto, Satoshi;
- Koga, Tomoaki;
- Ohba, Mai;
- Okuno, Toshiaki;
- Koike, Masato;
- Murakami, Akira;
- Matsuda, Akira;
- Yokomizo, Takehiko
Publication type:
Article
Leukotriene B4 receptor type 2 protects against pneumolysin-dependent acute lung injury.
Published in:
Scientific Reports, 2016, p. 34560, doi. 10.1038/srep34560
By:
- Shigematsu, Misako;
- Koga, Tomoaki;
- Ishimori, Ayako;
- Saeki, Kazuko;
- Ishii, Yumiko;
- Taketomi, Yoshitaka;
- Ohba, Mai;
- Jo-Watanabe, Airi;
- Okuno, Toshiaki;
- Harada, Norihiro;
- Harayama, Takeshi;
- Shindou, Hideo;
- Li, Jian-Dong;
- Murakami, Makoto;
- Hoka, Sumio;
- Yokomizo, Takehiko
Publication type:
Article
Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45579-3
By:
- Jo-Watanabe, Airi;
- Inaba, Toshiki;
- Osada, Takahiro;
- Hashimoto, Ryota;
- Nishizawa, Tomohiro;
- Okuno, Toshiaki;
- Ihara, Sayoko;
- Touhara, Kazushige;
- Hattori, Nobutaka;
- Oh-Hora, Masatsugu;
- Nureki, Osamu;
- Yokomizo, Takehiko
Publication type:
Article
Biochemical Characterization of Three BLT Receptors in Zebrafish.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0117888
By:
- Okuno, Toshiaki;
- Ishitani, Tohru;
- Yokomizo, Takehiko
Publication type:
Article
Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E2 accumulation in labor.
Published in:
PLoS ONE, 2021, v. 16, n. 4, p. 1, doi. 10.1371/journal.pone.0250638
By:
- Takahashi, Nanase;
- Okuno, Toshiaki;
- Fujii, Hiroki;
- Makino, Shintaro;
- Takahashi, Masaya;
- Ohba, Mai;
- Saeki, Kazuko;
- Itakura, Atsuo;
- Takeda, Satoru;
- Yokomizo, Takehiko
Publication type:
Article
Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.
Published in:
2021
By:
- Jimbo, Keisuke;
- Okuno, Toshiaki;
- Ohgaki, Ryuichi;
- Nishikubo, Kou;
- Kitamura, Yuri;
- Sakurai, Yumiko;
- Quan, Lili;
- Shoji, Hiromichi;
- Kanai, Yoshikatsu;
- Shimizu, Toshiaki;
- Yokomizo, Takehiko
Publication type:
Correction Notice
A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.
Published in:
PLoS ONE, 2020, v. 15, n. 11, p. 1, doi. 10.1371/journal.pone.0241869
By:
- Jimbo, Keisuke;
- Okuno, Toshiaki;
- Ohgaki, Ryuichi;
- Nishikubo, Kou;
- Kitamura, Yuri;
- Sakurai, Yumiko;
- Quan, Lili;
- Shoji, Hiromichi;
- Kanai, Yoshikatsu;
- Shimizu, Toshiaki;
- Yokomizo, Takehiko
Publication type:
Article
Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations.
Published in:
Journal of Dermatology, 2021, v. 48, n. 9, p. 1442, doi. 10.1111/1346-8138.16012
By:
- Oiwa, Tomohiro;
- Ishibashi, Mami;
- Okuno, Toshiaki;
- Ohba, Mai;
- Endo, Yuichiro;
- Uozumi, Ryuji;
- Ghazawi, Feras M.;
- Yoshida, Kazue;
- Niizeki, Hironori;
- Yokomizo, Takehiko;
- Nomura, Takashi;
- Kabashima, Kenji
Publication type:
Article
The leukotriene B4/BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis.
Published in:
FASEB Journal, 2023, v. 37, n. 2, p. 1, doi. 10.1096/fj.202201936R
By:
- Ryotaro Shioda;
- Airi Jo-Watanabe;
- Toshiaki Okuno;
- Kazuko Saeki;
- Maiko Nakayama;
- Yusuke Suzuki;
- Takehiko Yokomizo
Publication type:
Article
Lysophosphatidic acid receptor1/3 antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses.
Published in:
FASEB Journal, 2022, v. 36, n. 4, p. 1, doi. 10.1096/fj.202101678R
By:
- Hoshino, Yoko;
- Okuno, Toshiaki;
- Saigusa, Daisuke;
- Kano, Kuniyuki;
- Yamamoto, Shota;
- Shindou, Hideo;
- Aoki, Junken;
- Uchida, Kanji;
- Yokomizo, Takehiko;
- Ito, Nobuko
Publication type:
Article
Leukotriene A4 hydrolase deficiency protects mice from diet‐induced obesity by increasing energy expenditure through neuroendocrine axis.
Published in:
FASEB Journal, 2020, v. 34, n. 10, p. 13949, doi. 10.1096/fj.202001148R
By:
- Uzawa, Hirotsugu;
- Kohno, Daisuke;
- Koga, Tomoaki;
- Sasaki, Tsutomu;
- Fukunaka, Ayako;
- Okuno, Toshiaki;
- Jo‐Watanabe, Airi;
- Kazuno, Saiko;
- Miyatsuka, Takeshi;
- Kitamura, Tadahiro;
- Fujitani, Yoshio;
- Watada, Hirotaka;
- Saeki, Kazuko;
- Yokomizo, Takehiko
Publication type:
Article
Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction.
Published in:
FASEB Journal, 2020, v. 34, n. 6, p. 8749, doi. 10.1096/fj.202000041R
By:
- Horii, Yuma;
- Nakaya, Michio;
- Ohara, Hiroki;
- Nishihara, Hiroaki;
- Watari, Kenji;
- Nagasaka, Akiomi;
- Nakaya, Takeo;
- Sugiura, Yuki;
- Okuno, Toshiaki;
- Koga, Tomoaki;
- Tanaka, Akira;
- Yokomizo, Takehiko;
- Kurose, Hitoshi
Publication type:
Article
Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.
Published in:
FASEB Journal, 2019, v. 33, n. 12, p. 14528, doi. 10.1096/fj.201901570R
By:
- Toshiaki Okuno;
- Koutsogiannaki, Sophia;
- Lifei Hou;
- Weiming Bu;
- Ohto, Umeharu;
- Eckenhoff, Roderic G.;
- Takehiko Yokomizo;
- Koichi Yuki
Publication type:
Article
The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction.
Published in:
FASEB Journal, 2019, v. 33, n. 11, p. 12668, doi. 10.1096/fj.201901360R
By:
- Koutsogiannaki, Sophia;
- Lifei Hou;
- Babazada, Hasan;
- Toshiaki Okuno;
- Blazon-Brown, Nathan;
- Soriano, Sulpicio G.;
- Takehiko Yokomizo;
- Koichi Yuki
Publication type:
Article
Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating Th2 immune responses.
Published in:
FASEB Journal, 2019, v. 33, n. 3, p. 3392, doi. 10.1096/fj.201801805R
By:
- Toshiaki Hirakata;
- Hyeon-Cheol Lee;
- Mai Ohba;
- Kazuko Saeki;
- Toshiaki Okuno;
- Akira Murakami;
- Akira Matsuda;
- Takehiko Yokomizo
Publication type:
Article
Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production.
Published in:
FASEB Journal, 2017, v. 31, n. 4, p. 1584, doi. 10.1096/fj.201601095R
By:
- Toshiaki Okuno;
- Sophia Koutsogiannaki;
- Mai Ohba;
- Chamberlain, Matthew;
- Weiming Bu;
- Fu-Yan Lin;
- Eckenhoff, Roderic G.;
- Takehiko Yokomizo;
- Koichi Yuki
Publication type:
Article
Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE).
Published in:
FASEB Journal, 2016, v. 30, n. 5, p. 1811, doi. 10.1096/fj.201500117
By:
- Takako Ichiki;
- Tomoaki Koga;
- Toshiaki Okuno;
- Kazuko Saeki;
- Yasuhiko Yamamoto;
- Hiroshi Yamamoto;
- Masakiyo Sakaguchi;
- Takehiko Yokomizo
Publication type:
Article
Leukotriene B4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.
Published in:
FASEB Journal, 2016, v. 30, n. 2, p. 933, doi. 10.1096/fj.15-279653
By:
- Yumiko Ishii;
- Kazuko Saeki;
- Min Liu;
- Fumiyuki Sasaki;
- Tomoaki Koga;
- Keiko Kitajima;
- Chikara Meno;
- Toshiaki Okuno;
- Takehiko Yokomizo
Publication type:
Article
Leukotriene B4 receptor BLT2 negatively regulates allergic airway eosinophilia.
Published in:
FASEB Journal, 2013, v. 27, n. 8, p. 3306, doi. 10.1096/fj.12-217000
By:
- Yuko Matsunaga;
- Satoru Fukuyama;
- Toshiaki Okuno;
- Fumiyuki Sasaki;
- Takehiko Matsunobu;
- Yukari Asai;
- Koichiro Matsumoto;
- Kazuko Saeki;
- Masahiro Oike;
- Yukari Sadamura;
- Kentaro Machida;
- Yoichi Nakanishi;
- Masato Kubo;
- Takehiko Yokomizo;
- Hiromasa Inoue
Publication type:
Article
Helix 8 of leukotriene B4 receptor 1 inhibits ligand-induced internalization.
Published in:
FASEB Journal, 2012, v. 26, n. 10, p. 4068, doi. 10.1096/fj.12-212050
By:
- Aratake, Yoshifusa;
- Okuno, Toshiaki;
- Matsunobu, Takehiko;
- Saeki, Kazuko;
- Takayanagi, Ryoichi;
- Furuya, Sonoko;
- Yokomizo, Takehiko
Publication type:
Article
Protective role of the leukotriene B4 receptor BLT2 in murine inflammatory colitis.
Published in:
FASEB Journal, 2010, v. 24, n. 12, p. 4678, doi. 10.1096/fj.10-165050
By:
- Iizuka, Yoshiko;
- Okuno, Toshiaki;
- Saeki, Kazuko;
- Uozaki, Hiroshi;
- Okada, Shinji;
- Misaka, Takumi;
- Sato, Tetsuya;
- Toh, Hiroyuki;
- Fukayama, Masashi;
- Takeda, Naoki;
- Kita, Yoshihiro;
- Shimizu, Takao;
- Nakamura, Motonao;
- Yokomizo, Takehiko
Publication type:
Article
Helix 8 of leukotriene B4 type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum.
Published in:
FASEB Journal, 2009, v. 23, n. 5, p. 1470, doi. 10.1096/fj.08-125385
By:
- Yasuda, Daisuke;
- Okuno, Toshiaki;
- Yokomizo, Takehiko;
- Hori, Tetsuya;
- Hirota, Nobuaki;
- Hashidate, Tomomi;
- Miyano, Masashi;
- Shimizu, Takao;
- Nakamura, Motonao
Publication type:
Article
Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2.
Published in:
Journal of Biochemistry, 2023, v. 17, n. 4, p. 293, doi. 10.1093/jb/mvac105
By:
- Yasukawa, Ken;
- Okuno, Toshiaki;
- Ogawa, Narihito;
- Kobayashi, Yuichi;
- Yokomizo, Takehiko
Publication type:
Article
What is the natural ligand of GPR55?
Published in:
Journal of Biochemistry, 2011, v. 149, n. 5, p. 495, doi. 10.1093/jb/mvr022
By:
- Okuno, Toshiaki;
- Yokomizo, Takehiko
Publication type:
Article
Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis.
Published in:
Biomedicines, 2021, v. 9, n. 11, p. 1519, doi. 10.3390/biomedicines9111519
By:
- Ono, Yosuke;
- Kawakita, Takako;
- Yoshino, Osamu;
- Sato, Erina;
- Kano, Kuniyuki;
- Ohba, Mai;
- Okuno, Toshiaki;
- Ito, Masami;
- Koga, Kaori;
- Honda, Masako;
- Furue, Akiko;
- Hiraoka, Takehiro;
- Wada, Shinichiro;
- Iwasa, Takeshi;
- Yokomizo, Takehiko;
- Aoki, Junken;
- Maeda, Nagamasa;
- Unno, Nobuya;
- Osuga, Yutaka;
- Hirata, Shuji
Publication type:
Article
Cyclooxygenase inhibition in mice heightens adaptive‐ and innate‐type responses against inhaled protease allergen and IL‐33.
Published in:
Allergy, 2019, v. 74, n. 11, p. 2237, doi. 10.1111/all.13831
By:
- Maruyama, Natsuko;
- Takai, Toshiro;
- Kamijo, Seiji;
- Suchiva, Punyada;
- Ohba, Mai;
- Takeshige, Tomohito;
- Suzuki, Mayu;
- Hara, Mutsuko;
- Matsuno, Kei;
- Harada, Sonoko;
- Harada, Norihiro;
- Nakae, Susumu;
- Sudo, Katsuko;
- Okuno, Toshiaki;
- Yokomizo, Takehiko;
- Ogawa, Hideoki;
- Okumura, Ko;
- Ikeda, Shigaku
Publication type:
Article
Mechanism of isoflurane‑mediated breast cancer growth in vivo.
Published in:
Oncology Letters, 2024, v. 27, n. 6, p. N.PAG, doi. 10.3892/ol.2024.14420
By:
- Koutsogiannaki, Sophia;
- Wang, Wei;
- Hou, Lifei;
- Okuno, Toshiaki;
- Yuki, Koichi
Publication type:
Article
Urinary prostaglandin D2 metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants.
Published in:
2018
By:
- Shoji, Hiromichi;
- Ikeda, Naho;
- Kitamura, Tomohiro;
- Suganuma, Hiroki;
- Ohba, Mai;
- Okuno, Toshiaki;
- Yokomizo, Takehiko;
- Shimizu, Toshiaki
Publication type:
journal article
Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.
Published in:
Toxicological Sciences, 2017, v. 156, n. 2, p. 402, doi. 10.1093/toxsci/kfw261
By:
- Koutsogiannaki, Sophia;
- Schaefers, Matthew M.;
- Toshiaki Okuno;
- Mai Ohba;
- Takehiko Yokomizo;
- Priebe, Gregory P.;
- DiNardo, James A.;
- Sulpicio, Soriano G.;
- Koichi Yuki
Publication type:
Article
Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1.
Published in:
PLoS ONE, 2017, v. 12, n. 9, p. 1, doi. 10.1371/journal.pone.0185133
By:
- Sasaki, Fumiyuki;
- Koga, Tomoaki;
- Saeki, Kazuko;
- Okuno, Toshiaki;
- Kazuno, Saiko;
- Fujimura, Tsutomu;
- Ohkawa, Yasuyuki;
- Yokomizo, Takehiko
Publication type:
Article
n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy.
Published in:
2020
By:
- Ayana Suzumura;
- Hiroki Kaneko;
- Yasuhito Funahashi;
- Kei Takayama;
- Masatoshi Nagaya;
- Seina Ito;
- Toshiaki Okuno;
- Toshiaki Hirakata;
- Norie Nonobe;
- Keiko Kataoka;
- Hideyuki Shimizu;
- Rina Namba;
- Kazuhisa Yamada;
- Fuxiang Ye;
- Yoko Ozawa;
- Takehiko Yokomizo;
- Hiroko Terasaki;
- Suzumura, Ayana;
- Kaneko, Hiroki;
- Funahashi, Yasuhito
Publication type:
journal article

Found: 35

Eicosanoids in Skin Wound Healing.

The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders.

αDβ2 as a novel target of experimental polymicrobial sepsis.

Prostaglandin E<sub>2</sub> and its receptor EP2 trigger signaling that contributes to YAP‐mediated cell competition.

Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B<sub>4</sub> receptor 2.

Leukotriene B<sub>4</sub> receptor type 2 protects against pneumolysin-dependent acute lung injury.

Bicarbonate signalling via G protein-coupled receptor regulates ischaemia-reperfusion injury.

Biochemical Characterization of Three BLT Receptors in Zebrafish.

Up-regulation of cytosolic prostaglandin E synthase in fetal-membrane and amniotic prostaglandin E<sub>2</sub> accumulation in labor.

Correction: A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.

A novel mutation in the SLCO2A1 gene, encoding a prostaglandin transporter, induces chronic enteropathy.

Eicosanoid profiling in patients with complete form of pachydermoperiostosis carrying SLCO2A1 mutations.

The leukotriene B<sub>4</sub>/BLT1-dependent neutrophil accumulation exacerbates immune complex-mediated glomerulonephritis.

Lysophosphatidic acid receptor<sub>1/3</sub> antagonist inhibits the activation of satellite glial cells and reduces acute nociceptive responses.

Leukotriene A<sub>4</sub> hydrolase deficiency protects mice from diet‐induced obesity by increasing energy expenditure through neuroendocrine axis.

Leukotriene B<sub>4</sub> receptor 1 exacerbates inflammation following myocardial infarction.

Volatile anesthetics isoflurane and sevoflurane directly target and attenuate Toll-like receptor 4 system.

The volatile anesthetic sevoflurane reduces neutrophil apoptosis via Fas death domain-Fas-associated death domain interaction.

Dietary ω-3 fatty acids alter the lipid mediator profile and alleviate allergic conjunctivitis without modulating T<sub>h</sub>2 immune responses.

Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B<sub>4</sub> production.

Modulation of leukotriene B<sub>4</sub> receptor 1 signaling by receptor for advanced glycation end products (RAGE).

Leukotriene B<sub>4</sub> receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins.

Leukotriene B<sub>4</sub> receptor BLT2 negatively regulates allergic airway eosinophilia.

Helix 8 of leukotriene B<sub>4</sub> receptor 1 inhibits ligand-induced internalization.

Protective role of the leukotriene B<sub>4</sub> receptor BLT2 in murine inflammatory colitis.

Helix 8 of leukotriene B<sub>4</sub> type-2 receptor is required for the folding to pass the quality control in the endoplasmic reticulum.

Identification and characterization of bioactive metabolites of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B<sub>4</sub> receptor 2.

What is the natural ligand of GPR55?

Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis.

Cyclooxygenase inhibition in mice heightens adaptive‐ and innate‐type responses against inhaled protease allergen and IL‐33.

Mechanism of isoflurane‑mediated breast cancer growth in vivo.

Urinary prostaglandin D<sub>2</sub> metabolite excretion during the first six months of life was significantly lower in breast-fed than formula-fed infants.

Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis.

Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B<sub>4</sub> receptor 1.

n-3 Fatty Acid and Its Metabolite 18-HEPE Ameliorate Retinal Neuronal Cell Dysfunction by Enhancing Müller BDNF in Diabetic Retinopathy.