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HER2 G776S mutation promotes oncogenic potential in colorectal cancer cells when accompanied by loss of APC function.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-13189-y
By:
- Mitani, Yosuke;
- Ohashi, Shinya;
- Kikuchi, Osamu;
- Nakai, Yukie;
- Ida, Tomomi;
- Mizumoto, Ayaka;
- Yamamoto, Yoshihiro;
- Saito, Tomoki;
- Kataoka, Shigeki;
- Matsubara, Junichi;
- Yamada, Atsushi;
- Kanai, Masashi;
- Matsumoto, Shigemi;
- Sakai, Hiroaki;
- Yoshikawa, Kiyotsugu;
- Nakamura, Eijiro;
- Muto, Manabu
Publication type:
Article
Risk factors for the development of second primary esophageal squamous-cell carcinoma after endoscopic resection for esophageal squamous-cell carcinoma according to genetic polymorphisms related to alcohol and nicotine metabolism.
Published in:
Japanese Journal of Clinical Oncology, 2023, v. 53, n. 9, p. 774, doi. 10.1093/jjco/hyad070
By:
- Katada, Chikatoshi;
- Yokoyama, Tetsuji;
- Mure, Kanae;
- Doyama, Hisashi;
- Nakanishi, Hiroyoshi;
- Shimizu, Yuichi;
- Yamamoto, Keiko;
- Furue, Yasuaki;
- Tamaoki, Masashi;
- Koike, Tomoyuki;
- Kawahara, Yoshiro;
- Kiyokawa, Hirofumi;
- Konno, Maki;
- Yokoyama, Akira;
- Ohashi, Shinya;
- Ishikawa, Hideki;
- Muto, Manabu
Publication type:
Article
Molecular Mechanisms of Acetaldehyde-Mediated Carcinogenesis in Squamous Epithelium.
Published in:
International Journal of Molecular Sciences, 2017, v. 18, n. 9, p. 1943, doi. 10.3390/ijms18091943
By:
- Ayaka Mizumoto;
- Shinya Ohashi;
- Yusuke Amanuma;
- Manabu Muto;
- Kenshiro Hirohashi;
- Tomonari Matsuda
Publication type:
Article
Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report.
Published in:
2020
By:
- Mitani, Yosuke;
- Kanai, Masashi;
- Kou, Tadayuki;
- Kataoka, Shigeki;
- Doi, Keitaro;
- Matsubara, Junichi;
- Ohashi, Shinya;
- Matsumoto, Shigemi;
- Muto, Manabu
Publication type:
journal article
Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma.
Published in:
Scientific Reports, 2016, p. 22452, doi. 10.1038/srep22452
By:
- Kikuchi, Osamu;
- Ohashi, Shinya;
- Horibe, Tomohisa;
- Kohno, Masayuki;
- Nakai, Yukie;
- Miyamoto, Shin'ichi;
- Chiba, Tsutomu;
- Muto, Manabu;
- Kawakami, Koji
Publication type:
Article
Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.
Published in:
Scientific Reports, 2015, p. 14142, doi. 10.1038/srep14142
By:
- Amanuma, Yusuke;
- Ohashi, Shinya;
- Itatani, Yoshiro;
- Tsurumaki, Mihoko;
- Matsuda, Shun;
- Kikuchi, Osamu;
- Nakai, Yukie;
- Miyamoto, Shin'ichi;
- Oyama, Tsunehiro;
- Kawamoto, Toshihiro;
- Whelan, Kelly A.;
- Nakagawa, Hiroshi;
- Chiba, Tsutomu;
- Matsuda, Tomonari;
- Muto, Manabu
Publication type:
Article
Preclinical Validation of Talaporfin Sodium-Mediated Photodynamic Therapy for Esophageal Squamous Cell Carcinoma.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103126
By:
- Ohashi, Shinya;
- Kikuchi, Osamu;
- Tsurumaki, Mihoko;
- Nakai, Yukie;
- Kasai, Hiroi;
- Horimatsu, Takahiro;
- Miyamoto, Shin'ichi;
- Shimizu, Akira;
- Chiba, Tsutomu;
- Muto, Manabu
Publication type:
Article
Cross-Primed CD8<sup>+</sup> Cytotoxic T cells Induce Severe Helicobacter-associated Gastritis in the Absence of CD4<sup>+</sup> T cells.
Published in:
Helicobacter, 2007, v. 12, n. 5, p. 486, doi. 10.1111/j.1523-5378.2007.00536.x
By:
- Fukui, Toshiro;
- Nishio, Akiyoshi;
- Okazaki, Kazuichi;
- Kasahara, Katsuhiro;
- Saga, Kazuyuki;
- Tanaka, Junya;
- Uza, Norimitsu;
- Ueno, Satoru;
- Kido, Masahiro;
- Ohashi, Shinya;
- Asada, Masanori;
- Nakase, Hiroshi;
- Watanabe, Norihiko;
- Chiba, Tsutomu
Publication type:
Article
Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes.
Published in:
PLoS ONE, 2020, v. 15, n. 9, p. 1, doi. 10.1371/journal.pone.0239625
By:
- Chandramouleeswaran, Prasanna M.;
- Guha, Manti;
- Shimonosono, Masataka;
- Whelan, Kelly A.;
- Maekawa, Hisatsugu;
- Sachdeva, Uma M.;
- Ruthel, Gordon;
- Mukherjee, Sarmistha;
- Engel, Noah;
- Gonzalez, Michael V.;
- Garifallou, James;
- Ohashi, Shinya;
- Klein-Szanto, Andres J.;
- Mesaros, Clementina A.;
- Blair, Ian A.;
- Pellegrino da Silva, Renata;
- Hakonarson, Hakon;
- Noguchi, Eishi;
- Baur, Joseph A.;
- Nakagawa, Hiroshi
Publication type:
Article
Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1α-mediated mRNA transcription and continuous protein synthesis.
Published in:
FASEB Journal, 2012, v. 26, n. 6, p. 2620, doi. 10.1096/fj.11-198598
By:
- Natsuizaka, Mitsuteru;
- Naganuma, Seiji;
- Kagawa, Shingo;
- Ohashi, Shinya;
- Ahmadi, Azal;
- Subramanian, Harry;
- Chang, Sanders;
- Nakagawa, Kei J.;
- Xinjun Ji;
- Liebhaber, Stephen A.;
- Klein-Szanto, Andres J.;
- Nakagawa, Hiroshi
Publication type:
Article
ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment.
Published in:
Carcinogenesis, 2024, v. 45, n. 1/2, p. 95, doi. 10.1093/carcin/bgad085
By:
- Flashner, Samuel;
- Shimonosono, Masataka;
- Tomita, Yasuto;
- Matsuura, Norihiro;
- Ohashi, Shinya;
- Muto, Manabu;
- Klein-Szanto, Andres J;
- Diehl, J Alan;
- Chen, Che-Hong;
- Mochly-Rosen, Daria;
- Weinberg, Kenneth I;
- Nakagawa, Hiroshi
Publication type:
Article
Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
Published in:
Carcinogenesis, 2020, v. 41, n. 2, p. 194, doi. 10.1093/carcin/bgz091
By:
- Hirohashi, Kenshiro;
- Ohashi, Shinya;
- Amanuma, Yusuke;
- Nakai, Yukie;
- Ida, Tomomi;
- Baba, Kiichiro;
- Mitani, Yosuke;
- Mizumoto, Ayaka;
- Yamamoto, Yoshihiro;
- Kikuchi, Osamu;
- Matsubara, Junichi;
- Yamada, Atsushi;
- Miyamoto, Shin'ichi;
- Seno, Hiroshi;
- Matsuda, Tomonari;
- Muto, Manabu
Publication type:
Article
Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma.
Published in:
Carcinogenesis, 2017, v. 38, n. 11, p. 1073, doi. 10.1093/carcin/bgx095
By:
- Osamu Maehara;
- Goki Suda;
- Mitsuteru Natsuizaka;
- Shunsuke Ohnishi;
- Yoshito Komatsu;
- Fumiyuki Sato;
- Masato Nakai;
- Takuya Sho;
- Kenichi Morikawa;
- Koji Ogawa;
- Tomoe Shimazaki;
- Megumi Kimura;
- Ayaka Asano;
- Yoshiyuki Fujimoto;
- Shinya Ohashi;
- Shingo Kagawa;
- Hideaki Kinugasa;
- Seiji Naganuma;
- Whelan, Kelly A.;
- Hiroshi Nakagawa
Publication type:
Article
Insulin-like growth factor-binding protein-3 promotes transforming growth factor-β1-mediated epithelial-to-mesenchymal transition and motility in transformed human esophageal cells.
Published in:
Carcinogenesis, 2010, v. 31, n. 8, p. 1344, doi. 10.1093/carcin/bgq108
By:
- Natsuizaka, Mitsuteru;
- Ohashi, Shinya;
- Wong, Gabrielle S.;
- Ahmadi, Azal;
- Kalman, Ross A.;
- Budo, Daniela;
- Klein-Szanto, Andres J.;
- Herlyn, Meenhard;
- Diehl, J. Alan;
- Nakagawa, Hiroshi
Publication type:
Article
Hypoxia activates the cyclooxygenase-2–prostaglandin E synthase axis.
Published in:
Carcinogenesis, 2010, v. 31, n. 3, p. 427, doi. 10.1093/carcin/bgp326
By:
- Lee, James J.;
- Natsuizaka, Mitsuteru;
- Ohashi, Shinya;
- Wong, Gabrielle S.;
- Takaoka, Munenori;
- Michaylira, Carmen Z.;
- Budo, Daniela;
- Tobias, John W.;
- Kanai, Michiyuki;
- Shirakawa, Yasuhiro;
- Naomoto, Yoshio;
- Klein-Szanto, Andres J. P.;
- Haase, Volker H.;
- Nakagawa, Hiroshi
Publication type:
Article
Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.
Published in:
Journal of Experimental & Clinical Cancer Research (17569966), 2017, v. 36, p. 1, doi. 10.1186/s13046-017-0572-7
By:
- Masahiro Yoshioka;
- Shinya Ohashi;
- Tomomi Ida;
- Yukie Nakai;
- Osamu Kikuchi;
- Yusuke Amanuma;
- Junichi Matsubara;
- Atsushi Yamada;
- Shin'ichi Miyamoto;
- Mitsuteru Natsuizaka;
- Hiroshi Nakagawa;
- Tsutomu Chiba;
- Hiroshi Seno;
- Manabu Muto
Publication type:
Article
Regression of B-cell lymphoma of the liver with hepatitis C virus infection after treatment with pegylated interferon-alpha and ribavirin.
Published in:
2010
By:
- Oda, Yayoi;
- Kou, Tadayuki;
- Watanabe, Masaki;
- Sakuma, Yojiro;
- Taguchi, Nori;
- Kato, Yoko;
- Kudo, Yasushi;
- Yamauchi, Atsushi;
- Sugiura, Yasushi;
- Ohashi, Shinya;
- Asada, Masanori;
- Fukunaga, Toyokazu;
- Kawaguchi, Kiyotaka;
- Ito, Hiroaki;
- Nakamura, Takefumi;
- Yazumi, Shujiro
Publication type:
journal article
PS02.038: SAFETY AND EFFICACY OF REPETITIVE PHOTODYNAMIC THERAPY FOR RESIDUAL ESOPHAGEAL CANCER LESIONS AFTER INITIAL PHOTODYNAMIC THERAPY.
Published in:
Diseases of the Esophagus, 2018, v. 31, n. 13, p. 130, doi. 10.1093/dote/doy089.PS02.038
By:
- Tamaoki, Masashi;
- Amanuma, Yusuke;
- Horimatsu, Takahiro;
- Ohashi, Shinya;
- Muto, Manabu
Publication type:
Article
PS02.034: EFFICACY AND SAFETY OF SALVAGE PHOTODYNAMIC THERAPY USING TALAPORFIN SODIUM FOR LOCAL FAILURE AFTER CHEMORADIOTHERAPY IN PATIENTS WITH ESOPHAGEAL CANCER.
Published in:
Diseases of the Esophagus, 2018, v. 31, n. 13, p. 129, doi. 10.1093/dote/doy089.PS02.034
By:
- Amanuma, Yusuke;
- Ohashi, Shinya;
- Tamaoki, Masashi;
- Horimatsu, Takahiro;
- Muto, Manabu
Publication type:
Article
Association of local complete response with prognosis after salvage photodynamic therapy for esophageal squamous cell carcinoma.
Published in:
Digestive Endoscopy, 2021, v. 33, n. 3, p. 355, doi. 10.1111/den.13730
By:
- Amanuma, Yusuke;
- Horimatsu, Takahiro;
- Ohashi, Shinya;
- Tamaoki, Masashi;
- Muto, Manabu
Publication type:
Article
The CAM Model for CIC-DUX4 Sarcoma and Its Potential Use for Precision Medicine.
Published in:
2021
By:
- Komatsu, Aoi;
- Matsumoto, Kotaro;
- Yoshimatsu, Yuki;
- Sin, Yooksil;
- Kubota, Arisa;
- Saito, Tomoki;
- Mizumoto, Ayaka;
- Ohashi, Shinya;
- Muto, Manabu;
- Noguchi, Rei;
- Kondo, Tadashi;
- Tamanoi, Fuyuhiko
Publication type:
Abstract
Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.
Published in:
2019
By:
- Mizumoto, Ayaka;
- Ohashi, Shinya;
- Kamada, Mayumi;
- Saito, Tomoki;
- Nakai, Yukie;
- Baba, Kiichiro;
- Hirohashi, Kenshiro;
- Mitani, Yosuke;
- Kikuchi, Osamu;
- Matsubara, Junichi;
- Yamada, Atsushi;
- Takahashi, Tsukasa;
- Lee, Hyunjin;
- Okuno, Yasushi;
- Kanai, Masashi;
- Muto, Manabu
Publication type:
journal article
Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma.
Published in:
Cancer Science, 2023, v. 114, n. 12, p. 4664, doi. 10.1111/cas.15966
By:
- Nguyen Vu, Trang H.;
- Kikuchi, Osamu;
- Ohashi, Shinya;
- Saito, Tomoki;
- Ida, Tomomi;
- Nakai, Yukie;
- Cao, Yang;
- Yamamoto, Yoshihiro;
- Kondo, Yuki;
- Mitani, Yosuke;
- Kataoka, Shigeki;
- Kondo, Tomohiro;
- Katada, Chikatoshi;
- Yamada, Atsushi;
- Matsubara, Junichi;
- Muto, Manabu
Publication type:
Article

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