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Targeting glucosylceramide synthase sensitizes imatinib-resistant chronic myeloid leukemia cells via endogenous ceramide accumulation.
- Published in:
- Journal of Cancer Research & Clinical Oncology, 2011, v. 137, n. 10, p. 1535, doi. 10.1007/s00432-011-1016-y
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- Publication type:
- Article
mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity.
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- Laryngoscope Investigative Otolaryngology, 2020, v. 5, n. 2, p. 243, doi. 10.1002/lio2.370
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- Publication type:
- Article
Polyploid giant cancer cells are dependent on cholesterol for progeny formation through amitotic division.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12705-4
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- Publication type:
- Article
Regulation of PP2A by sphingolipid metabolism and signaling.
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- Frontiers in Oncology, 2015, v. 5, p. 1, doi. 10.3389/fonc.2014.00388
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- Publication type:
- Article
Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-32613-5
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- Publication type:
- Article
HPV/E7 induces chemotherapy-mediated tumor suppression by ceramide-dependent mitophagy.
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- EMBO Molecular Medicine, 2017, v. 9, n. 8, p. 1030, doi. 10.15252/emmm.201607088
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- Publication type:
- Article
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
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- EMBO Molecular Medicine, 2013, v. 5, n. 1, p. 105, doi. 10.1002/emmm.201201283
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- Publication type:
- Article
Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
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- EMBO Molecular Medicine, 2012, v. 4, n. 8, p. 761, doi. 10.1002/emmm.201200244
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- Publication type:
- Article
Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.
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- EMBO Molecular Medicine, 2012, v. 4, n. 2, p. 78, doi. 10.1002/emmm.201100189
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- Publication type:
- Article
L-threo-C<sub>6</sub>-pyridinium-ceramide Bromide, a Novel Cationic Ceramide, Induces NADPH Oxidase Activation, Mitochondrial Dysfunction and Loss in Cell Viability in INS 832/13 β-cells.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2012, v. 30, n. 4, p. 1051, doi. 10.1159/000341481
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- Publication type:
- Article
Sphingolipid metabolism in T cell responses after allogeneic hematopoietic cell transplantation.
- Published in:
- Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.904823
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- Publication type:
- Article
Co-ordinated over-expression of the MRP and γ-glutamylcysteine synthetase genes, but not MRD1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines.
- Published in:
- International Journal of Cancer, 1998, v. 75, n. 5, p. 757, doi. 10.1002/(SICI)1097-0215(19980302)75:5<757::AID-IJC15>3.0.CO;2-3
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- Publication type:
- Article
Down-regulation of apoptosis-related bcl-2 but not bcl-x.
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- International Journal of Cancer, 1996, v. 67, n. 5, p. 608, doi. 10.1002/(SICI)1097-0215(19960904)67:5<608::AID-IJC3>3.0.CO;2-Y
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- Publication type:
- Article
TGF-β receptor I/II trafficking and signaling at primary cilia are inhibited by ceramide to attenuate cell migration and tumor metastasis.
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- Science Signaling, 2017, v. 10, n. 502, p. 1, doi. 10.1126/scisignal.aam7464
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- Publication type:
- Article
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.
- Published in:
- Science Signaling, 2015, v. 8, n. 381, p. 1, doi. 10.1126/scisignal.aaa4998
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- Publication type:
- Article
Sphingosine Kinase-2 Maintains Viral Latency and Survival for KSHV-Infected Endothelial Cells.
- Published in:
- PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0102314
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- Publication type:
- Article
A New Mixed-Backbone Oligonucleotide against Glucosylceramide Synthase Sensitizes Multidrug-Resistant Tumors to Apoptosis.
- Published in:
- PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0006938
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- Publication type:
- Article
Phase I study of opaganib, an oral sphingosine kinase 2-specific inhibitor, in relapsed and/or refractory multiple myeloma.
- Published in:
- Annals of Hematology, 2023, v. 102, n. 2, p. 369, doi. 10.1007/s00277-022-05056-7
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- Publication type:
- Article
Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-09179-w
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- Publication type:
- Article
Targeting Sphingolipid Metabolism as a Therapeutic Strategy in Cancer Treatment.
- Published in:
- Cancers, 2022, v. 14, n. 9, p. N.PAG, doi. 10.3390/cancers14092183
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- Publication type:
- Article
The Role of Ceramide Metabolism and Signaling in the Regulation of Mitophagy and Cancer Therapy.
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- Cancers, 2021, v. 13, n. 10, p. 2475, doi. 10.3390/cancers13102475
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- Publication type:
- Article
Ceramide Synthase 6 Maximizes p53 Function to Prevent Progeny Formation from Polyploid Giant Cancer Cells.
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- Cancers, 2021, v. 13, n. 9, p. 2212, doi. 10.3390/cancers13092212
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- Publication type:
- Article
The Evolution of Care of Cancers of the Head and Neck Region: State of the Science in 2020.
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- Cancers, 2020, v. 12, n. 6, p. 1543, doi. 10.3390/cancers12061543
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- Publication type:
- Article
Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells.
- Published in:
- Oncogene, 1997, v. 14, n. 4, p. 499, doi. 10.1038/sj.onc.1200855
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- Publication type:
- Article
EXTH-51. C18-CERAMIDE ANALOGUE DRUG OVERCOMES RESISTANCE TO TEMOZOLOMIDE IN GLIOBLASTOMA.
- Published in:
- Neuro-Oncology, 2018, v. 20, p. vi96, doi. 10.1093/neuonc/noy148.399
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- Publication type:
- Article
Salivary gland neoplasms.
- Published in:
- 2004
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- Publication type:
- journal article
Pro‐survival lipid metabolism activates intracellular complement signaling to induce inflammasome‐mediated tumor metastasis.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.0R365
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- Publication type:
- Article
The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction.
- Published in:
- FASEB Journal, 2019, v. 33, n. 6, p. 7647, doi. 10.1096/fj.201802264R
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- Publication type:
- Article
Antiapoptotic roles of ceramide-synthase-6-generated C<sub>16</sub>-ceramide via selective regulation of the ATF6/ CHOP arm of ER-stress-response pathways.
- Published in:
- FASEB Journal, 2010, v. 24, n. 1, p. 296, doi. 10.1096/fj.09-135087
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- Publication type:
- Article
Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling.
- Published in:
- FASEB Journal, 2009, v. 23, n. 3, p. 751, doi. 10.1096/fj.08-120550
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- Publication type:
- Article
Thioredoxin-1 confines T cell alloresponse and pathogenicity in graft-versus-host disease.
- Published in:
- 2019
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- Publication type:
- journal article
Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1.
- Published in:
- FASEB Journal, 2007, v. 21, n. 12, p. 3386, doi. 10.1096/fj.07-8621com
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- Publication type:
- Article
Alterations of lipid metabolism provide serologic biomarkers for the detection of asymptomatic versus symptomatic COVID-19 patients.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-93857-7
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- Publication type:
- Article
Targeting LINC00152 activates cAMP/Ca<sup>2+</sup>/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer.
- Published in:
- Cell Death & Disease, 2024, v. 15, n. 6, p. 1, doi. 10.1038/s41419-024-06814-3
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- Publication type:
- Article
Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer.
- Published in:
- Cells (2073-4409), 2020, v. 9, n. 12, p. 2693, doi. 10.3390/cells9122693
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- Publication type:
- Article
<sup>1</sup>H<sup>N</sup>, <sup>13</sup>C, and <sup>15</sup>N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23–225).
- Published in:
- Biomolecular NMR Assignments, 2021, v. 15, n. 2, p. 383, doi. 10.1007/s12104-021-10034-7
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- Publication type:
- Article
Smoking-induced control of miR-133a-3p alters the expression of EGFR and HuR in HPV-infected oropharyngeal cancer.
- Published in:
- PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0205077
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- Publication type:
- Article
Sphingolipids in cancer: Regulation of pathogenesis and therapy
- Published in:
- FEBS Letters, 2006, v. 580, n. 23, p. 5467, doi. 10.1016/j.febslet.2006.08.052
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- Publication type:
- Article
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
- Published in:
- Nature Chemical Biology, 2012, v. 8, n. 12, p. 1008, doi. 10.1038/nchembio1212-1008c
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- Publication type:
- Article
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
- Published in:
- Nature Chemical Biology, 2012, v. 8, n. 10, p. 831, doi. 10.1038/nchembio.1059
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- Publication type:
- Article
Biomimetic Nanomaterials for the Immunomodulation of the Cardiosplenic Axis Postmyocardial Infarction.
- Published in:
- Advanced Materials, 2024, v. 36, n. 8, p. 1, doi. 10.1002/adma.202304615
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- Publication type:
- Article
BIOLOGICALLY ACTIVE SPHINGOLIPIDS IN CANCER PATHOGENESIS AND TREATMENT
- Published in:
- Nature Reviews Cancer, 2004, v. 4, n. 8, p. 604, doi. 10.1038/nrc1411
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- Publication type:
- Article
Alterations of lipid‐mediated mitophagy result in aging‐dependent sensorimotor defects.
- Published in:
- Aging Cell, 2023, v. 22, n. 10, p. 1, doi. 10.1111/acel.13954
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- Publication type:
- Article
Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells
- Published in:
- Otolaryngology-Head & Neck Surgery, 2005, v. 132, n. 1, p. 55, doi. 10.1016/j.otohns.2004.08.015
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- Publication type:
- Article
Telomerase modulation by gemcitabine and ceramide analogs in human head and neck cancer
- Published in:
- 2003
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- Publication type:
- Abstract