Works by Offen, Daniel

Results: 86

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis Results of Phase 1/2 and 2a Clinical Trials.

Published in:

JAMA Neurology, 2016, v. 73, n. 3, p. 337, doi. 10.1001/jamaneurol.2015.4321

By:

Petrou, Panayiota;
Gothelf, Yael;
Argov, Zohar;
Gotkine, Marc;
Levy, Yossef S.;
Kassis, Ibrahim;
Vaknin-Dembinsky, Adi;
Ben-Hur, Tamir;
Offen, Daniel;
Abramsky, Oded;
Melamed, Eldad;
Karussis, Dimitrios

Publication type:

Article

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder.

Published in:

Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01612-3

By:

Poleg, Shani;
Kourieh, Emad;
Ruban, Angela;
Shapira, Guy;
Shomron, Noam;
Barak, Boaz;
Offen, Daniel

Publication type:

Article

Myeloperoxidase Deficiency Inhibits Cognitive Decline in the 5XFAD Mouse Model of Alzheimer's Disease.

Published in:

Frontiers in Neuroscience, 2019, p. 1, doi. 10.3389/fnins.2019.00990

By:

Volkman, Rotem;
Ben-Zur, Tali;
Kahana, Anat;
Garty, Ben Zion;
Offen, Daniel

Publication type:

Article

Human Muscle Progenitor Cells Overexpressing Neurotrophic Factors Improve Neuronal Regeneration in a Sciatic Nerve Injury Mouse Model.

Published in:

Frontiers in Neuroscience, 2019, p. N.PAG, doi. 10.3389/fnins.2019.00151

By:

Guy, Reut;
Grynspan, Frida;
Ben-Zur, Tali;
Panski, Avraham;
Lamdan, Ron;
Danon, Uri;
Yaffe, David;
Offen, Daniel

Publication type:

Article

Toll-like receptor 3 deficiency decreases epileptogenesis in a pilocarpine model of SE-induced epilepsy in mice.

Published in:

Epilepsia (Series 4), 2017, v. 58, n. 4, p. 586, doi. 10.1111/epi.13688

By:

Gross, Adi;
Benninger, Felix;
Madar, Ravit;
Illouz, Tomer;
Griffioen, Kathleen;
Steiner, Israel;
Offen, Daniel;
Okun, Eitan

Publication type:

Article

Altered astrocytic response to activation in SOD1<sup>G93A</sup> mice and its implications on amyotrophic lateral sclerosis pathogenesis.

Published in:

Glia (0894-1491), 2013, v. 61, n. 3, p. 312, doi. 10.1002/glia.22428

By:

Benkler, Chen;
Ben‐Zur, Tali;
Barhum, Yael;
Offen, Daniel

Publication type:

Article

DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.

Published in:

2013

By:

Lev N;
Barhum Y;
Pilosof NS;
Ickowicz D;
Cohen HY;
Melamed E;
Offen D;
Lev, Nirit;
Barhum, Yael;
Pilosof, Neri S;
Ickowicz, Debby;
Cohen, Haim Y;
Melamed, Eldad;
Offen, Daniel

Publication type:

journal article

DJ-1 Protects Against Dopamine Toxicity: Implications for Parkinson’s Disease and Aging.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, v. 68, n. 3, p. 215, doi. 10.1093/gerona/gls147

By:

Lev, Nirit;
Barhum, Yael;
Pilosof, Neri S.;
Ickowicz, Debby;
Cohen, Haim Y.;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Mesenchymal Stem Cell Transplantation Promotes Neurogenesis and Ameliorates Autism Related Behaviors in BTBR Mice.

Published in:

Autism Research: Official Journal of the International Society for Autism Research, 2016, v. 9, n. 1, p. 17, doi. 10.1002/aur.1530

By:

Segal‐Gavish, Hadar;
Karvat, Golan;
Barak, Noy;
Barzilay, Ran;
Ganz, Javier;
Edry, Liat;
Aharony, Israel;
Offen, Daniel;
Kimchi, Tali

Publication type:

Article

Levodopa Toxicity and Apoptosis.

Published in:

1998

By:

Melamed, Eldad;
Offen, Daniel;
Shirvan, Anat;
Djaldetti, Ruth;
Barzilai, Ari;
Ziv, Ilan

Publication type:

Other

The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy.

Published in:

Journal of Neurology, 2004, v. 251, n. 3, p. 261, doi. 10.1007/s00415-004-0348-9

By:

Gilgun-Sherki, Yossi;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Therapeutic Potential of Neurotrophic Factors in Neurodegenerative Diseases.

Published in:

BioDrugs, 2005, v. 19, n. 2, p. 97, doi. 10.2165/00063030-200519020-00003

By:

Levy, Yossef S.;
Gilgun-Sherki, Yossi;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

A novel thiol antioxidant that crosses the blood brain barrier protects dopaminergic neurons in experimental models of Parkinson's disease.

Published in:

European Journal of Neuroscience, 2005, v. 21, n. 3, p. 637, doi. 10.1111/j.1460-9568.2005.03889.x

By:

Bahat‐Stroomza, Merav;
Gilgun‐Sherki, Yossi;
Offen, Daniel;
Panet, Hana;
Saada, Ann;
Krool‐Galron, Nili;
Barzilai, Aari;
Atlas, Daphne;
Melamed, Eldad

Publication type:

Article

Neuroprotective Effect of a DJ-1 Based Peptide in a Toxin Induced Mouse Model of Multiple System Atrophy.

Published in:

PLoS ONE, 2016, v. 11, n. 2, p. 1, doi. 10.1371/journal.pone.0148170

By:

Glat, Micaela Johanna;
Ben-Zur, Tali;
Barhum, Yael;
Offen, Daniel

Publication type:

Article

Introducing Transcription Factors to Multipotent Mesenchymal Stem Cells: Making Transdifferentiation Possible.

Published in:

Stem Cells, 2009, v. 27, n. 10, p. 2509, doi. 10.1002/stem.172

By:

Barzilay, Ran;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Migration of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Toward a Quinolinic Acid Lesion as Viewed by Magnetic Resonance Imaging.

Published in:

Stem Cells, 2008, v. 26, n. 10, p. 2542, doi. 10.1634/stemcells.2008-0240

By:

Sadan, Ofer;
Shemesh, Noam;
Barzilay, Ran;
Bahat-Stromza, Merav;
Melamed, Eldad;
Cohen, Yoram;
Offen, Daniel

Publication type:

Article

Immunohistochemical analysis of sympathetic involvement in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2013, v. 14, n. 5/6, p. 424, doi. 10.3109/21678421.2013.780622

By:

Kandinov, Boris;
Grigoriadis, Nikolaos C.;
Touloumi, Olga;
Drory, Vivian E.;
Offen, Daniel;
Korczyn, Amos D.

Publication type:

Article

A Chemical Chaperone-Based Drug Candidate is Effective in a Mouse Model of Amyotrophic Lateral Sclerosis (ALS).

Published in:

ChemMedChem, 2015, v. 10, n. 5, p. 850, doi. 10.1002/cmdc.201500045

By:

Getter, Tamar;
Zaks, Ilana;
Barhum, Yael;
Ben‐Zur, Tali;
Böselt, Sebastian;
Gregoire, Simpson;
Viskind, Olga;
Shani, Tom;
Gottlieb, Hugo;
Green, Omer;
Shubely, Moran;
Senderowitz, Hanoch;
Israelson, Adrian;
Kwon, Inchan;
Petri, Susanne;
Offen, Daniel;
Gruzman, Arie

Publication type:

Article

Alginate-coated magnetic nanoparticles for noninvasive MRI of extracellular calcium.

Published in:

NMR in Biomedicine, 2014, v. 27, n. 7, p. 774, doi. 10.1002/nbm.3117

By:

Bar ‐ Shir, Amnon;
Avram, Liat;
Yariv ‐ Shoushan, Shani;
Anaby, Debbie;
Cohen, Smadar;
Segev ‐ Amzaleg, Niva;
Frenkel, Dan;
Sadan, Ofer;
Offen, Daniel;
Cohen, Yoram

Publication type:

Article

Longitudinal MRI and MRSI characterization of the quinolinic acid rat model for excitotoxicity: peculiar apparent diffusion coefficients and recovery of N-acetyl aspartate levels.

Published in:

NMR in Biomedicine, 2010, v. 23, n. 2, p. 196, doi. 10.1002/nbm.1443

By:

Shemesh, Noam;
Sadan, Ofer;
Melamed, Eldad;
Offen, Daniel;
Cohen, Yoram

Publication type:

Article

Levodopa induces apoptosis in cultured neuronal cells-A possible accelerator of nigrostriatal degeneration in Parkinson's disease?

Published in:

Movement Disorders, 1997, v. 12, n. 1, p. 17, doi. 10.1002/mds.870120105

By:

Ziv, Ilan;
Zilkha-Falb, Rina;
Offen, Daniel;
Shirvan, Anat;
Barzilai, Ari;
Melamed, Eldad

Publication type:

Article

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63899-4

By:

Ganz, Javier;
Shacham, Talya;
Kramer, Maria;
Shenkman, Marina;
Eiger, Hagit;
Weinberg, Nitai;
Iancovici, Ori;
Roy, Somnath;
Simhaev, Luba;
Da'adoosh, Benny;
Engel, Hamutal;
Perets, Nisim;
Barhum, Yael;
Portnoy, Moshe;
Offen, Daniel;
Lederkremer, Gerardo Z.

Publication type:

Article

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice.

Published in:

Molecular Autism, 2018, v. 9, n. 1, p. N.PAG, doi. 10.1186/s13229-018-0240-6

By:

Perets, Nisim;
Hertz, Stav;
London, Michael;
Offen, Daniel

Publication type:

Article

DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0192954

By:

Molcho, Lior;
Ben-Zur, Tali;
Barhum, Yael;
Offen, Daniel

Publication type:

Article

Implantation of 3D Constructs Embedded with Oral Mucosa-Derived Cells Induces Functional Recovery in Rats with Complete Spinal Cord Transection.

Published in:

Frontiers in Neuroscience, 2017, p. 1, doi. 10.3389/fnins.2017.00589

By:

Ganz, Javier;
Sho, Erez;
Shaowei Guo;
Sheinin, Anton;
Arie, Ina;
Michaelevski, Izhak;
Pitaru, Sandu;
Offen, Daniel;
Levenberg, Shulamit

Publication type:

Article

Correction: Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia.

Published in:

2020

By:

Tsivion-Visbord, Hadas;
Perets, Nisim;
Sofer, Tamar;
Bikovski, Lior;
Goldshmit, Yona;
Ruban, Aangela;
Daniel, Offen

Publication type:

Correction Notice

Correction: Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia.

Published in:

2020

By:

Tsivion-Visbord, Hadas;
Perets, Nisim;
Sofer, Tamar;
Bikovski, Lior;
Goldshmit, Yona;
Ruban, Angela;
Daniel, Offen

Publication type:

Correction Notice

Correction: Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia.

Published in:

2020

By:

Tsivion-Visbord, Hadas;
Perets, Nisim;
Sofer, Tamar;
Bikovski, Lior;
Goldshmit, Yona;
Ruban, Aangela;
Daniel, Offen

Publication type:

Correction Notice

Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia.

Published in:

Translational Psychiatry, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41398-020-00988-y

By:

Tsivion-Visbord, Hadas;
Perets, Nisim;
Sofer, Tamar;
Bikovski, Lior;
Goldshmit, Yona;
Ruban, Aangela;
Daniel, Offen

Publication type:

Article

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Proposed Therapy in a Rat Model of Cerebral Small Vessel Disease.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11211, doi. 10.3390/ijms231911211

By:

Guy, Reut;
Herman, Shay;
Benyamini, Hadar;
Ben-Zur, Tali;
Kobo, Hila;
Pasmanik-Chor, Metsada;
Yaacobi, Dafna;
Barel, Eric;
Yagil, Chana;
Yagil, Yoram;
Offen, Daniel

Publication type:

Article

A Novel Rodent Model of Hypertensive Cerebral Small Vessel Disease with White Matter Hyperintensities and Peripheral Oxidative Stress.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 11, p. 5915, doi. 10.3390/ijms23115915

By:

Guy, Reut;
Volkman, Rotem;
Wilczynski, Ella;
Yagil, Chana;
Yagil, Yoram;
Findler, Michael;
Auriel, Eitan;
Nevo, Uri;
Offen, Daniel

Publication type:

Article

ND-13, a DJ-1-Derived Peptide, Attenuates the Renal Expression of Fibrotic and Inflammatory Markers Associated with Unilateral Ureter Obstruction.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7048, doi. 10.3390/ijms21197048

By:

De Miguel, Carmen;
Kraus, Abigayle C.;
Saludes, Mitchell A.;
Konkalmatt, Prasad;
Ruiz Domínguez, Almudena;
Asico, Laureano D.;
Latham, Patricia S.;
Offen, Daniel;
Jose, Pedro A.;
Cuevas, Santiago

Publication type:

Article

Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 3, p. 1144, doi. 10.3390/ijms21031144

By:

Angel, Ariel;
Volkman, Rotem;
Royal, Tabitha Grace;
Offen, Daniel

Publication type:

Article

Toll-Like Receptor-4 Inhibitor TAK-242 Attenuates Motor Dysfunction and Spinal Cord Pathology in an Amyotrophic Lateral Sclerosis Mouse Model.

Published in:

International Journal of Molecular Sciences, 2017, v. 18, n. 8, p. 1666, doi. 10.3390/ijms18081666

By:

Fellner, Avi;
Barhum, Yael;
Angel, Ariel;
Perets, Nisim;
Steiner, Israel;
Offen, Daniel;
Lev, Nirit

Publication type:

Article

Pathogenic Anti-DNA Antibodies in SLE: Idiotypic Families and Genetic Origins.

Published in:

International Reviews of Immunology, 1990, v. 5, n. 3/4, p. 295, doi. 10.3109/08830189009056736

By:

Paul, Elahna;
Manheimer-Lory, Audrey;
Livneh, Avi;
Solomon, Andrew;
Aranow, Cynthia;
Ghossein, Cybele;
Shefner, Rachel;
Offen, Daniel;
Pillinger, Michael;
Diamond, Betty

Publication type:

Article

Prediction of synonymous corrections by the BE-FF computational tool expands the targeting scope of base editing.

Published in:

Nucleic Acids Research, 2020, v. 48, n. W1, p. W340, doi. 10.1093/nar/gkaa215

By:

Rabinowitz, Roy;
Abadi, Shiran;
Almog, Shiri;
Offen, Daniel

Publication type:

Article

Harnessing neurogenesis for the possible treatment of Parkinson's disease.

Published in:

Journal of Comparative Neurology, 2014, v. 522, n. 12, p. 2817, doi. 10.1002/cne.23607

By:

Lamm, Omri;
Ganz, Javier;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Rare combination of myasthenia and motor neuronopathy, responsive to Msc-Ntf stem cell therapy.

Published in:

Muscle & Nerve, 2014, v. 49, n. 3, p. 455, doi. 10.1002/mus.24143

By:

Petrou, Panayiota;
Argov, Avizohar;
Lennon, Vanda A.;
Gotkine, Marc;
Kassis, Ibrahim;
Vaknin‐Dembinsky, Adi;
Ben‐Hur, Tamir;
Offen, Daniel;
Abramsky, Oded;
Melamed, Eldad;
Karussis, Dimitrios

Publication type:

Article

Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI.

Published in:

Magnetic Resonance in Medicine, 2012, v. 68, n. 3, p. spcone, doi. 10.1002/mrm.23300

By:

Shemesh, Noam;
Barazany, Daniel;
Sadan, Ofer;
Bar, Leah;
Zur, Yuval;
Barhum, Yael;
Sochen, Nir;
Offen, Daniel;
Assaf, Yaniv;
Cohen, Yoram

Publication type:

Article

Mapping apparent eccentricity and residual ensemble anisotropy in the gray matter using angular double-pulsed-field-gradient MRI.

Published in:

Magnetic Resonance in Medicine, 2012, v. 68, n. 3, p. 794, doi. 10.1002/mrm.23300

By:

Shemesh, Noam;
Barazany, Daniel;
Sadan, Ofer;
Bar, Leah;
Zur, Yuval;
Barhum, Yael;
Sochen, Nir;
Offen, Daniel;
Assaf, Yaniv;
Cohen, Yoram

Publication type:

Article

CrisPam: SNP-Derived PAM Analysis Tool for Allele-Specific Targeting of Genetic Variants Using CRISPR-Cas Systems.

Published in:

Frontiers in Genetics, 2020, v. 11, p. N.PAG, doi. 10.3389/fgene.2020.00851

By:

Rabinowitz, Roy;
Almog, Shiri;
Darnell, Roy;
Offen, Daniel

Publication type:

Article

BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 13, p. 2462, doi. 10.1093/hmg/ddx139

By:

Segal-Gavish, Hadar;
Gazit, Neta;
Barhum, Yael;
Ben-Zur, Tali;
Taler, Michal;
Hornfeld, Shay Henry;
Gil-Ad, Irit;
Weizman, Abraham;
Slutsky, Inna;
Niwa, Minae;
Kamiya, Atsushi;
Sawa, Akira;
Offen, Daniel;
Barzilay, Ran

Publication type:

Article

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 9, p. 2604, doi. 10.1093/hmg/ddv023

By:

Aharony, Israel;
Ehrnhoefer, Dagmar E.;
Shruster, Adi;
Xiaofan Qiu;
Franciosi, Sonia;
Hayden, Michael R.;
Offen, Daniel

Publication type:

Article

Increased RNA editing in maternal immune activation model of neurodevelopmental disease.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-19048-6

By:

Tsivion-Visbord, Hadas;
Kopel, Eli;
Feiglin, Ariel;
Sofer, Tamar;
Barzilay, Ran;
Ben-Zur, Tali;
Yaron, Orly;
Offen, Daniel;
Levanon, Erez Y.

Publication type:

Article

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127549

By:

Lev, Nirit;
Barhum, Yael;
Ben-Zur, Tali;
Aharony, Israel;
Trifonov, Lena;
Regev, Noa;
Melamed, Eldad;
Gruzman, Arie;
Offen, Daniel

Publication type:

Article

DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0117190

By:

Lev, Nirit;
Barhum, Yael;
Lotan, Itay;
Steiner, Israel;
Offen, Daniel

Publication type:

Article

Dopaminergic-Like Neurons Derived from Oral Mucosa Stem Cells by Developmental Cues Improve Symptoms in the Hemi-Parkinsonian Rat Model.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100445

By:

Ganz, Javier;
Arie, Ina;
Buch, Sigal;
Zur, Tali Ben;
Barhum, Yael;
Pour, Sammy;
Araidy, Shareef;
Pitaru, Sandu;
Offen, Daniel

Publication type:

Article

Wnt Signaling Enhances Neurogenesis and Improves Neurological Function after Focal Ischemic Injury.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040843

By:

Shruster, Adi;
Ben-Zur, Tali;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy.

Published in:

Journal of Neural Transmission, 2020, v. 127, n. 2, p. 205, doi. 10.1007/s00702-020-02158-2

By:

Glat, Micaela Johanna;
Stefanova, Nadia;
Wenning, Gregor Karl;
Offen, Daniel

Publication type:

Article

DJ-1 protects against dopamine toxicity.

Published in:

Journal of Neural Transmission, 2009, v. 116, n. 2, p. 151, doi. 10.1007/s00702-008-0134-4

By:

Lev, Nirit;
Ickowicz, Debby;
Barhum, Yael;
Lev, Shaul;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article