Works matching AU Offen, Daniel

Results: 85

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis Results of Phase 1/2 and 2a Clinical Trials.

Published in:

JAMA Neurology, 2016, v. 73, n. 3, p. 337, doi. 10.1001/jamaneurol.2015.4321

By:

Petrou, Panayiota;
Gothelf, Yael;
Argov, Zohar;
Gotkine, Marc;
Levy, Yossef S.;
Kassis, Ibrahim;
Vaknin-Dembinsky, Adi;
Ben-Hur, Tamir;
Offen, Daniel;
Abramsky, Oded;
Melamed, Eldad;
Karussis, Dimitrios

Publication type:

Article

Immunohistochemical analysis of sympathetic involvement in the SOD1-G93A transgenic mouse model of amyotrophic lateral sclerosis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2013, v. 14, n. 5/6, p. 424, doi. 10.3109/21678421.2013.780622

By:

Kandinov, Boris;
Grigoriadis, Nikolaos C.;
Touloumi, Olga;
Drory, Vivian E.;
Offen, Daniel;
Korczyn, Amos D.

Publication type:

Article

DJ-1 based peptide, ND-13, promote functional recovery in mouse model of focal ischemic injury.

Published in:

PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0192954

By:

Molcho, Lior;
Ben-Zur, Tali;
Barhum, Yael;
Offen, Daniel

Publication type:

Article

Genes to treat excitotoxicity ameliorate the symptoms of the disease in mice models of multiple system atrophy.

Published in:

Journal of Neural Transmission, 2020, v. 127, n. 2, p. 205, doi. 10.1007/s00702-020-02158-2

By:

Glat, Micaela Johanna;
Stefanova, Nadia;
Wenning, Gregor Karl;
Offen, Daniel

Publication type:

Article

DJ-1 protects against dopamine toxicity.

Published in:

Journal of Neural Transmission, 2009, v. 116, n. 2, p. 151, doi. 10.1007/s00702-008-0134-4

By:

Lev, Nirit;
Ickowicz, Debby;
Barhum, Yael;
Lev, Shaul;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

The role of oxidative stress in the pathogenesis of multiple sclerosis: The need for effective antioxidant therapy.

Published in:

Journal of Neurology, 2004, v. 251, n. 3, p. 261, doi. 10.1007/s00415-004-0348-9

By:

Gilgun-Sherki, Yossi;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Combined Gene Therapy to Reduce the Neuronal Damage in the Mouse Model of Focal Ischemic Injury.

Published in:

Journal of Molecular Neuroscience, 2018, v. 66, n. 2, p. 180, doi. 10.1007/s12031-018-1143-x

By:

Molcho, Lior;
Ben-Zur, Tali;
Barhum, Yael;
Angel, Ariel;
Glat, Mica;
Offen, Daniel

Publication type:

Article

Ectopic Muscle Expression of Neurotrophic Factors Improves Recovery After Nerve Injury.

Published in:

Journal of Molecular Neuroscience, 2016, v. 58, n. 1, p. 39, doi. 10.1007/s12031-015-0648-9

By:

Glat, Micaela;
Benninger, Felix;
Barhum, Yael;
Ben-Zur, Tali;
Kogan, Elena;
Steiner, Israel;
Yaffe, David;
Offen, Daniel

Publication type:

Article

Multifactorial Gene Therapy Enhancing the Glutamate Uptake System and Reducing Oxidative Stress Delays Symptom Onset and Prolongs Survival in the SOD1-G93A ALS Mouse Model.

Published in:

Journal of Molecular Neuroscience, 2016, v. 58, n. 1, p. 46, doi. 10.1007/s12031-015-0695-2

By:

Benkler, Chen;
Barhum, Yael;
Ben-Zur, Tali;
Offen, Daniel

Publication type:

Article

Knocking Out DJ-1 Attenuates Astrocytes Neuroprotection Against 6-Hydroxydopamine Toxicity.

Published in:

Journal of Molecular Neuroscience, 2013, v. 50, n. 3, p. 542, doi. 10.1007/s12031-013-9984-9

By:

Lev, Nirit;
Barhum, Yael;
Ben-Zur, Tali;
Melamed, Eldad;
Steiner, Israel;
Offen, Daniel

Publication type:

Article

Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS.

Published in:

Journal of Molecular Neuroscience, 2012, v. 48, n. 1, p. 176, doi. 10.1007/s12031-012-9805-6

By:

Fisher-Shoval, Yonit;
Barhum, Yael;
Sadan, Ofer;
Yust-Katz, Shlomit;
Ben-Zur, Tali;
Lev, Nirit;
Benkler, Chen;
Hod, Moshe;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis.

Published in:

Journal of Molecular Neuroscience, 2012, v. 46, n. 1, p. 162, doi. 10.1007/s12031-011-9559-6

By:

Ben-Pazi, Hilla;
Sadan, Ofer;
Offen, Daniel

Publication type:

Article

The 'Dying-Back' Phenomenon of Motor Neurons in ALS.

Published in:

Journal of Molecular Neuroscience, 2011, v. 43, n. 3, p. 470, doi. 10.1007/s12031-010-9467-1

By:

Dadon-Nachum, Michal;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Intracerebroventricular Transplantation of Human Mesenchymal Stem Cells Induced to Secrete Neurotrophic Factors Attenuates Clinical Symptoms in a Mouse Model of Multiple Sclerosis.

Published in:

Journal of Molecular Neuroscience, 2010, v. 41, n. 1, p. 129, doi. 10.1007/s12031-009-9302-8

By:

Barhum, Yael;
Gai-Castro, Sharon;
Bahat-Stromza, Merav;
Barzilay, Ran;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Levodopa induces apoptosis in cultured neuronal cells-A possible accelerator of nigrostriatal degeneration in Parkinson's disease?

Published in:

Movement Disorders, 1997, v. 12, n. 1, p. 17, doi. 10.1002/mds.870120105

By:

Ziv, Ilan;
Zilkha-Falb, Rina;
Offen, Daniel;
Shirvan, Anat;
Barzilai, Ari;
Melamed, Eldad

Publication type:

Article

Behavioral aspects and neurobiological properties underlying medical cannabis treatment in Shank3 mouse model of autism spectrum disorder.

Published in:

Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01612-3

By:

Poleg, Shani;
Kourieh, Emad;
Ruban, Angela;
Shapira, Guy;
Shomron, Noam;
Barak, Boaz;
Offen, Daniel

Publication type:

Article

Safety of repeated transplantations of neurotrophic factors‐secreting human mesenchymal stromal stem cells.

Published in:

Clinical & Translational Medicine, 2014, v. 3, n. 1, p. 1, doi. 10.1186/2001-1326-3-21

By:

Gothelf, Yael;
Abramov, Natalie;
Harel, Adrian;
Offen, Daniel

Publication type:

Article

A DJ-1 Based Peptide Attenuates Dopaminergic Degeneration in Mice Models of Parkinson's Disease via Enhancing Nrf2.

Published in:

PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127549

By:

Lev, Nirit;
Barhum, Yael;
Ben-Zur, Tali;
Aharony, Israel;
Trifonov, Lena;
Regev, Noa;
Melamed, Eldad;
Gruzman, Arie;
Offen, Daniel

Publication type:

Article

DJ-1 Knockout Augments Disease Severity and Shortens Survival in a Mouse Model of ALS.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0117190

By:

Lev, Nirit;
Barhum, Yael;
Lotan, Itay;
Steiner, Israel;
Offen, Daniel

Publication type:

Article

Dopaminergic-Like Neurons Derived from Oral Mucosa Stem Cells by Developmental Cues Improve Symptoms in the Hemi-Parkinsonian Rat Model.

Published in:

PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100445

By:

Ganz, Javier;
Arie, Ina;
Buch, Sigal;
Zur, Tali Ben;
Barhum, Yael;
Pour, Sammy;
Araidy, Shareef;
Pitaru, Sandu;
Offen, Daniel

Publication type:

Article

Wnt Signaling Enhances Neurogenesis and Improves Neurological Function after Focal Ischemic Injury.

Published in:

PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0040843

By:

Shruster, Adi;
Ben-Zur, Tali;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Astrocyte-Like Cells Derived From Human Oral Mucosa Stem Cells Provide Neuroprotection In Vitro and In Vivo.

Published in:

Stem Cells Translational Medicine, 2014, v. 3, n. 3, p. 375, doi. 10.5966/sctm.2013-0074

By:

GANZ, JAVIER;
ARIE, INA;
BEN-ZUR, TALI;
DADON-NACHUM, MICHAL;
POUR, SAMMY;
ARAIDY, SHAREEF;
PITARU, SANDU;
OFFEN, DANIEL

Publication type:

Article

BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 13, p. 2462, doi. 10.1093/hmg/ddx139

By:

Segal-Gavish, Hadar;
Gazit, Neta;
Barhum, Yael;
Ben-Zur, Tali;
Taler, Michal;
Hornfeld, Shay Henry;
Gil-Ad, Irit;
Weizman, Abraham;
Slutsky, Inna;
Niwa, Minae;
Kamiya, Atsushi;
Sawa, Akira;
Offen, Daniel;
Barzilay, Ran

Publication type:

Article

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

Published in:

Human Molecular Genetics, 2015, v. 24, n. 9, p. 2604, doi. 10.1093/hmg/ddv023

By:

Aharony, Israel;
Ehrnhoefer, Dagmar E.;
Shruster, Adi;
Xiaofan Qiu;
Franciosi, Sonia;
Hayden, Michael R.;
Offen, Daniel

Publication type:

Article

Voluntary exercise improves cognitive deficits in female dominant-negative DISC1 transgenic mouse model of neuropsychiatric disorders.

Published in:

2019

By:

Segal-Gavish, Hadar;
Barzilay, Ran;
Rimoni, Ofri;
Offen, Daniel

Publication type:

Report

Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression.

Published in:

World Journal of Biological Psychiatry, 2014, v. 15, n. 1, p. 76, doi. 10.3109/15622975.2013.841993

By:

Kaminitz, Ayelet;
Barzilay, Ran;
Segal, Hadar;
Taler, Michal;
Offen, Daniel;
Gil-Ad, Irit;
Mechoulam, Raphael;
Weizman, Abraham

Publication type:

Article

CSF-derived extracellular vesicles from patients with Parkinson's disease induce symptoms and pathology.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 1, p. 209, doi. 10.1093/brain/awac261

By:

Herman, Shay;
Djaldetti, Ruth;
Mollenhauer, Brit;
Offen, Daniel

Publication type:

Article

DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging.

Published in:

2013

By:

Lev N;
Barhum Y;
Pilosof NS;
Ickowicz D;
Cohen HY;
Melamed E;
Offen D;
Lev, Nirit;
Barhum, Yael;
Pilosof, Neri S;
Ickowicz, Debby;
Cohen, Haim Y;
Melamed, Eldad;
Offen, Daniel

Publication type:

journal article

DJ-1 Protects Against Dopamine Toxicity: Implications for Parkinson’s Disease and Aging.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2013, v. 68, n. 3, p. 215, doi. 10.1093/gerona/gls147

By:

Lev, Nirit;
Barhum, Yael;
Pilosof, Neri S.;
Ickowicz, Debby;
Cohen, Haim Y.;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Computer-Aided Design and Synthesis of 1-{4-[(3,4-Dihydroxybenzylidene)amino]phenyl}- 5-oxopyrrolidine-3-carboxylic Acid as an Nrf2 Enhancer.

Published in:

ChemPlusChem, 2018, v. 83, n. 5, p. 320, doi. 10.1002/cplu.201700539

By:

Kahremany, Shirin;
Babaev, Ilana;
Hasin, Pinhas;
Tamir, Tigist Y.;
Ben‐Zur, Tali;
Cohen, Guy;
Jiang, Zhengyu;
Weintraub, Sagiv;
Offen, Daniel;
Rahimipour, Shai;
Major, M. Ben;
Senderowitz, Hanoch;
Gruzman, Arie

Publication type:

Article

Intrastriatal transplantation of neurotrophic factor-secreting human mesenchymal stem cells improves motor function and extends survival in R6/2 transgenic mouse model for Huntington's disease.

Published in:

PLoS Currents, 2012, p. 344, doi. 10.1371/4f7f6dc013d4e

By:

Sadan, Ofer;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Levodopa Toxicity and Apoptosis.

Published in:

1998

By:

Melamed, Eldad;
Offen, Daniel;
Shirvan, Anat;
Djaldetti, Ruth;
Barzilai, Ari;
Ziv, Ilan

Publication type:

Other

Induction of Adult Human Bone Marrow Mesenchymal Stromal Cells into Functional Astrocyte-Like Cells: Potential for Restorative Treatment in Parkinson’s Disease.

Published in:

Journal of Molecular Neuroscience, 2009, v. 39, n. 1/2, p. 199, doi. 10.1007/s12031-008-9166-3

By:

Bahat-Stroomza, Merav;
Barhum, Yael;
Levy, Yossef;
Karpov, Olga;
Bulvik, Shlomo;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Spinal Cord mRNA Profile in Patients with ALS: Comparison with Transgenic Mice Expressing the Human SOD-1 Mutant.

Published in:

Journal of Molecular Neuroscience, 2009, v. 38, n. 2, p. 85, doi. 10.1007/s12031-007-9004-z

By:

Offen, Daniel;
Barhum, Yael;
Melamed, Eldad;
Embacher, Norbert;
Schindler, Christoph;
Ransmayr, Gerhard

Publication type:

Article

DJ-1 Changes in G93A-SOD1 Transgenic Mice: Implications for Oxidative Stress in ALS.

Published in:

Journal of Molecular Neuroscience, 2009, v. 38, n. 2, p. 94, doi. 10.1007/s12031-008-9138-7

By:

Lev, Nirit;
Ickowicz, Debby;
Barhum, Yael;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Role of DJ-1 in parkinson’s disease.

Published in:

2007

By:

Lev, Nirit;
Roncevich, Dusan;
Ickowicz, Debby;
Melamed, Eldad;
Offen, Daniel

Publication type:

Correction Notice

Role of DJ-1 in Parkinson's disease.

Published in:

Journal of Molecular Neuroscience, 2006, v. 29, n. 3, p. 215, doi. 10.1385/JMN:29:3:215

By:

Lev, Nirit;
Roncevich, Dusan;
Ickowicz, Debby;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Analysis of gene expression in MOG-induced experimental autoimmune encephalomyelitis after treatment with a novel brain-penetrating antioxidant.

Published in:

Journal of Molecular Neuroscience, 2005, v. 27, n. 1, p. 125, doi. 10.1385/JMN:27:1:125

By:

Gilgun-Sherki, Yossi;
Barhum, Yael;
Atlas, Daphne;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Embryonic and adult stem cells as a source for cell therapy in Parkinson’s disease.

Published in:

Journal of Molecular Neuroscience, 2004, v. 24, n. 3, p. 353, doi. 10.1385/JMN:24:3:353

By:

Levy, Yossef;
Stroomza, Merav;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Oxidative stress, induced by 6-hydroxydopamine, reduces proteasome activities in PC12 cells.

Published in:

Journal of Molecular Neuroscience, 2004, v. 24, n. 3, p. 387, doi. 10.1385/JMN:24:3:387

By:

Elkon, Hanoch;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Induction of neuron-specific enolase promoter and neuronal markers in differentiated mouse bone marrow stromal cells.

Published in:

Journal of Molecular Neuroscience, 2003, v. 21, n. 2, p. 121, doi. 10.1385/JMN:21:2:121

By:

Levy, Yossef;
Merims, Doron;
Panet, Hanna;
Barhum, Yael;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Antioxidant treatment in alzheimer’s disease.

Published in:

Journal of Molecular Neuroscience, 2003, v. 21, n. 1, p. 1, doi. 10.1385/JMN:21:1:1

By:

Gilgun-Sherki, Yossi;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article

Mutant and wild-type α-synuclein interact with mitochondrial cytochrome C oxidase.

Published in:

Journal of Molecular Neuroscience, 2002, v. 18, n. 3, p. 229, doi. 10.1385/JMN:18:3:229

By:

Elkon, Hanock;
Don, Jermy;
Melamed, Eldad;
Ziv, Ilan;
Shirvan, Anat;
Offen, Daniel

Publication type:

Article

Mice overexpressing Bcl-2 in their neurons are resistant to myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE).

Published in:

Journal of Molecular Neuroscience, 2000, v. 15, n. 3, p. 167, doi. 10.1385/JMN:15:3:167

By:

Offen, Daniel;
Kaye, Joel;
Bernard, Ora;
Merims, Doron;
Coire, Clare;
Panet, Hana;
Melamed, Eldad;
Ben-Nun, A.

Publication type:

Article

Mesenchymal stem cell‐derived exosomes mitigate amyloid β‐induced retinal toxicity: Insights from rat model and cellular studies.

Published in:

Journal of Extracellular Biology, 2025, v. 4, n. 1, p. 1, doi. 10.1002/jex2.70024

By:

Qarawani, Amanda;
Naaman, Efrat;
Ben‐Zvi Elimelech, Rony;
Harel, Michal;
Sigal‐Dror, Shahaf;
Ben‐Zur, Tali;
Ziv, Tamar;
Offen, Daniel;
Zayit‐Soudry, Shiri

Publication type:

Article

A novel specific PERK activator reduces toxicity and extends survival in Huntington's disease models.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-63899-4

By:

Ganz, Javier;
Shacham, Talya;
Kramer, Maria;
Shenkman, Marina;
Eiger, Hagit;
Weinberg, Nitai;
Iancovici, Ori;
Roy, Somnath;
Simhaev, Luba;
Da'adoosh, Benny;
Engel, Hamutal;
Perets, Nisim;
Barhum, Yael;
Portnoy, Moshe;
Offen, Daniel;
Lederkremer, Gerardo Z.

Publication type:

Article

Promising Opportunities for Treating Neurodegenerative Diseases with Mesenchymal Stem Cell-Derived Exosomes.

Published in:

Biomolecules (2218-273X), 2020, v. 10, n. 9, p. 1320, doi. 10.3390/biom10091320

By:

Guy, Reut;
Offen, Daniel

Publication type:

Article

Increased RNA editing in maternal immune activation model of neurodevelopmental disease.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-19048-6

By:

Tsivion-Visbord, Hadas;
Kopel, Eli;
Feiglin, Ariel;
Sofer, Tamar;
Barzilay, Ran;
Ben-Zur, Tali;
Yaron, Orly;
Offen, Daniel;
Levanon, Erez Y.

Publication type:

Article

A low molecular weight copper chelator crosses the blood–brain barrier and attenuates experimental autoimmune encephalomyelitis.

Published in:

Journal of Neurochemistry, 2004, v. 89, n. 5, p. 1241, doi. 10.1111/j.1471-4159.2004.02428.x

By:

Offen, Daniel;
Gilgun-Sherki, Yossi;
Barhum, Yael;
Benhar, Moran;
Grinberg, Leonid;
Reich, Reuven;
Melamed, Eldad;
Atlas, Daphne

Publication type:

Article

Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced....

Published in:

Journal of Neurochemistry, 2001, v. 77, n. 2, p. 391, doi. 10.1046/j.1471-4159.2001.00213.x

By:

Panet, Hana;
Barzilai, Ari;
Daily, Dvora;
Melamed, Eldad;
Offen, Daniel

Publication type:

Article