Works by O'Toole, Edel

Results: 70

3D model of harlequin ichthyosis reveals inflammatory therapeutic targets.
Published in:
2020
By:
- Enjalbert, Florence;
- Dewan, Priya;
- Caley, Matthew P.;
- Jones, Eleri M.;
- Morse, Mary A.;
- Kelsell, David P.;
- Enright, Anton J.;
- O’Toole, Edel A.;
- O'Toole, Edel A
Publication type:
journal article
Homozygous HOXC13 Variant Causes Pure Hair and Nail Ectodermal Dysplasia via Reduction in Protein Stability.
Published in:
Human Mutation, 2024, v. 2024, p. 1, doi. 10.1155/2024/6420246
By:
- Clowes, Virginia;
- Ma, Xiaolun;
- Maude, Hannah;
- Dennis, Catherine;
- Gao, Qing;
- Quinn, Geraldine;
- O'Toole, Edel A.;
- Batta, Kapila;
- Cebola, Inês;
- Cui, Wei;
- Aziz, Aziz ur Rehman
Publication type:
Article
Epidermal basement membrane-mesenchymal interactions.
Published in:
2008
By:
- O’Toole, Edel
Publication type:
Abstract
A deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro.
Published in:
2007
By:
- Man, Y K Stella;
- Trolove, Caroline;
- Tattersall, Daniel;
- Thomas, Anna C;
- Papakonstantinopoulou, Annie;
- Patel, Drashnika;
- Scott, Claire;
- Chong, Jiehan;
- Jagger, Daniel J;
- O'Toole, Edel A;
- Navsaria, Harshad;
- Curtis, Michael A;
- Kelsell, David P
Publication type:
journal article
A Deafness-Associated Mutant Human Connexin 26 Improves the Epithelial Barrier In Vitro.
Published in:
Journal of Membrane Biology, 2007, v. 218, n. 1-3, p. 29, doi. 10.1007/s00232-007-9025-0
By:
- Man, Y. K. Stella;
- Trolove, Caroline;
- Tattersall, Daniel;
- Thomas, Anna C.;
- Papakonstantinopoulou, Annie;
- Patel, Drashnika;
- Scott, Claire;
- Jiehan Chong;
- Jagger, Daniel J.;
- O'Toole, Edel A.;
- Navsaria, Harshad;
- Curtis, Michael A.;
- Kelsell, David P.
Publication type:
Article
Pachyonychia congenita: pathogenesis of pain and approaches to treatment.
Published in:
Clinical & Experimental Dermatology, 2024, v. 49, n. 12, p. 1510, doi. 10.1093/ced/llae199
By:
- McCarthy, Rebecca L;
- Brito, Marianne de;
- O'Toole, Edel A
Publication type:
Article
A case of Olmsted syndrome with dramatic response to erlotinib.
Published in:
Clinical & Experimental Dermatology, 2024, v. 49, n. 12, p. 1755, doi. 10.1093/ced/llae193
By:
- Oldham, Jaimie;
- O'Toole, Edel
Publication type:
Article
Loss-of-function FLG mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London.
Published in:
Clinical & Experimental Dermatology, 2024, v. 49, n. 12, p. 1547, doi. 10.1093/ced/llae185
By:
- Hughes, Aaron J;
- Barbosa, Elsa;
- Cernova, Jeva;
- Thomas, Bjorn R;
- O'Shaughnessy, Ryan F L;
- O'Toole, Edel A
Publication type:
Article
Cathepsin-C mutation in an individual with phenotypic features of Haim--Munk syndrome: a case report.
Published in:
Clinical & Experimental Dermatology, 2023, v. 48, n. 11, p. 1298, doi. 10.1093/ced/llad241
By:
- McCarthy, Rebecca L.;
- Gnanappiragasam, Dushyanth;
- Scorer, Matthew;
- Taylor, Marisa;
- O'Toole, Edel A.
Publication type:
Article
Tuberous xanthoma secondary to homozygous familial hypercholesterolaemia: a life‐threatening diagnosis.
Published in:
Clinical & Experimental Dermatology, 2022, v. 47, n. 12, p. 2336, doi. 10.1111/ced.15394
By:
- Kazmi, Ahmed;
- Frewen, John;
- McDonald, Bryan;
- Davison, James;
- O'Toole, Edel
Publication type:
Article
QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction.
Published in:
Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-52587-w
By:
- Maharaj, Avinaash V.;
- Ishida, Miho;
- Rybak, Anna;
- Elfeky, Reem;
- Andrews, Afiya;
- Joshi, Aakash;
- Elmslie, Frances;
- Joensuu, Anni;
- Kantojärvi, Katri;
- Jia, Raina Y.;
- Perry, John R. B.;
- O'Toole, Edel A.;
- McGuffin, Liam J.;
- Hwa, Vivian;
- Storr, Helen L.
Publication type:
Article
RNA-seq Analysis of Host and Viral Gene Expression Highlights Interaction between Varicella Zoster Virus and Keratinocyte Differentiation.
Published in:
PLoS Pathogens, 2014, v. 10, n. 1, p. 1, doi. 10.1371/journal.ppat.1003896
By:
- Jones, Meleri;
- Dry, Inga R.;
- Frampton, Dan;
- Singh, Manuraj;
- Kanda, Ravinder K.;
- Yee, Michael B.;
- Kellam, Paul;
- Hollinshead, Michael;
- Kinchington, Paul R.;
- O'Toole, Edel A.;
- Breuer, Judith
Publication type:
Article
Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway.
Published in:
Journal of Cellular Physiology, 2008, v. 214, n. 1, p. 47, doi. 10.1002/jcp.21160
By:
- O'Toole, Edel A.;
- Van Koningsveld, Rudolf;
- Mei Chen;
- Woodley, David T.
Publication type:
Article
Phosphorylation of focal adhesion kinase (pp125<sup>FAK</sup>) is increased in human keratinocytes induced to migrate by extracellular matrices.
Published in:
Journal of Cellular Physiology, 2001, v. 188, n. 1, p. 24, doi. 10.1002/jcp.1093
By:
- Yurko, Mary A.;
- O'Toole, Edel A.;
- Woodley, David T.
Publication type:
Article
Analysis of hedgehog signaling in periocular sebaceous carcinoma.
Published in:
Graefe's Archive of Clinical & Experimental Ophthalmology, 2018, v. 256, n. 4, p. 853, doi. 10.1007/s00417-018-3900-5
By:
- Bladen, John C.;
- Moosajee, Mariya;
- Tracey-White, Dhani;
- Beaconsfield, Michèle;
- O’Toole, Edel A.;
- Philpott, Michael P.
Publication type:
Article
Erosive lichen planus: an unmet disease burden.
Published in:
Frontiers in Medicine, 2024, p. 1, doi. 10.3389/fmed.2024.1457667
By:
- Macken, John H.;
- Senusi, Amal;
- O'Toole, Edel A.;
- Caley, Matthew;
- Rognoni, Emanuel;
- Fortune, Farida
Publication type:
Article
Diagnosis and Management of Inherited Palmoplantar Keratodermas.
Published in:
Acta Dermato-Venereologica, 2020, v. 100, p. 168, doi. 10.2340/00015555-3430
By:
- THOMAS, Bjorn R.;
- O'TOOLE, Edel A.
Publication type:
Article
Severe atypical juvenile pityriasis rubra pilaris diagnosed in adulthood with a dramatic improvement with ustekinumab.
Published in:
Skin Health & Disease, 2024, v. 4, n. 4, p. 1, doi. 10.1002/ski2.389
By:
- McCarthy, Rebecca L.;
- Oldham, Jaimie;
- Barbosa, Elsa;
- Sinclair, Catriona;
- Cunningham, Malvina;
- O'Toole, Edel A.
Publication type:
Article
Vitamin D deficiency and atopic dermatitis severity in a Bangladeshi population living in East London: A cross‐sectional study.
Published in:
Skin Health & Disease, 2024, v. 4, n. 3, p. 1, doi. 10.1002/ski2.358
By:
- McCarthy, Rebecca L.;
- Tawfik, Soha S.;
- Theocharopoulos, Ioannis;
- Atkar, Ravinder;
- McDonald, Bryan;
- Dhoat, Sasha;
- Hughes, Aaron;
- Thomas, Bjorn R.;
- O'Toole, Edel A.
Publication type:
Article
Expanding the Phenotypic Spectrum of Olmsted Syndrome.
Published in:
Journal of Investigative Dermatology, 2015, v. 135, n. 11, p. 2879, doi. 10.1038/jid.2015.217
By:
- Wilson, Neil J;
- Cole, Christian;
- Milstone, Leonard M;
- Kiszewski, Ana E;
- Hansen, C David;
- O'Toole, Edel A;
- Schwartz, Mary E;
- McLean, W H Irwin;
- Smith, Frances J D
Publication type:
Article
Exoming into Rare Skin Disease: EGFR Deficiency.
Published in:
Journal of Investigative Dermatology, 2014, v. 134, n. 10, p. 2486, doi. 10.1038/jid.2014.228
By:
- Brooke, Matthew A;
- O'Toole, Edel A;
- Kelsell, David P
Publication type:
Article
Targeted Sequence Capture and High-Throughput Sequencing in the Molecular Diagnosis of Ichthyosis and Other Skin Diseases.
Published in:
Journal of Investigative Dermatology, 2013, v. 133, n. 2, p. 573, doi. 10.1038/jid.2012.332
By:
- Scott, Claire A;
- Plagnol, Vincent;
- Nitoiu, Daniela;
- Bland, Philip J;
- Blaydon, Diana C;
- Chronnell, Catherine M;
- Poon, Daniel S;
- Bourn, David;
- Gárdos, László;
- Császár, Andrea;
- Tihanyi, Mariann;
- Rustin, Malcolm;
- Burrows, Nigel P;
- Bennett, Chris;
- Harper, John I;
- Conrad, Bernard;
- Verma, Ishwar C;
- Taibjee, Saleem M;
- Moss, Celia;
- O'toole, Edel A
Publication type:
Article
Axl Promotes Cutaneous Squamous Cell Carcinoma Survival through Negative Regulation of Pro-Apoptotic Bcl-2 Family Members.
Published in:
Journal of Investigative Dermatology, 2011, v. 131, n. 2, p. 509, doi. 10.1038/jid.2010.326
By:
- Papadakis, Emmanouil S.;
- Cichoń, Monika A.;
- Vyas, Jashmin J.;
- Patel, Nakul;
- Ghali, Lucy;
- Cerio, Rino;
- Storey, Alan;
- O'Toole, Edel A.
Publication type:
Article
Keratin K6c Mutations Cause Focal Palmoplantar Keratoderma.
Published in:
Journal of Investigative Dermatology, 2010, v. 130, n. 2, p. 425, doi. 10.1038/jid.2009.215
By:
- Wilson, Neil J.;
- Messenger, Andrew G.;
- Leachman, Sancy A.;
- O'Toole, Edel A.;
- Lane, E. Birgitte;
- McLean, W. H. Irwin;
- Smith, Frances J. D.
Publication type:
Article
Patients with Recessive Dystrophic Epidermolysis Bullosa Develop Squamous-Cell Carcinoma Regardless of Type VII Collagen Expression.
Published in:
Journal of Investigative Dermatology, 2007, v. 127, n. 10, p. 2438, doi. 10.1038/sj.jid.5700878
By:
- Pourreyron, Celine;
- Cox, Georgie;
- Xin Mao;
- Volz, Andreas;
- Baksh, Nuzhat;
- Wong, Tracy;
- Fassihi, Hiva;
- Arita, Ken;
- O'Toole, Edel A.;
- Ocampo-Candiani, Jorge;
- Mei Chen;
- Hart, Ian R.;
- Bruckner-Tuderman, Leena;
- Salas-Alanis, Julio C.;
- McGrath, John A.;
- Leigh, Irene M.;
- South, Andrew P.
Publication type:
Article
Clinical and Genetic Heterogeneity of Erythrokeratoderma Variabilis.
Published in:
Journal of Investigative Dermatology, 2005, v. 125, n. 5, p. 920, doi. 10.1111/j.0022-202X.2005.23919.x
By:
- Common, John E. A.;
- O'Toole, Edel A.;
- Leigh, Irene M.;
- Thomas, Anna;
- Griffiths, William A. D.;
- Venning, Vanessa;
- Grabczynska, Sophie;
- Periš, Zdravko;
- Kansky, Aleksej;
- Kelsell, David P.
Publication type:
Article
Upregulation of keratin 15 is required for varicella-zoster virus replication in keratinocytes and is attenuated in the live attenuated vOka vaccine strain.
Published in:
Virology Journal, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12985-024-02514-8
By:
- Tommasi, Cristina;
- Yogev, Ohad;
- Yee, Michael B.;
- Drousioti, Andriani;
- Jones, Meleri;
- Ring, Alice;
- Singh, Manuraj;
- Dry, Inga;
- Atkins, Oscar;
- Naeem, Aishath S.;
- Kriplani, Nisha;
- Akbar, Arne N.;
- Haas, Jürgen G.;
- O'Toole, Edel A.;
- Kinchington, Paul R.;
- Breuer, Judith
Publication type:
Article
Keratins and skin disease.
Published in:
Cell & Tissue Research, 2015, v. 360, n. 3, p. 583, doi. 10.1007/s00441-014-2105-4
By:
- Knöbel, Maria;
- O'Toole, Edel;
- Smith, Frances
Publication type:
Article
Matrix metalloproteinases and epidermal wound repair.
Published in:
Cell & Tissue Research, 2013, v. 351, n. 2, p. 255, doi. 10.1007/s00441-012-1410-z
By:
- Martins, Vera;
- Caley, Matthew;
- O'Toole, Edel
Publication type:
Article
Prevalence and Characterization of Itch in Pachyonychia Congenita.
Published in:
2021
By:
- Steele, Lloyd;
- Schwartz, Janice;
- Hansen, C. David;
- O'Toole, Edel A.
Publication type:
Letter
The Epidermolysis Bullosa Acquisita Antigen (Type VII Collagen) is Present in Human Colon and Patients with Crohn's Disease have Autoantibodies to Type VII Collagen.
Published in:
Journal of Investigative Dermatology, 2002, v. 118, n. 6, p. 1059, doi. 10.1046/j.1523-1747.2002.01772.x
By:
- Chen, Mei;
- O'Toole, Edel A;
- Sanghavi, Jigisha;
- Mahmud, Nasir;
- Kelleher, Dermot;
- Weir, Donald;
- Fairley, Janet A;
- Woodley, David T
Publication type:
Article
Thalidomide Increases Human Keratinocyte Migration and Proliferation.
Published in:
Journal of Investigative Dermatology, 1999, v. 113, n. 5, p. 0
By:
- Nasca, Maria R.;
- O’Toole, Edel A.;
- Palicharla, Prema;
- West, Dennis P.;
- Woodley, David T.
Publication type:
Article
NC1 Domain of Type VII Collagen Binds to the β3 Chain of Laminin 5 Via a Unique Subdomain Within the Fibronectin-Like Repeats.
Published in:
Journal of Investigative Dermatology, 1999, v. 112, n. 2, p. 177, doi. 10.1046/j.1523-1747.1999.00491.x
By:
- Chen, Mei;
- Marinkovich, M. Peter;
- Jones, Jonathan C. R.;
- O’Toole, Edel A.;
- Li, Yu-Yu;
- Woodley, David T.
Publication type:
Article
Ultraviolet A Irradiation Upregulates Type VII Collagen Expression in Human Dermal Fibroblasts.
Published in:
Journal of Investigative Dermatology, 1997, v. 108, n. 2, p. 125, doi. 10.1111/1523-1747.ep12332300
By:
- Chen, Mei;
- Petersen, Marta J.;
- Li, Hai-Li;
- Cai, Xiao-Yan;
- O'Toole, Edel A.;
- Woodley, David T.
Publication type:
Article
Development of an ELISA for Rapid Detection of Anti-Type VII Collagen Autoantibodies in Epidermolysis Bullosa Acquisita.
Published in:
Journal of Investigative Dermatology, 1997, v. 108, n. 1, p. 68, doi. 10.1111/1523-1747.ep12285634
By:
- Chen, Mei;
- Chan, Lawrence S.;
- Cai, Xiaoyan;
- O'Toole, Edel A.;
- Sample, Jeanna C.;
- Woodley, David T.
Publication type:
Article
Enhanced Modulation of Keratinocyte Motility by Transforming Growth Factor-∝ (TGF-∝) Relative to Epidermal Growth Factor (EGF).
Published in:
Journal of Investigative Dermatology, 1996, v. 106, n. 4, p. 590, doi. 10.1111/1523-1747.ep12345083
By:
- Cha, Donald;
- O'Brien, Patricia;
- O'Toole, Edel A.;
- Woodley, David T.;
- Hudson, Laurie G.
Publication type:
Article
Mainstreaming genetic testing in dermatology in the UK.
Published in:
British Journal of Dermatology, 2024, v. 191, n. 5, p. 832, doi. 10.1093/bjd/ljae305
By:
- O'Connor, Cathal;
- Passby, Lauren;
- Fields, Carly;
- McGrath, John;
- O'Toole, Edel A;
- Rajan, Neil
Publication type:
Article
A cross-sectional study of erythromelalgia in patients with pachyonychia congenita.
Published in:
British Journal of Dermatology, 2024, v. 191, n. 2, p. 300, doi. 10.1093/bjd/ljae143
By:
- McCarthy, Rebecca L;
- Schwartz, Janice;
- Oldham, Jaimie;
- Bodemer, Christine;
- Greco, Celine;
- Hovnanian, Alain;
- Hansen, C David;
- O'Toole, Edel A
Publication type:
Article
P33 Skinvaders: gamification of the skin barrier to engage school-age children in the biology of the skin.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e94, doi. 10.1093/bjd/ljae105.055
By:
- Brito, Marianne de;
- Green, Freddy;
- McCarthy, Rebecca;
- Rees, Martin;
- Balkwill, Frances;
- O'Toole, Edel Ann
Publication type:
Article
P17 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e86, doi. 10.1093/bjd/ljae105.039
By:
- Ahmed, Abubkr;
- Kirk, Thomas;
- O'Toole, Edel;
- Rognoni, Emanuel
Publication type:
Article
P15 Understanding the role of cathepsin H in atopic dermatitis pathogenesis.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e85, doi. 10.1093/bjd/ljae105.037
By:
- Tachie-Menson, Theresa;
- Hughes, Aaron;
- O'Toole, Edel;
- O'Shaughnessy, Ryan
Publication type:
Article
P12 Transcriptional and epigenetic changes drive increased cellular plasticity in keloid fibroblasts.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e84, doi. 10.1093/bjd/ljae105.034
By:
- Tekkela, Stavroula;
- Hight-Warburton, Willow;
- Shaw, Tanya;
- Philpott, Mike;
- O'Toole, Edel;
- Rognoni, Emanuel
Publication type:
Article
P10 Janus kinase inhibitors to restore skin barrier function in a mouse model of Harlequin ichthyosis.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e83, doi. 10.1093/bjd/ljae105.032
By:
- Giusto, Elena;
- Jones, Eleri;
- Enjalbert, Florence;
- Ahmed, Abubkr;
- Caley, Matthew;
- Rognoni, Emanuel;
- O'Toole, Edel
Publication type:
Article
O19 Improvement of a junctional epidermolysis bullosa mouse model.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e77, doi. 10.1093/bjd/ljae105.019
By:
- Jones, Eleri;
- Garcha, Priya;
- Aumailley, Monique;
- O'Toole, Edel;
- Rognoni, Emanuel;
- Caley, Matthew
Publication type:
Article
O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics.
Published in:
British Journal of Dermatology, 2024, v. 190, n. 6, p. e71, doi. 10.1093/bjd/ljae105.008
By:
- Summan, Simranpreet;
- Mayes, Andrew;
- Gunn, David;
- Madapura, Pradeepa;
- Gautrot, Julien;
- Caley, Matthew;
- O'Toole, Edel
Publication type:
Article
P11 A Rare and Serious Cause of "Blueberry Muffin Syndrome".
Published in:
British Journal of Dermatology, 2024, v. 190, p. i7, doi. 10.1093/bjd/ljad483.020
By:
- Oldham, Jaimie;
- Dunnigan, Anna;
- Barbosa, Elsa;
- Huang, Sylvia;
- Dhoat, Sasha;
- McDonald, Bryan;
- O'Toole, Edel;
- Atkar, Ravinder
Publication type:
Article
P31 Dissecting the epigenetic and transcriptional regulators in keloid scars.
Published in:
British Journal of Dermatology, 2023, v. 189, n. 1, p. e26, doi. 10.1093/bjd/ljad174.052
By:
- Tekkela, Stavroula;
- Drudi, Elena M;
- Shaw, Tanya;
- Philpott, Mike;
- O'Toole, Edel;
- Rognoni, Emanuel
Publication type:
Article
P16 How does skin ageing-related basement membrane collagen loss affect the nucleus?
Published in:
British Journal of Dermatology, 2023, v. 189, n. 1, p. e20, doi. 10.1093/bjd/ljad174.037
By:
- Summan, Simranpreet Kaur;
- Mayes, Andrew;
- Gunn, David;
- Gautrot, Julien;
- Caley, Matthew;
- O'Toole, Edel
Publication type:
Article
P08 Dissection of the molecular and cellular heterogeneity of dermal fibroblasts in skin fibrosis.
Published in:
British Journal of Dermatology, 2023, v. 189, n. 1, p. e17, doi. 10.1093/bjd/ljad174.030
By:
- Ahmed, Abubkr;
- Kirk, Thomas;
- Forster, Laura;
- O'Toole, Edel;
- Gupta, Himadri;
- Rognoni, Emanuel
Publication type:
Article
O16 The novel roles of laminin α3 in epidermal barrier function and metabolism.
Published in:
British Journal of Dermatology, 2023, v. 189, n. 1, p. e11, doi. 10.1093/bjd/ljad174.016
By:
- Parzymies, Piotr;
- Jones, Eleri Mai;
- Mayes, Andrew;
- Messenger, David;
- O'Toole, Edel;
- Caley, Matthew
Publication type:
Article