Works matching AU O'Rahilly, S

Results: 91

Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

Published in:

1997

By:

Montague CT;
Prins JB;
Sanders L;
Digby JE;
O'Rahilly S;
Montague, C T;
Prins, J B;
Sanders, L;
Digby, J E;
O'Rahilly, S

Publication type:

journal article

Investigating the involvement of the ATF6α pathway of the unfolded protein response in adipogenesis.

Published in:

2012

By:

Lowe CE;
Dennis RJ;
Obi U;
O'Rahilly S;
Rochford JJ;
Lowe, C E;
Dennis, R J;
Obi, U;
O'Rahilly, S;
Rochford, J J

Publication type:

journal article

Human obesity as a heritable disorder of the central control of energy balance.

Published in:

2008

By:

O'Rahilly S;
Farooqi IS;
O'Rahilly, S;
Farooqi, I S

Publication type:

journal article

Erratum: Digenic inheritance of severe insulin resistance in a human pedigree.

Published in:

2002

By:

Savage, D B;
Agostini, M;
Barroso, I;
Gurnell, M;
Luan, J;
Meirhaeghe, A;
Harding, A-H;
Ihrke, G;
Rajanayagam, O;
Soos, M A;
George, S;
Berger, D;
Thomas, E L;
Bell, J D;
Meeran, K;
Ross, R J;
Vidal-Puig, A;
Wareham, N J;
O'Rahilly, S

Publication type:

Correction Notice

Hypoglycemia due to an Insulin Binding Antibody in a Patient with an IgA-κ Myeloma.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2007, v. 92, n. 6, p. 2013, doi. 10.1210/jc.2007-0075

By:

Halsall, D. J.;
Mangi, M.;
Fahie-Wilson, M. N.;
Wark, G.;
Mainwaring-Burton, R.;
O’Rahilly, S.;
Soos, M.

Publication type:

Article

Elevated plasma adiponectin in humans with genetically defective insulin receptors.

Published in:

2006

By:

Semple, R K;
Soos, M A;
Luan, J;
Mitchell, C S;
Wilson, J C;
Gurnell, M;
Cochran, E K;
Gorden, P;
Chatterjee, V K K;
Wareham, N J;
O'Rahilly, S

Publication type:

journal article

Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism.

Published in:

2005

By:

Semple, R K;
Achermann, J C;
Ellery, J;
Farooqi, I S;
Karet, F E;
Stanhope, R G;
O'rahilly, S;
Aparicio, S A

Publication type:

journal article

Severe insulin resistance, diabetes mellitus, hypertriglyceridemia, and pseudoacromegaly.

Published in:

Journal of Clinical Endocrinology & Metabolism, 1996, v. 81, n. 10, p. 3465, doi. 10.1210/jc.81.10.3465

By:

KUMAR, S.;
DURRINGTON, P. N.;
O'RAHILLY, S.;
LAING, I.;
HUMPHREYS, P. J.;
OLUKOGA, A. O.;
BHATNAGAR, D.;
MACKNESS, M. I.;
DAVIS, J. R.;
BOULTON, A. J.

Publication type:

Article

Insulin-mediated pseudoacromegaly: clinical and biochemical characterization of a syndrome of selective insulin resistance.

Published in:

1993

By:

Flier, J S;
Moller, D E;
Moses, A C;
O'Rahilly, S;
Chaiken, R L;
Grigorescu, F;
Elahi, D;
Kahn, B B;
Weinreb, J E;
Eastman, R

Publication type:

journal article

Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling.

Published in:

Diabetologia, 2011, v. 54, n. 5, p. 1057, doi. 10.1007/s00125-011-2066-z

By:

Raffan, E.;
Soos, M.;
Rocha, N.;
Tuthill, A.;
Thomsen, A.;
Hyden, C.;
Gregory, J.;
Hindmarsh, P.;
Dattani, M.;
Cochran, E.;
Kaabi, J.;
Gorden, P.;
Barroso, I.;
Morling, N.;
O'Rahilly, S.;
Semple, R.

Publication type:

Article

Leptin therapy in lipodystrophy.

Published in:

2010

By:

Savage, D.;
O’Rahilly, S.

Publication type:

Editorial

Correlation of the leptin:adiponectin ratio with measures of insulin resistance in non-diabetic individuals.

Published in:

Diabetologia, 2009, v. 52, n. 11, p. 2345, doi. 10.1007/s00125-009-1508-3

By:

Finucane, F.;
Luan, J.;
Wareham, N.;
Sharp, S.;
O’Rahilly, S.;
Balkau, B.;
Flyvbjerg, A.;
Walker, M.;
Højlund, K.;
Nolan, J.;
Savage, D.

Publication type:

Article

IRS2 variants and syndromes of severe insulin resistance.

Published in:

2009

By:

Bottomley, W.;
Soos, M.;
Adams, C.;
Guran, T.;
Howlett, T.;
Mackie, A.;
Miell, J.;
Monson, J.;
Temple, R.;
Tenenbaum-Rakover, Y.;
Tymms, J.;
Savage, D.;
Semple, R.;
O’Rahilly, S.;
Barroso, I.

Publication type:

Letter

PPARGC1A coding variation may initiate impaired NEFA clearance during glucose challenge.

Published in:

Diabetologia, 2007, v. 50, n. 3, p. 569, doi. 10.1007/s00125-006-0580-1

By:

Franks, P.;
Ekelund, U.;
Brage, S.;
Luan, J.;
Schafer, A.;
O’Rahilly, S.;
Barroso, I.;
Wareham, N.

Publication type:

Article

Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations.

Published in:

Diabetologia, 2007, v. 50, n. 3, p. 555, doi. 10.1007/s00125-006-0534-7

By:

Collins, S.;
Luan, J.;
Thompson, A.;
Daly, A.;
Semple, R.;
O’Rahilly, S.;
Wareham, N.;
Barroso, I.

Publication type:

Article

WNT10B mutations in human obesity.

Published in:

Diabetologia, 2006, v. 49, n. 4, p. 678, doi. 10.1007/s00125-006-0144-4

By:

Christodoulides, C.;
Scarda, A.;
Granzotto, M.;
Milan, G.;
Nora, E. Dalla;
Keogh, J.;
De Pergola, G.;
Stirling, H.;
Pannacciulli, N.;
Sethi, J. K.;
Federspil, G.;
Vidal-Puig, A.;
Farooqi, I. S.;
O’Rahilly, S.;
Vettor, R.

Publication type:

Article

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.

Published in:

Diabetologia, 2006, v. 49, n. 3, p. 501, doi. 10.1007/s00125-005-0130-2

By:

Barroso, I.;
Luan, J.;
Sandhu, M. S.;
Franks, P. W.;
Crowley, V.;
Schafer, A. J.;
O'Rahilly, S.;
Wareham, N. J.

Publication type:

Article

Large-scale studies of the association between variation at the TNF/ LTA locus and susceptibility to type 2 diabetes.

Published in:

Diabetologia, 2005, v. 48, n. 10, p. 2013, doi. 10.1007/s00125-005-1902-4

By:

Zeggini, E.;
Groves, C. J.;
Parkinson, J. R. C.;
Halford, S. R.;
Owen, K. R.;
Frayling, T. M.;
Walker, M.;
Hitman, G. A.;
Levy, J. C.;
O'Rahilly, S.;
Hattersley, A. T.;
McCarthy, M. I.

Publication type:

Article

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.

Published in:

Diabetologia, 2004, v. 47, n. 12, p. 2168, doi. 10.1007/s00125-004-1575-4

By:

Liew, C. F.;
Groves, C. J.;
Wiltshire, S.;
Zeggini, E.;
Frayling, T. M.;
Owen, K. R.;
Walker, M.;
Hitman, G. A.;
Levy, J. C.;
O’Rahilly, S.;
Hattersley, A. T.;
Johnston, D. G.;
McCarthy, M. I.

Publication type:

Article

Natural variants of human p85α phosphoinositide 3-kinase in severe insulin resistance: a novel variant with impaired insulin-stimulated lipid kinase activity.

Published in:

Diabetologia, 2000, v. 43, n. 3, p. 321, doi. 10.1007/s001250050050

By:

Baynes, K. C. R.;
Beeton, C. A.;
Panayotou, G.;
Stein, R.;
Soos, M.;
Hansen, T.;
Simpson, H.;
O'Rahilly, S.;
Shepherd, P. R.;
Whitehead, J. P.

Publication type:

Article

The role of melanocortin signalling in the control of body weight: evidence from human and murine genetic models.

Published in:

QJM: An International Journal of Medicine, 2000, v. 93, n. 1, p. 7, doi. 10.1093/qjmed/93.1.7

By:

Yeo, G.S.H.;
Farooqi, I.S.;
Challis, B.G.;
Jackson, R.S.;
O'Rahilly, S.

Publication type:

Article

Hypercalcaemia associated with granulomatous lymphadenitis and elevated 1,25 dihydroxyvitamin D concentration in a dog.

Published in:

Journal of Small Animal Practice, 2006, v. 47, n. 4, p. 207, doi. 10.1111/j.1748-5827.2006.00019.x

By:

Mellanby, R. J.;
Mellor, P.;
Villiers, E. J.;
Herrtage, M. E.;
Halsall, D.;
O'Rahilly, S.;
McNeil, P. E.;
Mee, A. P.;
Berry, J. L.

Publication type:

Article

Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.

Published in:

2001

By:

Savage, David B.;
Sewter, Ciaran P.;
Klenk, Ellen S.;
Segal, David G.;
Vidal-Puig, Antonio;
Considine, Robert V.;
O'Rahilly, Stephen;
Savage, D B;
Sewter, C P;
Klenk, E S;
Segal, D G;
Vidal-Puig, A;
Considine, R V;
O'Rahilly, S

Publication type:

journal article

Evidence for gene-nutrient interaction at the PPARgamma locus.

Published in:

2001

By:

Luan, Jian'an;
Browne, Paul O.;
Harding, Anne-Helen;
Halsall, David J.;
O'Rahilly, Stephen;
Chatterjee, V.K. Krishna;
Wareham, Nicholas J.;
Luan, J;
Browne, P O;
Harding, A H;
Halsall, D J;
O'Rahilly, S;
Chatterjee, V K;
Wareham, N J

Publication type:

journal article

Naturally occurring amino acid substitutions at Arg1174 in the human insulin receptor result in differential effects on receptor biosynthesis and hybrid formation, leading to discordant clinical phenotypes.

Published in:

2000

By:

Rau, Harald;
Kocova, Mirjana;
O'Rahilly, Stephen;
Whitehead, Jonathan P.;
Rau, H;
Kocova, M;
O'Rahilly, S;
Whitehead, J P

Publication type:

journal article

The perils of portliness: causes and consequences of visceral adiposity.

Published in:

2000

By:

Montague, C T;
O'Rahilly, S

Publication type:

journal article

The CART gene and human obesity: mutational analysis and population genetics.

Published in:

2000

By:

Challis, B G;
Yeo, G S;
Farooqi, I S;
Luan, J;
Aminian, S;
Halsall, D J;
Keogh, J M;
Wareham, N J;
O'Rahilly, S

Publication type:

journal article

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.

Published in:

2000

By:

Huxtable, Stewart J.;
Saker, Philip J.;
Haddad, Lema;
Walker, Mark;
Frayling, Timothy M.;
Levy, Jonathan C.;
Hitman, Graham A.;
O'Rahilly, Stephen;
Hattersley, Andrew T.;
McCarthy, Mark I.;
Huxtable, S J;
Saker, P J;
Haddad, L;
Walker, M;
Frayling, T M;
Levy, J C;
Hitman, G A;
O'Rahilly, S;
Hattersley, A T;
McCarthy, M I

Publication type:

journal article

Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients.

Published in:

1998

By:

Krook, Anna;
Dighy, Janet;
O'Rahilly, Stephen;
Zierath, Juleen R.;
Wallberg-Henriksson, Harriet;
Krook, A;
Digby, J;
O'Rahilly, S;
Zierath, J R;
Wallberg-Henriksson, H

Publication type:

journal article

Depot-related gene expression in human subcutaneous and omental adipocytes.

Published in:

1998

By:

Montague, Carl T.;
Prins, Johannes B.;
Sanders, Louise;
Zhang, Junlong;
Sewter, Ciaran P.;
Digby, Janet;
Byrne, Christopher D.;
O'Rahilly, Stephen;
Montague, C T;
Prins, J B;
Sanders, L;
Zhang, J;
Sewter, C P;
Digby, J;
Byrne, C D;
O'Rahilly, S

Publication type:

journal article

Multiple molecular mechanisms of insulin receptor dysfunction in a patient with Donohue syndrome.

Published in:

1998

By:

Whitehead, Jonathan P.;
Soos, Maria A.;
Jackson, R.;
Tasic, V.;
Kocova, M.;
O'Rahilly, S.;
Whitehead, J P;
Soos, M A

Publication type:

journal article

Molecular scanning of the insulin receptor substrate 1 gene in subjects with severe insulin resistance: detection and functional analysis of a naturally occurring mutation in a YMXM motif.

Published in:

1998

By:

Whitehead, J P;
Humphreys, P;
Krook, A;
Jackson, R;
Hayward, A;
Lewis, H;
Siddle, K;
O'Rahilly, S

Publication type:

journal article

Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes.

Published in:

1998

By:

Digby, Janet E.;
Montague, Carl T.;
Sewter, Ciaran P.;
Sanders, Louise;
Wilkison, William O.;
O'Rahilly, Stephen;
Prins, Johannes B.;
Digby, J E;
Montague, C T;
Sewter, C P;
Sanders, L;
Wilkison, W O;
O'Rahilly, S;
Prins, J B

Publication type:

journal article

Tumor necrosis factor-alpha induces apoptosis of human adipose cells.

Published in:

1997

By:

Prins, J B;
Niesler, C U;
Winterford, C M;
Bright, N A;
Siddle, K;
O'Rahilly, S;
Walker, N I;
Cameron, D P

Publication type:

journal article

Excessive secretion of insulin precursors characterizes and predicts gestational diabetes.

Published in:

1995

By:

Swinn, Robert A.;
Wareham, Nicholas J.;
Gregory, Robert;
Curling, Victoria;
Clark, Penelope M.;
Dalton, Kevin J.;
Edwards, Owen M.;
O'Rahilly, Stephen;
Swinn, R A;
Wareham, N J;
Gregory, R;
Curling, V;
Clark, P M;
Dalton, K J;
Edwards, O M;
O'Rahilly, S

Publication type:

journal article

Molecular scanning of the insulin receptor gene in syndromes of insulin resistance.

Published in:

1994

By:

Krook, Anna;
Kumar, Sudhesh;
Laing, Ian;
Boulton, Andrew J. M.;
Wass, John A. H.;
O'Rahilly, Stephen;
Krook, A;
Kumar, S;
Laing, I;
Boulton, A J;
Wass, J A;
O'Rahilly, S

Publication type:

journal article

Availability of type II diabetic families for detection of diabetes susceptibility genes.

Published in:

1993

By:

Cook, Joanne T. E.;
Page, Renée C. L.;
O'Rahilly, Steven;
Levy, Jonathan;
Holman, Rury;
Barrow, Beryl;
Hattersley, Andrew T.;
Shaw, J. Andrew G.;
Wainscoat, James S.;
Turner, Robert C.;
Cook, J T;
Page, R C;
O'Rahilly, S;
Levy, J;
Holman, R;
Barrow, B;
Hattersley, A T;
Shaw, A G;
Wainscoat, J S;
Turner, R C

Publication type:

journal article

Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms.

Published in:

1991

By:

O'Rahilly, Stephen;
Choi, Woong H.;
Patel, Pushpa;
Turner, Robert C.;
Flier, Jeffrey S.;
Moller, David E.;
O'Rahilly, S;
Choi, W H;
Patel, P;
Turner, R C;
Flier, J S;
Moller, D E

Publication type:

journal article

Prenatal analysis of the insulin receptor gene in a family with leprechaunism.

Published in:

1995

By:

Krook, A.;
Bell, J. A.;
Robertson, M. E.;
Brueton, L.;
O'Rahilly, S.

Publication type:

journal article

Genetic factors in human obesity.

Published in:

Obesity Reviews, 2007, v. 8, p. 37, doi. 10.1111/j.1467-789X.2007.00315.x

By:

Farooqi, I. S.;
O'Rahilly, S.

Publication type:

Article

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

Published in:

Molecular Psychiatry, 2014, v. 19, n. 12, p. 1341, doi. 10.1038/mp.2014.126

By:

Ziauddeen, H;
Chamberlain, S R;
Nathan, P J;
Koch, A;
Maltby, K;
Bush, M;
Tao, W X;
Napolitano, A;
Skeggs, A L;
Brooke, A C;
Cheke, L;
Clayton, N S;
Sadaf Farooqi, I;
O'Rahilly, S;
Waterworth, D;
Song, K;
Hosking, L;
Richards, D B;
Fletcher, P C;
Bullmore, E T

Publication type:

Article

Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects.

Published in:

Molecular Psychiatry, 2013, v. 18, n. 12, p. 1287, doi. 10.1038/mp.2012.154

By:

Ziauddeen, H;
Chamberlain, S R;
Nathan, P J;
Koch, A;
Maltby, K;
Bush, M;
Tao, W X;
Napolitano, A;
Skeggs, A L;
Brooke, A C;
Cheke, L;
Clayton, N S;
Sadaf Farooqi, I;
O'Rahilly, S;
Waterworth, D;
Song, K;
Hosking, L;
Richards, D B;
Fletcher, P C;
Bullmore, E T

Publication type:

Article

Expression of the thermogenic nuclear hormone receptor coactivator PGC-1a is reduced in the adipose tissue of morbidly obese subjects.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2004, v. 28, n. 1, p. 176, doi. 10.1038/sj.ijo.0802482

By:

Semple, R.K.;
Crowley, V.C.;
Sewter, C.P.;
Laudes, M.;
Christodoulides, C.;
Considine, R.V.;
Vidal-Puig, A.;
O'Rahilly, S.

Publication type:

Article

Adipose depot-specific expression of cIAP2 in human preadipocytes and modulation of expression by serum factors and TNFα.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2001, v. 25, n. 7, p. 1027, doi. 10.1038/sj.ijo.0801649

By:

Niesler, C U;
Prins, J B;
O'Rahilly, S;
Siddle, K;
Montague, C T

Publication type:

Article

Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2001, v. 25, n. 4, p. 472, doi. 10.1038/sj.ijo.0801584

By:

Halsall, D J;
Luan, J;
Saker, P;
Huxtable, S;
Farooqi, I S;
Keogh, J;
Wareham, N J;
O'Rahilly, S

Publication type:

Article

Depot-related and thiazolidinedione-responsive expression of uncoupling protein 2 (UCP2) in human adipocytes.

Published in:

International Journal of Obesity & Related Metabolic Disorders, 2000, v. 24, n. 5, p. 585, doi. 10.1038/sj.ijo.0801201

By:

Digby, J E;
Crowley, V E F;
Sewter, C P;
Whitehead, J P;
Prins, J B;
O’Rahilly, S

Publication type:

Article

A classification of videoconferencing related illness: the Zoomnotic diseases.

Published in:

QJM: An International Journal of Medicine, 2021, v. 114, n. 3, p. 159, doi. 10.1093/qjmed/hcaa316

By:

Rowitch, D H;
O'Rahilly, S;
Smith, G C S

Publication type:

Article

Letter to Editor Response to: Is zoomnosis a human-driven human zoonosis? A call for action.

Published in:

QJM: An International Journal of Medicine, 2021, v. 114, n. 2, p. 143, doi. 10.1093/qjmed/hcab006

By:

Rowitch, D H;
O'Rahilly, S;
Smith, G C S

Publication type:

Article

Psychiatric co-morbidities in patients attending specialist obesity services in the UK.

Published in:

QJM: An International Journal of Medicine, 2006, v. 99, n. 5, p. 317, doi. 10.1093/qjmed/hcl041

By:

A. Tuthill;
H. Slawik;
S. O'Rahilly;
N. Finer

Publication type:

Article

Mechanistic insights into insulin resistance in the genetic era.

Published in:

Diabetic Medicine, 2011, v. 28, n. 12, p. 1476, doi. 10.1111/j.1464-5491.2011.03463.x

By:

Parker, V. E. R.;
Savage, D. B.;
O'Rahilly, S.;
Semple, R. K.

Publication type:

Article