Works by O'Neill, Luke A. J.

Results: 69

Outfoxing Foxo1 with miR-182.

Published in:

Nature Immunology, 2010, v. 11, n. 11, p. 983, doi. 10.1038/ni1110-983

By:

O'Neill, Luke A J

Publication type:

Article

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21.

Published in:

Nature Immunology, 2010, v. 11, n. 2, p. 141, doi. 10.1038/ni.1828

By:

Sheedy, Frederick J.;
Palsson-McDermott, Eva;
Hennessy, Elizabeth J.;
Martin, Cara;
O'Leary, John J.;
Qingguo Ruan;
Johnson, Derek S.;
Youhai Chen;
O'Neill, Luke A. J.

Publication type:

Article

The immune system as an invisible, silent Grand Fugue.

Published in:

2009

By:

O'Neill, Luke A. J.;
O'Farrelly, Cliona

Publication type:

Arts/Entertainment Review

TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88–independent TLR4 pathway.

Published in:

Nature Immunology, 2009, v. 10, n. 6, p. 579, doi. 10.1038/ni.1727

By:

Palsson-McDermott, Eva M;
Doyle, Sarah L;
McGettrick, Anne F;
Hardy, Matthew;
Husebye, Harald;
Banahan, Kathy;
Gong, Mei;
Golenbock, Douglas;
Espevik, Terje;
O'Neill, Luke A J

Publication type:

Article

'Fine tuning' TLR signaling.

Published in:

Nature Immunology, 2008, v. 9, n. 5, p. 459, doi. 10.1038/ni0508-459

By:

O'Neill, Luke A J

Publication type:

Article

DisSARMing Toll-like receptor signaling.

Published in:

Nature Immunology, 2006, v. 7, n. 10, p. 1023, doi. 10.1038/ni1006-1023

By:

O'Neill, Luke A. J.

Publication type:

Article

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.

Published in:

Nature Immunology, 2006, v. 7, n. 2, p. 148, doi. 10.1038/ni1299

By:

Mansell, Ashley;
Smith, Rosealee;
Doyle, Sarah L;
Gray, Pearl;
Fenner, Jennifer E;
Crack, Peter J;
Nicholson, Sandra E;
Hilton, Douglas J;
O'Neill, Luke A J;
Hertzog, Paul J

Publication type:

Article

How NOD-ing off leads to Crohn disease.

Published in:

Nature Immunology, 2004, v. 5, n. 8, p. 776, doi. 10.1038/ni0804-776

By:

O'Neill, Luke A. J.

Publication type:

Article

ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance.

Published in:

Nature Immunology, 2004, v. 5, n. 4, p. 373, doi. 10.1038/ni1050

By:

Brint, Elizabeth K.;
Damo Xu;
Liu, Haiying;
Dunne, Aisling;
McKenzie, Andrew N. J.;
O'Neill, Luke A. J.;
Liew, Foo Y.

Publication type:

Article

The Inflammasome in Atherosclerosis and Type 2 Diabetes.

Published in:

Science Translational Medicine, 2011, v. 3, n. 81, p. 1, doi. 10.1126/scitranslmed.3001902

By:

Masters, Seth L.;
Latz, Eicke;
O'Neill, Luke A. J.

Publication type:

Article

Stopping Sepsis by Targeting Sphingosine Kinase 1.

Published in:

Science Translational Medicine, 2010, v. 2, n. 36, p. 1, doi. 10.1126/scitranslmed.3001299

By:

O'Neill, Luke A. J.

Publication type:

Article

4-octyl itaconate reduces human NLRP3 inflammasome constitutive activation with the cryopyrin-associated periodic syndrome p.R262W, p.D305N and p.T350M variants.

Published in:

Cellular & Molecular Life Sciences, 2025, v. 82, n. 1, p. 1, doi. 10.1007/s00018-025-05699-5

By:

Molina-Lopez, Cristina;
Hurtado-Navarro, Laura;
O'Neill, Luke A. J.;
Pelegrin, Pablo

Publication type:

Article

NLRP3, the inflammasome and COVID-19 infection.

Published in:

QJM: An International Journal of Medicine, 2023, v. 116, n. 7, p. 502, doi. 10.1093/qjmed/hcad011

By:

Yin, Maureen;
Marrone, Laura;
Peace, Christian G;
O'Neill, Luke A J

Publication type:

Article

The role of the electron transport chain in immunity.

Published in:

FASEB Journal, 2021, v. 35, n. 12, p. 1, doi. 10.1096/fj.202101161R

By:

Yin, Maureen;
O'Neill, Luke A. J.

Publication type:

Article

C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.

Published in:

Cells (2073-4409), 2023, v. 12, n. 23, p. 2707, doi. 10.3390/cells12232707

By:

Wright, Oliver;
Harris, Anna;
Nguyen, Van Dien;
Zhou, You;
Durand, Maxim;
Jayyaratnam, Abbie;
Gormley, Darren;
O'Neill, Luke A. J.;
Triantafilou, Kathy;
Nichols, Eva Maria;
Booty, Lee M.

Publication type:

Article

An Emerging Role for Type I Interferons as Critical Regulators of Blood Coagulation.

Published in:

Cells (2073-4409), 2023, v. 12, n. 5, p. 778, doi. 10.3390/cells12050778

By:

Ryan, Tristram A. J.;
O'Neill, Luke A. J.

Publication type:

Article

ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-κB Acetylation.

Published in:

Cells (2073-4409), 2021, v. 10, n. 11, p. 2962, doi. 10.3390/cells10112962

By:

Santarsiero, Anna;
Convertini, Paolo;
Todisco, Simona;
Pierri, Ciro L.;
De Grassi, Anna;
Williams, Niamh C.;
Iacobazzi, Dominga;
De Stefano, Giulio;
O'Neill, Luke A. J.;
Infantino, Vittoria

Publication type:

Article

Metabolic reprograming in macrophage polarization.

Published in:

Frontiers in Immunology, 2014, v. 5, p. 1, doi. 10.3389/fimmu.2014.00420

By:

Galván-Peña, Silvia;
O'Neill, Luke A. J.

Publication type:

Article

How does interleukin-1 activate cells?

Published in:

Kidney International, 1992, v. 41, n. 3, p. 546, doi. 10.1038/ki.1992.78

By:

O'Neill, Luke A. J.

Publication type:

Article

Krebs cycle rewired for macrophage and dendritic cell effector functions.

Published in:

FEBS Letters, 2017, v. 591, n. 19, p. 2992, doi. 10.1002/1873-3468.12744

By:

Ryan, Dylan Gerard;
O'Neill, Luke A. J.

Publication type:

Article

Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Published in:

2017

By:

Kim, Richard Y.;
Pinkerton, James W.;
Essilfie, Ama T.;
Robertson, Avril A. B.;
Baines, Katherine J.;
Brown, Alexandra C.;
Mayall, Jemma R.;
Ali, M. Khadem;
Starkey, Malcolm R.;
Hansbro, Nicole G.;
Hirota, Jeremy A.;
Wood, Lisa G.;
Simpson, Jodie L.;
Knight, Darryl A.;
Wark, Peter A.;
Gibson, Peter G.;
O'Neill, Luke A. J.;
Cooper, Matthew A.;
Horvat, Jay C.;
Hansbro, Philip M.

Publication type:

journal article

HIF1α and metabolic reprogramming in inflammation.

Published in:

2016

By:

Corcoran, Sarah E.;
O'Neill, Luke A. J.

Publication type:

journal article

The history of Toll-like receptors - redefining innate immunity.

Published in:

Nature Reviews Immunology, 2013, v. 13, n. 6, p. 453, doi. 10.1038/nri3446

By:

O'Neill, Luke A. J.;
Golenbock, Douglas;
Bowie, Andrew G.

Publication type:

Article

A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation.

Published in:

Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.00141

By:

Williams, Niamh C.;
O’Neill, Luke A. J.

Publication type:

Article

Metabolic Reprogramming in Stromal and Immune Cells in Rheumatoid Arthritis and Osteoarthritis: Therapeutic Possibilities.

Published in:

European Journal of Immunology, 2025, v. 55, n. 4, p. 1, doi. 10.1002/eji.202451381

By:

Henry, Órlaith C.;
O'Neill, Luke A. J.

Publication type:

Article

Innate immune signaling and immunothrombosis: New insights and therapeutic opportunities.

Published in:

European Journal of Immunology, 2022, v. 52, n. 7, p. 1024, doi. 10.1002/eji.202149410

By:

Ryan, Tristram A. J.;
O'Neill, Luke A. J.

Publication type:

Article

Toll-like receptors: key activators of leucocytes and regulator of haematopoiesis.

Published in:

British Journal of Haematology, 2007, v. 139, n. 2, p. 185, doi. 10.1111/j.1365-2141.2007.06802.x

By:

McGettrick, Anne F.;
O'Neill, Luke A. J.

Publication type:

Article

Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy.

Published in:

Frontiers in Drug Discovery, 2023, p. 1, doi. 10.3389/fddsv.2023.1294454

By:

Yukun Min;
O’Neill, Luke A. J.

Publication type:

Article

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling.

Published in:

Nature Reviews Immunology, 2007, v. 7, n. 5, p. 353, doi. 10.1038/nri2079

By:

O'Neill, Luke A. J.;
Bowie, Andrew G.

Publication type:

Article

Negative regulation of toll-like receptor-mediated immune responses.

Published in:

2005

By:

Liew, Foo Y.;
Xu, Damo;
Brint, Elizabeth K.;
O'Neill, Luke A. J.

Publication type:

journal article

Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models.

Published in:

Frontiers in Immunology, 2025, p. 1, doi. 10.3389/fimmu.2025.1544973

By:

Drzewicka, Katarzyna;
Głuchowska, Katarzyna M.;
Mlącki, Michal;
Hofman, Bartłomiej;
Tuszyńska, Irina;
Ryan, Tristram A. J.;
Piwowar, Katarzyna;
Wilczyński, Bartosz;
Dymkowska, Dorota;
Grzybowski, Marcin M.;
Dymek, Barbara;
Rejczak, Tomasz;
Lisiecki, Kamil;
Gołębiowski, Adam;
Jagielski, Adam;
Muchowicz, Angelika;
Ryan, Dylan;
Zabłocki, Krzysztof;
O'Neill, Luke A. J.;
Zasłona, Zbigniew

Publication type:

Article

How important are Toll-like receptors for antimicrobial responses?

Published in:

Cellular Microbiology, 2007, v. 9, n. 8, p. 1891, doi. 10.1111/j.1462-5822.2007.00965.x

By:

Carpenter, Susan;
O'Neill, Luke A. J.

Publication type:

Article

A novel function of InlB from Listeria monocytogenes: activation of NF-κB in J774 macrophages.

Published in:

Cellular Microbiology, 2000, v. 2, n. 2, p. 127, doi. 10.1046/j.1462-5822.2000.00038.x

By:

Mansell, Ashley;
Braun, Laurence;
Cossart, Pascale;
O'neill, Luke A. J.

Publication type:

Article

The Warburg effect then and now: From cancer to inflammatory diseases.

Published in:

BioEssays, 2013, v. 35, n. 11, p. 965, doi. 10.1002/bies.201300084

By:

Palsson‐McDermott, Eva M.;
O'Neill, Luke A. J.

Publication type:

Article

Daily variation in macrophage phagocytosis is clock‐independent and dispensable for cytokine production.

Published in:

Immunology, 2019, v. 157, n. 2, p. 122, doi. 10.1111/imm.13053

By:

Geiger, Sarah S.;
Curtis, Annie M.;
O'Neill, Luke A. J.;
Siegel, Richard M.

Publication type:

Article

Innate immune memory: a paradigm shift in understanding host defense.

Published in:

Nature Immunology, 2015, v. 16, n. 7, p. 675, doi. 10.1038/ni.3178

By:

Netea, Mihai G;
Latz, Eicke;
Mills, Kingston H G;
O'Neill, Luke A J

Publication type:

Article

Glycolytic reprogramming by TLRs in dendritic cells.

Published in:

Nature Immunology, 2014, v. 15, n. 4, p. 314, doi. 10.1038/ni.2852

By:

O'Neill, Luke A J

Publication type:

Article

Genetic variation in Toll-like receptors and disease susceptibility.

Published in:

Nature Immunology, 2012, v. 13, n. 6, p. 535, doi. 10.1038/ni.2284

By:

Netea, Mihai G;
Wijmenga, Cisca;
O'Neill, Luke A J

Publication type:

Article

A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?

Published in:

Nature Immunology, 2012, v. 13, n. 4, p. 352, doi. 10.1038/ni.2228

By:

Wen, Haitao;
Ting, Jenny P-Y;
O'Neill, Luke A J

Publication type:

Article

Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.

Published in:

Journal of Crohn's & Colitis, 2018, v. 12, n. 7, p. 835, doi. 10.1093/ecco-jcc/jjy038

By:

Johnston, Daniel G. W.;
Williams, Michelle A.;
Thaiss, Christoph A.;
Cabrera-Rubio, Raul;
Raverdeau, Mathilde;
McEntee, Craig;
Cotter, Paul D.;
Elinav, Eran;
O'Neill, Luke A. J.;
Corr, Sinéad C.

Publication type:

Article

Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4.

Published in:

Immunology, 2004, v. 113, n. 2, p. 153, doi. 10.1111/j.1365-2567.2004.01976.x

By:

Pålsson-McDermott, Eva M.;
O'Neill, Luke A. J.

Publication type:

Article

Endothelin-1 Increases Arachidonic Acid Release in C6 Glioma Cells Through a Potassium-Modulated Influx of Calcium.

Published in:

Journal of Neurochemistry, 1996, v. 67, n. 2, p. 830, doi. 10.1046/j.1471-4159.1996.67020830.x

By:

Dunica, Dara J.;
Griffiths, Roger;
Williams, D. Clive;
O'Neill, Luke A. J.

Publication type:

Article

Metabolic regulation of type I interferon production.

Published in:

Immunological Reviews, 2024, v. 323, n. 1, p. 276, doi. 10.1111/imr.13318

By:

O'Carroll, Shane M.;
Henkel, Fiona D. R.;
O'Neill, Luke A. J.

Publication type:

Article

Metabolic regulation of NLRP3.

Published in:

Immunological Reviews, 2018, v. 281, n. 1, p. 88, doi. 10.1111/imr.12608

By:

Hughes, Mark M.;
O'Neill, Luke A. J.

Publication type:

Article

NLRP3 at the interface of metabolism and inflammation.

Published in:

Immunological Reviews, 2015, v. 265, n. 1, p. 53, doi. 10.1111/imr.12285

By:

Haneklaus, Moritz;
O'Neill, Luke A. J.

Publication type:

Article

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress.

Published in:

Immunological Reviews, 2008, v. 226, n. 1, p. 10, doi. 10.1111/j.1600-065X.2008.00701.x

By:

O'Neill, Luke A. J.

Publication type:

Article

Listeria monocytogenes infection in the face of innate immunity.

Published in:

Cellular Microbiology, 2009, v. 11, n. 5, p. 703, doi. 10.1111/j.1462-5822.2009.01294.x

By:

Corr, Sinead C.;
O'Neill, Luke A. J.

Publication type:

Article

Loss of the molecular clock in myeloid cells exacerbates T cell-mediated CNS autoimmune disease.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02111-0

By:

Sutton, Caroline E.;
Finlay, Conor M.;
Raverdeau, Mathilde;
DeCourcey, Joseph;
Mills, Kingston H. G.;
Zaslona, Zbigniew;
O'Neill, Luke A. J.;
Early, James O.;
Curtis, Annie M.

Publication type:

Article

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.

Published in:

Nature Medicine, 2012, v. 18, n. 5, p. 791, doi. 10.1038/nm.2717

By:

Doyle, Sarah L;
Campbell, Matthew;
Ozaki, Ema;
Salomon, Robert G;
Mori, Andres;
Kenna, Paul F;
Farrar, Gwyneth Jane;
Kiang, Anna-Sophia;
Humphries, Marian M;
Lavelle, Ed C;
O'Neill, Luke A J;
Hollyfield, Joe G;
Humphries, Peter

Publication type:

Article

Bacteria fight back against Toll-like receptors.

Published in:

Nature Medicine, 2008, v. 14, n. 4, p. 370, doi. 10.1038/nm0408-370

By:

O'Neill, Luke A. J.

Publication type:

Article