Works by O'Neill, Alex J.

Results: 30

Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections.

Published in:

Nature Reviews Microbiology, 2011, v. 9, n. 1, p. 62, doi. 10.1038/nrmicro2474

By:

Hurdle, Julian G.;
O'Neill, Alex J.;
Chopra, Ian;
Lee, Richard E.

Publication type:

Article

Potential for repurposing the personal care product preservatives bronopol and bronidox as broad-spectrum antibiofilm agents for topical application.

Published in:

2019

By:

Lee, Victoria E;
O'Neill, Alex J

Publication type:

journal article

Cryptic silver resistance is prevalent and readily activated in certain Gram-negative pathogens.

Published in:

2017

By:

Elkrewi, Elham;
Randall, Christopher P.;
O'Neill, Alex J.;
Ooi, Nicola;
Cottell, Jennifer L.

Publication type:

journal article

Silver resistance in Gram-negative bacteria: a dissection of endogenous and exogenous mechanisms.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2015, v. 70, n. 4, p. 1037, doi. 10.1093/jac/dku523

By:

Randall, Christopher P.;
Gupta, Arya;
Jackson, Nicole;
Busse, David;
O'Neill, Alex J.

Publication type:

Article

The silver cation (Ag+): antistaphylococcal activity, mode of action and resistance studies.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 1, p. 131, doi. 10.1093/jac/dks372

By:

Randall, Christopher P.;
Oyama, Linda B.;
Bostock, Julieanne M.;
Chopra, Ian;
O'Neill, Alex J.

Publication type:

Article

Transposon library screening for identification of genetic loci participating in intrinsic susceptibility and acquired resistance to antistaphylococcal agents.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2013, v. 68, n. 1, p. 12, doi. 10.1093/jac/dks373

By:

Blake, Katy L.;
O'Neill, Alex J.

Publication type:

Article

In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2005, v. 56, n. 6, p. 1166, doi. 10.1093/jac/dki387

By:

Julian G. Hurdle;
Alex J. O'Neill;
Lona Mody;
Ian Chopra;
Suzanne F. Bradley

Publication type:

Article

The isoleucyl-tRNA synthetase mutation V588F conferring mupirocin resistance in glycopeptide-intermediate Staphylococcus aureus is not associated with a significant fitness burden.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2004, v. 53, n. 1, p. 102

By:

Julian G. Hurdle;
Alex J. O'Neill;
Ian Chopra

Publication type:

Article

Mutation frequencies for resistance to fusidic acid and rifampicin in Staphylococcus aureus.

Published in:

2001

By:

O'Neill, Alex J.;
Cove, Jonathan H.;
Chopra, Ian;
O'Neill, A J;
Cove, J H;
Chopra, I

Publication type:

journal article

Population Diversification in <i>Staphylococcus aureus</i> Biofilms May Promote Dissemination and Persistence.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0062513

By:

Savage, Victoria J.;
Chopra, Ian;
O’Neill, Alex J.

Publication type:

Article

Increased Mutability of Staphylococci in Biofilms as a Consequence of Oxidative Stress.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047695

By:

Ryder, Victoria J.;
Chopra, Ian;
O'Neill, Alex J.

Publication type:

Article

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0039922

By:

Škedelj, Veronika;
Arsovska, Emilija;
Tomašić, Tihomir;
Kroflič, Ana;
Hodnik, Vesna;
Hrast, Martina;
Bešter-Rogač, Marija;
Anderluh, Gregor;
Gobec, Stanislav;
Bostock, Julieanne;
Chopra, Ian;
O'Neill, Alex J.;
Randall, Christopher;
Zega, Anamarija;
Cascales, Eric

Publication type:

Article

The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors.

Published in:

Molecular Microbiology, 2009, v. 72, n. 2, p. 335, doi. 10.1111/j.1365-2958.2009.06648.x

By:

Blake, Katy L.;
O'Neill, Alex J.;
Mengin-Lecreulx, Dominique;
Henderson, Peter J. F.;
Bostock, Julieanne M.;
Dunsmore, Colin J.;
Simmons, Katie J.;
Fishwick, Colin W. G.;
Leeds, Jennifer A.;
Chopra, Ian

Publication type:

Article

A target-protection mechanism of antibiotic resistance at atomic resolution: insights into FusB-type fusidic acid resistance.

Published in:

Scientific Reports, 2016, p. 19524, doi. 10.1038/srep19524

By:

Tomlinson, Jennifer H.;
Thompson, Gary S.;
Kalverda, Arnout P.;
Zhuravleva, Anastasia;
O'Neill, Alex J.

Publication type:

Article

The native ABC-F proteins of Staphylococcus aureus do not contribute to intrinsic resistance against ribosome-targeting antibacterial drugs.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 10, p. 2601, doi. 10.1093/jac/dkad238

By:

Galarion, Luiza H;
Trigwell, James;
Mohamad, Merianne;
Nakamoto, Jose A;
Clarke, Justin E;
Atkinson, Gemma C;
O'Neill, Alex J

Publication type:

Article

Resistance to antibacterial antifolates in multidrug-resistant Staphylococcus aureus: prevalence estimates and genetic basis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 5, p. 1201, doi. 10.1093/jac/dkad063

By:

Kime, Louise;
Waring, Tina;
Mohamad, Merianne;
Mann, Benjamin F;
O'Neill, Alex J

Publication type:

Article

An extensively validated whole-cell biosensor for specific, sensitive and high-throughput detection of antibacterial inhibitors targeting cell-wall biosynthesis.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 3, p. 646, doi. 10.1093/jac/dkac429

By:

Galarion, Luiza H;
Mitchell, Jennifer K;
Randall, Christopher P;
O'Neill, Alex J

Publication type:

Article

Comment on: Identification of a novel tedizolid resistance mutation in rpoB of MRSA after in vitro serial passage.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2023, v. 78, n. 1, p. 317, doi. 10.1093/jac/dkac397

By:

Galarion, Luiza H;
Clarke, Justin E;
Schofield, Harry;
O'Neill, Alex J

Publication type:

Article

Creating a framework to align antimicrobial resistance (AMR) research with the global guidance: a viewpoint.

Published in:

2022

By:

Mitchell, Jessica;
O'Neill, Alex J;
King, Rebecca

Publication type:

journal article

A platform for detecting cross-resistance in antibacterial drug discovery.

Published in:

2021

By:

Galarion, Luiza H;
Mohamad, Merianne;
Alzeyadi, Zeyad;
Randall, Christopher P;
O'Neill, Alex J

Publication type:

journal article

An Engineered Escherichia coli Community for Studying Quorum Sensing.

Published in:

SynBio, 2023, v. 1, n. 2, p. 144, doi. 10.3390/synbio1020010

By:

Li, Yuwei;
Clarke, Justin E.;
O'Neill, Alex J.;
Goycoolea, Francisco M.;
Smith, James

Publication type:

Article

Structural basis of ABCF-mediated resistance to pleuromutilin, lincosamide, and streptogramin A antibiotics in Gram-positive pathogens.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23753-1

By:

Crowe-McAuliffe, Caillan;
Murina, Victoriia;
Turnbull, Kathryn Jane;
Kasari, Marje;
Mohamad, Merianne;
Polte, Christine;
Takada, Hiraku;
Vaitkevicius, Karolis;
Johansson, Jörgen;
Ignatova, Zoya;
Atkinson, Gemma C.;
O'Neill, Alex J.;
Hauryliuk, Vasili;
Wilson, Daniel N.

Publication type:

Article

Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of MSD-819 (6-chloro-2-quinoxalinecarboxylic acid 1,4-dioxide).

Published in:

Journal of Antibiotics, 2017, v. 70, n. 3, p. 317, doi. 10.1038/ja.2016.140

By:

Ooi, Nicola;
O'Neill, Alex J

Publication type:

Article

Mechanistic investigation into antibacterial behaviour of suspensions of ZnO nanoparticles against E. coli.

Published in:

Journal of Nanoparticle Research, 2010, v. 12, n. 5, p. 1625, doi. 10.1007/s11051-009-9711-1

By:

Lingling Zhang;
Yunhong Jiang;
Ding, Yulong;
Daskalakis, Nikolaos;
Jeuken, Lars;
Povey, Malcolm;
O'Neill, Alex J.;
York, David W.

Publication type:

Article

Rotating wall vessel exposure alters protein secretion and global gene expression in Staphylococcus aureus.

Published in:

International Journal of Astrobiology, 2012, v. 11, n. 2, p. 71, doi. 10.1017/S1473550411000346

By:

Rosado, Helena;
O'Neill, Alex J.;
Blake, Katy L.;
Walther, Meik;
Long, Paul F.;
Hinds, Jason;
Taylor, Peter W.

Publication type:

Article

Epistasis analysis uncovers hidden antibiotic resistance-associated fitness costs hampering the evolution of MRSA.

Published in:

Genome Biology, 2018, v. 19, n. 1, p. 1, doi. 10.1186/s13059-018-1469-2

By:

Maho Yokoyama;
Stevens, Emily;
Laabei, Maisem;
Bacon, Leann;
Heesom, Kate;
Bayliss, Sion;
Ooi, Nicola;
O’Neill, Alex J.;
Murray, Ewan;
Williams, Paul;
Lubben, Anneke;
Reeksting, Shaun;
Meric, Guillaume;
Pascoe, Ben;
Sheppard, Samuel K.;
Recker, Mario;
Hurst, Laurence D.;
Massey, Ruth C.

Publication type:

Article

1-((2,4-Dichlorophenethyl)Amino)-3-Phenoxypropan-2-ol Kills Pseudomonas aeruginosa through Extensive Membrane Damage.

Published in:

Frontiers in Microbiology, 2018, p. 1, doi. 10.3389/fmicb.2018.00129

By:

Defraine, Valerie;
Liebens, Veerle;
Loos, Evelien;
Swings, Toon;
Weytjens, Bram;
Fierro, Carolina;
Marchal, Kathleen;
Sharkey, Liam;
O’Neill, Alex J.;
Corbau, Romu;
Marchand, Arnaud;
Chaltin, Patrick;
Fauvart, Maarten;
Michiels, Jan

Publication type:

Article

Sal-type ABC-F proteins: intrinsic and common mediators of pleuromutilin resistance by target protection in staphylococci.

Published in:

Nucleic Acids Research, 2022, v. 50, n. 4, p. 2128, doi. 10.1093/nar/gkac058

By:

Mohamad, Merianne;
Nicholson, David;
Saha, Chayan Kumar;
Hauryliuk, Vasili;
Edwards, Thomas A;
Atkinson, Gemma C;
Ranson, Neil A;
O'Neill, Alex J

Publication type:

Article

Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa.

Published in:

PLoS ONE, 2016, v. 11, n. 5, p. 1, doi. 10.1371/journal.pone.0155139

By:

Gerits, Evelien;
Blommaert, Eline;
Lippell, Anna;
O’Neill, Alex J.;
Weytjens, Bram;
De Maeyer, Dries;
Fierro, Ana Carolina;
Marchal, Kathleen;
Marchand, Arnaud;
Chaltin, Patrick;
Spincemaille, Pieter;
De Brucker, Katrijn;
Thevissen, Karin;
Cammue, Bruno P. A.;
Swings, Toon;
Liebens, Veerle;
Fauvart, Maarten;
Verstraeten, Natalie;
Michiels, Jan

Publication type:

Article

Impaired Alanine Transport or Exposure to d-Cycloserine Increases the Susceptibility of MRSA to β-lactam Antibiotics.

Published in:

2020

By:

Gallagher, Laura A;
Shears, Rebecca K;
Fingleton, Claire;
Alvarez, Laura;
Waters, Elaine M;
Clarke, Jenny;
Bricio-Moreno, Laura;
Campbell, Christopher;
Yadav, Akhilesh K;
Razvi, Fareha;
O'Neill, Eoghan;
O'Neill, Alex J;
Cava, Felipe;
Fey, Paul D;
Kadioglu, Aras;
O'gara, James P

Publication type:

journal article