Works by O'Kane, Cahir J.

Results: 40

Hereditary spastic paraplegias: membrane traffic and the motor pathway.

Published in:

2011

By:

Blackstone, Craig;
O'Kane, Cahir J.;
Reid, Evan

Publication type:

journal article

Hereditary spastic paraplegias: membrane traffic and the motor pathway.

Published in:

Nature Reviews Neuroscience, 2011, v. 12, n. 2, p. 118, doi. 10.1038/nrn2990

By:

Blackstone, Craig;
O'Kane, Cahir J.;
Reid, Evan

Publication type:

Article

Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. 1, doi. 10.3389/fnins.2020.00048

By:

Öztürk, Zeynep;
O'Kane, Cahir J.;
Pérez-Moreno, Juan José

Publication type:

Article

Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation.

Published in:

Journal of Cell Biology, 2003, v. 160, n. 6, p. 899, doi. 10.1083/jcb.200208180

By:

Liu, Hongjun;
Mardahl-Dumesnil, Michelle;
Sweeney, Sean T.;
O'Kane, Cahir J.;
Bernstein, Sanford I.

Publication type:

Article

Lysosomal positioning coordinates cellular nutrient responses.

Published in:

Nature Cell Biology, 2011, v. 13, n. 4, p. 453, doi. 10.1038/ncb2204

By:

Korolchuk, Viktor I.;
Saiki, Shinji;
Lichtenberg, Maike;
Siddiqi, Farah H.;
Roberts, Esteban A.;
Imarisio, Sara;
Jahreiss, Luca;
Sarkar, Sovan;
Futter, Marie;
Menzies, Fiona M.;
O'Kane, Cahir J.;
Deretic, Vojo;
Rubinsztein, David C.

Publication type:

Article

Dynein mutations impair autophagic clearance of aggregate-prone proteins.

Published in:

Nature Genetics, 2005, v. 37, n. 7, p. 771, doi. 10.1038/ng1591

By:

Ravikumar, Brinda;
Acevedo-Arozena, Abraham;
Imarisio, Sara;
Berger, Zdenek;
Vacher, Coralie;
O'Kane, Cahir J.;
Brown, Steve D. M.;
Rubinsztein, David C.

Publication type:

Article

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Published in:

Nature Genetics, 2004, v. 36, n. 6, p. 585, doi. 10.1038/ng1362

By:

Ravikumar, Brinda;
Vacher, Coralie;
Berger, Zdenek;
Davies, Janet E.;
Luo, Shouqing;
Oroz, Lourdes G.;
Scaravilli, Francesco;
Easton, Douglas F.;
Duden, Rainer;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

The DrosDel Collection: A Set of P-Element Insertions for Generating Custom Chromosomal Aberrations in Drosophila melanogaster.

Published in:

Genetics, 2004, v. 167, n. 2, p. 797, doi. 10.1534/genetics.104.026658

By:

Ryder, Edward;
Blows, Fiona;
Ashburner, Michael;
Bautista-Llacer, Rosa;
Coulson, Darin;
Drummond, Jenny;
Webster, Jane;
Gubb, David;
Gunton, Nicola;
Johnson, Glynnis;
O'Kane, Cahir J.;
Huen, David;
Sharma, Punita;
Asztalos, Zoltan;
Baisch, Heiko;
Schulze, Janet;
Kube, Maria;
Kittlasu, Kathrin;
Reuter, Gunter;
Maroy, Peter

Publication type:

Article

How neurons maintain their axons long-term: an integrated view of axon biology and pathology.

Published in:

Frontiers in Neuroscience, 2023, p. 1, doi. 10.3389/fnins.2023.1236815

By:

Smith, Gaynor;
Sweeney, Sean T.;
O'Kane, Cahir J.;
Prokop, Andreas

Publication type:

Article

Cell ablation using wild-type and cold-sensitive ricin-a chain in drosophila embryonic mesoderm.

Published in:

Genesis: The Journal of Genetics & Development, 2002, v. 34, n. 1/2, p. 132, doi. 10.1002/gene.10129

By:

Allen, Marcus J.;
O'Kane, Cahir J.;
Moffat, Kevin G.

Publication type:

Article

Rev-GFP transgenic lines for studies of nucleocytoplasmic transport in drosophila.

Published in:

Genesis: The Journal of Genetics & Development, 2002, v. 34, n. 1/2, p. 139, doi. 10.1002/gene.10121

By:

Chan, H.Y. Edwin;
Tung, Christine K.C.;
O'Kane, Cahir J.

Publication type:

Article

α-Synuclein impairs macroautophagy: implications for Parkinson's disease.

Published in:

Journal of Cell Biology, 2010, v. 190, n. 6, p. 1023, doi. 10.1083/jcb.201003122

By:

Winslow, Ashley R.;
Chen, Chien-Wen;
Corrochano, Silvia;
Acevedo-Arozena, Abraham;
Gordon, David E.;
Peden, Andrew A.;
Lichtenberg, Maike;
Menzies, Fiona M.;
Ravikumar, Brinda;
Imarisio, Sara;
Brown, Steve;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Rhabdomere biogenesis in Drosophila photoreceptors is acutely sensitive to phosphatidic acid levels.

Published in:

Journal of Cell Biology, 2009, v. 185, n. 1, p. 129, doi. 10.1083/jcb.200807027

By:

Raghu, Padinjat;
Coessens, Elise;
Manifava, Maria;
Georgiev, Plamen;
Pettitt, Trevor;
Wood, Eleanor;
Garcia-Murillas, Isaac;
Okkenhaug, Hanneke;
Trivedi, Deepti;
Qifeng Zhang;
Razzaq, Azam;
Zaid, Ola;
Wakelam, Michael;
O'Kane, Cahir J.;
Ktistakis, Nicholas

Publication type:

Article

Eps 15 and Dap 160 control synaptic vesicle membrane retrieval and synapse development.

Published in:

Journal of Cell Biology, 2007, v. 178, n. 2, p. 309, doi. 10.1083/jcb.200701030

By:

Koh, Tong-Wey;
Venken, Koen J. T.;
Pan, Hongling;
Zhou, Yi;
Bellen, Hugo J.;
Korolchuk, Viktor I.;
Wairkar, Yogesh P.;
O'Kane, Cahir J.;
Jiao, Wei;
Evergren, Emma;
Shupliakov, Oleg;
Robinson, Iain M.

Publication type:

Article

GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila.

Published in:

G3: Genes | Genomes | Genetics, 2019, v. 9, n. 2, p. 453, doi. 10.1534/g3.118.200809

By:

Pérez-Moreno, Juan J.;
O'Kane, Cahir J.

Publication type:

Article

Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca<sup>2+</sup> dynamics.

Published in:

Journal of Cell Biology, 2023, v. 222, n. 6, p. 1, doi. 10.1083/jcb.202112101

By:

José Pérez-Moreno, Juan;
Smith, Rebecca C.;
Oliva, Megan K.;
Gallo, Filomena;
Ojha, Shainy;
Müller, Karin H.;
O'Kane, Cahir J.

Publication type:

Article

Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules.

Published in:

Nature Neuroscience, 2007, v. 10, n. 2, p. 177, doi. 10.1038/nn1841

By:

Xinnan Wang;
Shaw, W. Robert;
Tsang, Hilda T. H.;
Reid, Evan;
O'Kane, Cahir J.

Publication type:

Article

CCT complex restricts neuropathogenic protein aggregation via autophagy.

Published in:

Nature Communications, 2016, v. 7, n. 12, p. 13821, doi. 10.1038/ncomms13821

By:

Pavel, Mariana;
Imarisio, Sara;
Menzies, Fiona M.;
Jimenez-Sanchez, Maria;
Siddiqi, Farah H.;
Wu, Xiaoting;
Renna, Maurizio;
O'Kane, Cahir J.;
Crowther, Damian C.;
Rubinsztein, David C.

Publication type:

Article

Corrigendum: PICALM modulates autophagy activity and tau accumulation.

Published in:

Nature Communications, 2015, v. 6, n. 1, p. 6110, doi. 10.1038/ncomms7110

By:

Moreau, Kevin;
Fleming, Angeleen;
Imarisio, Sara;
Lopez Ramirez, Ana;
Mercer, Jacob L.;
Jimenez-Sanchez, Maria;
Bento, Carla F.;
Puri, Claudia;
Zavodszky, Eszter;
Siddiqi, Farah;
Lavau, Catherine P.;
Betton, Maureen;
O'Kane, Cahir J.;
Wechsler, Daniel S.;
Rubinsztein, David C.

Publication type:

Article

PICALM modulates autophagy activity and tau accumulation.

Published in:

Nature Communications, 2014, v. 5, n. 9, p. 4998, doi. 10.1038/ncomms5998

By:

Moreau, Kevin;
Fleming, Angeleen;
Imarisio, Sara;
Lopez Ramirez, Ana;
Mercer, Jacob L.;
Jimenez-Sanchez, Maria;
Bento, Carla F.;
Puri, Claudia;
Zavodszky, Eszter;
Siddiqi, Farah;
Lavau, Catherine P.;
Betton, Maureen;
O'Kane, Cahir J.;
Wechsler, Daniel S.;
Rubinsztein, David C.

Publication type:

Article

Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larval Drosophila.

Published in:

Frontiers in Physiology, 2023, p. 1, doi. 10.3389/fphys.2023.1111244

By:

Mohamed, Abdulkadir;
Malekou, Iro;
Sim, Timothy;
O’Kane, Cahir J.;
Maait, Yousef;
Scullion, Benjamin;
Masuda-Nakagawa, Liria M.

Publication type:

Article

Virtual Fly Brain--An interactive atlas of the Drosophila nervous system.

Published in:

Frontiers in Physiology, 2023, v. 14, p. 1, doi. 10.3389/fphys.2023.1076533

By:

Court, Robert;
Costa, Marta;
Pilgrim, Clare;
Millburn, Gillian;
Holmes, Alex;
McLachlan, Alex;
Larkin, Aoife;
Matentzoglu, Nicolas;
Kir, Huseyin;
Parkinson, Helen;
Brown, Nicolas H.;
O'Kane, Cahir J.;
Armstrong, J. Douglas;
Jefferis, Gregory S. X. E.;
Osumi-Sutherland, David

Publication type:

Article

Editorial: Hereditary Spastic Paraplegias: At the Crossroads of Molecular Pathways and Clinical Options.

Published in:

2021

By:

Martinuzzi, Andrea;
Blackstone, Craig;
O'Kane, Cahir J.;
Stevanin, Giovanni

Publication type:

Editorial

Endoplasmic Reticulum Lumenal Indicators in Drosophila Reveal Effects of HSP-Related Mutations on Endoplasmic Reticulum Calcium Dynamics.

Published in:

Frontiers in Neuroscience, 2020, v. 14, p. N.PAG, doi. 10.3389/fnins.2020.00816

By:

Oliva, Megan K.;
Pérez-Moreno, Juan José;
O'Shaughnessy, Jillian;
Wardill, Trevor J.;
O'Kane, Cahir J.

Publication type:

Article

Reticulon-like-1, the Drosophila orthologue of the Hereditary Spastic Paraplegia gene reticulon 2, is required for organization of endoplasmic reticulum and of distal motor axons.

Published in:

Human Molecular Genetics, 2012, v. 21, n. 15, p. 3356, doi. 10.1093/hmg/dds167

By:

O'Sullivan, Niamh C.;
Jahn, Thomas R.;
Reid, Evan;
O'Kane, Cahir J.

Publication type:

Article

Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease.

Published in:

Human Molecular Genetics, 2010, v. 19, n. 17, p. 3413, doi. 10.1093/hmg/ddq253

By:

Underwood, Benjamin R.;
Imarisio, Sara;
Fleming, Angeleen;
Rose, Claudia;
Krishna, Gauri;
Heard, Phoebe;
Quick, Marie;
Korolchuk, Viktor I.;
Renna, Maurizio;
Sarkar, Sovan;
García-Arencibia, Moisés;
O'Kane, Cahir J.;
Murphy, Michael P.;
Rubinsztein, David C.

Publication type:

Article

The hereditary spastic paraplegia proteins NIPA1, spastin and spartin are inhibitors of mammalian BMP signalling.

Published in:

Human Molecular Genetics, 2009, v. 18, n. 20, p. 3805, doi. 10.1093/hmg/ddp324

By:

Tsang, Hilda T.H.;
Edwards, Thomas L.;
Wang, Xinnan;
Connell, James W.;
Davies, Rachel J.;
Durrington, Hannah J.;
O'Kane, Cahir J.;
Luzio, J. Paul;
Reid, Evan

Publication type:

Article

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

Published in:

Human Molecular Genetics, 2008, v. 17, n. 2, p. 170, doi. 10.1093/hmg/ddm294

By:

Sarkar, Sovan;
Krishna, Gauri;
Imarisio, Sara;
Saiki, Shinji;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Variation in the Structure of Bird Nests between Northern Manitoba and Southeastern Ontario.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019087

By:

Rocha, João J. E.;
Korolchuk, Viktor I.;
Robinson, Iain M.;
O'Kane, Cahir J.

Publication type:

Article

Network Adaptation Improves Temporal Representation of Naturalistic Stimuli in Drosophila Eye: I Dynamics.

Published in:

PLoS ONE, 2009, v. 4, n. 1, p. 1, doi. 10.1371/journal.pone.0004307

By:

Lei Zheng;
Nikolaev, Anton;
Wardill, Trevor J.;
O'Kane, Cahir J.;
de Polavieja, Gonzalo G.;
Juusola, Mikko

Publication type:

Article

Network Adaptation Improves Temporal Representation of Naturalistic Stimuli in Drosophila Eye: II Mechanisms.

Published in:

PLoS ONE, 2009, v. 4, n. 1, p. 1, doi. 10.1371/journal.pone.0004306

By:

Nikolaev, Anton;
Lei Zheng;
Wardill, Trevor J.;
O'Kane, Cahir J.;
de Polavieja, Gonzalo G.;
Juusola, Mikko

Publication type:

Article

Rapamycin pre-treatment protects against apoptosis.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 7, p. 1209, doi. 10.1093/hmg/ddl036

By:

Ravikumar, Brinda;
Berger, Zdenek;
Vacher, Coralie;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Deleterious and protective properties of an aggregate-prone protein with a polyalanine expansion.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 3, p. 453, doi. 10.1093/hmg/ddi460

By:

Berger, Zdenek;
Davies, Janet E.;
Luo, Shouqing;
Pasco, Matthieu Y.;
Majoul, Irina;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Rapamycin alleviates toxicity of different aggregate-prone proteins.

Published in:

Human Molecular Genetics, 2006, v. 15, n. 3, p. 433, doi. 10.1093/hmg/ddi458

By:

Berger, Zdenek;
Ravikumar, Brinda;
Menzies, Fiona M.;
Oroz, Lourdes Garcia;
Underwood, Benjamin R.;
Pangalos, Menelas N.;
Schmitt, Ina;
Wullner, Ullrich;
Evert, Bernd O.;
O'Kane, Cahir J.;
Rubinsztein, David C.

Publication type:

Article

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 20, p. 3003, doi. 10.1093/hmg/ddi331

By:

Berger, Zdenek;
Ttofi, Evangelia K.;
Michel, Claire H.;
Pasco, Matthieu Y.;
Tenant, Sean;
Rubinsztein, David C.;
O'Kane, Cahir J.

Publication type:

Article

Comparative evolutionary analysis of VPS33 homologues: genetic and functional insights.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 10, p. 1261, doi. 10.1093/hmg/ddi137

By:

Gissen, Paul;
Johnson, Colin A.;
Gentle, Dean;
Hurst, Laurence D.;
Doherty, Aidan J.;
O'Kane, Cahir J.;
Kelly, Deirdre A.;
Maher, Eamonn R.

Publication type:

Article

A single GABAergic neuron mediates feedback of odor-evoked signals in the mushroom body of larval Drosophila.

Published in:

Frontiers in Neural Circuits, 2014, v. 8, p. 1, doi. 10.3389/fncir.2014.00035

By:

Masuda-Nakagawa, Liria M.;
Kei Ito;
Takeshi Awasaki;
O'Kane, Cahir J.

Publication type:

Article

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Published in:

Nature Chemical Biology, 2008, v. 4, n. 5, p. 295, doi. 10.1038/nchembio.79

By:

Williams, Andrea;
Sarkar, Sovan;
Cuddon, Paul;
Ttofi, Evangelia K.;
Saiki, Shinji;
Siddiqi, Farah H.;
Jahreiss, Luca;
Fleming, Angeleen;
Pask, Dean;
Goldsmith, Paul;
O'Kane, Cahir J.;
Floto, Rodrigo Andres;
Rubinsztein, David C.

Publication type:

Article

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

Published in:

Nature Chemical Biology, 2007, v. 3, n. 6, p. 331, doi. 10.1038/nchembio883

By:

Sarkar, Sovan;
Perlstein, Ethan O.;
Imarisio, Sara;
Pineau, Sandra;
Cordenier, Axelle;
Maglathlin, Rebecca L.;
Webster, John A.;
Lewis, Timothy A.;
O'Kane, Cahir J.;
Schreiber, Stuart L.;
Rubinsztein, David C.

Publication type:

Article

NeuroGeM, a knowledgebase of genetic modifiers in neurodegenerative diseases.

Published in:

BMC Medical Genomics, 2013, v. 6, n. 1, p. 1, doi. 10.1186/1755-8794-6-52

By:

Dokyun Na;
Rouf, Mushfiqur;
O'Kane, Cahir J.;
Rubinsztein, David C.;
Gsponer, Jörg

Publication type:

Article