Works matching AU O'Donoghue, Anthony J.

Results: 47

Structural elucidation of recombinant Trichomonas vaginalis 20S proteasome bound to covalent inhibitors.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-53022-w

By:

Silhan, Jan;
Fajtova, Pavla;
Bartosova, Jitka;
Hurysz, Brianna M.;
Almaliti, Jehad;
Miyamoto, Yukiko;
Eckmann, Lars;
Gerwick, William H.;
O'Donoghue, Anthony J.;
Boura, Evzen

Publication type:

Article

Small molecule in situ resin capture provides a compound first approach to natural product discovery.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49367-x

By:

Bogdanov, Alexander;
Salib, Mariam N.;
Chase, Alexander B.;
Hammerlindl, Heinz;
Muskat, Mitchell N.;
Luedtke, Stephanie;
da Silva, Elany Barbosa;
O'Donoghue, Anthony J.;
Wu, Lani F.;
Altschuler, Steven J.;
Molinski, Tadeusz F.;
Jensen, Paul R.

Publication type:

Article

A multiplex method for rapidly identifying viral protease inhibitors.

Published in:

Molecular Systems Biology, 2025, v. 21, n. 2, p. 158, doi. 10.1038/s44320-024-00082-1

By:

Hong, Seo Jung;
Resnick, Samuel J;
Iketani, Sho;
Cha, Ji Won;
Albert, Benjamin Alexander;
Fazekas, Christopher T;
Chang, Ching-Wen;
Liu, Hengrui;
Dagan, Shlomi;
Abagyan, Michael R;
Fajtová, Pavla;
Culbertson, Bruce;
Brace, Brooklyn;
Reddem, Eswar R;
Forouhar, Farhad;
Glickman, J Fraser;
Balkovec, James M;
Stockwell, Brent R;
Shapiro, Lawrence;
O'Donoghue, Anthony J

Publication type:

Article

Development of Potent and Highly Selective Epoxyketone‐Based Plasmodium Proteasome Inhibitors.

Published in:

Chemistry - A European Journal, 2023, v. 29, n. 20, p. 1, doi. 10.1002/chem.202203958

By:

Almaliti, Jehad;
Fajtová, Pavla;
Calla, Jaeson;
LaMonte, Gregory M.;
Feng, Mudong;
Rocamora, Frances;
Ottilie, Sabine;
Glukhov, Evgenia;
Boura, Evzen;
Suhandynata, Raymond T.;
Momper, Jeremiah D.;
Gilson, Michael K.;
Winzeler, Elizabeth A.;
Gerwick, William H.;
O'Donoghue, Anthony J.

Publication type:

Article

Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing.

Published in:

Angewandte Chemie, 2023, v. 135, n. 4, p. 1, doi. 10.1002/ange.202214394

By:

Jin, Zhicheng;
Li, Yi;
Li, Ke;
Zhou, Jiajing;
Yeung, Justin;
Ling, Chuxuan;
Yim, Wonjun;
He, Tengyu;
Cheng, Yong;
Xu, Ming;
Creyer, Matthew N.;
Chang, Yu‐Ci;
Fajtová, Pavla;
Retout, Maurice;
Qi, Baiyan;
Li, Shuzhou;
O'Donoghue, Anthony J.;
Jokerst, Jesse V.

Publication type:

Article

A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening.

Published in:

Angewandte Chemie, 2022, v. 134, n. 9, p. 1, doi. 10.1002/ange.202113617

By:

Cheng, Yong;
Borum, Raina M.;
Clark, Alex E.;
Jin, Zhicheng;
Moore, Colman;
Fajtová, Pavla;
O'Donoghue, Anthony J.;
Carlin, Aaron F.;
Jokerst, Jesse V.

Publication type:

Article

A Charge‐Switchable Zwitterionic Peptide for Rapid Detection of SARS‐CoV‐2 Main Protease.

Published in:

Angewandte Chemie, 2022, v. 134, n. 9, p. 1, doi. 10.1002/ange.202112995

By:

Jin, Zhicheng;
Mantri, Yash;
Retout, Maurice;
Cheng, Yong;
Zhou, Jiajing;
Jorns, Alec;
Fajtova, Pavla;
Yim, Wonjun;
Moore, Colman;
Xu, Ming;
Creyer, Matthew N.;
Borum, Raina M.;
Zhou, Jingcheng;
Wu, Zhuohong;
He, Tengyu;
Penny, William F.;
O'Donoghue, Anthony J.;
Jokerst, Jesse V.

Publication type:

Article

Discovery of Triple Inhibitors of Both SARS-CoV-2 Proteases and Human Cathepsin L.

Published in:

Pharmaceuticals (14248247), 2022, v. 15, n. 6, p. 744, doi. 10.3390/ph15060744

By:

Meewan, Ittipat;
Kattoula, Jacob;
Kattoula, Julius Y.;
Skinner, Danielle;
Fajtová, Pavla;
Giardini, Miriam A.;
Woodworth, Brendon;
McKerrow, James H.;
Lage de Siqueira-Neto, Jair;
O'Donoghue, Anthony J.;
Abagyan, Ruben

Publication type:

Article

Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of Fasciola hepatica.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 7, p. 1, doi. 10.1371/journal.pntd.0002269

By:

Corvo, Ileana;
O'Donoghue, Anthony J.;
Pastro, Lucía;
Pi-Denis, Natalia;
Eroy-Reveles, Alegra;
Roche, Leda;
McKerrow, James H.;
Dalton, John P.;
Craik, Charles S.;
Caffrey, Conor R.;
Tort, José F.

Publication type:

Article

Dissecting the Active Site of the Collagenolytic Cathepsin L3 Protease of the Invasive Stage of <i>Fasciola hepatica</i>.

Published in:

PLoS Neglected Tropical Diseases, 2013, v. 7, n. 7, p. 1, doi. 10.1371/journal.pntd.0002269

By:

Corvo, Ileana;
O'Donoghue, Anthony J.;
Pastro, Lucía;
Pi-Denis, Natalia;
Eroy-Reveles, Alegra;
Roche, Leda;
McKerrow, James H.;
Dalton, John P.;
Craik, Charles S.;
Caffrey, Conor R.;
Tort, José F.

Publication type:

Article

The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.

Published in:

Biological Chemistry, 2019, v. 400, n. 12, p. 1629, doi. 10.1515/hsz-2019-0103

By:

Ivry, Sam L.;
Knudsen, Giselle M.;
Caiazza, Francesco;
Sharib, Jeremy M.;
Jaradeh, Katrin;
Ravalin, Matthew;
O'Donoghue, Anthony J.;
Kirkwood, Kimberly S.;
Craik, Charles S.

Publication type:

Article

The lysosomal aminopeptidase tripeptidyl peptidase 1 displays increased activity in malignant pancreatic cysts.

Published in:

Biological Chemistry, 2019, v. 400, n. 11, p. 1629, doi. 10.1515/hsz-2019-0103

By:

Ivry, Sam L.;
Knudsen, Giselle M.;
Caiazza, Francesco;
Sharib, Jeremy M.;
Jaradeh, Katrin;
Ravalin, Matthew;
O’Donoghue, Anthony J.;
Kirkwood, Kimberly S.;
Craik, Charles S.

Publication type:

Article

An internally quenched peptide as a new model substrate for rhomboid intramembrane proteases.

Published in:

Biological Chemistry, 2018, v. 399, n. 12, p. 1389, doi. 10.1515/hsz-2018-0255

By:

Arutyunova, Elena;
Jiang, Zhenze;
Yang, Jian;
Kulepa, Ayodeji N.;
Young, Howard S.;
Verhelst, Steven;
O'Donoghue, Anthony J.;
Lemieux, M. Joanne

Publication type:

Article

Characterization of PdCP1, a serine carboxypeptidase from Pseudogymnoascus destructans, the causal agent of White-nose Syndrome.

Published in:

Biological Chemistry, 2018, v. 399, n. 12, p. 1375, doi. 10.1515/hsz-2018-0240

By:

Beekman, Chapman;
Jiang, Zhenze;
Suzuki, Brian M.;
Palmer, Jonathan M.;
Lindner, Daniel L.;
O'Donoghue, Anthony J.;
Knudsen, Giselle M.;
Bennett, Richard J.

Publication type:

Article

Procathepsin E is highly abundant but minimally active in pancreatic ductal adenocarcinoma tumors.

Published in:

Biological Chemistry, 2016, v. 397, n. 9, p. 871, doi. 10.1515/hsz-2016-0138

By:

O'Donoghue, Anthony J.;
Ivry, Sam L.;
Chaudhury, Chaity;
Hostetter, Daniel R.;
Hanahan, Douglas;
Craik, Charles S.

Publication type:

Article

Improved Scalable Synthesis of Clinical Candidate KZR‐616, a Selective Immunoproteasome Inhibitor.

Published in:

ChemistrySelect, 2021, v. 6, n. 44, p. 12461, doi. 10.1002/slct.202103455

By:

Almaliti, Jehad;
Fajtová, Pavla;
O'Donoghue, Anthony J.;
AlHindy, Momen;
Gerwick, William H.

Publication type:

Article

Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome.

Published in:

Microbiome, 2019, v. 7, n. 1, p. N.PAG, doi. 10.1186/s40168-019-0636-3

By:

Quinn, Robert A.;
Adem, Sandeep;
Mills, Robert H.;
Comstock, William;
DeRight Goldasich, Lindsay;
Humphrey, Gregory;
Aksenov, Alexander A.;
Melnik, Alexei V.;
da Silva, Ricardo;
Ackermann, Gail;
Bandeira, Nuno;
Gonzalez, David J.;
Conrad, Doug;
O'Donoghue, Anthony J.;
Knight, Rob;
Dorrestein, Pieter C.

Publication type:

Article

Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system.

Published in:

Frontiers in Microbiology, 2023, p. 1, doi. 10.3389/fmicb.2023.1199085

By:

Røyseth, Victoria;
Hurysz, Brianna M.;
Kaczorowska, Anna-Karina;
Dorawa, Sebastian;
Fedøy, Anita-Elin;
Arsın, Hasan;
Serafim, Mateus Sá M.;
Myers, Samuel A.;
Werbowy, Olesia;
Kaczorowski, Tadeusz;
Stokke, Runar;
O'Donoghue, Anthony J.;
Steen, Ida Helene

Publication type:

Article

Development of an Antiviral Medicinal Plant and Natural Product Database (avMpNp Database) from Biodiversity.

Published in:

Chemistry & Biodiversity, 2024, v. 21, n. 12, p. 1, doi. 10.1002/cbdv.202400285

By:

Quadros de Azevedo, Daniela;
Vinícius Viera Nóia, João;
Ribeiro, Yasmim Carla M.;
Alves dos Reis, Raphael;
Ribeiro, Paulo Henrique Otoni;
Almeida Moura, Gustavo;
Mendes, Pamela;
Barbosa de Souza, Ana Beatriz;
Carpini Mermejo, Sofia;
Serafim, Mateus Sá Magalhães;
Fernandes, Thaís Helena Maciel;
O'Donoghue, Anthony J.;
Campos, Alessandra C. Faria Aguiar;
Campos, Sérgio Vale Aguiar;
Gonçalves Maltarollo, Vinícius;
Oliveira Castilho, Rachel

Publication type:

Article

Peptide Amphiphile Mediated Co‐assembly for Nanoplasmonic Sensing.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 4, p. 1, doi. 10.1002/anie.202214394

By:

Jin, Zhicheng;
Li, Yi;
Li, Ke;
Zhou, Jiajing;
Yeung, Justin;
Ling, Chuxuan;
Yim, Wonjun;
He, Tengyu;
Cheng, Yong;
Xu, Ming;
Creyer, Matthew N.;
Chang, Yu‐Ci;
Fajtová, Pavla;
Retout, Maurice;
Qi, Baiyan;
Li, Shuzhou;
O'Donoghue, Anthony J.;
Jokerst, Jesse V.

Publication type:

Article

A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 9, p. 1, doi. 10.1002/anie.202113617

By:

Cheng, Yong;
Borum, Raina M.;
Clark, Alex E.;
Jin, Zhicheng;
Moore, Colman;
Fajtová, Pavla;
O'Donoghue, Anthony J.;
Carlin, Aaron F.;
Jokerst, Jesse V.

Publication type:

Article

A Charge‐Switchable Zwitterionic Peptide for Rapid Detection of SARS‐CoV‐2 Main Protease.

Published in:

Angewandte Chemie International Edition, 2022, v. 61, n. 9, p. 1, doi. 10.1002/anie.202112995

By:

Jin, Zhicheng;
Mantri, Yash;
Retout, Maurice;
Cheng, Yong;
Zhou, Jiajing;
Jorns, Alec;
Fajtova, Pavla;
Yim, Wonjun;
Moore, Colman;
Xu, Ming;
Creyer, Matthew N.;
Borum, Raina M.;
Zhou, Jingcheng;
Wu, Zhuohong;
He, Tengyu;
Penny, William F.;
O'Donoghue, Anthony J.;
Jokerst, Jesse V.

Publication type:

Article

Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 12, p. 1, doi. 10.1002/pro.5225

By:

Fajtova, Pavla;
Hurysz, Brianna M.;
Miyamoto, Yukiko;
Serafim, Mateus Sá M.;
Jiang, Zhenze;
Vazquez, Julia M.;
Trujillo, Diego F.;
Liu, Lawrence J.;
Somani, Urvashi;
Almaliti, Jehad;
Myers, Samuel A.;
Caffrey, Conor R.;
Gerwick, William H.;
McMinn, Dustin L.;
Kirk, Christopher J.;
Boura, Evzen;
Eckmann, Lars;
O'Donoghue, Anthony J.

Publication type:

Article

Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 8, p. 1, doi. 10.1002/pro.5110

By:

Mahoney, Matthew W.;
Helander, Jonathan;
Kooner, Anoopjit S.;
Norman, Mariah;
Damalanka, Vishnu C.;
De Bona, Paolo;
Kasperkiewicz, Paulina;
Rut, Wioletta;
Poreba, Marcin;
Kashipathy, Maithri M.;
Battaile, Kevin P.;
Lovell, Scott;
O'Donoghue, Anthony J.;
Craik, Charles S.;
Drag, Marcin;
Janetka, James W.

Publication type:

Article

Global substrate specificity profiling of post‐translational modifying enzymes.

Published in:

Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 3, p. 584, doi. 10.1002/pro.3352

By:

Ivry, Sam L.;
Meyer, Nicole O.;
Winter, Michael B.;
Bohn, Markus F.;
Knudsen, Giselle M.;
O'Donoghue, Anthony J.;
Craik, Charles S.

Publication type:

Article

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin.

Published in:

Frontiers in Cellular & Infection Microbiology, 2020, v. 10, p. 1, doi. 10.3389/fcimb.2020.00066

By:

Dvořáková, Hana;
Leontovyč, Roman;
Macháček, Tomáš;
O'Donoghue, Anthony J.;
Šedo, Ondřej;
Zdráhal, Zbyněk;
Craik, Charles S.;
Caffrey, Conor R.;
Horák, Petr;
Mikeš, Libor

Publication type:

Article

Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis.

Published in:

PLoS ONE, 2024, v. 19, n. 10, p. 1, doi. 10.1371/journal.pone.0308672

By:

Nieskens, Noelle M.;
Miyamoto, Yukiko;
Hurysz, Brianna M.;
O'Donoghue, Anthony J.;
Eckmann, Lars

Publication type:

Article

Comprehensive proteolytic profiling of Aedes aegypti mosquito midgut extracts: Unraveling the blood meal protein digestion system.

Published in:

PLoS Neglected Tropical Diseases, 2025, v. 19, n. 2, p. 1, doi. 10.1371/journal.pntd.0012555

By:

O'Donoghue, Anthony J.;
Lui, Chenxi;
Simington, Carter J.;
Montermoso, Saira;
Moreno-Galvez, Elizabeth;
Serafim, Mateus Sá M.;
Burata, Olive E.;
Lucero, Rachael M.;
Nguyen, James T.;
Fong, Daniel;
Tran, Khanh;
Millan, Neomi;
Gallimore, Jamie M.;
Parungao, Kamille;
Fong, Jonathan;
Suzuki, Brian M.;
Jiang, Zhenze;
Isoe, Jun;
Rascón Jr, Alberto A.

Publication type:

Article

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.

Published in:

Parasites & Vectors, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13071-022-05556-5

By:

Jedlickova, Lucie;
Peterkova, Kristyna;
Boateng, Enoch Mensah;
Ulrychova, Lenka;
Vacek, Vojtech;
Kutil, Zsofia;
Jiang, Zhenze;
Novakova, Zora;
Snajdr, Ivan;
Kim, Juan;
O'Donoghue, Anthony J.;
Barinka, Cyril;
Dvorak, Jan

Publication type:

Article

Characterization of glutamate carboxypeptidase 2 orthologs in trematodes.

Published in:

Parasites & Vectors, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13071-022-05556-5

By:

Jedlickova, Lucie;
Peterkova, Kristyna;
Boateng, Enoch Mensah;
Ulrychova, Lenka;
Vacek, Vojtech;
Kutil, Zsofia;
Jiang, Zhenze;
Novakova, Zora;
Snajdr, Ivan;
Kim, Juan;
O'Donoghue, Anthony J.;
Barinka, Cyril;
Dvorak, Jan

Publication type:

Article

Global identification of peptidase specificity by multiplex substrate profiling.

Published in:

Nature Methods, 2012, v. 9, n. 11, p. 1095, doi. 10.1038/nmeth.2182

By:

O'Donoghue, Anthony J;
Eroy-Reveles, A Alegra;
Knudsen, Giselle M;
Ingram, Jessica;
Zhou, Min;
Statnekov, Jacob B;
Greninger, Alexander L;
Hostetter, Daniel R;
Qu, Gang;
Maltby, David A;
Anderson, Marc O;
DeRisi, Joseph L;
McKerrow, James H;
Burlingame, Alma L;
Craik, Charles S

Publication type:

Article

Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.

Published in:

Biochemical Journal, 2015, v. 465, n. 1, p. 163, doi. 10.1042/BJ20140809

By:

Sharma, Vidhu;
Panwar, Preety;
O'Donoghue, Anthony J.;
Cui, Haoran;
Guido, Rafael V. C.;
Cralk, Charles S.;
Bromme, Dieter

Publication type:

Article

Engineering of multiple trypsin/chymotrypsin sites in Cry3A to enhance its activity against Monochamus alternatus Hope larvae.

Published in:

Pest Management Science, 2020, v. 76, n. 9, p. 3117, doi. 10.1002/ps.5866

By:

Guo, Yajie;
Wang, Yafang;
O'Donoghue, Anthony J;
Jiang, Zhenze;
Carballar‐Lejarazú, Rebeca;
Liang, Guanghong;
Hu, Xia;
Wang, Rong;
Xu, Lei;
Guan, Xiong;
Zhang, Feiping;
Wu, Songqing

Publication type:

Article

A GMR enzymatic assay for quantifying nuclease and peptidase activity.

Published in:

Frontiers in Bioengineering & Biotechnology, 2024, p. 1, doi. 10.3389/fbioe.2024.1363186

By:

Sveiven, Michael;
Serrano, Ana K.;
Rosenberg, Joshua;
Conrad, Douglas J.;
Hall, Drew A.;
O'Donoghue, Anthony J.

Publication type:

Article

IL-1β is an innate immune sensor of microbial proteolysis.

Published in:

Science Immunology, 2016, v. 1, n. 2, p. 1, doi. 10.1126/sciimmunol.aah3539

By:

LaRock, Christopher N.;
Todd, Jordan;
LaRock, Doris L.;
Olson, Joshua;
O'Donoghue, Anthony J.;
Robertson, Avril A. B.;
Cooper, Matthew A.;
Hoffman, Hal M.;
Nizet, Victor

Publication type:

Article

Giant magnetoresistive biosensors for real-time quantitative detection of protease activity.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-62910-2

By:

Adem, Sandeep;
Jain, Sonal;
Sveiven, Michael;
Zhou, Xiahan;
O'Donoghue, Anthony J.;
Hall, Drew A.

Publication type:

Article

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.

Published in:

PLoS Neglected Tropical Diseases, 2018, v. 12, n. 4, p. 1, doi. 10.1371/journal.pntd.0006446

By:

Leontovyč, Adrian;
Ulrychová, Lenka;
O’Donoghue, Anthony J.;
Vondrášek, Jiří;
Marešová, Lucie;
Hubálek, Martin;
Fajtová, Pavla;
Chanová, Marta;
Jiang, Zhenze;
Craik, Charles S.;
Caffrey, Conor R.;
Mareš, Michael;
Dvořák, Jan;
Horn, Martin

Publication type:

Article

Global Substrate Profiling of Proteases in Human Neutrophil Extracellular Traps Reveals Consensus Motif Predominantly Contributed by Elastase.

Published in:

PLoS ONE, 2013, v. 8, n. 9, p. 1, doi. 10.1371/journal.pone.0075141

By:

O’Donoghue, Anthony J.;
Jin, Ye;
Knudsen, Giselle M.;
Perera, Natascha C.;
Jenne, Dieter E.;
Murphy, John E.;
Craik, Charles S.;
Hermiston, Terry W.

Publication type:

Article

Immunoproteasome functions explained by divergence in cleavage specificity and regulation.

Published in:

eLife, 2017, p. 1, doi. 10.7554/eLife.27364.001

By:

Winter, Michael B.;
La Greca, Florencia;
Arastu-Kapur, Shirin;
Caiazza, Francesco;
Cimermancic, Peter;
Buchholz, Tonia J.;
Anderl, Janet L.;
Ravalin, Matthew;
Bohn, Markus F.;
Sali, Andrej;
O'Donoghue, Anthony J.;
Craik, Charles S.

Publication type:

Article

Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates.

Published in:

Protein Science: A Publication of the Protein Society, 2025, v. 34, n. 6, p. 1, doi. 10.1002/pro.70180

By:

Silva, Elany B.;
Jiang, Zhenze;
Liu, Chenxi;
Fajtová, Pavla;
Teixeira, Thaiz R.;
de Castro Fiorini Maia, Giovana;
Liu, Lawrence J.;
El‐Sakkary, Nelly;
Skinner, Danielle E.;
Syed, Ali;
Wang, Steven C;
Caffrey, Conor R.;
O'Donoghue, Anthony J.

Publication type:

Article

Structure Elucidation, Biosynthetic Gene Cluster Distribution, and Biological Activities of Ketomemicin Analogs in Salinispora.

Published in:

Marine Drugs, 2025, v. 23, n. 3, p. 126, doi. 10.3390/md23030126

By:

Castro-Falcón, Gabriel;
Guillén-Matus, Dulce G.;
Silva, Elany Barbosa Da;
Guo, Wentao;
Ross, Alicia;
Sá Magalhães Serafim, Mateus;
Fernandes, Thaís Helena Maciel;
Tantillo, Dean J.;
O'Donoghue, Anthony J.;
Jensen, Paul R.

Publication type:

Article

Structural Insights into Salinosporamide a Mediated Inhibition of the Human 20S Proteasome.

Published in:

Molecules, 2025, v. 30, n. 6, p. 1386, doi. 10.3390/molecules30061386

By:

Sülzen, Hagen;
Fajtova, Pavla;
O'Donoghue, Anthony J.;
Silhan, Jan;
Boura, Evzen

Publication type:

Article

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma.

Published in:

Molecules, 2020, v. 25, n. 18, p. 4071, doi. 10.3390/molecules25184071

By:

Maffioli, Elisa;
Jiang, Zhenze;
Nonnis, Simona;
Negri, Armando;
Romeo, Valentina;
Lietz, Christopher B.;
Hook, Vivian;
Ristagno, Giuseppe;
Baselli, Giuseppe;
Kistler, Erik B.;
Aletti, Federico;
O'Donoghue, Anthony J.;
Tedeschi, Gabriella;
Iadarola, Paolo

Publication type:

Article

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.

Published in:

PLoS Neglected Tropical Diseases, 2016, v. 10, n. 8, p. 1, doi. 10.1371/journal.pntd.0004893

By:

Goupil, Louise S.;
Ivry, Sam L.;
Hsieh, Ivy;
Suzuki, Brian M.;
Craik, Charles S.;
O’Donoghue, Anthony J.;
McKerrow, James H.

Publication type:

Article

Molecular characterization and functional analysis of the Schistosoma mekongi Ca<sup>2+</sup>-dependent cysteine protease (calpain)

Published in:

Parasites & Vectors, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13071-019-3639-9

By:

Chaimon, Salisa;
Limpanont, Yanin;
Reamtong, Onrapak;
Ampawong, Sumate;
Phuphisut, Orawan;
Chusongsang, Phiraphol;
Ruangsittichai, Jiraporn;
Boonyuen, Usa;
Watthanakulpanich, Dorn;
O’Donoghue, Anthony J.;
Caffrey, Conor R.;
Adisakwattana, Poom

Publication type:

Article

Targeting proteasomes in infectious organisms to combat disease.

Published in:

FEBS Journal, 2017, v. 284, n. 10, p. 1503, doi. 10.1111/febs.14029

By:

Bibo-Verdugo, Betsaida;
Jiang, Zhenze;
Caffrey, Conor R.;
O'Donoghue, Anthony J.

Publication type:

Article

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.

Published in:

PLoS Pathogens, 2016, v. 12, n. 12, p. 1, doi. 10.1371/journal.ppat.1006051

By:

Clarke, Starlynn C.;
O'Donoghue, Anthony J.;
La Greca, Florencia;
Craik, Charles S.;
Dumesic, Phillip A.;
Homer, Christina M.;
Madhani, Hiten D.;
Pallova, Lenka;
Majer, Pavel

Publication type:

Article