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Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics.
Published in:
Human Genomics, 2004, v. 1, n. 2, p. 98, doi. 10.1186/1479-7364-1-2-98
By:
- Burren, Oliver S.;
- Healy, Barry C.;
- Lam, Alex C.;
- Schuilenburg, Helen;
- Dolman, Geoffrey E.;
- Everett, Vincent H.;
- Laneri, Davide;
- Nutland, Sarah;
- Rance, Helen E.;
- Payne, Felicity;
- Smyth, Deborah;
- Lowe, Chris;
- Barratt, Bryan J.;
- Twells, Rebecca C.J.;
- Rainbow, Daniel B.;
- Wicker, Linda S.;
- Todd, John A.;
- Walker, Neil M.;
- Smink, Luc J.
Publication type:
Article
No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility.
Published in:
Diabetes/Metabolism Research & Reviews, 2006, v. 22, n. 5, p. 356, doi. 10.1002/dmrr.628
By:
- Pask, Rebecca;
- Cooper, Jason D.;
- Walker, Neil M.;
- Nutland, Sarah;
- Hutchings, Jayne;
- Dunger, David B.;
- Nejentsev, Sergey;
- Todd, John A.
Publication type:
Article
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource.
Published in:
Nature Genetics, 2009, v. 41, n. 9, p. 1011, doi. 10.1038/ng.434
By:
- Dendrou, Calliope A.;
- Plagnol, Vincent;
- Fung, Erik;
- Yang, Jennie H. M.;
- Downes, Kate;
- Cooper, Jason D.;
- Nutland, Sarah;
- Coleman, Gillian;
- Himsworth, Matthew;
- Hardy, Matthew;
- Burren, Oliver;
- Healy, Barry;
- Walker, Neil M.;
- Koch, Kerstin;
- Ouwehand, Willem H.;
- Bradley, John R.;
- Wareham, Nicholas J.;
- Todd, John A.;
- Wicker, Linda S.
Publication type:
Article
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
Published in:
Nature Genetics, 2007, v. 39, n. 7, p. 857, doi. 10.1038/ng2068
By:
- Todd, John A.;
- Walker, Neil M.;
- Cooper, Jason D.;
- Smyth, Deborah J.;
- Downes, Kate;
- Plagnol, Vincent;
- Bailey, Rebecca;
- Nejentsev, Sergey;
- Field, Sarah F.;
- Payne, Felicity;
- Lowe, Christopher E.;
- Szeszko, Jeffrey S.;
- Hafler, Jason P.;
- Zeitels, Lauren;
- Yang, Jennie H. M.;
- Vella, Adrian;
- Nutland, Sarah;
- Stevens, Helen E.;
- Schuilenburg, Helen;
- Coleman, Gillian
Publication type:
Article
Population structure, differential bias and genomic control in a large-scale, case-control association study.
Published in:
Nature Genetics, 2005, v. 37, n. 11, p. 1243, doi. 10.1038/ng1653
By:
- Clayton, David G.;
- Walker, Neil M.;
- Smyth, Deborah J.;
- Pask, Rebecca;
- Cooper, Jason D.;
- Maier, Lisa M.;
- Smink, Luc J.;
- Lam, Alex C.;
- Ovington, Nigel R.;
- Stevens, Helen E.;
- Nutland, Sarah;
- Howson, Joanna M. M.;
- Faham, Malek;
- Moorhead, Martin;
- Jones, Hywel B.;
- Falkowski, Matthew;
- Hardenbol, Paul;
- Willis, Thomas D.;
- Todd, John A.
Publication type:
Article
Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes.
Published in:
2005
By:
- Smyth, Deborah J.;
- Howson, Joanna M. M.;
- Lowe, Christopher E.;
- Walker, Neil M.;
- Lam, Alex C.;
- Nutland, Sarah;
- Hutchings, Jayne;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Guja, Cristian;
- Ionescu-Tirgoviste, Constantin;
- Undlien, Dag E.;
- Rønningen, Kjersti S.;
- Savage, David;
- Dunger, David B.;
- Twells, Rebecca C. J.;
- McArdle, Wendy L.;
- Strachan, David P.;
- Todd, John A.
Publication type:
Letter
Parameters for reliable results in genetic association studies in common disease.
Published in:
Nature Genetics, 2002, v. 30, n. 2, p. 149, doi. 10.1038/ng825
By:
- Dahlman, Ingrid;
- Eaves, Iain A.;
- Kosoy, Roman;
- Morrison, V. Anne;
- Heward, Joanne;
- Gough, Stephen C.L.;
- Allahabadia, Amit;
- Franklyn, Jayne A.;
- Tuomilehto, Jaakko;
- Tuomilehto-Wolf, Eva;
- Cucca, Francesco;
- Guja, Cristian;
- Ionescu-Tirgoviste, Constantin;
- Stevens, Helen;
- Carr, Philippa;
- Nutland, Sarah;
- McKinney, Patricia;
- Shield, Julian P.;
- Wang, William
Publication type:
Article
Haplotype tagging for the identification of common disease genes.
Published in:
Nature Genetics, 2001, v. 29, n. 2, p. 233, doi. 10.1038/ng1001-233
By:
- Johnson, Gillian C.L.;
- Esposito, Laura;
- Barratt, Bryan J.;
- Smith, Annabel N.;
- Heward, Joanne;
- Di Genova, Gianfranco;
- Ueda, Hironori;
- Cordell, Heather J.;
- Eaves, Iain A.;
- Dudbridge, Frank;
- Twells, Rebecca C.J.;
- Payne, Felicity;
- Hughes, Wil;
- Nutland, Sarah;
- Stevens, Helen;
- Carr, Phillipa;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Gough, Stephen C.L.
Publication type:
Article
The genetically isolated populations of Finland and Sardinia may not be a panacea for linkage disequilibrium mapping of common disease genes.
Published in:
Nature Genetics, 2000, v. 25, n. 3, p. 320, doi. 10.1038/77091
By:
- Eaves, Iain A.;
- Merriman, Tony R.;
- Barber, Rachael A.;
- Nutland, Sarah;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Cucca, Francesco;
- Todd, John A.
Publication type:
Article
Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients.
Published in:
Diabetologia, 2014, v. 57, n. 2, p. 366, doi. 10.1007/s00125-013-3113-8
By:
- Downes, Kate;
- Marcovecchio, M.;
- Clarke, Pamela;
- Cooper, Jason;
- Ferreira, Ricardo;
- Howson, Joanna;
- Jolley, Jennifer;
- Nutland, Sarah;
- Stevens, Helen;
- Walker, Neil;
- Wallace, Chris;
- Dunger, David;
- Todd, John
Publication type:
Article
Reduced Expression of IFIH1 Is Protective for Type 1 Diabetes.
Published in:
PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012646
By:
- Downes, Kate;
- Pekalski, Marcin;
- Angus, Karen L.;
- Hardy, Matthew;
- Nutland, Sarah;
- Smyth, Deborah J.;
- Walker, Neil M.;
- Wallace, Chris;
- Todd, John A.
Publication type:
Article
Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes.
Published in:
Human Genetics, 2003, v. 113, n. 2, p. 99, doi. 10.1007/s00439-003-0940-6
By:
- Twells, Rebecca C. J.;
- Mein, Charles A.;
- Payne, Felicity;
- Veijola, Riitta;
- Gilbey, Matthew;
- Bright, Matthew;
- Timms, Andrew;
- Nakagawa, Yusuke;
- Snook, Hywel;
- Nutland, Sarah;
- Rance, Helen E.;
- Carr, Philippa;
- Dudbridge, Frank;
- Cordell, Heather J.;
- Cooper, Jason;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Phillips, Michael;
- Metzker, Michael;
- Hess, J. Fred
Publication type:
Article
Discovery, linkage disequilibrium and association analyses of polymorphisms of the immune complement inhibitor, decay-accelerating factor gene (DAF/CD55) in type 1 diabetes.
Published in:
BMC Genetics, 2006, v. 7, p. 22, doi. 10.1186/1471-2156-7-22
By:
- Taniguchi, Hidenori;
- Lowe, Christopher E;
- Cooper, Jason D;
- Smyth, Deborah J;
- Bailey, Rebecca;
- Nutland, Sarah;
- Healy, Barry C;
- Lam, Alex C;
- Burren, Oliver;
- Walker, Neil M;
- Smink, Luc J;
- Wicker, Linda S;
- Todd, John A
Publication type:
Article
Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes.
Published in:
BMC Genetics, 2005, v. 6, p. 9, doi. 10.1186/1471-2156-6-9
By:
- Maier, Lisa M;
- Smyth, Deborah J;
- Vella, Adrian;
- Payne, Felicity;
- Cooper, Jason D;
- Pask, Rebecca;
- Lowe, Christopher;
- Hulme, John;
- Smink, Luc J;
- Fraser, Heather;
- Moule, Carolyn;
- Hunter, Kara M;
- Chamberlain, Giselle;
- Walker, Neil;
- Nutland, Sarah;
- Undlien, Dag E;
- Rønningen, Kjersti S;
- Guja, Cristian;
- Ionescu-Tirgovişte, Constantin;
- Savage, David A
Publication type:
Article
The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients.
Published in:
Journal of Investigative Dermatology, 2014, v. 134, n. 6, p. 1779, doi. 10.1038/jid.2013.324
By:
- Di Meglio, Paola;
- Villanova, Federica;
- Napolitano, Luca;
- Tosi, Isabella;
- Barberio, Manuela Terranova;
- Mak, Rose K;
- Nutland, Sarah;
- Smith, Catherine H;
- Barker, Jonathan N W N;
- Todd, John A;
- Nestle, Frank O
Publication type:
Article
The IL23R A/Gln381 Allele Promotes IL-23 Unresponsiveness in Human Memory T-Helper 17 Cells and Impairs Th17 Responses in Psoriasis Patients.
Published in:
Journal of Investigative Dermatology, 2013, v. 133, n. 10, p. 2381, doi. 10.1038/jid.2013.170
By:
- Di Meglio, Paola;
- Villanova, Federica;
- Napolitano, Luca;
- Tosi, Isabella;
- Terranova Barberio, Manuela;
- Mak, Rose K;
- Nutland, Sarah;
- Smith, Catherine H;
- Barker, Jonathan N W N;
- Todd, John A;
- Nestle, Frank O
Publication type:
Article
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease.
Published in:
Nature, 2003, v. 423, n. 6939, p. 506, doi. 10.1038/nature01621
By:
- Ueda, Hironori;
- Howson, Joanna M. M.;
- Esposito, Laura;
- Heward, Joanne;
- Snook, Hywel;
- Chamberlain, Giselle;
- Rainbow, Daniel B.;
- Hunter, Kara M. D.;
- Smith, Annabel N.;
- Di Genova, Gianfranco;
- Herr, Mathias H.;
- Dahlman, Ingrid;
- Payne, Felicity;
- Smyth, Deborah;
- Lowe, Christopher;
- Twells, Rebecca C. J.;
- Howlett, Sarah;
- Healy, Barry;
- Nutland, Sarah
Publication type:
Article
Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene.
Published in:
Human Molecular Genetics, 2012, v. 21, n. 2, p. 322, doi. 10.1093/hmg/ddr468
By:
- Davison, Lucy J.;
- Wallace, Chris;
- Cooper, Jason D.;
- Cope, Nathan F.;
- Wilson, Nicola K.;
- Smyth, Deborah J.;
- Howson, Joanna M.M.;
- Saleh, Nada;
- Al-Jeffery, Abdullah;
- Angus, Karen L.;
- Stevens, Helen E.;
- Nutland, Sarah;
- Duley, Simon;
- Coulson, Richard M.R.;
- Walker, Neil M.;
- Burren, Oliver S.;
- Rice, Catherine M.;
- Cambien, Francois;
- Zeller, Tanja;
- Munzel, Thomas
Publication type:
Article
Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).
Published in:
Trials, 2015, v. 16, n. 1, p. 1, doi. 10.1186/s13063-015-0583-7
By:
- Heywood, James;
- Evangelou, Marina;
- Goymer, Donna;
- Kennet, Jane;
- Anselmiova, Katerina;
- Guy, Catherine;
- O'Brien, Criona;
- Nutland, Sarah;
- Brown, Judy;
- Walker, Neil M.;
- Todd, John A.;
- Waldron-Lynch, Frank
Publication type:
Article
Effective recruitment of participants to a phase I study using the internet and publicity releases through charities and patient organisations: analysis of the adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D).
Published in:
2015
By:
- Heywood, James;
- Evangelou, Marina;
- Goymer, Donna;
- Kennet, Jane;
- Anselmiova, Katerina;
- Guy, Catherine;
- O'Brien, Criona;
- Nutland, Sarah;
- Brown, Judy;
- Walker, Neil M;
- Todd, John A;
- Waldron-Lynch, Frank
Publication type:
journal article
Alloantibodies against low-frequency human platelet antigens do not account for a significant proportion of cases of fetomaternal alloimmune thrombocytopenia: evidence from 1054 cases.
Published in:
Transfusion, 2009, v. 49, n. 10, p. 2084, doi. 10.1111/j.1537-2995.2009.02246.x
By:
- Ghevaert, Cedric;
- Rankin, Angela;
- Huiskes, Elly;
- Porcelijn, Leendert;
- Javela, Kaija;
- Kekomaki, Riitta;
- Bakchoul, Tamam;
- Santoso, Sentot;
- Nutland, Sarah;
- Smyth, Deborah J.;
- Smith, Graham A.;
- McBride, Simon;
- Watkins, Nicholas A.;
- Ouwehand, Willem H.
Publication type:
Article
A Genome-Wide Assessment of the Genetic Basis of Type 1 Diabetes and Its Biology.
Published in:
Diabetes, 2007, v. 56, p. A103
By:
- Todd, John A.;
- Clayton, David G.;
- Downes, Kate;
- Dunger, David B.;
- Guja, Cristian;
- Leung, Hin-Tak;
- Nutland, Sarah;
- Plagnol, Vincent;
- Smyth, Deborah J.;
- Stevens, Helen E.;
- Ionescu-Tirgoviste, Constantin;
- Tuomilehto, Jaakko;
- Walker, Neil M.;
- Widmer, Barry
Publication type:
Article
No Evidence for Association of OAS1 With Type 1 Diabetes in Unaffected Siblings or Type 1 Diabetic Cases.
Published in:
Diabetes, 2006, v. 55, n. 5, p. 1525, doi. 10.2337/db05-1452
By:
- Smyth, Deborah J.;
- Cooper, Jason D.;
- Lowe, Christopher E.;
- Nutland, Sarah;
- Walker, Neil M.;
- Clayton, David G.;
- Todd, John A.
Publication type:
Article
Analysis of Polymorphisms of the Interleukin-18 Gene in Type 1 Diabetes and Hardy-Weinberg Equilibrium Testing.
Published in:
Diabetes, 2006, v. 55, n. 2, p. 559, doi. 10.2337/diabetes.55.02.06.db05-0826
By:
- Szeszko, Jeffrey S.;
- Howson, Joanna M. M.;
- Cooper, Jason D.;
- Walker, Nell M.;
- Twells, Rebecca C. J.;
- Stevens, Helen E.;
- Nutland, Sarah L.;
- Todd, John A.
Publication type:
Article
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
Published in:
2004
By:
- Smyth, Deborah;
- Cooper, Jason D.;
- Collins, Joanne E.;
- Heward, Joanne M.;
- Franklyn, Jayne A.;
- Howson, Joanna M. M.;
- Vella, Adrian;
- Nutland, Sarah;
- Rance, Helen E.;
- Maier, Lisa;
- Barratt, Bryan J.;
- Guja, Cristian;
- Ionescu-Tirgoviste, Constantin;
- Savage, David A.;
- Dunger, David B.;
- Widmer, Barry;
- Strachan, David P.;
- Ring, Susan M.;
- Walker, Neil;
- Clayton, David G.
Publication type:
journal article
Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes.
Published in:
2004
By:
- Nejentsev, Sergey;
- Cooper, Jason D.;
- Godfrey, Lisa;
- Howson, Joanna M. M.;
- Rance, Helen;
- Nutland, Sarah;
- Walker, Neil M.;
- Guja, Cristian;
- Ionescu-Tirgoviste, Constantin;
- Savage, David A.;
- Undlien, Dag E.;
- Rønningen, Kjersti S.;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Gillespie, Kathleen M.;
- Ring, Susan M.;
- Strachan, David P.;
- Widmer, Barry;
- Dunger, David;
- Todd, John A.
Publication type:
journal article
Lack of association of the Ala(45)Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes.
Published in:
2004
By:
- Vella, Adrian;
- Howson, Joanna M. M.;
- Barratt, Bryan J.;
- Twells, Rebecca C. J.;
- Rance, Helen E.;
- Nutland, Sarah;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Undlien, Dag E.;
- Rønningen, Kjersti S.;
- Guja, Cristian;
- Ionescu-Tîrgoviste, Constantin;
- Savage, David A.;
- Todd, John A.;
- Rønningen, Kjersti S;
- Ionescu-Tîrgovişte, Constantin
Publication type:
journal article
Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb.
Published in:
2004
By:
- Payne, Felicity;
- Smyth, Deborah J.;
- Pask, Rebecca;
- Barratt, Bryan J.;
- Cooper, Jason D.;
- Twells, Rebecca C.J.;
- Walker, Neil M.;
- Lam, Alex C.;
- Smink, Luc J.;
- Nutland, Sarah;
- Rance, Helen E.;
- Todd, John A.
Publication type:
journal article
A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes.
Published in:
2002
By:
- Johnson, Gillian C.L.;
- Payne, Felicity;
- Nutland, Sarah;
- Stevens, Helen;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Todd, John A.
Publication type:
journal article
Investigating the utility of combining Φ29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping.
Published in:
BMC Biotechnology, 2004, v. 4, p. 15, doi. 10.1186/1472-6750-4-15
By:
- Pask, Rebecca;
- Rance, Helen E.;
- Barratt, Bryan J.;
- Nutland, Sarah;
- Smyth, Deborah J.;
- Sebastian, Meera;
- Twells, Rebecca C. J.;
- Smith, Anne;
- Lam, Alex C.;
- Smink, Luc J.;
- Walker, Neil M.;
- Todd, John A.
Publication type:
Article
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.
Published in:
Human Molecular Genetics, 2004, v. 13, n. 15, p. 1633, doi. 10.1093/hmg/ddh169
By:
- Nejentsev, Sergey;
- Godfrey, Lisa;
- Snook, Hywel;
- Rance, Helen;
- Nutland, Sarah;
- Walker, Neil M.;
- Lam, Alex C.;
- Guja, Cristian;
- Ionescu-Tirgoviste, Constantin;
- Undlien, Dag E.;
- Rønningen, Kjersti S.;
- Tuomilehto-Wolf, Eva;
- Tuomilehto, Jaakko;
- Newport, Melanie J.;
- Clayton, David G.;
- Todd, John A.
Publication type:
Article
A correlation between the relative predisposition of MHC class II alleles to type 1 diabetes and the structure of their proteins.
Published in:
Human Molecular Genetics, 2001, v. 10, n. 19, p. 2025, doi. 10.1093/hmg/10.19.2025
By:
- Cucca, Francesco;
- Lampis, Rosannna;
- Congia, Mauro;
- Angius, Efisio;
- Nutland, Sarah;
- Bain, Stephen C.;
- Barnett, Anthony H.;
- Todd, John A.
Publication type:
Article
Evidence of association with type 1 diabetes in the SLC11A1 gene region.
Published in:
BMC Medical Genetics, 2011, v. 12, n. 1, p. 59, doi. 10.1186/1471-2350-12-59
By:
- Yang, Jennie H. M.;
- Downes, Kate;
- Howson, Joanna M. M.;
- Nutland, Sarah;
- Stevens, Helen E.;
- Walker, Neil M.;
- Todd, John A.
Publication type:
Article
Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
Published in:
BMC Medical Genetics, 2006, v. 7, p. 20, doi. 10.1186/1471-2350-7-20
By:
- Smyth, Deborah J;
- Howson, Joanna MM;
- Payne, Felicity;
- Maier, Lisa M;
- Bailey, Rebecca;
- Holland, Kieran;
- Lowe, Christopher E;
- Cooper, Jason D;
- Hulme, John S;
- Vella, Adrian;
- Dahlman, Ingrid;
- Lam, Alex C;
- Nutland, Sarah;
- Walker, Neil M;
- Twells, Rebecca CJ;
- Todd, John A
Publication type:
Article

Found: 34