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HLTF disrupts Cas9-DNA post-cleavage complexes to allow DNA break processing.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-50080-y
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- Publication type:
- Article
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells.
- Published in:
- eLife, 2024, p. 1, doi. 10.7554/eLife.91611
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- Publication type:
- Article
Pathogenic CANVAS (AAGGG)<sub>n</sub> repeats stall DNA replication due to the formation of alternative DNA structures.
- Published in:
- Nucleic Acids Research, 2024, v. 52, n. 8, p. 4361, doi. 10.1093/nar/gkae124
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- Publication type:
- Article
The mission to ensure continued funding for excellent basic research.
- Published in:
- EMBO Reports, 2023, v. 24, n. 7, p. 1, doi. 10.15252/embr.202357498
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- Publication type:
- Article
Rapid and precise genotyping of transgene zygosity in mice using an allele-specific method.
- Published in:
- Life Science Alliance, 2023, v. 6, n. 6, p. 1, doi. 10.26508/lsa.202201729
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- Publication type:
- Article
DNA-PK promotes DNA end resection at DNA double strand breaks in G<sub>0</sub> cells.
- Published in:
- eLife, 2022, p. 1, doi. 10.7554/eLife.74700
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- Publication type:
- Article
LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.
- Published in:
- eLife, 2021, p. 1, doi. 10.7554/eLife.68466
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- Publication type:
- Article
CTCF is a barrier for 2C-like reprogramming.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25072-x
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- Publication type:
- Article
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
- Published in:
- EMBO Journal, 2021, v. 40, n. 2, p. 1, doi. 10.15252/embj.2020107130
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- Publication type:
- Article
ATR inhibition potentiates ionizing radiation‐induced interferon response via cytosolic nucleic acid‐sensing pathways.
- Published in:
- EMBO Journal, 2020, v. 39, n. 14, p. 1, doi. 10.15252/embj.2019104036
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- Publication type:
- Article
53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy.
- Published in:
- Nucleic Acids Research, 2020, v. 48, n. 3, p. 1314, doi. 10.1093/nar/gkz1139
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- Publication type:
- Article
ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14654-w
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- Publication type:
- Article
Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03948-9
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- Publication type:
- Article
Atm reactivation reverses ataxia telangiectasia phenotypes in vivo.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 3, p. 1, doi. 10.1038/s41419-018-0357-8
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- Publication type:
- Article
Replication fork reversal triggers fork degradation in BRCA2-defective cells.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01164-5
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- Publication type:
- Article
Thwarting endogenous stress: BRCA protects against aldehyde toxicity.
- Published in:
- EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1331, doi. 10.15252/emmm.201708194
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- Publication type:
- Article
Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.
- Published in:
- PLoS ONE, 2017, v. 12, n. 1, p. 1, doi. 10.1371/journal.pone.0170903
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- Publication type:
- Article
53 BP1 ablation rescues genomic instability in mice expressing ' RING-less' BRCA1.
- Published in:
- EMBO Reports, 2016, v. 17, n. 11, p. 1532, doi. 10.15252/embr.201642497
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- Publication type:
- Article
Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML.
- Published in:
- Science Signaling, 2016, v. 9, n. 445, p. 1, doi. 10.1126/scisignal.aad8243
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- Publication type:
- Article
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
- Published in:
- Nature Communications, 2016, v. 7, n. 8, p. 12425, doi. 10.1038/ncomms12425
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- Publication type:
- Article
The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study.
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- 2016
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- Publication type:
- journal article
Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals.
- Published in:
- PLoS Genetics, 2015, v. 11, n. 10, p. 1, doi. 10.1371/journal.pgen.1005462
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- Publication type:
- Article
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining.
- Published in:
- Nucleic Acids Research, 2015, v. 43, n. 10, p. 4950, doi. 10.1093/nar/gkv336
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- Publication type:
- Article
Replication initiation and genome instability: a crossroads for DNA and RNA synthesis.
- Published in:
- Cellular & Molecular Life Sciences, 2014, v. 71, n. 23, p. 4545, doi. 10.1007/s00018-014-1721-1
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- Publication type:
- Article
DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier.
- Published in:
- Nature, 2014, v. 514, n. 7520, p. 107, doi. 10.1038/nature13483
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- Publication type:
- Article
A new Riff: Rif1 eats its cake and has it too.
- Published in:
- EMBO Reports, 2014, v. 15, n. 6, p. 622, doi. 10.1002/embr.201438825
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- Publication type:
- Article
End-joining, translocations and cancer.
- Published in:
- Nature Reviews Cancer, 2013, v. 13, n. 7, p. 443, doi. 10.1038/nrc3537
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- Publication type:
- Article
The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo.
- Published in:
- EMBO Journal, 2012, v. 31, n. 20, p. 4045, doi. 10.1038/emboj.2012.247
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- Publication type:
- Article
DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes.
- Published in:
- Nature, 2012, v. 484, n. 7392, p. 69, doi. 10.1038/nature10909
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- Publication type:
- Article
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair.
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- Journal of Cell Biology, 2011, v. 193, n. 2, p. 295, doi. 10.1083/jcb.201009074
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- Publication type:
- Article
Multiple Organ System Defects and Transcriptional Dysregulation in the Nipbl<sup>+/-</sup> Mouse, a Model of Cornelia de Lange Syndrome.
- Published in:
- PLoS Genetics, 2009, v. 5, n. 9, p. 1, doi. 10.1371/journal.pgen.1000650
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- Publication type:
- Article
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.
- Published in:
- Nature Genetics, 2009, v. 41, n. 8, p. 891, doi. 10.1038/ng.420
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- Publication type:
- Article
Mechanisms promoting translocations in editing and switching peripheral B cells.
- Published in:
- Nature, 2009, v. 460, n. 7252, p. 231, doi. 10.1038/nature08159
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- Publication type:
- Article
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
- Published in:
- 2009
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- Publication type:
- Correction notice
Histone H2AX is integral to hypoxia-driven neovascularization.
- Published in:
- Nature Medicine, 2009, v. 15, n. 5, p. 553, doi. 10.1038/nm.1947
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- Publication type:
- Article
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.
- Published in:
- 2009
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- Publication type:
- Letter
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
- Published in:
- Journal of Cell Biology, 2008, v. 183, n. 5, p. 777, doi. 10.1083/jcb.200805154
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- Publication type:
- Article
53BP1 facilitates long-range DNA end-joining during V(D)J recombination.
- Published in:
- 2008
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- Publication type:
- Letter
Antigen receptor diversification and chromosome translocations.
- Published in:
- Nature Immunology, 2007, v. 8, n. 8, p. 801, doi. 10.1038/ni1498
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- Publication type:
- Article
Heterochromatin is refractory to γ-H2AX modification in yeast and mammals.
- Published in:
- Journal of Cell Biology, 2007, v. 178, n. 2, p. 209, doi. 10.1083/jcb.200612031
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- Publication type:
- Article
Chromatin dynamics and the preservation of genetic information.
- Published in:
- Nature, 2007, v. 447, n. 7147, p. 951, doi. 10.1038/nature05980
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- Publication type:
- Article
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.
- Published in:
- Nature, 2007, v. 447, n. 7145, p. 725, doi. 10.1038/nature05862
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- Publication type:
- Article
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.
- Published in:
- Nature, 2007, v. 447, n. 7145, p. 730, doi. 10.1038/nature05842
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- Publication type:
- Article
Positional stability of single double-strand breaks in mammalian cells.
- Published in:
- Nature Cell Biology, 2007, v. 9, n. 6, p. 675, doi. 10.1038/ncb1591
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- Publication type:
- Article
Histone H2AX functions in hypoxia-driven neovascularisation.
- Published in:
- FASEB Journal, 2007, v. 21, n. 5, p. A14
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- Publication type:
- Article
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
- Published in:
- Journal of Cell Biology, 2007, v. 176, n. 5, p. 581, doi. 10.1083/jcb.200608130
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- Publication type:
- Article
Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1.
- Published in:
- European Journal of Immunology, 2007, v. 37, n. 1, p. 235, doi. 10.1002/eji.200636789
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- Publication type:
- Article
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo.
- Published in:
- 2006
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- Publication type:
- Letter
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks.
- Published in:
- Journal of Cell Biology, 2006, v. 172, n. 6, p. 823, doi. 10.1083/jcb.200510015
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- Publication type:
- Article
Role of genomic instability and p53 in AID-induced c-myc–Igh translocations.
- Published in:
- Nature, 2006, v. 440, n. 7080, p. 105, doi. 10.1038/nature04495
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- Publication type:
- Article