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Deep learning based CETSA feature prediction cross multiple cell lines with latent space representation.
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- Scientific Reports, 2024, v. 14, n. 1, p. 1, doi. 10.1038/s41598-024-51193-6
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- Article
IMPRINTS.CETSA and IMPRINTS.CETSA.app: an R package and a Shiny application for the analysis and interpretation of IMPRINTS-CETSA data.
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- Briefings in Bioinformatics, 2024, v. 25, n. 3, p. 1, doi. 10.1093/bib/bbae128
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- Article
Recent advances in proteome‐wide label‐free target deconvolution for bioactive small molecules.
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- Medicinal Research Reviews, 2021, v. 41, n. 6, p. 2893, doi. 10.1002/med.21788
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- Article
Mutant p53-reactivating compound APR-246 synergizes with asparaginase in inducing growth suppression in acute lymphoblastic leukemia cells.
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- Cell Death & Disease, 2021, v. 12, n. 7, p. 1, doi. 10.1038/s41419-021-03988-y
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- Article
Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome.
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- Nature Protocols, 2020, v. 15, n. 6, p. 1881, doi. 10.1038/s41596-020-0310-z
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- Article
CETSA-based target engagement of taxanes as biomarkers for efficacy and resistance.
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- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-55526-8
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- Article
Identifying purine nucleoside phosphorylase as the target of quinine using cellular thermal shift assay.
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- Science Translational Medicine, 2019, v. 11, n. 473, p. N.PAG, doi. 10.1126/scitranslmed.aau3174
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- Article
An efficient proteome-wide strategy for discovery and characterization of cellular nucleotide-protein interactions.
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- PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0208273
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- Article
Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality.
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- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-02287-5
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- Article
Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD.
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- BMC Biology, 2016, v. 14, p. 1, doi. 10.1186/s12915-016-0300-3
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- Article
The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
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- FEBS Journal, 2016, v. 283, n. 6, p. 1107, doi. 10.1111/febs.13655
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- Article
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.
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- Nature Communications, 2016, v. 7, n. 3, p. 11040, doi. 10.1038/ncomms11040
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- Article
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.
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- PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0143947
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- Article
Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays.
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- Scientific Reports, 2015, p. 12116, doi. 10.1038/srep12116
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- Article
Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate.
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- PLoS ONE, 2015, v. 10, n. 6, p. 1, doi. 10.1371/journal.pone.0131507
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- Article
The cellular thermal shift assay for evaluating drug target interactions in cells.
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- Nature Protocols, 2014, v. 9, n. 9, p. 2100, doi. 10.1038/nprot.2014.138
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- Article
Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
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- Nature Structural & Molecular Biology, 2014, v. 21, n. 8, p. 728, doi. 10.1038/nsmb.2860
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- Article
Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A.
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- Biological Chemistry, 2014, v. 395, n. 7/8, p. 881, doi. 10.1515/hsz-2014-0106
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- Article
Structural and Biochemical Characterization of Human PR70 in Isolation and in Complex with the Scaffolding Subunit of Protein Phosphatase 2A.
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- PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101846
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- Article
Engineering protein thermostability using a generic activity-independent biophysical screen inside the cell.
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- Nature Communications, 2013, v. 4, n. 12, p. 2901, doi. 10.1038/ncomms3901
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- Article
Nanobody Mediated Crystallization of an Archeal Mechanosensitive Channel.
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- PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0077984
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- Article
Structural insights into substrate recognition in proton-dependent oligopeptide transporters.
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- EMBO Reports, 2013, v. 14, n. 9, p. 804, doi. 10.1038/embor.2013.107
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- Article
Structural and Biophysical Characterization of the Cytoplasmic Domains of Human BAP29 and BAP31.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071111
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- Article
Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.
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- Nature Structural & Molecular Biology, 2013, v. 20, n. 6, p. 766, doi. 10.1038/nsmb.2569
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- Article
The crystal structure of the DNA-binding domain of vIRF-1 from the oncogenic KSHV reveals a conserved fold for DNA binding and reinforces its role as a transcription factor.
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- Nucleic Acids Research, 2013, v. 41, n. 7, p. 4295, doi. 10.1093/nar/gkt082
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- Article
Optimisation of Over-Expression in E. coli and Biophysical Characterisation of Human Membrane Protein Synaptogyrin 1.
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- PLoS ONE, 2012, v. 7, n. 6, p. 1, doi. 10.1371/journal.pone.0038244
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- Article
Pan-Pathway Based Interaction Profiling of FDAApproved Nucleoside and Nucleobase Analogs with Enzymes of the Human Nucleotide Metabolism.
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- PLoS ONE, 2012, v. 7, n. 5, p. 1, doi. 10.1371/journal.pone.0037724
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- Article
Cofactor mobility determines reaction outcome in the IMPDH and GMPR (?-?)<sub>8</sub> barrel enzymes.
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- Nature Chemical Biology, 2011, v. 7, n. 12, p. 950, doi. 10.1038/nchembio.693
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- Article
HF-EPR, Raman, UV/VIS Light Spectroscopic, and DFT Studies of the Ribonucleotide Reductase R2 Tyrosyl Radical from Epstein-Barr Virus.
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- PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025022
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- Article
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization.
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- Nature Structural & Molecular Biology, 2011, v. 18, n. 3, p. 316, doi. 10.1038/nsmb.2007
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- Article
Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1 M. Welin et al. Studies of the human PRTFDC1.
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- FEBS Journal, 2010, v. 277, n. 23, p. 4920, doi. 10.1111/j.1742-4658.2010.07897.x
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- Article
Structural studies of tri-functional human GART.
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- Nucleic Acids Research, 2010, v. 38, n. 20, p. 7308, doi. 10.1093/nar/gkq595
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- Article
The Crystal Structure of the Dachshund Domain of Human SnoN Reveals Flexibility in the Putative Protein Interaction Surface.
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- PLoS ONE, 2010, v. 5, n. 9, p. 1, doi. 10.1371/journal.pone.0012907
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- Article
Crystal structure of the shutoff and exonuclease protein from the oncogenic Kaposi’s sarcoma-associated herpesvirus.
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- FEBS Journal, 2009, v. 276, n. 22, p. 6636, doi. 10.1111/j.1742-4658.2009.07374.x
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- Article
Enabling IMAC purification of low abundance recombinant proteins from E. coli lysates.
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- 2009
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- Publication type:
- Letter
The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins.
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- Proteins, 2009, v. 74, n. 1, p. 18, doi. 10.1002/prot.22128
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- Article
The structure of the PP2A regulatory subunit B56γ: The remaining piece of the PP2A jigsaw puzzle.
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- Proteins, 2009, v. 74, n. 1, p. 212, doi. 10.1002/prot.22150
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- Article
The crystal structure of human cleavage and polyadenylation specific factor-5 reveals a dimeric Nudix protein with a conserved catalytic site.
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- Proteins, 2008, v. 73, n. 4, p. 1047, doi. 10.1002/prot.22198
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- Article
Completing the family portrait of the anti-apoptotic Bcl-2 proteins: Crystal structure of human Bfl-1 in complex with Bim
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- FEBS Letters, 2008, v. 582, n. 25/26, p. 3590, doi. 10.1016/j.febslet.2008.09.028
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- Article
Engineering membrane protein overproduction in Escherichia coli.
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- Protein Science: A Publication of the Protein Society, 2008, v. 17, n. 4, p. 673, doi. 10.1110/ps.073242508
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- Article
Protein production and purification.
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- Nature Methods, 2008, v. 5, n. 2, p. 135, doi. 10.1038/nmeth.f.202
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- Article
Structural basis for synthesis of inflammatory mediators by human leukotriene C<sub>4</sub> synthase.
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- 2007
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- Publication type:
- Letter
The structure of human collapsin response mediator protein 2, a regulator of axonal growth.
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- Journal of Neurochemistry, 2007, v. 101, n. 4, p. 906, doi. 10.1111/j.1471-4159.2006.04401.x
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- Article
An efficient and generic strategy for producing soluble human proteins and domains in E. coli by screening construct libraries.
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- Proteins, 2006, v. 65, n. 2, p. 266, doi. 10.1002/prot.21090
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- Article
Colony filtration blot: a new screening method for soluble protein expression in Escherichia coli.
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- Nature Methods, 2005, v. 2, n. 7, p. 507, doi. 10.1038/nmeth767
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- Article
An efficient strategy for high-throughput expression screening of recombinant integral membrane proteins.
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- Protein Science: A Publication of the Protein Society, 2005, v. 14, n. 3, p. 676, doi. 10.1110/ps.041127005
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- Article
Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase.
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- Nature Structural & Molecular Biology, 2004, v. 11, n. 11, p. 1142, doi. 10.1038/nsmb838
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- Publication type:
- Article
A protein carboxylate coordinated oxo-centered tri-nuclear iron complex with possible implications for ferritin mineralization
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- FEBS Letters, 2004, v. 567, n. 2/3, p. 179, doi. 10.1016/j.febslet.2004.04.068
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- Article
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold
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- FEBS Letters, 2004, v. 565, n. 1-3, p. 59, doi. 10.1016/j.febslet.2004.03.085
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- Article
A prokaryotic alternative oxidase present in the bacterium Novosphingobium aromaticivorans
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- FEBS Letters, 2003, v. 552, n. 2/3, p. 189, doi. 10.1016/S0014-5793(03)00920-7
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- Article