Works by Nobuhisa Iwata

Results: 57

Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients.

Published in:

Genes to Cells, 2023, v. 28, n. 4, p. 319, doi. 10.1111/gtc.13010

By:

Shirotani, Keiro;
Watanabe, Kaori;
Hatta, Daisuke;
Kutoku, Yumiko;
Ohsawa, Yutaka;
Sunada, Yoshihide;
Kondo, Takayuki;
Inoue, Haruhisa;
Iwata, Nobuhisa

Publication type:

Article

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab.

Published in:

Life Science Alliance, 2024, v. 7, n. 12, p. 1, doi. 10.26508/lsa.202402650

By:

Nobuhisa Iwata;
Satoshi Tsubuki;
Misaki Sekiguchi;
Kaori Watanabe-Iwata;
Yukio Matsuba;
Naoko Kamano;
Ryo Fujioka;
Risa Takamura;
Naoto Watamura;
Naomasa Kakiya;
Naomi Mihira;
Takahiro Morito;
Keiro Shirotani;
Mann, David M. A.;
Robinson, Andrew C.;
Shoko Hashimoto;
Hiroki Sasaguri;
Takashi Saito;
Makoto Higuchi;
Saido, Takaomi C.

Publication type:

Article

Biochemical Identification of the Neutral Endopeptidase Family Member Responsible for the Catabolism of Amyloid β Peptide in the Brain1.

Published in:

Journal of Biochemistry, 2000, v. 128, n. 6, p. 897, doi. 10.1093/oxfordjournals.jbchem.a022839

By:

Takaki, Yoshie;
Iwata, Nobuhisa;
Tsubuki, Satoshi;
Taniguchi, Sayuri;
Toyoshima, Satoshi;
Lu, Bao;
Gerard, Norma P.;
Gerard, Craig;
Lee, Hahn-Jun;
Shirotani, Keiro;
Saido, Takaomi C.

Publication type:

Article

Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography.

Published in:

Journal of Neuroscience, 2007, v. 27, n. 41, p. 10957, doi. 10.1523/JNEUROSCI.0673-07.2007

By:

Maeda, Jun;
Bin Ji;
Irie, Toshiaki;
Tomiyama, Takami;
Maruyama, Masahiro;
Okauchi, Takashi;
Staufenbiel, Matthias;
Iwata, Nobuhisa;
Ono, Maiko;
Saido, Takaomi C.;
Suzuki, Kazutoshi;
Mori, Hiroshi;
Higuchi, Makoto;
Suhara, Tetsuya

Publication type:

Article

Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 4, p. 991, doi. 10.1523/JNEUROSCI.4792-03.2004

By:

Iwata, Nobuhisa;
Mizukami, Hiroaki;
Shirotani, Keiro;
Takaki, Yoshie;
Muramatsu, Shin-ichi;
Lu, Bao;
Gerard, Norma P.;
Gerard, Craig;
Ozawa, Keiya;
Saido, Takaomi C.

Publication type:

Article

The potential role of amyloid in the pathogenesis of age-related macular degeneration.

Published in:

Journal of Clinical Investigation, 2005, v. 115, n. 10, p. 2793, doi. 10.1172/JCI24635

By:

Yoshida, Takeshi;
Ohno-Matsui, Kyoko;
Ichinose, Shizuko;
Sato, Tetsuji;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Hisatomi, Toshio;
Mochizuki, Manabu;
Morita, Ikuo

Publication type:

Article

Gene therapy in Alzheimer’s disease – potential for disease modification.

Published in:

Journal of Cellular & Molecular Medicine, 2010, v. 14, n. 4, p. 741, doi. 10.1111/j.1582-4934.2010.01038.x

By:

Nilsson, Per;
Iwata, Nobuhisa;
Muramatsu, Shin-ichi;
Tjernberg, Lars O.;
Winblad, Bengt;
Saido, Takaomi C.

Publication type:

Article

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2025, v. 45, n. 23, p. 1, doi. 10.1523/JNEUROSCI.2152-24.2025

By:

Takahiro Morito;
Shoko Hashimoto;
Risa Takamura;
Naoto Watamura;
Naomasa Kakiya;
Ryo Fujioka;
Naomi Mihara;
Misaki Sekiguchi;
Kaori Watanabe-Iwata;
Naoko Kamano;
Mohan Qi;
Yukio Matsuba;
Satoshi Tsubuki;
Takashi Saito;
Nobuhisa Iwata;
Hiroki Sasaguri;
Saido, Takaomi C.

Publication type:

Article

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Published in:

Proteomics, 2015, v. 15, n. 19, p. 3349, doi. 10.1002/pmic.201400211

By:

Nilsson, Per;
Loganathan, Krishnapriya;
Sekiguchi, Misaki;
Winblad, Bengt;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Tjernberg, Lars O.

Publication type:

Article

Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum.

Published in:

European Journal of Neuroscience, 2001, v. 13, n. 5, p. 935, doi. 10.1046/j.0953-816X.2001.01462.x

By:

Sekine‐Aizawa, Yoko;
Hama, Emi;
Watanabe, Kaori;
Tsubuki, Satoshi;
Kanai‐Azuma, Masami;
Kanai, Yoshiakira;
Arai, Hiroyuki;
Aizawa, Hiroyuki;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Article

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-β and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 12, p. 4720, doi. 10.1523/JNEUROSCI.3076-10.2011

By:

Maeda, Jun;
Ming-Rong Zhang;
Okauchi, Takashi;
Bin Ji;
Ono, Maiko;
Hattori, Satoko;
Kumata, Katsushi;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Trojanowski, John Q.;
Lee, Virginia M.-Y.;
Staufenbiel, Matthias;
Tomiyama, Takami;
Mori, Hiroshi;
Fukumura, Toshimitsu;
Suhara, Tetsuya;
Higuchi, Makoto

Publication type:

Article

Cleavage of the Vesicular GABA Transporter under Excitotoxic Conditions Is Followed by Accumulation of the Truncated Transporter in Nonsynaptic Sites.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 12, p. 4622, doi. 10.1523/JNEUROSCI.3541-10.2011

By:

Gomes, João R.;
Lobo, Andrea C.;
Melo, Carlos V.;
Inácio, Ana R.;
Takano, Jiro;
Iwata, Nobuhisa;
Saido, Takaomi C.;
de Almeida, Luís P.;
Wieloch, Tadeusz;
Duarte, Carlos B.

Publication type:

Article

Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease.

Published in:

Annals of Neurology, 2005, v. 57, n. 6, p. 832

By:

Masahiro Maruyama;
Makoto Higuchi;
Yoshie Takaki;
Yukio Matsuba;
Haruko Tanji;
Miyako Nemoto;
Naoki Tomita;
Toshifumi Matsui;
Nobuhisa Iwata;
Hiroaki Mizukami;
Shin‐Ichi Muramatsu;
Keiya Ozawa;
Takaomi C. Saido;
Hiroyuki Arai;
Hidetada Sasaki

Publication type:

Article

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-43535-6

By:

Shirotani, Keiro;
Hori, Yuma;
Yoshizaki, Ryohei;
Higuchi, Eri;
Colonna, Marco;
Saito, Takashi;
Hashimoto, Shoko;
Saido, Takaomi C.;
Iwata, Nobuhisa

Publication type:

Article

Single App knock-in mouse models of Alzheimer's disease.

Published in:

Nature Neuroscience, 2014, v. 17, n. 5, p. 661, doi. 10.1038/nn.3697

By:

Saito, Takashi;
Matsuba, Yukio;
Mihira, Naomi;
Takano, Jiro;
Nilsson, Per;
Itohara, Shigeyoshi;
Iwata, Nobuhisa;
Saido, Takaomi C

Publication type:

Article

Potent amyloidogenicity and pathogenicity of A?43.

Published in:

Nature Neuroscience, 2011, v. 14, n. 8, p. 1023, doi. 10.1038/nn.2858

By:

Saito, Takashi;
Suemoto, Takahiro;
Brouwers, Nathalie;
Sleegers, Kristel;
Funamoto, Satoru;
Mihira, Naomi;
Matsuba, Yukio;
Yamada, Kazuyuki;
Nilsson, Per;
Takano, Jiro;
Nishimura, Masaki;
Iwata, Nobuhisa;
Van Broeckhoven, Christine;
Ihara, Yasuo;
Saido, Takaomi C.

Publication type:

Article

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.

Published in:

EMBO Molecular Medicine, 2015, v. 7, n. 2, p. 175, doi. 10.15252/emmm.201404438

By:

Kizuka, Yasuhiko;
Kitazume, Shinobu;
Fujinawa, Reiko;
Saito, Takashi;
Iwata, Nobuhisa;
Saido, Takaomi C;
Nakano, Miyako;
Yamaguchi, Yoshiki;
Hashimoto, Yasuhiro;
Staufenbiel, Matthias;
Hatsuta, Hiroyuki;
Murayama, Shigeo;
Manya, Hiroshi;
Endo, Tamao;
Taniguchi, Naoyuki

Publication type:

Article

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain.

Published in:

Science Signaling, 2024, v. 17, n. 848, p. 1, doi. 10.1126/scisignal.adk1822

By:

Watamura, Naoto;
Kakiya, Naomasa;
Fujioka, Ryo;
Kamano, Naoko;
Takahashi, Mika;
Nilsson, Per;
Saito, Takashi;
Iwata, Nobuhisa;
Fujisawa, Shigeyoshi;
Saido, Takaomi C.

Publication type:

Article

Proline-rich transmembrane protein 2 knock-in mice present dopamine-dependent motor deficits.

Published in:

Journal of Biochemistry, 2023, v. 174, n. 6, p. 561, doi. 10.1093/jb/mvad074

By:

Hatta, Daisuke;
Kanamoto, Kaito;
Makiya, Shiho;
Watanabe, Kaori;
Kishino, Tatsuya;
Kinoshita, Akira;
Yoshiura, Koh-Ichiro;
Kurotaki, Naohiro;
Shirotani, Keiro;
Iwata, Nobuhisa

Publication type:

Article

role of TREM2 N-glycans in trafficking to the cell surface and signal transduction of TREM2.

Published in:

Journal of Biochemistry, 2022, v. 172, n. 6, p. 347, doi. 10.1093/jb/mvac073

By:

Shirotani, Keiro;
Hatta, Daisuke;
Wakita, Naoki;
Watanabe, Kaori;
Iwata, Nobuhisa

Publication type:

Article

A simplified and sensitive method to identify Alzheimer's disease biomarker candidates using patient-derived induced pluripotent stem cells (iPSCs).

Published in:

Journal of Biochemistry, 2017, v. 162, n. 6, p. 391, doi. 10.1093/jb/mvx058

By:

Keiro Shirotani;
Kazuya Matsuo;
Sumio Ohtsuki;
Takeshi Masuda;
Masashi Asai;
Yumiko Kutoku;
Yutaka Ohsawa;
Yoshihide Sunada;
Takayuki Kondo;
Haruhisa Inoue;
Nobuhisa Iwata

Publication type:

Article

Paradigm shift from diagnosing patients based on common symptoms to categorizing patients into subtypes with different pathogenic mechanisms to guide treatment for Alzheimer's disease.

Published in:

Journal of Biochemistry, 2017, v. 161, n. 6, p. 463, doi. 10.1093/jb/mvx015

By:

Keiro Shirotani;
Masashi Asai;
Nobuhisa Iwata

Publication type:

Article

Reply to: 'Clearance of amyloid b-peptide from brain: transport or metabolism?'.

Published in:

Nature Medicine, 2000, v. 6, n. 7, p. 718, doi. 10.1038/77399

By:

Iwata, Nobuhisa;
Tsubuki, Satoshi;
Hama, Emi;
Takaki, Yoshie;
Shirotani, Keiro;
Saido, Takaomi C.

Publication type:

Article

Identification of the major Aβ1?42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition.

Published in:

Nature Medicine, 2000, v. 6, n. 2, p. 143, doi. 10.1038/72237

By:

Iwata, Nobuhisa;
Tsubuki, Satoshi;
Takaki, Yoshie;
Watanabe, Kaori;
Sekiguchi, Misaki;
Hosoki, Emi;
Kawashima-Morishima, Maho;
Lee, Hahn-Jun;
Hama, Emi;
Sekine-Aizawa, Yoko;
Saido, Takaomi C.

Publication type:

Article

PROLINE-RICH TRANSMEMBRANE PROTEIN 2 KNOCK-IN MICE PRESENT NIGROSTRIATAL DOPAMINERGIC HYPERACTIVITY AND INCREASED SUSCEPTIBILITY TO L-DOPA-INDUCED MOTOR DEFICITS.

Published in:

International Journal of Neuropsychopharmacology, 2025, v. 28, p. 1346, doi. 10.1093/ijnp/pyae059.616

By:

Daisuke Hatta;
Kaito Kanamoto;
Shiho Makiya;
Kaori Watanabe;
Tatsuya Kishino;
Yuki Fuchigami;
Shigeru Kawakami;
Akira Kinoshita;
Koh-Ichiro Yoshiura;
Naohiro Kurotaki;
Keiro Shirotani;
Nobuhisa Iwata

Publication type:

Article

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.

Published in:

Nature Communications, 2012, v. 3, n. 12, p. 1307, doi. 10.1038/ncomms2303

By:

Yamashita, Takenari;
Hideyama, Takuto;
Hachiga, Kosuke;
Teramoto, Sayaka;
Takano, Jiro;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Kwak, Shin

Publication type:

Article

Proline‐rich transmembrane protein 2 regulates the magnitude and frequency of dopamine release by repetitive neuronal stimuli in the striatum of L‐dopa‐treated mice.

Published in:

Neuropsychopharmacology Reports, 2024, v. 44, n. 4, p. 829, doi. 10.1002/npr2.12478

By:

Hatta, Daisuke;
Makiya, Shiho;
Kanamoto, Kaito;
Watanabe, Kaori;
Fuchigami, Yuki;
Kawakami, Shigeru;
Kinoshita, Akira;
Yoshiura, Koh‐Ichiro;
Kurotaki, Naohiro;
Shirotani, Keiro;
Iwata, Nobuhisa

Publication type:

Article

Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification.

Published in:

International Journal of Alzheimer's Disease, 2009, v. 2009, p. 1, doi. 10.4061/2009/689285

By:

Kokubo, Hideko;
Kayed, Rakez;
Glabe, Charles G.;
Staufenbiel, Matthias;
Saido, Takaomi C.;
Iwata, Nobuhisa;
Yamaguchi, Haruyasu

Publication type:

Article

Somatostatin regulates brain amyloidßpeptide Aß42 through modulation of proteolytic degradation.

Published in:

Nature Medicine, 2005, v. 11, n. 4, p. 434, doi. 10.1038/nm1206

By:

Saito, Takashi;
Iwata, Nobuhisa;
Tsubuki, Satoshi;
Takaki, Yoshie;
Takano, Jiro;
Huang, Shu-Ming;
Suemoto, Takahiro;
Higuchi, Makoto;
Saido, Takaomi C.

Publication type:

Article

Activity‐dependent cleavage of dyskinesia‐related proline‐rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons.

Published in:

FASEB Journal, 2020, v. 34, n. 1, p. 180, doi. 10.1096/fj.201902148R

By:

Hatta, Daisuke;
Shirotani, Keiro;
Hori, Yuma;
Kurotaki, Naohiro;
Iwata, Nobuhisa

Publication type:

Article

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.

Published in:

FASEB Journal, 2012, v. 26, n. 3, p. 1204, doi. 10.1096/fj.11-187740

By:

Higuchi, Makoto;
Iwata, Nobuhisa;
Matsuba, Yukio;
Takano, Jiro;
Suemoto, Takahiro;
Maeda, Jun;
Ji, Bin;
Ono, Maiko;
Staufenbiel, Matthias;
Suhara, Tetsuya;
Saido, Takaomi C.

Publication type:

Article

An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.

Published in:

FASEB Journal, 2011, v. 25, n. 10, p. 3720, doi. 10.1096/fj.11-182154

By:

Asai, Masashi;
Yagishita, Sosuke;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Ishiura, Shoichi;
Maruyama, Kei

Publication type:

Article

Calpastatin, an endogenous calpain-inhibitor protein, regulates the cleavage of the Cdk5 activator p35 to p25.

Published in:

Journal of Neurochemistry, 2011, v. 117, n. 3, p. 504, doi. 10.1111/j.1471-4159.2011.07222.x

By:

Sato, Ko;
Minegishi, Seiji;
Takano, Jiro;
Plattner, Florian;
Saito, Taro;
Asada, Akiko;
Kawahara, Hiroyuki;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Hisanaga, Shin-ichi

Publication type:

Article

The novel β-secretase inhibitor KMI-429 reduces amyloid β peptide production in amyloid precursor protein transgenic and wild-type mice.

Published in:

Journal of Neurochemistry, 2006, v. 96, n. 2, p. 533, doi. 10.1111/j.1471-4159.2005.03576.x

By:

Asai, Masashi;
Hattori, Chinatsu;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Sasagawa, Noboru;
Szabó, Beáta;
Hashimoto, Yasuhiro;
Maruyama, Kei;
Tanuma, Sei-ichi;
Kiso, Yoshiaki;
Ishiura, Shoichi

Publication type:

Article

Altered expression of neprilysin family members in the pituitary gland of sleep-disturbed rats, an animal model of severe fatigue.

Published in:

Journal of Neurochemistry, 2005, v. 95, n. 4, p. 1156, doi. 10.1111/j.1471-4159.2005.03436.x

By:

Ogawa, Tokiko;
Kiryu-Seo, Sumiko;
Tanaka, Masaaki;
Konishi, Hiroyuki;
Iwata, Nobuhisa;
Saido, Takaomi;
Watanabe, Yasuyoshi;
Kiyama, Hiroshi

Publication type:

Article

Therapeutic strategies of Alzheimer's disease through manipulation of Aβ metabolism: a focus on Aβ-degrading peptidase, neprilysin.

Published in:

Drug Development Research, 2002, v. 56, n. 2, p. 171, doi. 10.1002/ddr.10073

By:

Fukami, Shinjiro;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Article

Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice.

Published in:

NPJ Vaccines, 2020, v. 5, n. 1, p. 1, doi. 10.1038/s41541-020-0172-y

By:

Takeuchi, Hiroki;
Imamura, Keiko;
Ji, Bin;
Tsukita, Kayoko;
Enami, Takako;
Takao, Keizo;
Miyakawa, Tsuyoshi;
Hasegawa, Masato;
Sahara, Naruhiko;
Iwata, Nobuhisa;
Inoue, Makoto;
Hara, Hideo;
Tabira, Takeshi;
Ono, Maiko;
Trojanowski, John Q.;
Lee, Virginia M.-Y.;
Takahashi, Ryosuke;
Suhara, Tetsuya;
Higuchi, Makoto;
Inoue, Haruhisa

Publication type:

Article

19F and1H MRI detection of amyloidßplaques in vivo.

Published in:

Nature Neuroscience, 2005, v. 8, n. 4, p. 527, doi. 10.1038/nn1422

By:

Higuchi, Makoto;
Iwata, Nobuhisa;
Matsuba, Yukio;
Sato, Kumi;
Sasamoto, Kazumi;
Saido, Takaomi C

Publication type:

Article

Anti-Aβ Drug Screening Platform Using Human iPS Cell- Derived Neurons for the Treatment of Alzheimer's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025788

By:

Yahata, Naoki;
Asai, Masashi;
Kitaoka, Shiho;
Takahashi, Kazutoshi;
Asaka, Isao;
Hioki, Hiroyuki;
Kaneko, Takeshi;
Maruyama, Kei;
Saido, Takaomi C.;
Nakahata, Tatsutoshi;
Asada, Takashi;
Yamanaka, Shinya;
Iwata, Nobuhisa;
Inoue, Haruhisa

Publication type:

Article

Recent Advances in the Modeling of Alzheimer's Disease.

Published in:

Frontiers in Neuroscience, 2022, v. 16, p. 1, doi. 10.3389/fnins.2022.807473

By:

Sasaguri, Hiroki;
Hashimoto, Shoko;
Watamura, Naoto;
Sato, Kaori;
Takamura, Risa;
Nagata, Kenichi;
Tsubuki, Satoshi;
Ohshima, Toshio;
Yoshiki, Atsushi;
Sato, Kenya;
Kumita, Wakako;
Sasaki, Erika;
Kitazume, Shinobu;
Nilsson, Per;
Winblad, Bengt;
Saito, Takashi;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Article

Involvement of calpains in adult neurogenesis: implications for stroke.

Published in:

Frontiers in Cellular Neuroscience, 2015, v. 8/9, p. 1, doi. 10.3389/fncel.2015.00022

By:

Machado, Vanessa M.;
Morte, Maria I.;
Carreira, Bruno P.;
Azevedo, Maria M.;
Jiro Takano;
Nobuhisa Iwata;
Saido, Takaomi C.;
Asmussen, Hannelore;
Horwitz, Alan R.;
Carvalho, Caetana M.;
Araújo, Inês M.

Publication type:

Article

Glycosylation regulates degradation of bace1 in lysosome.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P193, doi. 10.1016/j.jalz.2014.04.227

By:

Kitazume, Shinobu;
Kizuka, Yasuhiko;
Fujinawa, Reiko;
Saito, Takashi;
Iwata, Nobuhisa;
Saido, Takaomi;
Nakano, Miyako;
Yamaguchi, Yoshiki;
Hashimoto, Yasuhiro;
Staufenbiel, Matthias;
Hatsuta, Hiroyuki;
Murayama, Shigeo;
Manya, Hiroshi;
Endo, Tamao;
Taniguchi, Naoyuki

Publication type:

Article

Autophagy deficiency increases beta-amyloid pathology and memory impairment in APP transgenic mice

Published in:

2012

By:

Nilsson, Per;
Iwata, Nobuhisa;
Sekiguchi, Misaki;
Saito, Takashi;
Saido, Takaomi

Publication type:

Abstract

APP knock-in mouse: A novel and more relevant model mouse for Alzheimer's disease

Published in:

2012

By:

Saito, Takashi;
Matsuba, Yukio;
Mihira, Naomi;
Iwata, Nobuhisa;
Takano, Jiro;
Nilsson, Per;
Saido, Takaomi

Publication type:

Abstract

Brain endothelial cells produce amyloid-β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form

Published in:

2011

By:

Tachida, Yuriko;
Kato, Masaki;
Yamaguchi, Yoshiki;
Honda, Takashi;
Hashimoto, Yasuhiro;
Wada, Yoshinao;
Saito, Takashi;
Iwata, Nobuhisa;
Taniguchi, Naoyuki

Publication type:

Abstract

Reactive astrogliosis enhances pyroGlu-Aβ formation via up regulation of glutaminyl cyclase, and reduced neprilysin activity exacerbates this process

Published in:

2010

By:

Iwata, Nobuhisa;
Higuchi, Makoto;
Tsubuki, Satoshi;
Staufenbiel, Matthias;
Saido, Takaomi C.

Publication type:

Abstract

Aβ43 is potently amyloidogenic in vivo

Published in:

2010

By:

Saito, Takashi;
Suemoto, Takahiro;
Mihira, Naomi;
Matsuba, Yukio;
Takano, Jiro;
Nilsson, Per;
Nishimura, Masaki;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Abstract

Deletion of vitamin E increases Aβ accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer's disease

Published in:

2010

By:

Yokota, Takanori;
Nishida, Yoichiro;
Ito, Shingo;
Ohtsuki, Sumio;
Iwata, Nobuhisa;
Saido, Takaomi;
Yanagisawa, Katsuhiko;
Mizusawa, Hidehiro;
Terasaki, Testuya

Publication type:

Abstract

Reduced neprilysin activity is associated with increased formation of pyroglutamylated amyloid-β peptides through upregulation of aminopeptidases and glutaminyl cyclase in brain

Published in:

2009

By:

Iwata, Nobuhisa;
Tsubuki, Satoshi;
Staufenbiel, Matthias;
Saido, Takaomi C.

Publication type:

Abstract

The biological effects of R278I-Presenilin-1 familial mutation on γ-secretase activity and amyloid pathology

Published in:

2009

By:

Saito, Takashi;
Suemoto, Takahiro;
Mihira, Naomi;
Matsuba, Yukio;
Takano, Jiro;
Nishimura, Masaki;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Abstract