Works by Nishimura, Akiyuki

Results: 33

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.

Published in:

Frontiers in Pharmacology, 2018, p. 1, doi. 10.3389/fphar.2018.00523

By:

Sunggip, Caroline;
Kakeru Shimoda;
Sayaka Oda;
Tomohiro Tanaka;
Kazuhiro Nishiyama;
Supachoke Mangmool;
Akiyuki Nishimura;
Takuro Numaga-Tomita;
Motohiro Nishida

Publication type:

Article

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway.

Published in:

Frontiers in Pharmacology, 2017, p. 1, doi. 10.3389/fphar.2017.00428

By:

Sarawuth Phosri;
Ajaree Arieyawong;
Kwanchai Bunrukchai;
Warisara Parichatikanond;
Akiyuki Nishimura;
Motohiro Nishida;
Supachoke Mangmool

Publication type:

Article

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice.

Published in:

Nature Communications, 2025, v. 16, p. 1, doi. 10.1038/s41467-024-55661-5

By:

Nishimura, Akiyuki;
Ogata, Seiryo;
Tang, Xiaokang;
Hengphasatporn, Kowit;
Umezawa, Keitaro;
Sanbo, Makoto;
Hirabayashi, Masumi;
Kato, Yuri;
Ibuki, Yuko;
Kumagai, Yoshito;
Kobayashi, Kenta;
Kanda, Yasunari;
Urano, Yasuteru;
Shigeta, Yasuteru;
Akaike, Takaaki;
Nishida, Motohiro

Publication type:

Article

Ligand-Independent Spontaneous Activation of Purinergic P2Y 6 Receptor Under Cell Culture Soft Substrate.

Published in:

Cells (2073-4409), 2025, v. 14, n. 3, p. 216, doi. 10.3390/cells14030216

By:

Nishimura, Akiyuki;
Nishiyama, Kazuhiro;
Ito, Tomoya;
Mi, Xinya;
Kato, Yuri;
Inoue, Asuka;
Aoki, Junken;
Nishida, Motohiro

Publication type:

Article

A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.

Published in:

Cells (2073-4409), 2022, v. 11, n. 13, p. N.PAG, doi. 10.3390/cells11132041

By:

Shimauchi, Tsukasa;
Numaga-Tomita, Takuro;
Kato, Yuri;
Morimoto, Hiroyuki;
Sakata, Kosuke;
Matsukane, Ryosuke;
Nishimura, Akiyuki;
Nishiyama, Kazuhiro;
Shibuta, Atsushi;
Horiuchi, Yutoku;
Kurose, Hitoshi;
Kim, Sang Geon;
Urano, Yasuteru;
Ohshima, Takashi;
Nishida, Motohiro

Publication type:

Article

Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody Production after SARS-CoV-2 Vaccine.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 19, p. 10379, doi. 10.3390/ijms251910379

By:

Atef, Yara;
Ito, Tomoya;
Masuda, Akitsu;
Kato, Yuri;
Nishimura, Akiyuki;
Kanda, Yasunari;
Kunisawa, Jun;
Kusakabe, Takahiro;
Nishida, Motohiro

Publication type:

Article

Inhibition of Drp1–Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria–Lipid Droplet Contact.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 10, p. 5446, doi. 10.3390/ijms25105446

By:

Ariyoshi, Kohei;
Nishiyama, Kazuhiro;
Kato, Yuri;
Mi, Xinya;
Ito, Tomoya;
Azuma, Yasu-Taka;
Nishimura, Akiyuki;
Nishida, Motohiro

Publication type:

Article

Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 4, p. 2401, doi. 10.3390/ijms25042401

By:

Nishiyama, Kazuhiro;
Kato, Yuri;
Nishimura, Akiyuki;
Mi, Xinya;
Nagata, Ryu;
Mori, Yasuo;
Azuma, Yasu-Taka;
Nishida, Motohiro

Publication type:

Article

Knockout of Purinergic P2Y 6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 4, p. 3800, doi. 10.3390/ijms24043800

By:

Nishiyama, Kazuhiro;
Ariyoshi, Kohei;
Nishimura, Akiyuki;
Kato, Yuri;
Mi, Xinya;
Kurose, Hitoshi;
Kim, Sang Geon;
Nishida, Motohiro

Publication type:

Article

Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post‐ischaemic blood flow recovery.

Published in:

British Journal of Pharmacology, 2023, v. 180, n. 1, p. 94, doi. 10.1111/bph.15942

By:

Numaga‐Tomita, Takuro;
Shimauchi, Tsukasa;
Kato, Yuri;
Nishiyama, Kazuhiro;
Nishimura, Akiyuki;
Sakata, Kosuke;
Inada, Hiroyuki;
Kita, Satomi;
Iwamoto, Takahiro;
Nabekura, Junichi;
Birnbaumer, Lutz;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.

Published in:

2019

By:

Nishiyama, Kazuhiro;
Numaga‐Tomita, Takuro;
Fujimoto, Yasuyuki;
Tanaka, Tomohiro;
Toyama, Chiemi;
Nishimura, Akiyuki;
Yamashita, Tomohiro;
Matsunaga, Naoya;
Koyanagi, Satoru;
Azuma, Yasu‐Taka;
Ibuki, Yuko;
Uchida, Koji;
Ohdo, Shigehiro;
Nishida, Motohiro;
Numaga-Tomita, Takuro;
Azuma, Yasu-Taka

Publication type:

journal article

Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive inotropy through β-adrenoceptors.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34194-9

By:

Oda, Sayaka;
Nishiyama, Kazuhiro;
Furumoto, Yuka;
Yamaguchi, Yohei;
Nishimura, Akiyuki;
Tang, Xiaokang;
Kato, Yuri;
Numaga-Tomita, Takuro;
Kaneko, Toshiyuki;
Mangmool, Supachoke;
Kuroda, Takuya;
Okubo, Reishin;
Sanbo, Makoto;
Hirabayashi, Masumi;
Sato, Yoji;
Nakagawa, Yasuaki;
Kuwahara, Koichiro;
Nagata, Ryu;
Iribe, Gentaro;
Mori, Yasuo

Publication type:

Article

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-46252-2

By:

Sudi, Suhaini Binti;
Tanaka, Tomohiro;
Oda, Sayaka;
Nishiyama, Kazuhiro;
Nishimura, Akiyuki;
Sunggip, Caroline;
Mangmool, Supachoke;
Numaga-Tomita, Takuro;
Nishida, Motohiro

Publication type:

Article

2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46652-7

By:

Cui, Qi;
Shieh, Meg;
Pan, Tony W.;
Nishimura, Akiyuki;
Matsunaga, Tetsuro;
Kelly, Shane S.;
Xu, Shi;
Jung, Minkyung;
Ogata, Seiryo;
Morita, Masanobu;
Yoshitake, Jun;
Chen, Xiaoyan;
Robinson, Jerome R.;
Qian, Wei-Jun;
Nishida, Motohiro;
Akaike, Takaaki;
Xian, Ming

Publication type:

Article

Cardiac remodeling: novel pathophysiological mechanisms and therapeutic strategies.

Published in:

Journal of Biochemistry, 2024, v. 176, n. 4, p. 255, doi. 10.1093/jb/mvae031

By:

Nishida, Motohiro;
Mi, Xinya;
Ishii, Yukina;
Kato, Yuri;
Nishimura, Akiyuki

Publication type:

Article

Identification of a Novel Prenyl and Palmitoyl Modification at the CaaX Motif of Cdc42 That Regulates RhoGDI Binding.

Published in:

Molecular & Cellular Biology, 2013, v. 33, n. 7, p. 1417, doi. 10.1128/MCB.01398-12

By:

Nishimura, Akiyuki;
Linder, Maurine E.

Publication type:

Article

Mitochondrial dynamics in exercise physiology.

Published in:

Pflügers Archiv: European Journal of Physiology, 2020, v. 472, n. 2, p. 137, doi. 10.1007/s00424-019-02258-3

By:

Tanaka, Tomohiro;
Nishimura, Akiyuki;
Nishiyama, Kazuhiro;
Goto, Takumi;
Numaga-Tomita, Takuro;
Nishida, Motohiro

Publication type:

Article

TRPC channels in exercise-mimetic therapy.

Published in:

Pflügers Archiv: European Journal of Physiology, 2019, v. 471, n. 3, p. 507, doi. 10.1007/s00424-018-2211-3

By:

Numaga-Tomita, Takuro;
Oda, Sayaka;
Nishiyama, Kazuhiro;
Tanaka, Tomohiro;
Nishimura, Akiyuki;
Nishida, Motohiro

Publication type:

Article

TRPC6-Mediated Zn 2+ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells.

Published in:

Biomolecules (2218-273X), 2025, v. 15, n. 2, p. 267, doi. 10.3390/biom15020267

By:

Su, Chenlin;
Mi, Xinya;
Ito, Tomoya;
Kato, Yuri;
Nishimura, Akiyuki;
Nagata, Ryu;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism.

Published in:

British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4328, doi. 10.1111/bph.16487

By:

Kato, Yuri;
Ariyoshi, Kohei;
Nohara, Yasunobu;
Matsunaga, Naoya;
Shimauchi, Tsukasa;
Shindo, Naoya;
Nishimura, Akiyuki;
Mi, Xinya;
Kim, Sang Geon;
Ide, Tomomi;
Kawanishi, Eiji;
Ojida, Akio;
Nakashima, Naoki;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01311-y

By:

Takaaki Akaike;
Tomoaki Ida;
Fan-Yan Wei;
Motohiro Nishida;
Yoshito Kumagai;
Alam, Md. Morshedul;
Hideshi Ihara;
Tomohiro Sawa;
Tetsuro Matsunaga;
Shingo Kasamatsu;
Akiyuki Nishimura;
Masanobu Morita;
Kazuhito Tomizawa;
Akira Nishimura;
Watanabe, Satoshi;
Inaba, Kenji;
Hiroshi Shima;
Nobuhiro Tanuma;
Minkyung Jung;
Shigemoto Fujii

Publication type:

Article

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.

Published in:

FASEB Journal, 2019, v. 33, n. 9, p. 9785, doi. 10.1096/fj.201802811R

By:

Takuro Numaga-Tomita;
Tsukasa Shimauchi;
Sayaka Oda;
Tomohiro Tanaka;
Kazuhiro Nishiyama;
Akiyuki Nishimura;
Birnbaumer, Lutz;
Yasuo Mori;
Motohiro Nishida

Publication type:

Article

A novel type of G protein inhibitor, YM-254890, acts as a Gq-specific guanine nucleotide dissociation inhibitor via the switch I region of Galpha subunit.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A983, doi. 10.1096/fasebj.21.6.a983-a

By:

Nishimura, Akiyuki;
Yo Sugawara;
Takasaki, Jun;
Taniguchi, Masatushi;
Mizuno, Norikazu;
Itoh, Hiroshi

Publication type:

Article

Modulation of P2Y6R expression exacerbates pressure overload-induced cardiac remodeling in mice.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-70956-5

By:

Shimoda, Kakeru;
Nishimura, Akiyuki;
Sunggip, Caroline;
Ito, Tomoya;
Nishiyama, Kazuhiro;
Kato, Yuri;
Tanaka, Tomohiro;
Tozaki-Saitoh, Hidetoshi;
Tsuda, Makoto;
Nishida, Motohiro

Publication type:

Article

Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells.

Published in:

Genes to Cells, 2006, v. 11, n. 5, p. 487, doi. 10.1111/j.1365-2443.2006.00959.x

By:

Nishimura, Akiyuki;
Okamoto, Miyuki;
Sugawara, Yo;
Mizuno, Norikazu;
Yamauchi, Junji;
Itoh, Hiroshi

Publication type:

Article

Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.

Published in:

Science Signaling, 2022, v. 15, n. 716, p. 1, doi. 10.1126/scisignal.abj0644

By:

Nishiyama, Kazuhiro;
Nishimura, Akiyuki;
Shimoda, Kakeru;
Tanaka, Tomohiro;
Kato, Yuri;
Shibata, Takahiro;
Tanaka, Hiroshi;
Kurose, Hitoshi;
Azuma, Yasu-Taka;
Ihara, Hideshi;
Kumagai, Yoshito;
Akaike, Takaaki;
Eaton, Philip;
Uchida, Koji;
Nishida, Motohiro

Publication type:

Article

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.

Published in:

Science Signaling, 2019, v. 12, n. 587, p. N.PAG, doi. 10.1126/scisignal.aaw1920

By:

Nishimura, Akiyuki;
Shimoda, Kakeru;
Tanaka, Tomohiro;
Toyama, Takashi;
Nishiyama, Kazuhiro;
Shinkai, Yasuhiro;
Numaga-Tomita, Takuro;
Yamazaki, Daiju;
Kanda, Yasunari;
Akaike, Takaaki;
Kumagai, Yoshito;
Nishida, Motohiro

Publication type:

Article

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.

Published in:

Science Signaling, 2018, v. 11, n. 556, p. 1, doi. 10.1126/scisignal.aat5185

By:

Nishimura, Akiyuki;
Shimauchi, Tsukasa;
Tanaka, Tomohiro;
Shimoda, Kakeru;
Toyama, Takashi;
Kitajima, Naoyuki;
Ishikawa, Tatsuya;
Shindo, Naoya;
Numaga-Tomita, Takuro;
Yasuda, Satoshi;
Sato, Yoji;
Kuwahara, Koichiro;
Kumagai, Yoshito;
Akaike, Takaaki;
Ide, Tomomi;
Ojida, Akio;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

Eco-pharma research aimed at developing COVID-19 therapeutic agent.

Published in:

Folia Pharmacologica Japonica, 2022, v. 157, n. 2, p. 119, doi. 10.1254/fpj.21070

By:

Yuri Kato;
Kazuhiro Nishiyama;
Akiyuki Nishimura;
Motohiro Nishida

Publication type:

Article

Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.

Published in:

Science Signaling, 2016, v. 9, n. 411, p. 1, doi. 10.1126/scisignal.aac9187

By:

Akiyuki Nishimura;
Sunggip, Caroline;
Hidetoshi Tozaki-Saitoh;
Tsukasa Shimauchi;
Takuro Numaga-Tomita;
Katsuya Hirano;
Ide, Tomomi;
Boeynaems, Jean-Marie;
Hitoshi Kurose;
Makoto Tsuda;
Robaye, Bernard;
Kazuhide Inoue;
Motohiro Nishida

Publication type:

Article

Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice.

Published in:

Marine Drugs, 2023, v. 21, n. 1, p. 52, doi. 10.3390/md21010052

By:

Tang, Xiaokang;
Nishimura, Akiyuki;
Ariyoshi, Kohei;
Nishiyama, Kazuhiro;
Kato, Yuri;
Vasileva, Elena A.;
Mishchenko, Natalia P.;
Fedoreyev, Sergey A.;
Stonik, Valentin A.;
Kim, Hyoung-Kyu;
Han, Jin;
Kanda, Yasunari;
Umezawa, Keitaro;
Urano, Yasuteru;
Akaike, Takaaki;
Nishida, Motohiro

Publication type:

Article

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

Published in:

Scientific Reports, 2016, p. 39383, doi. 10.1038/srep39383

By:

Numaga-Tomita, Takuro;
Kitajima, Naoyuki;
Kuroda, Takuya;
Nishimura, Akiyuki;
Miyano, Kei;
Yasuda, Satoshi;
Kuwahara, Koichiro;
Sato, Yoji;
Ide, Tomomi;
Birnbaumer, Lutz;
Sumimoto, Hideki;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

Published in:

Scientific Reports, 2016, p. 37001, doi. 10.1038/srep37001

By:

Kitajima, Naoyuki;
Numaga-Tomita, Takuro;
Watanabe, Masahiko;
Kuroda, Takuya;
Nishimura, Akiyuki;
Miyano, Kei;
Yasuda, Satoshi;
Kuwahara, Koichiro;
Sato, Yoji;
Ide, Tomomi;
Birnbaumer, Lutz;
Sumimoto, Hideki;
Mori, Yasuo;
Nishida, Motohiro

Publication type:

Article

Works by Nishimura, Akiyuki

TRPC5-eNOS Axis Negatively Regulates ATP-Induced Cardiomyocyte Hypertrophy.

Stimulation of Adenosine A2B Receptor Inhibits Endothelin-1-Induced Cardiac Fibroblast Proliferation and α-Smooth Muscle Actin Synthesis Through the cAMP/Epac/PI3K/Akt-Signaling Pathway.

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice.

Ligand-Independent Spontaneous Activation of Purinergic P2Y 6 Receptor Under Cell Culture Soft Substrate.

A TRPC3/6 Channel Inhibitor Promotes Arteriogenesis after Hind-Limb Ischemia.

Diabetic Mice Spleen Vulnerability Contributes to Decreased Persistence of Antibody Production after SARS-CoV-2 Vaccine.

Inhibition of Drp1–Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria–Lipid Droplet Contact.

Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

Knockout of Purinergic P2Y 6 Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis.

Inhibition of transient receptor potential cation channel 6 promotes capillary arterialization during post‐ischaemic blood flow recovery.

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes.

Myocardial TRPC6-mediated Zn<sup>2+</sup> influx induces beneficial positive inotropy through β-adrenoceptors.

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy.

2H-Thiopyran-2-thione sulfine, a compound for converting H<sub>2</sub>S to HSOH/H<sub>2</sub>S<sub>2</sub> and increasing intracellular sulfane sulfur levels.

Cardiac remodeling: novel pathophysiological mechanisms and therapeutic strategies.

Identification of a Novel Prenyl and Palmitoyl Modification at the CaaX Motif of Cdc42 That Regulates RhoGDI Binding.

Mitochondrial dynamics in exercise physiology.

TRPC channels in exercise-mimetic therapy.

TRPC6-Mediated Zn 2+ Influx Negatively Regulates Contractile Differentiation of Vascular Smooth Muscle Cells.

Inhibition of dynamin‐related protein 1‐filamin interaction improves systemic glucose metabolism.

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.

A novel type of G protein inhibitor, YM-254890, acts as a Gq-specific guanine nucleotide dissociation inhibitor via the switch I region of Galpha subunit.

Modulation of P2Y<sub>6</sub>R expression exacerbates pressure overload-induced cardiac remodeling in mice.

Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells.

Redox-dependent internalization of the purinergic P2Y<sub>6</sub> receptor limits colitis progression.

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.

Eco-pharma research aimed at developing COVID-19 therapeutic agent.

Purinergic P2Y<sub>6</sub> receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension.

Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice.

TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.