Works by Nieng Yan

Results: 57

Structural insights into the mechanism of abscisic acid signaling by PYL proteins.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 12, p. 1230, doi. 10.1038/nsmb.1730

By:

Ping Yin;
He Fan;
Qi Hao;
Xiaoqiu Yuan;
Di Wu;
Yuxuan Pang;
Chuangye Yan;
Wenqi Li;
Jiawei Wang;
Nieng Yan

Publication type:

Article

Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 12, p. 1084, doi. 10.1038/nsmb1179

By:

Zhuoru Wu;
Nieng Yan;
Liang Feng;
Oberstein, Adam;
Hanchi Yan;
Baker, Rosanna P.;
Lichuan Gu;
Jeffrey, Philip D.;
Urban, Sinisa;
Yigong Shi

Publication type:

Article

Small-Molecule Screen Identifies l-Kynurenine as a Competitive Inhibitor of TAA1/TAR Activity in Ethylene-Directed Auxin Biosynthesis and Root Growth in Arabidopsis.

Published in:

Plant Cell, 2011, v. 23, n. 11, p. 3944, doi. 10.1105/tpc.111.089029

By:

He, Wenrong;
Brumos, Javier;
Li, Hongjiang;
Ji, Yusi;
Ke, Meng;
Gong, Xinqi;
Zeng, Qinglong;
Li, Wenyang;
Zhang, Xinyan;
An, Fengying;
Wen, Xing;
Li, Pengpeng;
Chu, Jinfang;
Sun, Xiaohong;
Yan, Cunyu;
Yan, Nieng;
Xie, De-Yu;
Raikhel, Natasha;
Yang, Zhenbiao;
Stepanova, Anna N.

Publication type:

Article

Molecular basis of ligand recognition and transport by glucose transporters.

Published in:

Nature, 2015, v. 526, n. 7573, p. 391, doi. 10.1038/nature14655

By:

Deng, Dong;
Sun, Pengcheng;
Yan, Chuangye;
Ke, Meng;
Jiang, Xin;
Xiong, Lei;
Ren, Wenlin;
Hirata, Kunio;
Yamamoto, Masaki;
Fan, Shilong;
Yan, Nieng

Publication type:

Article

Cryo-EM structure of human glucose transporter GLUT4.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30235-5

By:

Yuan, Yafei;
Kong, Fang;
Xu, Hanwen;
Zhu, Angqi;
Yan, Nieng;
Yan, Chuangye

Publication type:

Article

Molecular basis for inhibiting human glucose transporters by exofacial inhibitors.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-30326-3

By:

Wang, Nan;
Zhang, Shuo;
Yuan, Yafei;
Xu, Hanwen;
Defossa, Elisabeth;
Matter, Hans;
Besenius, Melissa;
Derdau, Volker;
Dreyer, Matthias;
Halland, Nis;
He, Kaihui Hu;
Petry, Stefan;
Podeschwa, Michael;
Tennagels, Norbert;
Jiang, Xin;
Yan, Nieng

Publication type:

Article

Identification and Characterization of ABA Receptors in Oryza sativa.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0095246

By:

He, Yuan;
Hao, Qi;
Li, Wenqi;
Yan, Chuangye;
Yan, Nieng;
Yin, Ping

Publication type:

Article

Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 5, p. 420, doi. 10.1038/nsmb764

By:

Nieng Yan;
Jie-Wei Wu;
Jijie Chai;
Wenyu Li;
Yigong Shi

Publication type:

Article

Cannabidiol inhibits Nav channels through two distinct binding sites.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39307-6

By:

Huang, Jian;
Fan, Xiao;
Jin, Xueqin;
Jo, Sooyeon;
Zhang, Hanxiong Bear;
Fujita, Akie;
Bean, Bruce P.;
Yan, Nieng

Publication type:

Article

Structural mapping of Nav1.7 antagonists.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38942-3

By:

Wu, Qiurong;
Huang, Jian;
Fan, Xiao;
Wang, Kan;
Jin, Xueqin;
Huang, Gaoxingyu;
Li, Jiaao;
Pan, Xiaojing;
Yan, Nieng

Publication type:

Article

Cannabidiol inhibits Nav channels through two distinct binding sites.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-39307-6

By:

Huang, Jian;
Fan, Xiao;
Jin, Xueqin;
Jo, Sooyeon;
Zhang, Hanxiong Bear;
Fujita, Akie;
Bean, Bruce P.;
Yan, Nieng

Publication type:

Article

Structural mapping of Nav1.7 antagonists.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38942-3

By:

Wu, Qiurong;
Huang, Jian;
Fan, Xiao;
Wang, Kan;
Jin, Xueqin;
Huang, Gaoxingyu;
Li, Jiaao;
Pan, Xiaojing;
Yan, Nieng

Publication type:

Article

Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35026-6

By:

Yao, Xia;
Wang, Yan;
Wang, Zhifei;
Fan, Xiao;
Wu, Di;
Huang, Jian;
Mueller, Alexander;
Gao, Sarah;
Hu, Miaohui;
Robinson, Carol V.;
Yu, Yong;
Gao, Shuai;
Yan, Nieng

Publication type:

Article

Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35026-6

By:

Yao, Xia;
Wang, Yan;
Wang, Zhifei;
Fan, Xiao;
Wu, Di;
Huang, Jian;
Mueller, Alexander;
Gao, Sarah;
Hu, Miaohui;
Robinson, Carol V.;
Yu, Yong;
Gao, Shuai;
Yan, Nieng

Publication type:

Article

Structural biology of voltage-gated calcium channels.

Published in:

Channels (19336950), 2024, v. 18, n. 1, p. 1, doi. 10.1080/19336950.2023.2290807

By:

Yao, Xia;
Gao, Shuai;
Yan, Nieng

Publication type:

Article

A structural atlas of druggable sites on Nav channels.

Published in:

Channels (19336950), 2024, v. 18, n. 1, p. 1, doi. 10.1080/19336950.2023.2287832

By:

Li, Zhangqiang;
Wu, Qiurong;
Yan, Nieng

Publication type:

Article

Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin.

Published in:

Nature Communications, 2018, p. 1, doi. 10.1038/s41467-018-06075-7

By:

Deshun Gong;
Ximin Chi;
Kang Ren;
Gaoxingyu Huang;
Gewei Zhou;
Nieng Yan;
Jianlin Lei;
Qiang Zhou

Publication type:

Article

Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect.

Published in:

IUBMB Life, 2022, v. 74, n. 12, p. 1180, doi. 10.1002/iub.2668

By:

Jiang, Xin;
Yan, Nieng;
Deng, Dong;
Yan, Chuangye

Publication type:

Article

Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization.

Published in:

PLoS Biology, 2004, v. 2, n. 1, p. 0001, doi. 10.1371/journal.pbio.0020015

By:

Huh, Jun R.;
Vernooy, Stephanie Y.;
Hong Yu;
Nieng Yan;
Yigong Shi;
Ming Guo;
Hay, Bruce A.;
Miller, Kathryn

Publication type:

Article

Multiple Apoptotic Caspase Cascades Are Required in Nonapoptotic Roles for Drosophila Spermatid Individualization.

Published in:

PLoS Biology, 2003, v. 1, n. 12, p. 1, doi. 10.1371/journal.pbio.0020015

By:

Huh, Jun R;
Vernooy, Stephanie Y;
Yu, Hong;
Yan, Nieng;
Shi, Yigong;
Guo, Ming;
Hay, Bruce A

Publication type:

Article

Monolayer Graphene-covered Grids Enable 2.6-Å Single-particle Cryo-EM Reconstruction of 52-kDa Streptavidin.

Published in:

2020

By:

Han, Yimo;
Fan, Xiao;
Wang, Haozhe;
Zhao, Fang;
Tully, Christopher;
Kong, Jing;
Yao, Nan;
Yan, Nieng

Publication type:

Abstract

Monolayer Graphene-covered Grids Enable 2.6-Å Single-particle Cryo-EM Reconstruction of 52-kDa Streptavidin.

Published in:

2020

By:

Han, Yimo;
Fan, Xiao;
Wang, Haozhe;
Zhao, Fang;
Tully, Christopher;
Kong, Jing;
Yao, Nan;
Yan, Nieng

Publication type:

Abstract

Structural basis of ion transport and inhibition in ferroportin.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19458-6

By:

Pan, Yaping;
Ren, Zhenning;
Gao, Shuai;
Shen, Jiemin;
Wang, Lie;
Xu, Zhichun;
Yu, Ye;
Bachina, Preetham;
Zhang, Hanzhi;
Fan, Xiao;
Laganowsky, Arthur;
Yan, Nieng;
Zhou, Ming

Publication type:

Article

Histone H1.2 as a trigger for apoptosis.

Published in:

Nature Structural Biology, 2003, v. 10, n. 12, p. 983, doi. 10.1038/nsb1203-983

By:

Nieng Yan;
Yigong Shi

Publication type:

Article

Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination.

Published in:

Nature Structural Biology, 2003, v. 10, n. 11, p. 892, doi. 10.1038/nsb989

By:

Chai, Jijie;
Yan, Nieng;
Huh, Jun R;
Wu, Jia-Wei;
Li, Wenyu;
Hay, Bruce A;
Shi, Yigong

Publication type:

Article

Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs.

Published in:

Cell Discovery, 2019, v. 5, n. 1, p. N.PAG, doi. 10.1038/s41421-019-0082-1

By:

Jiang, Xin;
Wu, Jianping;
Ke, Meng;
Zhang, Shuo;
Yuan, Yafei;
Lin, Jason Ye;
Yan, Nieng

Publication type:

Article

Engineered XylE as a tool for mechanistic investigation and ligand discovery of the glucose transporters GLUTs.

Published in:

Cell Discovery, 2019, v. 5, n. 1, p. N.PAG, doi. 10.1038/s41421-019-0082-1

By:

Jiang, Xin;
Wu, Jianping;
Ke, Meng;
Zhang, Shuo;
Yuan, Yafei;
Lin, Jason Ye;
Yan, Nieng

Publication type:

Article

CryoPROS: Correcting misalignment caused by preferred orientation using AI-generated auxiliary particles.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-59797-w

By:

Zhang, Hui;
Zheng, Dihan;
Wu, Qiurong;
Yan, Nieng;
Peng, Han;
Hu, Qi;
Peng, Ying;
Yan, Zhaofeng;
Shi, Zuoqiang;
Bao, Chenglong;
Hu, Mingxu

Publication type:

Article

Cryo-EM structure of L-fucokinase/GDP-fucose pyrophosphorylase (FKP) in Bacteroides fragilis.

Published in:

2019

By:

Liu, Ying;
Hu, Huifang;
Wang, Jia;
Zhou, Qiang;
Wu, Peng;
Yan, Nieng;
Wang, Hong-Wei;
Wu, Jia-Wei;
Sun, Linfeng

Publication type:

Letter

Simulating the ion permeation and ion selection for a eukaryotic voltage-gated sodium channel NaVPaS.

Published in:

Protein & Cell, 2018, v. 9, n. 6, p. 580, doi. 10.1007/s13238-018-0522-y

By:

Zhang, Juanrong;
Mao, Wenzhi;
Ren, Yanhui;
Sun, Rui-Ning;
Yan, Nieng;
Gong, Haipeng

Publication type:

Article

Structure-based assessment of diseaserelated mutations in human voltage-gated sodium channels.

Published in:

Protein & Cell, 2017, v. 8, n. 6, p. 401, doi. 10.1007/s13238-017-0372-z

By:

Weiyun Huang;
Minhao Liu;
Yan, S. Frank;
Nieng Yan

Publication type:

Article

The recombinant expression systems for structure determination of eukaryotic membrane proteins.

Published in:

Protein & Cell, 2014, v. 5, n. 9, p. 658, doi. 10.1007/s13238-014-0086-4

By:

He, Yuan;
Wang, Kan;
Yan, Nieng

Publication type:

Article

Revisiting the TALE repeat.

Published in:

Protein & Cell, 2014, v. 5, n. 4, p. 297, doi. 10.1007/s13238-014-0035-2

By:

Deng, Dong;
Yan, Chuangye;
Wu, Jianping;
Pan, Xiaojing;
Yan, Nieng

Publication type:

Article

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine**.

Published in:

Angewandte Chemie, 2021, v. 133, n. 20, p. 11575, doi. 10.1002/ange.202102196

By:

Li, Zhangqiang;
Jin, Xueqin;
Wu, Tong;
Huang, Gaoxingyu;
Wu, Kun;
Lei, Jianlin;
Pan, Xiaojing;
Yan, Nieng

Publication type:

Article

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Cav1.1 by Dihydropyridine Compounds**.

Published in:

Angewandte Chemie, 2021, v. 133, n. 6, p. 3168, doi. 10.1002/ange.202011793

By:

Gao, Shuai;
Yan, Nieng

Publication type:

Article

Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel.

Published in:

Nature, 2009, v. 462, n. 7272, p. 467, doi. 10.1038/nature08610

By:

Yi Wang;
Yongjian Huang;
Jiawei Wang;
Chao Cheng;
Weijiao Huang;
Peilong Lu;
Ya-Nan Xu;
Pengye Wang;
Nieng Yan;
Yigong Shi

Publication type:

Article

Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.

Published in:

Nature, 2005, v. 437, n. 7060, p. 831, doi. 10.1038/nature04002

By:

Nieng Yan;
Chai, Jijie;
Eui Seung Lee;
Lichuan Gu;
Qun Liu;
Jiaqing He;
Jia-Wei Wu;
Kokel, David;
Huilin Li;
Quan Hao;
Ding Xue;
Yigong Shi

Publication type:

Article

Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-10234-9

By:

Hongwu Qian;
Pingping Cao;
Miaohui Hu;
Shuai Gao;
Nieng Yan;
Xin Gong

Publication type:

Article

The shape of human squalene epoxidase expands the arsenal against cancer.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08866-y

By:

Brown, Andrew J.;
Chua, Ngee Kiat;
Yan, Nieng

Publication type:

Article

Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine**.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 20, p. 11474, doi. 10.1002/anie.202102196

By:

Li, Zhangqiang;
Jin, Xueqin;
Wu, Tong;
Huang, Gaoxingyu;
Wu, Kun;
Lei, Jianlin;
Pan, Xiaojing;
Yan, Nieng

Publication type:

Article

Structural Basis of the Modulation of the Voltage‐Gated Calcium Ion Channel Cav1.1 by Dihydropyridine Compounds**.

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 6, p. 3131, doi. 10.1002/anie.202011793

By:

Gao, Shuai;
Yan, Nieng

Publication type:

Article

2:1 Stoichiometry of the CED-4-CED-9 Complex and the Tetrameric CED-4.

Published in:

Cell Cycle, 2006, v. 5, n. 1, p. 31, doi. 10.4161/cc.5.1.2263

By:

Nieng Yan;
Yanhui Xu;
Yigong Shi

Publication type:

Article

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters.

Published in:

Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 3, p. 546, doi. 10.1002/pro.2858

By:

Deng, Dong;
Yan, Nieng

Publication type:

Article

Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition.

Published in:

Cell Research, 2015, v. 25, n. 4, p. 401, doi. 10.1038/cr.2015.32

By:

Gong, Xin;
Li, Jingxian;
Shao, Wei;
Wu, Jianping;
Qian, Hongwu;
Ren, Ruobing;
Espenshade, Peter;
Yan, Nieng

Publication type:

Article

Crystal structure of a bacterial homologue of SWEET transporters.

Published in:

Cell Research, 2014, v. 24, n. 12, p. 1486, doi. 10.1038/cr.2014.144

By:

Wang, Jing;
Yan, Chuangye;
Li, Yini;
Yan, Nieng;
Hu, Qi;
Hirata, Kunio;
Yamamoto, Masaki

Publication type:

Article

Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13.

Published in:

Cell Research, 2013, v. 23, n. 12, p. 1369, doi. 10.1038/cr.2013.143

By:

Li, Wenqi;
Wang, Li;
Sheng, Xinlei;
Yan, Chuangye;
Zhou, Rui;
Hang, Jing;
Yin, Ping;
Yan, Nieng

Publication type:

Article

Analysis of the selectivity filter of the voltage-gated sodium channel NavRh.

Published in:

Cell Research, 2013, v. 23, n. 3, p. 409, doi. 10.1038/cr.2012.173

By:

Zhang, Xu;
Xia, Mengdie;
Li, Yang;
Liu, Huihui;
Jiang, Xin;
Ren, Wenlin;
Wu, Jianping;
DeCaen, Paul;
Yu, Feng;
Huang, Sheng;
He, Jianhua;
Clapham, David E;
Yan, Nieng;
Gong, Haipeng

Publication type:

Article

The conformational shifts of the voltage sensing domains between NavRh and NavAb.

Published in:

Cell Research, 2013, v. 23, n. 3, p. 444, doi. 10.1038/cr.2012.158

By:

Zhang, Xu;
Yan, Nieng

Publication type:

Article

Recognition of methylated DNA by TAL effectors.

Published in:

Cell Research, 2012, v. 22, n. 10, p. 1502, doi. 10.1038/cr.2012.127

By:

Deng, Dong;
Yin, Ping;
Yan, Chuangye;
Pan, Xiaojing;
Gong, Xinqi;
Qi, Shiqian;
Xie, Tian;
Mahfouz, Magdy;
Zhu, Jian-Kang;
Yan, Nieng;
Shi, Yigong

Publication type:

Article

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.

Published in:

Nature, 2015, v. 517, n. 7532, p. 50, doi. 10.1038/nature14063

By:

Yan, Zhen;
Bai, Xiao-chen;
Yan, Chuangye;
Wu, Jianping;
Li, Zhangqiang;
Xie, Tian;
Peng, Wei;
Yin, Chang-cheng;
Li, Xueming;
Scheres, Sjors H. W.;
Shi, Yigong;
Yan, Nieng

Publication type:

Article