Works by Nicolotti, Orazio

Results: 85

Synthesis and biological evaluation of 3,5‐diaryl‐pyrazole derivatives as potential antiprostate cancer agents.

Published in:

Archiv der Pharmazie, 2021, v. 354, n. 12, p. 1, doi. 10.1002/ardp.202100225

By:

Anil, Derya;
Caykoylu, Emine U.;
Sanli, Fatma;
Gambacorta, Nicola;
Karatas, Omer F.;
Nicolotti, Orazio;
Algul, Oztekin;
Burmaoglu, Serdar

Publication type:

Article

Design of enamides as new selective monoamine oxidase‐B inhibitors.

Published in:

Journal of Pharmacy & Pharmacology, 2020, v. 72, n. 7, p. 916, doi. 10.1111/jphp.13264

By:

Kavully, Fathima Sahla;
Oh, Jong Min;
Dev, Sanal;
Kaipakasseri, Swafvan;
Palakkathondi, Ashique;
Vengamthodi, Ajeesh;
Abdul Azeez, Rinshana Fathima;
Tondo, Anna Rita;
Nicolotti, Orazio;
Kim, Hoon;
Bijo Mathew

Publication type:

Article

Making sense of chemical space network shows signs of criticality.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-48107-3

By:

Amoroso, Nicola;
Gambacorta, Nicola;
Mastrolorito, Fabrizio;
Togo, Maria Vittoria;
Trisciuzzi, Daniela;
Monaco, Alfonso;
Pantaleo, Ester;
Altomare, Cosimo Damiano;
Ciriaco, Fulvio;
Nicolotti, Orazio

Publication type:

Article

Short-term anti-remodeling effects of gliflozins in diabetic patients with heart failure and reduced ejection fraction: an explainable artificial intelligence approach.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1175606

By:

Mele, Marco;
Imbrici, Paola;
Mele, Antonietta;
Togo, Maria Vittoria;
Dinoi, Giorgia;
Correale, Michele;
Brunetti, Natale Daniele;
Nicolotti, Orazio;
De Luca, Annamaria;
Altomare, Cosimo Damiano;
Liantonio, Antonella;
Amoroso, Nicola

Publication type:

Article

1‐Oxa‐2,6‐Diazaspiro[3.3]heptane as a New Potential Piperazine Bioisostere – Flow‐Assisted Preparation and Derivatisation by Strain‐Release of Azabicyclo[1.1.0]butanes.

Published in:

Advanced Synthesis & Catalysis, 2024, v. 366, n. 18, p. 3894, doi. 10.1002/adsc.202400781

By:

Graziano, Elena;
Natho, Philipp;
Andresini, Michael;
Mastrolorito, Fabrizio;
Mahdi, Iktedar;
Mesto, Ernesto;
Colella, Marco;
Degennaro, Leonardo;
Nicolotti, Orazio;
Luisi, Renzo

Publication type:

Article

Investigation on Novel E/Z 2-Benzylideneindan-1-One-Based Photoswitches with AChE and MAO-B Dual Inhibitory Activity.

Published in:

Molecules, 2023, v. 28, n. 15, p. 5857, doi. 10.3390/molecules28155857

By:

Paolino, Marco;
de Candia, Modesto;
Purgatorio, Rosa;
Catto, Marco;
Saletti, Mario;
Tondo, Anna Rita;
Nicolotti, Orazio;
Cappelli, Andrea;
Brizzi, Antonella;
Mugnaini, Claudia;
Corelli, Federico;
Altomare, Cosimo D.

Publication type:

Article

Assessing the Role of a Malonamide Linker in the Design of Potent Dual Inhibitors of Factor Xa and Cholinesterases.

Published in:

Molecules, 2022, v. 27, n. 13, p. 4269, doi. 10.3390/molecules27134269

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
Samarelli, Francesco;
Lopopolo, Gianfranco;
de Candia, Modesto;
Catto, Marco;
Nicolotti, Orazio;
Altomare, Cosimo D.

Publication type:

Article

Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors.

Published in:

Molecules, 2022, v. 27, n. 12, p. 3801, doi. 10.3390/molecules27123801

By:

Alagöz, Mehmet Abdullah;
Oh, Jong Min;
Zenni, Yaren Nur;
Özdemir, Zeynep;
Abdelgawad, Mohamed A.;
Naguib, Ibrahim A.;
Ghoneim, Mohammed M.;
Gambacorta, Nicola;
Nicolotti, Orazio;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

Selected Class of Enamides Bearing Nitro Functionality as Dual-Acting with Highly Selective Monoamine Oxidase-B and BACE1 Inhibitors.

Published in:

Molecules, 2021, v. 26, n. 19, p. 6004, doi. 10.3390/molecules26196004

By:

Venkidath, Anusree;
Oh, Jong Min;
Dev, Sanal;
Amin, Elham;
Rasheed, Shebina P.;
Vengamthodi, Ajeesh;
Gambacorta, Nicola;
Khames, Ahmed;
Abdelgawad, Mohamed A.;
George, Ginson;
Nicolotti, Orazio;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.

Published in:

Molecules, 2021, v. 26, n. 17, p. 5208, doi. 10.3390/molecules26175208

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
de Candia, Modesto;
Catto, Marco;
Rullo, Mariagrazia;
Pisani, Leonardo;
Nicolotti, Orazio;
Altomare, Cosimo D.

Publication type:

Article

Homobivalent Lamellarin-Like Schiff Bases: In Vitro Evaluation of Their Cancer Cell Cytotoxicity and Multitargeting Anti-Alzheimer's Disease Potential.

Published in:

Molecules, 2021, v. 26, n. 2, p. 359, doi. 10.3390/molecules26020359

By:

Nevskaya, Alisa A.;
Anikina, Lada V.;
Purgatorio, Rosa;
Catto, Marco;
Nicolotti, Orazio;
de Candia, Modesto;
Pisani, Leonardo;
Borisova, Tatiana N.;
Miftyakhova, Almira R.;
Varlamov, Aleksey V.;
Nevskaya, Elena Yu.;
Borisov, Roman S.;
Voskressensky, Leonid G.;
Altomare, Cosimo D.;
Geronikaki, Athina

Publication type:

Article

Pharmacophore Modeling and 3D-QSAR Study of Indole and Isatin Derivatives as Antiamyloidogenic Agents Targeting Alzheimer's Disease †.

Published in:

Molecules, 2020, v. 25, n. 23, p. 5773, doi. 10.3390/molecules25235773

By:

Purgatorio, Rosa;
Gambacorta, Nicola;
Catto, Marco;
de Candia, Modesto;
Pisani, Leonardo;
Espargaró, Alba;
Sabaté, Raimon;
Cellamare, Saverio;
Nicolotti, Orazio;
Altomare, Cosimo D.;
McPhee, Derek J.

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors.

Published in:

Molecules, 2020, v. 25, n. 22, p. 5371, doi. 10.3390/molecules25225371

By:

Çeçen, Muhammed;
Oh, Jong Min;
Özdemir, Zeynep;
Büyüktuncel, Saliha Ebru;
Uysal, Mehtap;
Abdelgawad, Mohamed A.;
Musa, Arafa;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon;
Filippis, Barbara De;
Eckert, Gunter Peter

Publication type:

Article

Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to.

Published in:

Molecules, 2020, v. 25, n. 18, p. 4210, doi. 10.3390/molecules25184210

By:

Carofiglio, Francesca;
Trisciuzzi, Daniela;
Gambacorta, Nicola;
Leonetti, Francesco;
Stefanachi, Angela;
Nicolotti, Orazio;
Schenone, Silvia

Publication type:

Article

Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity.

Published in:

Molecules, 2020, v. 25, n. 18, p. 4064, doi. 10.3390/molecules25184064

By:

Tran, Thai-Son;
Tran, Thanh-Dao;
Tran, The-Huan;
Mai, Thanh-Tan;
Nguyen, Ngoc-Le;
Thai, Khac-Minh;
Le, Minh-Tri;
Nicolotti, Orazio

Publication type:

Article

Synthesis, Antimicrobial Activity and Molecular Docking of Novel Thiourea Derivatives Tagged with Thiadiazole, Imidazole and Triazine Moieties as Potential DNA Gyrase and Topoisomerase IV Inhibitors.

Published in:

Molecules, 2020, v. 25, n. 12, p. 2766, doi. 10.3390/molecules25122766

By:

Hashem, Heba E.;
Amr, Abd El-Galil E.;
Nossier, Eman S.;
Elsayed, Elsayed A.;
Azmy, Eman M.;
Castagnolo, Daniele;
Nicolotti, Orazio

Publication type:

Article

Novel Class of Chalcone Oxime Ethers as Potent Monoamine Oxidase-B and Acetylcholinesterase Inhibitors.

Published in:

Molecules, 2020, v. 25, n. 10, p. 2356, doi. 10.3390/molecules25102356

By:

Oh, Jong Min;
Rangarajan, T. M.;
Chaudhary, Reeta;
Singh, Rishi Pal;
Singh, Manjula;
Singh, Raj Pal;
Tondo, Anna Rita;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

Development of a Rapid Mass Spectrometric Determination of AMP and Cyclic AMP for PDE3 Activity Study: Application and Computational Analysis for Evaluating the Effect of a Novel 2-oxo-1,2-dihydropyridine-3-carbonitrile Derivative as PDE-3 Inhibitor.

Published in:

Molecules, 2020, v. 25, n. 8, p. 1817, doi. 10.3390/molecules25081817

By:

Cicalini, Ilaria;
De Filippis, Barbara;
Gambacorta, Nicola;
Di Michele, Antonio;
Valentinuzzi, Silvia;
Ammazzalorso, Alessandra;
Della Valle, Alice;
Amoroso, Rosa;
Nicolotti, Orazio;
Del Boccio, Piero;
Giampietro, Letizia

Publication type:

Article

Design, Synthesis and Biological Evaluation of Phenyl Urea Derivatives as IDO1 Inhibitors.

Published in:

Molecules, 2020, v. 25, n. 6, p. 1447, doi. 10.3390/molecules25061447

By:

Zhou, Chuan;
Lai, Fangfang;
Sheng, Li;
Chen, Xiaoguang;
Li, Yan;
Feng, Zhiqiang;
Nicolotti, Orazio

Publication type:

Article

Synthesis of New Series of 2-C-(β-D-glucopyranosyl)-Pyrimidines and Their Evaluation as Inhibitors of Some Glycoenzymes.

Published in:

Molecules, 2020, v. 25, n. 3, p. 701, doi. 10.3390/molecules25030701

By:

Szennyes, Eszter;
Gyémánt, Gyöngyi;
Somsák, László;
Bokor, Éva;
Nicolotti, Orazio

Publication type:

Article

Methyltransferase Inhibitors: Competing with, or Exploiting the Bound Cofactor.

Published in:

Molecules, 2019, v. 24, n. 24, p. 4492, doi. 10.3390/molecules24244492

By:

Ferreira de Freitas, Renato;
Ivanochko, Danton;
Schapira, Matthieu;
Nicolotti, Orazio

Publication type:

Article

2-Arylidene-1-indandiones as Pleiotropic Agents with Antioxidant and Inhibitory Enzymes Activities †.

Published in:

Molecules, 2019, v. 24, n. 23, p. 4411, doi. 10.3390/molecules24234411

By:

Kouzi, Olympia;
Pontiki, Eleni;
Hadjipavlou-Litina, Dimitra;
Nicolotti, Orazio

Publication type:

Article

Novel C7-Substituted Coumarins as Selective Monoamine Oxidase Inhibitors: Discovery, Synthesis and Theoretical Simulation.

Published in:

Molecules, 2019, v. 24, n. 21, p. 4003, doi. 10.3390/molecules24214003

By:

Wang, Dong;
Hong, Ren-Yuan;
Guo, Mengyao;
Liu, Yi;
Chen, Nianhang;
Li, Xun;
Kong, De-Xin;
Nicolotti, Orazio

Publication type:

Article

Accelerating Drug Discovery by Early Protein Drug Target Prediction Based on a Multi-Fingerprint Similarity Search †.

Published in:

Molecules, 2019, v. 24, n. 12, p. 2233, doi. 10.3390/molecules24122233

By:

Montaruli, Michele;
Alberga, Domenico;
Ciriaco, Fulvio;
Trisciuzzi, Daniela;
Tondo, Anna Rita;
Mangiatordi, Giuseppe Felice;
Nicolotti, Orazio;
Pedretti, Alessandro

Publication type:

Article

Searching for Multi-Targeting Neurotherapeutics against Alzheimer’s: Discovery of Potent AChE-MAO B Inhibitors through the Decoration of the 2H-Chromen-2-one Structural Motif.

Published in:

Molecules, 2016, v. 21, n. 3, p. 362, doi. 10.3390/molecules21030362

By:

Pisani, Leonardo;
Farina, Roberta;
Soto-Otero, Ramon;
Denora, Nunzio;
Mangiatordi, Giuseppe Felice;
Nicolotti, Orazio;
Mendez-Alvarez, Estefania;
Altomare, Cosimo Damiano;
Catto, Marco;
Carotti, Angelo

Publication type:

Article

Retrospective Clinical Investigation into the Association Between Abnormal Blood Clotting, Oral Anticoagulant Therapy, and Medium-Term Mortality in a Cohort of COVID-19 Patients.

Published in:

Biomedicines, 2025, v. 13, n. 3, p. 535, doi. 10.3390/biomedicines13030535

By:

Dinoi, Giorgia;
Togo, Maria Vittoria;
Guida, Pietro;
Deruvo, Caterina;
Samarelli, Francesco;
Imbrici, Paola;
Nicolotti, Orazio;
De Luca, Annamaria;
Mastroianni, Franco;
Liantonio, Antonella;
Altomare, Cosimo Damiano

Publication type:

Article

Recent Advances in the Discovery of Novel Drugs on Natural Molecules.

Published in:

Biomedicines, 2024, v. 12, n. 6, p. 1254, doi. 10.3390/biomedicines12061254

By:

Quintieri, Laura;
Caputo, Leonardo;
Nicolotti, Orazio

Publication type:

Article

Rational Discovery of Antiviral Whey Protein-Derived Small Peptides Targeting the SARS-CoV-2 Main Protease.

Published in:

Biomedicines, 2022, v. 10, n. 5, p. 1067, doi. 10.3390/biomedicines10051067

By:

Gambacorta, Nicola;
Caputo, Leonardo;
Quintieri, Laura;
Monaci, Linda;
Ciriaco, Fulvio;
Nicolotti, Orazio

Publication type:

Article

Generation of Stilbene Glycoside with Promising Cell Rejuvenation Activity through Biotransformation by the Entomopathogenic Fungus Beauveria bassiana.

Published in:

Biomedicines, 2021, v. 9, n. 5, p. 555, doi. 10.3390/biomedicines9050555

By:

Ha, Sang Keun;
Kang, Min Cheol;
Lee, Seulah;
Darlami, Om;
Shin, Dongyun;
Choi, Inwook;
Kim, Ki Hyun;
Kim, Sun Yeou;
Caputo, Leonardo;
Quintieri, Laura;
Nicolotti, Orazio

Publication type:

Article

N-Alkylation of Anthracycline Antibiotics by Natural Sesquiterpene Lactones as a Way to Obtain Antitumor Agents with Reduced Side Effects.

Published in:

Biomedicines, 2021, v. 9, n. 5, p. 547, doi. 10.3390/biomedicines9050547

By:

Neganova, Margarita;
Semakov, Alexey;
Aleksandrova, Yulia;
Yandulova, Ekaterina;
Pukhov, Sergey;
Anikina, Lada;
Klochkov, Sergey;
Caputo, Leonardo;
Quintieri, Laura;
Nicolotti, Orazio

Publication type:

Article

Optimized Synthesis of New N-Mustards Based on 2-Mercaptobenzoxazole Derivatives with Antitumor Activity.

Published in:

Biomedicines, 2021, v. 9, n. 5, p. 476, doi. 10.3390/biomedicines9050476

By:

Cheptea, Corina;
Sunel, Valeriu;
Morosanu, Ana Cezarina;
Dimitriu, Dan Gheorghe;
Dulcescu-Oprea, Mihaela Maria;
Angheluta, Mihai-Daniel;
Miron, Mihaela;
Nechifor, Cristina Delia;
Dorohoi, Dana Ortansa;
Malancus, Razvan Nicolae;
Caputo, Leonardo;
Quintieri, Laura;
Nicolotti, Orazio

Publication type:

Article

Growth hormone secretagogues modulate inflammation and fibrosis in mdx mouse model of Duchenne muscular dystrophy.

Published in:

Frontiers in Immunology, 2023, v. 14, p. 1, doi. 10.3389/fimmu.2023.1119888

By:

Boccanegra, Brigida;
Cappellari, Ornella;
Mantuano, Paola;
Trisciuzzi, Daniela;
Mele, Antonietta;
Tulimiero, Lisamaura;
De Bellis, Michela;
Cirmi, Santa;
Sanarica, Francesca;
Cerchiara, Alessandro Giovanni;
Conte, Elena;
Meanti, Ramona;
Rizzi, Laura;
Bresciani, Elena;
Denoyelle, Severine;
Fehrentz, Jean-Alain;
Cruciani, Gabriele;
Nicolotti, Orazio;
Liantonio, Antonella;
Torsello, Antonio

Publication type:

Article

Mind the Gap! A Journey towards Computational Toxicology.

Published in:

Molecular Informatics, 2016, v. 35, n. 8/9, p. 294, doi. 10.1002/minf.201501017

By:

Mangiatordi, Giuseppe Felice;
Alberga, Domenico;
Altomare, Cosimo Damiano;
Carotti, Angelo;
Catto, Marco;
Cellamare, Saverio;
Gadaleta, Domenico;
Lattanzi, Gianluca;
Leonetti, Francesco;
Pisani, Leonardo;
Stefanachi, Angela;
Trisciuzzi, Daniela;
Nicolotti, Orazio

Publication type:

Article

Discovery of a Potent and Selective Hetero-Bivalent AChE Inhibitor via Bioisosteric Replacement.

Published in:

Molecular Informatics, 2011, v. 30, n. 2/3, p. 133, doi. 10.1002/minf.201000126

By:

Nicolotti, Orazio;
Pisani, Leonardo;
Catto, Marco;
Leonetti, Francesco;
Giangreco, Ilenia;
Stefanachi, Angela;
Carotti, Angelo

Publication type:

Article

Synthesis of N ′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 13, p. 5830, doi. 10.3390/app11135830

By:

Sellitepe, Hasan Erdinç;
Oh, Jong Min;
Doğan, İnci Selin;
Yildirim, Sercan;
Aksel, Ahmet Buğra;
Jeong, Geum Seok;
Khames, Ahmed;
Abdelgawad, Mohamed A.;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

In silico development of potential InhA inhibitors through 3D-QSAR analysis, virtual screening and molecular dynamics.

Published in:

Journal of Biomolecular Structure & Dynamics, 2025, v. 43, n. 3, p. 1329, doi. 10.1080/07391102.2023.2291549

By:

Bhaskar, Vaishnav;
Kumar, Sunil;
Sujathan Nair, Aathira;
Gokul, S.;
Rajappan Krishnendu, Prayaga;
Benny, Sonu;
Amrutha, C. T.;
Manisha, Deepthi S.;
Bhaskar, Vaishnavi;
Mary Zachariah, Subin;
Aneesh, T. P.;
Abdelgawad, Mohamed A.;
Ghoneim, Mohammed M.;
Pappachen, Leena K.;
Nicolotti, Orazio;
Mathew, Bijo

Publication type:

Article

Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics.

Published in:

Journal of Biomolecular Structure & Dynamics, 2020, v. 38, n. 17, p. 5219, doi. 10.1080/07391102.2019.1704883

By:

Delre, Pietro;
Alberga, Domenico;
Gijsbers, Abril;
Sánchez-Puig, Nuria;
Nicolotti, Orazio;
Saviano, Michele;
Siliqi, Dritan;
Mangiatordi, Giuseppe Felice

Publication type:

Article

From Deep Learning to the Discovery of Promising VEGFR‐2 Inhibitors.

Published in:

ChemMedChem, 2024, v. 19, n. 16, p. 1, doi. 10.1002/cmdc.202400108

By:

Yucel, Mehmet Ali;
Adal, Ercan;
Aktekin, Mine Buga;
Hepokur, Ceylan;
Gambacorta, Nicola;
Nicolotti, Orazio;
Algul, Oztekin

Publication type:

Article

Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors.

Published in:

ChemMedChem, 2020, v. 15, n. 23, p. 2257, doi. 10.1002/cmdc.202000491

By:

Jeong, Geum Seok;
Kaipakasseri, Swafvan;
Lee, Sang Ryong;
Marraiki, Najat;
Batiha, Gaber El‐Saber;
Dev, Sanal;
Palakkathondi, Ashique;
Kavully, Fathima Sahla;
Gambacorta, Nicola;
Nicolotti, Orazio;
Mathew, Bijo;
Kim, Hoon

Publication type:

Article

A New Potent and Selective Monoamine Oxidase‐B Inhibitor with Extended Conjugation in a Chalcone Framework: 1‐[4‐(Morpholin‐4‐yl)phenyl]‐5‐phenylpenta‐2,4‐dien‐1‐one.

Published in:

ChemMedChem, 2020, v. 15, n. 17, p. 1629, doi. 10.1002/cmdc.202000305

By:

Maliyakkal, Naseer;
Eom, Bo Hyun;
Heo, Jeong Hyun;
Abdullah Almoyad, Mohammad Ali;
Thomas Parambi, Della Grace;
Gambacorta, Nicola;
Nicolotti, Orazio;
Beeran, Asmy Appadath;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Tetrahydro‐β‐carboline Derivatives as Selective Sub‐Nanomolar Gelatinase Inhibitors.

Published in:

ChemMedChem, 2018, v. 13, n. 13, p. 1343, doi. 10.1002/cmdc.201800237

By:

Mangiatordi, Giuseppe Felice;
Guzzo, Tatiana;
Rossano, Eugenio Claudio;
Trisciuzzi, Daniela;
Alberga, Domenico;
Fasciglione, Giovanni;
Coletta, Massimiliano;
Topai, Alessandra;
Nicolotti, Orazio

Publication type:

Article

Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2024, v. 20, n. 7, p. 561, doi. 10.1080/17425255.2023.2298827

By:

Vittoria Togo, Maria;
Mastrolorito, Fabrizio;
Orfino, Angelica;
Graps, Elisabetta Anna;
Tondo, Anna Rita;
Altomare, Cosimo Damiano;
Ciriaco, Fulvio;
Trisciuzzi, Daniela;
Nicolotti, Orazio;
Amoroso, Nicola

Publication type:

Article

Targeting protein-protein interactions with low molecular weight and short peptide modulators: insights on disease pathways and starting points for drug discovery.

Published in:

Expert Opinion on Drug Discovery, 2023, v. 18, n. 7, p. 737, doi. 10.1080/17460441.2023.2218641

By:

Trisciuzzi, Daniela;
Villoutreix, Bruno O.;
Siragusa, Lydia;
Baroni, Massimo;
Cruciani, Gabriele;
Nicolotti, Orazio

Publication type:

Article

Exploration of a new class of monoamine oxidase B inhibitors by assembling benzyloxy pharmacophore on halogenated chalcones.

Published in:

Chemical Biology & Drug Design, 2023, v. 102, n. 2, p. 271, doi. 10.1111/cbdd.14238

By:

Singh, Ashutosh Kumar;
Kim, Seong‐Min;
Oh, Jong Min;
Abdelgawad, Mohamed A.;
Ghoneim, Mohammed M.;
Rangarajan, T. M.;
Kumar, Sunil;
Sudevan, Sachithra Thazhathuveedu;
Trisciuzzi, Daniela;
Nicolotti, Orazio;
Kim, Hoon;
Mathew, Bijo

Publication type:

Article

Automated identification of structurally heterogeneous and patentable antiproliferative hits as potential tubulin inhibitors.

Published in:

Chemical Biology & Drug Design, 2018, v. 92, n. 1, p. 1161, doi. 10.1111/cbdd.13200

By:

Mangiatordi, Giuseppe Felice;
Trisciuzzi, Daniela;
Iacobazzi, Rosamaria;
Denora, Nunzio;
Pisani, Leonardo;
Catto, Marco;
Leonetti, Francesco;
Alberga, Domenico;
Nicolotti, Orazio

Publication type:

Article

Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.

Published in:

Chemical Biology & Drug Design, 2016, v. 88, n. 6, p. 820, doi. 10.1111/cbdd.12811

By:

Stefanachi, Angela;
Mangiatordi, Giuseppe Felice;
Tardia, Piero;
Alberga, Domenico;
Leonetti, Francesco;
Niso, Mauro;
Colabufo, Nicola Antonio;
Adamo, Carlo;
Nicolotti, Orazio;
Cellamare, Saverio

Publication type:

Article

Cover Feature: Persulfate Reaction in a Hair‐Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13‐Diamino‐4,7,10‐Trioxatridecane (ChemistryOpen 5/2018).

Published in:

ChemistryOpen, 2018, v. 7, n. 5, p. 311, doi. 10.1002/open.201800052

By:

Gargano, Emanuele M.;
Mangiatordi, Giuseppe F.;
Weber, Ingo;
Goebel, Carsten;
Alberga, Domenico;
Nicolotti, Orazio;
Ruess, Wolfgang;
Wierlacher, Stefan

Publication type:

Article

Persulfate Reaction in a Hair‐Bleaching Formula: Unveiling the Unconventional Reactivity of 1,13‐Diamino‐4,7,10‐Trioxatridecane.

Published in:

ChemistryOpen, 2018, v. 7, n. 5, p. 319, doi. 10.1002/open.201800013

By:

Gargano, Emanuele M.;
Mangiatordi, Giuseppe F.;
Weber, Ingo;
Goebel, Carsten;
Alberga, Domenico;
Nicolotti, Orazio;
Ruess, Wolfgang;
Wierlacher, Stefan

Publication type:

Article

Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data.

Published in:

Chemistry Central Journal, 2015, v. 9, p. 1, doi. 10.1186/s13065-015-0139-7

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Pizzo, Fabiola;
Gadaleta, Domenico;
Lombardo, Anna;
Nicolotti, Orazio;
Benfenati, Emilio

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium-like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors.

Published in:

ChemMedChem, 2010, v. 5, n. 9, p. 1616, doi. 10.1002/cmdc.201000210

By:

Pisani, Leonardo;
Catto, Marco;
Giangreco, Ilenia;
Leonetti, Francesco;
Nicolotti, Orazio;
Stefanachi, Angela;
Cellamare, Saverio;
Carotti, Angelo

Publication type:

Article