Works by Nichols, Colin G.

Results: 84

Bayliss–Starling Prize Lecture: KATP channel pathophysiology – a whole‐body odyssey.

Published in:

Journal of Physiology, 2025, v. 603, n. 11, p. 3293, doi. 10.1113/JP287415

By:

Nichols, Colin G.

Publication type:

Article

Control of neurovascular coupling by ATP-sensitive potassium channels.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2025, v. 45, n. 6, p. 1130, doi. 10.1177/0271678X251313906

By:

Bowen, Ryan M;
York, Nathaniel W;
Padawer-Curry, Jonah;
Bauer, Adam Q;
Lee, Jin-Moo;
Nichols, Colin G

Publication type:

Article

Chronic Antidiabetic Sulfonylureas In Vivo: Reversible Effects on Mouse Pancreatic β-Cells.

Published in:

PLoS Medicine, 2008, v. 5, n. 10, p. 1473, doi. 10.1371/journal.pmed.0050206

By:

Remedi, Maria Sara;
Nichols, Colin G.

Publication type:

Article

Cantú Syndrome Resulting from Activating Mutation in the KCNJ8 Gene.

Published in:

Human Mutation, 2014, v. 35, n. 7, p. 809, doi. 10.1002/humu.22555

By:

Cooper, Paige E.;
Reutter, Heiko;
Woelfle, Joachim;
Engels, Hartmut;
Grange, Dorothy K.;
Haaften, Gijs;
Bon, Bregje W.;
Hoischen, Alexander;
Nichols, Colin G.

Publication type:

Article

Heterologous expression of the Na+,K+-ATPase γ subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore.

Published in:

Journal of Physiology, 2001, v. 535, n. 2, p. 407, doi. 10.1111/j.1469-7793.2001.t01-1-00407.x

By:

Sha, Qun;
Lansbery, Kristan L.;
Distefano, Darcy;
Mercer, Robert W.;
Nichols, Colin G.

Publication type:

Article

Expression of a functional Kir4 family inward rectifier K+ channel from a gene cloned from mouse liver.

Published in:

Journal of Physiology, 1999, v. 514, n. 3, p. 639, doi. 10.1111/j.1469-7793.1999.639ad.x

By:

Pearson, Wade L.;
Dourado, Michelle;
Schreiber, Matthew;
Salkoff, Lawrence;
Nichols, Colin G.

Publication type:

Article

Pathophysiological Consequences of KATP Channel Overactivity and Pharmacological Response to Glibenclamide in Skeletal Muscle of a Murine Model of Cantù Syndrome.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.604885

By:

Scala, Rosa;
Maqoud, Fatima;
Zizzo, Nicola;
Mele, Antonietta;
Camerino, Giulia Maria;
Zito, Francesco Alfredo;
Ranieri, Girolamo;
McClenaghan, Conor;
Harter, Theresa M.;
Nichols, Colin G.;
Tricarico, Domenico

Publication type:

Article

The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.

Published in:

2008

By:

Koster, Joseph C;
Cadario, Francesco;
Peruzzi, Cinzia;
Colombo, Carlo;
Nichols, Colin G;
Barbetti, Fabrizio

Publication type:

journal article

C-terminal determinants of Kir4.2 channel expression.

Published in:

2006

By:

Pearson, Wade L.;
Skatchkov, Serguei N.;
Eaton, Misty J.;
Nichols, Colin G.

Publication type:

journal article

Electrophysiology of Human iPSC-derived Vascular Smooth Muscle Cells and Cell-autonomous Consequences of Cantú Syndrome Mutations.

Published in:

Function, 2024, v. 5, n. 5, p. 1, doi. 10.1093/function/zqae027

By:

Hanson, Alex;
McClenaghan, Conor;
Weng, Kuo-Chan;
Colijn, Sarah;
Stratman, Amber N;
Halabi, Carmen M;
Grange, Dorothy K;
Silva, Jonathan R;
Nichols, Colin G

Publication type:

Article

Lymphatic contractile dysfunction in mouse models of Cantú Syndrome with KATP channel gain-of-function.

Published in:

Function, 2023, v. 4, n. 3, p. 1, doi. 10.1093/function/zqad017

By:

Davis, Michael J;
Castorena-Gonzalez, Jorge A;
Kim, Hae Jin;
Li, Min;
Remedi, Maria;
Nichols, Colin G

Publication type:

Article

Oxidation Driven Reversal of PIP2-dependent Gating in GIRK2 Channels.

Published in:

Function, 2023, v. 4, n. 3, p. 1, doi. 10.1093/function/zqad016

By:

Lee, Sun-Joo;
Maeda, Shoji;
Gao, Jian;
Nichols, Colin G

Publication type:

Article

Bridging Personal and Population in Excitability Diseases: Will Studies of Rare Diseases Bring Generalizable Mechanisms From Monogenic Channelopathies?

Published in:

Function, 2022, v. 3, n. 1, p. 1, doi. 10.1093/function/zqab072

By:

Nichols, Colin G;
McClenaghan, Conor

Publication type:

Article

The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome.

Published in:

Function, 2020, v. 1, n. 1, p. 1, doi. 10.1093/function/zqaa004

By:

McClenaghan, Conor;
Yan Huang;
Matkovich, Scot J.;
Kovacs, Attila;
Weinheimer, Carla J.;
Perez, Ron;
Broekelmann, Thomas J.;
Harter, Theresa M.;
Jin-Moo Lee;
Remedi, Maria S.;
Nichols, Colin G.

Publication type:

Article

On the Mechanism of Inhibition of KATP Channels by Glibenclamide in Rat Ventricular Myocytes.

Published in:

Journal of Cardiovascular Electrophysiology, 1993, v. 4, n. 1, p. 38, doi. 10.1111/j.1540-8167.1993.tb01210.x

By:

Ripoll, Cristina;
Lederer, W. Jon;
Nichols, Colin G.

Publication type:

Article

Activation of ATP-Sensitive Potassium Channels Underlies Contractile Failure in Single Human Cardiac Myocytes During Complete Metabolic Inhibition.

Published in:

Journal of Cardiovascular Electrophysiology, 1992, v. 3, n. 1, p. 56, doi. 10.1111/j.1540-8167.1992.tb01096.x

By:

Cohen, Neri M.;
Lederer, W. J.;
Nichols, Colin G.

Publication type:

Article

Molecular biology of KATP channels and implications for health and disease.

Published in:

IUBMB Life, 2009, v. 61, n. 10, p. 971, doi. 10.1002/iub.246

By:

Akrouh, Alejandro;
Halcomb, S. Eliza;
Nichols, Colin G.;
Sala-Rabanal, Monica

Publication type:

Article

Fibroblast Growth Factor Receptor 1 Signaling in Adult Cardiomyocytes Increases Contractility and Results in a Hypertrophic Cardiomyopathy.

Published in:

PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0082979

By:

Cilvik, Sarah N.;
Wang, Joy I.;
Lavine, Kory J.;
Uchida, Keita;
Castro, Angela;
Gierasch, Carolyn M.;
Weinheimer, Carla J.;
House, Stacey L.;
Kovacs, Attila;
Nichols, Colin G.;
Ornitz, David M.

Publication type:

Article

Functional Characterization of a Novel KCNJ11 in Frame Mutation-Deletion Associated with Infancy-Onset Diabetes and a Mild Form of Intermediate DEND: A Battle between KATP Gain of Channel Activity and Loss of Channel Expression

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063758

By:

Lin, Yu-Wen;
Li, Anlong;
Grasso, Valeria;
Battaglia, Domenica;
Crinò, Antonino;
Colombo, Carlo;
Barbetti, Fabrizio;
Nichols, Colin G.

Publication type:

Article

Differential Lipid Dependence of the Function of Bacterial Sodium Channels.

Published in:

PLoS ONE, 2013, v. 8, n. 4, p. 1, doi. 10.1371/journal.pone.0061216

By:

D'Avanzo, Nazzareno;
McCusker, Emily C.;
Powl, Andrew M.;
Miles, Andrew J.;
Nichols, Colin G.;
Wallace, B. A.

Publication type:

Article

Enantioselective Protein-Sterol Interactions Mediate Regulation of Both Prokaryotic and Eukaryotic Inward Rectifier K+ Channels by Cholesterol.

Published in:

PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0019393

By:

D'Avanzo, Nazzareno;
Hyrc, Krzysztof;
Enkvetchakul, Decha;
Covey, Douglas F.;
Nichols, Colin G.

Publication type:

Article

Diet-induced glucose intolerance in mice with decreased beta-cell ATP-sensitive K+ channels.

Published in:

2004

By:

Remedi, Maria S.;
Koster, Joseph. C.;
Markova, Kamelia;
Seino, Susumu;
Miki, Takashi;
Patton, Brian L.;
McDaniel, Michael L.;
Nichols, Colin G.

Publication type:

journal article

HIV protease inhibitors acutely impair glucose-stimulated insulin release.

Published in:

2003

By:

Koster, Joseph C.;
Remedi, Maria S.;
Qiu, Haijun;
Nichols, Colin G.;
Hruz, Paul W.

Publication type:

journal article

Functional analyses of novel mutations in the sulfonylurea receptor 1 associated with persistent...

Published in:

Diabetes, 1998, v. 47, n. 7, p. 1145, doi. 10.2337/diabetes.47.7.1145

By:

Show-Ling Shyng;
Ferrigni, Tycho;
Shepard, Jeremiah B.;
Nestorowicz, Ann;
Glaser, Benjamin;
Permutt, M. Alan;
Nichols, Colin G.

Publication type:

Article

Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.

Published in:

Pediatric Diabetes, 2017, v. 18, n. 8, p. 777, doi. 10.1111/pedi.12489

By:

Remedi, Maria S.;
Thomas, Mareen;
Nichols, Colin G.;
Marshall, Bess A.

Publication type:

Article

Glyburide ameliorates motor coordination and glucose homeostasis in a child with diabetes associated with the KCNJ11/ S225T, del226-232 mutation.

Published in:

Pediatric Diabetes, 2012, v. 13, n. 8, p. 656, doi. 10.1111/j.1399-5448.2012.00874.x

By:

Battaglia, Domenica;
Lin, Yu-Wen;
Brogna, Claudia;
Crinò, Antonino;
Grasso, Valeria;
Mozzi, Alessia F;
Russo, Lucia;
Spera, Sabrina;
Colombo, Carlo;
Ricci, Stefano;
Nichols, Colin G;
Mercuri, Eugenio;
Barbetti, Fabrizio

Publication type:

Article

Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutation.

Published in:

Pediatric Diabetes, 2010, v. 11, n. 4, p. 286, doi. 10.1111/j.1399-5448.2009.00557.x

By:

Wambach, Jennifer A.;
Marshall, Bess A.;
Koster, Joseph C.;
White, Neil H.;
Nichols, Colin G.

Publication type:

Article

Focal congenital hyperinsulinism managed by medical treatment: a diagnostic algorithm based on molecular genetic screening.

Published in:

Clinical Endocrinology, 2014, v. 81, n. 5, p. 679, doi. 10.1111/cen.12400

By:

Maiorana, Arianna;
Barbetti, Fabrizio;
Boiani, Arianna;
Rufini, Vittoria;
Pizzoferro, Milena;
Francalanci, Paola;
Faletra, Flavio;
Nichols, Colin G.;
Grimaldi, Chiara;
Ville de Goyet, Jean;
Rahier, Jacques;
Henquin, Jean‐Claude;
Dionisi‐Vici, Carlo

Publication type:

Article

Large‐conductance calcium‐activated K+ channels, rather than KATP channels, mediate the inhibitory effects of nitric oxide on mouse lymphatic pumping.

Published in:

British Journal of Pharmacology, 2021, v. 178, n. 20, p. 4119, doi. 10.1111/bph.15602

By:

Kim, Hae Jin;
Li, Min;
Nichols, Colin G.;
Davis, Michael J.

Publication type:

Article

Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters.

Published in:

Nature Communications, 2023, v. 14, p. 1, doi. 10.1038/s41467-022-35756-7

By:

Matamoros, Marcos;
Ng, Xue Wen;
Brettmann, Joshua B.;
Piston, David W.;
Nichols, Colin G.

Publication type:

Article

A novel ABCC9 variant in a Greek family with Cantu syndrome affecting multiple generations highlights the functional role of the SUR2B NBD1.

Published in:

American Journal of Medical Genetics. Part A, 2024, v. 194, n. 12, p. 1, doi. 10.1002/ajmg.a.63815

By:

Gao, Jian;
Ververi, Athina;
Thompson, Ellen;
Tryon, Rob;
Sotiriadis, Alexandros;
Rouvalis, Fotios;
Grange, Dorothy K.;
Giannios, Christos;
Nichols, Colin G.

Publication type:

Article

Glibenclamide treatment in a Cantú syndrome patient with a pathogenic ABCC9 gain‐of‐function variant: Initial experience.

Published in:

American Journal of Medical Genetics. Part A, 2019, v. 179, n. 8, p. 1585, doi. 10.1002/ajmg.a.61200

By:

Ma, Alan;
Gurnasinghani, Sunita;
Kirk, Edwin P.;
McClenaghan, Conor;
Singh, Gautam K.;
Grange, Dorothy K.;
Pandit, Chetan;
Zhu, Yung;
Roscioli, Tony;
Elakis, George;
Buckley, Michael;
Mehta, Bhavesh;
Roberts, Philip;
Mervis, Jonathan;
Biggin, Andrew;
Nichols, Colin G.

Publication type:

Article

Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic KATP channels causes neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits.

Published in:

Channels (19336950), 2012, v. 6, n. 2, p. 133, doi. 10.4161/chan.19980

By:

Lin, Yu-Wen;
Akrouh, Alejandro;
Hsu, YeouChing;
Hughes, Nkecha;
Nichols, Colin G.;
De León, Diva D.

Publication type:

Article

Cloning and expression of an inwardly rectifying ATP-regulated potassium channel.

Published in:

Nature, 1993, v. 362, n. 6415, p. 31, doi. 10.1038/362031a0

By:

Ho, Kevin;
Nichols, Colin G.

Publication type:

Article

Molecular basis of TRPV3 channel blockade by intracellular polyamines.

Published in:

Communications Biology, 2025, p. 1, doi. 10.1038/s42003-025-08103-x

By:

Zhang, Jingying;
Yuan, Peng;
Nichols, Colin G.;
Maksaev, Grigory

Publication type:

Article

Genetic heterogeneity in familial hyperinsulinism.

Published in:

Human Molecular Genetics, 1998, v. 7, n. 7, p. 1119, doi. 10.1093/hmg/7.7.1119

By:

Nestorowicz, Ann;
Glaser, Benjamin;
Wilson, Beth A.;
Shyng, Show‐Ling;
Nichols, Colin G.;
Stanley, Charles A.;
Thornton, Paul S.;
Permutt, M. Alan

Publication type:

Article

Cantú syndrome: Findings from 74 patients in the International Cantú Syndrome Registry.

Published in:

American Journal of Medical Genetics. Part C: Seminars in Medical Genetics, 2019, v. 181, n. 4, p. 658, doi. 10.1002/ajmg.c.31753

By:

Grange, Dorothy K.;
Roessler, Helen I.;
McClenaghan, Conor;
Duran, Karen;
Shields, Kathleen;
Remedi, Maria S.;
Knoers, Nine V. A. M.;
Lee, Jin‐Moo;
Kirk, Edwin P.;
Scurr, Ingrid;
Smithson, Sarah F.;
Singh, Gautam K.;
Haelst, Mieke M.;
Nichols, Colin G.;
Haaften, Gijs

Publication type:

Article

Voltage-Dependent Gating in a "Voltage Sensor-Less" Ion Channel.

Published in:

PLoS Biology, 2010, v. 8, n. 2, p. 1, doi. 10.1371/journal.pbio.1000315

By:

Kurata, Harley T.;
Rapedius, Markus;
Kleinman, Marc J.;
Baukrowitz, Thomas;
Nichols, Colin G.

Publication type:

Article

Critical Role of Gap Junction Coupled KATP Channel Activity for Regulated Insulin Secretion.

Published in:

PLoS Biology, 2006, v. 4, n. 2, p. e26, doi. 10.1371/journal.pbio.0040026

By:

Rocheleau, Jonathan V.;
Remedi, Maria S.;
Granada, Butch;
Head, W. Steven;
Koster, Joseph C.;
Nichols, Colin G.;
Piston, David W.

Publication type:

Article

Beta‐cell excitability and excitability‐driven diabetes in adult Zebrafish islets.

Published in:

Physiological Reports, 2019, v. 7, n. 11, p. N.PAG, doi. 10.14814/phy2.14101

By:

Emfinger, Christopher H.;
Lőrincz, Réka;
Wang, Yixi;
York, Nathaniel W.;
Singareddy, Soma S.;
Ikle, Jennifer M.;
Tryon, Robert C.;
McClenaghan, Conor;
Shyr, Zeenat A.;
Huang, Yan;
Reissaus, Christopher A.;
Meyer, Dirk;
Piston, David W.;
Hyrc, Krzysztof;
Remedi, Maria S.;
Nichols, Colin G.

Publication type:

Article

The Polyamine Spermine Potentiates the Propagation of Negatively Charged Molecules through the Astrocytic Syncytium.

Published in:

Biomolecules (2218-273X), 2022, v. 12, n. 12, p. 1812, doi. 10.3390/biom12121812

By:

Benedikt, Jan;
Malpica-Nieves, Christian J.;
Rivera, Yomarie;
Méndez-González, Miguel;
Nichols, Colin G.;
Veh, Rüdiger W.;
Eaton, Misty J.;
Skatchkov, Serguei N.

Publication type:

Article

Preferential Gq signaling in diabetes: an electrical switch in incretin action and in diabetes progression?

Published in:

2020

By:

Nichols, Colin G.;
York, Nathaniel W.;
Remedi, Maria S.

Publication type:

journal article

Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity.

Published in:

2020

By:

McClenaghan, Conor;
Yan Huang;
Zihan Yan;
Harter, Theresa M.;
Halabi, Carmen M.;
Chalk, Rod;
Kovacs, Attila;
van Haaften, Gijs;
Remedi, Maria S.;
Nichols, Colin G.;
Huang, Yan;
Yan, Zihan;
Harter, Theresa

Publication type:

journal article

ATP-sensitive potassium channels in zebrafish cardiac and vascular smooth muscle.

Published in:

Journal of Physiology, 2022, v. 600, n. 2, p. 299, doi. 10.1113/JP282157

By:

Singareddy, Soma S.;
Roessler, Helen I.;
McClenaghan, Conor;
Ikle, Jennifer M.;
Tryon, Robert C.;
van Haaften, Gijs;
Nichols, Colin G.

Publication type:

Article

Kir6.1‐dependent KATP channels in lymphatic smooth muscle and vessel dysfunction in mice with Kir6.1 gain‐of‐function.

Published in:

Journal of Physiology, 2020, v. 598, n. 15, p. 3107, doi. 10.1113/JP279612

By:

Davis, Michael J.;
Kim, Hae Jin;
Zawieja, Scott D.;
Castorena‐Gonzalez, Jorge A.;
Gui, Peichun;
Li, Min;
Saunders, Brian T.;
Zinselmeyer, Bernd H.;
Randolph, Gwendalyn J.;
Remedi, Maria S.;
Nichols, Colin G.

Publication type:

Article

A Unique High-Output Cardiac Hypertrophy Phenotype Arising From Low Systemic Vascular Resistance in Cantu Syndrome.

Published in:

Journal of the American Heart Association, 2022, v. 11, n. 24, p. 1, doi. 10.1161/JAHA.122.027363

By:

Singh, Gautam K.;
McClenaghan, Conor;
Aggarwal, Manish;
Hongjie Gu;
Remedi, Maria S.;
Grange, Dorothy K.;
Nichols, Colin G.

Publication type:

Article

Adenosine Triphosphate-Sensitive Potassium Channel Kir Subunits Implicated in Cardioprotection by Diazoxide.

Published in:

2015

By:

Henn, Matthew C.;
Janjua, M. Burhan;
Kanter, Evelyn M.;
Makepeace, Carol M.;
Schuessler, Richard B.;
Nichols, Colin G.;
Lawton, Jennifer S.

Publication type:

journal article

Coronavirus Proteins as Ion Channels: Current and Potential Research.

Published in:

Frontiers in Immunology, 2020, v. 11, p. N.PAG, doi. 10.3389/fimmu.2020.573339

By:

McClenaghan, Conor;
Hanson, Alex;
Lee, Sun-Joo;
Nichols, Colin G.

Publication type:

Article

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS.

Published in:

EMBO Molecular Medicine, 2023, v. 15, n. 6, p. 1, doi. 10.15252/emmm.202216883

By:

McClenaghan, Conor;
Mukadam, Maya A;
Roeglin, Jacob;
Tryon, Robert C;
Grabner, Manfred;
Dayal, Anamika;
Meyer, Gretchen A;
Nichols, Colin G

Publication type:

Article

Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion.

Published in:

EMBO Molecular Medicine, 2012, v. 4, n. 5, p. 424, doi. 10.1002/emmm.201200218

By:

Finol-Urdaneta, Rocio K.;
Remedi, Maria S.;
Raasch, Walter;
Becker, Stefan;
Clark, Robert B.;
Strüver, Nina;
Pavlov, Evgeny;
Nichols, Colin G.;
French, Robert J.;
Terlau, Heinrich

Publication type:

Article