Works matching AU Ngo, Shyuan

Results: 36

Appetite loss in patients with motor neuron disease: impact on weight loss and neural correlates of visual food cues.

Published in:

Brain Communications, 2025, v. 7, n. 2, p. 1, doi. 10.1093/braincomms/fcaf111

By:

Chang, Jeryn;
Shaw, Thomas B;
McCombe, Pamela A;
Henderson, Robert D;
Lucia, Diana;
Guo, Christine C;
Lv, Jinglei;
Garner, Kelly;
Bollmann, Saskia;
Ngo, Shyuan T;
Steyn, Frederik J

Publication type:

Article

17α‐estradiol acts through hypothalamic pro‐opiomelanocortin expressing neurons to reduce feeding behavior.

Published in:

Aging Cell, 2018, v. 17, n. 1, p. 1, doi. 10.1111/acel.12703

By:

Steyn, Frederik J.;
Ngo, Shyuan T.;
Chen, Vicky Ping;
Bailey‐Downs, Lora C.;
Xie, Teresa Y.;
Ghadami, Martin;
Brimijoin, Stephen;
Freeman, Willard M.;
Rubinstein, Marcelo;
Low, Malcolm J.;
Stout, Michael B.

Publication type:

Article

An fMRI dataset for appetite neural correlates in people living with Motor Neuron Disease.

Published in:

Scientific Data, 2025, v. 12, n. 1, p. 1, doi. 10.1038/s41597-025-04828-w

By:

Chang, Jeryn;
Lv, JingLei;
Guo, Christine C.;
Lucia, Diana;
Bollmann, Saskia;
Garner, Kelly;
McCombe, Pamela A.;
Henderson, Robert D.;
Shaw, Thomas B.;
Steyn, Frederik J.;
Ngo, Shyuan T.

Publication type:

Article

Triheptanoin Protects Motor Neurons and Delays the Onset of Motor Symptoms in a Mouse Model of Amyotrophic Lateral Sclerosis.

Published in:

PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0161816

By:

Tefera, Tesfaye W.;
Wong, Yide;
Barkl-Luke, Mallory E.;
Ngo, Shyuan T.;
Thomas, Nicola K.;
McDonald, Tanya S.;
Borges, Karin

Publication type:

Article

Ghrelin as a treatment for amyotrophic lateral sclerosis.

Published in:

Journal of Neuroendocrinology, 2021, v. 33, n. 7, p. 1, doi. 10.1111/jne.12938

By:

Ngo, Shyuan T.;
Wang, Hao;
Henderson, Robert D.;
Bowers, Cyril;
Steyn, Frederik J.

Publication type:

Article

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45646-9

By:

San Gil, Rebecca;
Pascovici, Dana;
Venturato, Juliana;
Brown-Wright, Heledd;
Mehta, Prachi;
Madrid San Martin, Lidia;
Wu, Jemma;
Luan, Wei;
Chui, Yi Kit;
Bademosi, Adekunle T.;
Swaminathan, Shilpa;
Naidoo, Serey;
Berning, Britt A.;
Wright, Amanda L.;
Keating, Sean S.;
Curtis, Maurice A.;
Faull, Richard L. M.;
Lee, John D.;
Ngo, Shyuan T.;
Lee, Albert

Publication type:

Article

A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-45646-9

By:

San Gil, Rebecca;
Pascovici, Dana;
Venturato, Juliana;
Brown-Wright, Heledd;
Mehta, Prachi;
Madrid San Martin, Lidia;
Wu, Jemma;
Luan, Wei;
Chui, Yi Kit;
Bademosi, Adekunle T.;
Swaminathan, Shilpa;
Naidoo, Serey;
Berning, Britt A.;
Wright, Amanda L.;
Keating, Sean S.;
Curtis, Maurice A.;
Faull, Richard L. M.;
Lee, John D.;
Ngo, Shyuan T.;
Lee, Albert

Publication type:

Article

Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis.

Published in:

Scientific Reports, 2016, p. 37968, doi. 10.1038/srep37968

By:

Fogarty, Matthew J.;
Klenowski, Paul M.;
Lee, John D.;
Drieberg-Thompson, Joy R.;
Bartlett, Selena E.;
Ngo, Shyuan T.;
Hilliard, Massimo A.;
Bellingham, Mark C.;
Noakes, Peter G.

Publication type:

Article

Skeletal Muscle Metabolism: Origin or Prognostic Factor for Amyotrophic Lateral Sclerosis (ALS) Development?

Published in:

Cells (2073-4409), 2021, v. 10, n. 6, p. 1449, doi. 10.3390/cells10061449

By:

Quessada, Cyril;
Bouscary, Alexandra;
René, Frédérique;
Valle, Cristiana;
Ferri, Alberto;
Ngo, Shyuan T.;
Loeffler, Jean-Philippe

Publication type:

Article

A Road Map for Remote Digital Health Technology for Motor Neuron Disease.

Published in:

2021

By:

Eijk, Ruben P A van;
Beelen, Anita;
Kruitwagen, Esther T;
Murray, Deirdre;
Radakovic, Ratko;
Hobson, Esther;
Knox, Liam;
Helleman, Jochem;
Burke, Tom;
Pérez, Miguel Ángel Rubio;
Reviers, Evy;
Genge, Angela;
Steyn, Frederik J;
Ngo, Shyuan;
Eaglesham, John;
Roes, Kit C B;
Berg, Leonard H van den;
Hardiman, Orla;
McDermott, Christopher J;
van Eijk, Ruben P A

Publication type:

journal article

Altered TDP-43 Structure and Function: Key Insights into Aberrant RNA, Mitochondrial, and Cellular and Systemic Metabolism in Amyotrophic Lateral Sclerosis.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 8, p. 709, doi. 10.3390/metabo12080709

By:

Jiang, Leanne;
Ngo, Shyuan T.

Publication type:

Article

Biomarkers of Metabolism in Amyotrophic Lateral Sclerosis.

Published in:

Frontiers in Neurology, 2019, p. N.PAG, doi. 10.3389/fneur.2019.00191

By:

Kirk, Siobhan E.;
Tracey, Timothy J.;
Steyn, Frederik J.;
Ngo, Shyuan T.

Publication type:

Article

Associations of postprandial ghrelin, liver‐expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosis.

Published in:

European Journal of Neurology, 2024, v. 31, n. 1, p. 1, doi. 10.1111/ene.16052

By:

Howe, Stephanie L.;
Holdom, Cory J.;
McCombe, Pamela A.;
Henderson, Robert D.;
Zigman, Jeffrey M.;
Ngo, Shyuan T.;
Steyn, Frederik J.

Publication type:

Article

Lower hypothalamic volume with lower body mass index is associated with shorter survival in patients with amyotrophic lateral sclerosis.

Published in:

European Journal of Neurology, 2023, v. 30, n. 1, p. 57, doi. 10.1111/ene.15589

By:

Chang, Jeryn;
Shaw, Thomas B.;
Holdom, Cory J.;
McCombe, Pamela A.;
Henderson, Robert D.;
Fripp, Jurgen;
Barth, Markus;
Guo, Christine C.;
Ngo, Shyuan T.;
Steyn, Frederik J.

Publication type:

Article

Venous creatinine as a biomarker for loss of fat‐free mass and disease progression in patients with amyotrophic lateral sclerosis.

Published in:

European Journal of Neurology, 2021, v. 28, n. 11, p. 3615, doi. 10.1111/ene.15003

By:

Holdom, Cory J.;
Janse van Mantgem, Mark R.;
van Eijk, Ruben P. A.;
Howe, Stephanie L.;
van den Berg, Leonard H.;
McCombe, Pamela A.;
Henderson, Robert D.;
Ngo, Shyuan T.;
Steyn, Frederik J.

Publication type:

Article

Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease.

Published in:

Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00010

By:

Tracey, Timothy J.;
Steyn, Frederik J.;
Wolvetang, Ernst J.;
Ngo, Shyuan T.

Publication type:

Article

Altered Metabolic Homeostasis in Amyotrophic Lateral Sclerosis: Mechanisms of Energy Imbalance and Contribution to Disease Progression.

Published in:

Neurodegenerative Diseases, 2016, v. 16, n. 5/6, p. 382, doi. 10.1159/000446502

By:

Ioannides, Zara a.;
Ngo, Shyuan T.;
Henderson, Robert D.;
McCombe, Pamela a.;
Steyn, Frederik J.

Publication type:

Article

Neural agrin increases postsynaptic ACh receptor packing by elevating rapsyn protein at the mouse neuromuscular synapse.

Published in:

Developmental Neurobiology (19328451), 2008, v. 68, n. 9, p. 1153, doi. 10.1002/dneu.20654

By:

Brockhausen, Jennifer;
Cole, Rebecca N.;
Gervásio, Othon L.;
Ngo, Shyuan T.;
Noakes, Peter G.;
Phillips, William D.

Publication type:

Article

Gut microbiota in ALS: possible role in pathogenesis?

Published in:

Expert Review of Neurotherapeutics, 2019, v. 19, n. 9, p. 785, doi. 10.1080/14737175.2019.1623026

By:

McCombe, Pamela A.;
Henderson, Robert D.;
Lee, Aven;
Lee, John D.;
Woodruff, Trent M.;
Restuadi, Restuadi;
McRae, Allan;
Wray, Naomi R.;
Ngo, Shyuan;
Steyn, Frederik J.

Publication type:

Article

A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis.

Published in:

EMBO Molecular Medicine, 2015, v. 7, n. 5, p. 526, doi. 10.15252/emmm.201404433

By:

Palamiuc, Lavinia;
Schlagowski, Anna;
Ngo, Shyuan T;
Vernay, Aurelia;
Dirrig‐Grosch, Sylvie;
Henriques, Alexandre;
Boutillier, Anne‐Laurence;
Zoll, Joffrey;
Echaniz‐Laguna, Andoni;
Loeffler, Jean‐Philippe;
René, Frédérique

Publication type:

Article

Low plasma hyaluronan is associated with faster functional decline in patients with amyotrophic lateral sclerosis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2022, v. 23, n. 1/2, p. 42, doi. 10.1080/21678421.2021.1918721

By:

Holdom, Cory J.;
Ngo, Shyuan T.;
McCombe, Pamela A.;
Henderson, Robert D.;
Steyn, Frederik J.

Publication type:

Article

Disorders of sleep and wakefulness in amyotrophic lateral sclerosis (ALS): a systematic review.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2021, v. 22, n. 3/4, p. 161, doi. 10.1080/21678421.2020.1844755

By:

Lucia, Diana;
McCombe, Pamela A.;
Henderson, Robert D.;
Ngo, Shyuan T.

Publication type:

Article

Progression and survival of patients with motor neuron disease relative to their fecal microbiota.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2020, v. 21, n. 7/8, p. 549, doi. 10.1080/21678421.2020.1772825

By:

Ngo, Shyuan T.;
Restuadi, Restuadi;
McCrae, Allan F.;
Van Eijk, Ruben P.;
Garton, Fleur;
Henderson, Robert D.;
Wray, Naomi R.;
McCombe, Pamela A.;
Steyn, Frederik J.

Publication type:

Article

Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2019, v. 20, n. 7/8, p. 497, doi. 10.1080/21678421.2019.1621346

By:

Ngo, Shyuan T.;
van Eijk, Ruben P.A.;
Chachay, V.;
van den Berg, Leonard H.;
McCombe, Pamela A.;
Henderson, Robert D.;
Steyn, Frederik J.

Publication type:

Article

Anthropometric measures are not accurate predictors of fat mass in ALS.

Published in:

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, 2017, v. 18, n. 7/8, p. 486, doi. 10.1080/21678421.2017.1317811

By:

Ioannides, Zara A.;
Steyn, Frederik J.;
Henderson, Robert D.;
Mccombe, Pamela A.;
Ngo, Shyuan T.

Publication type:

Article

CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?

Published in:

Cell & Bioscience, 2021, v. 11, n. 1, p. 1, doi. 10.1186/s13578-020-00511-2

By:

Tefera, Tesfaye Wolde;
Steyn, Frederik J.;
Ngo, Shyuan T.;
Borges, Karin

Publication type:

Article

Skeletal muscle in amyotrophic lateral sclerosis.

Published in:

Brain: A Journal of Neurology, 2023, v. 146, n. 11, p. 4425, doi. 10.1093/brain/awad202

By:

Shefner, Jeremy M;
Musaro, Antonio;
Ngo, Shyuan T;
Lunetta, Christian;
Steyn, Frederik J;
Robitaille, Richard;
Carvalho, Mamede De;
Rutkove, Seward;
Ludolph, Albert C;
Dupuis, Luc

Publication type:

Article

Exploring targets and therapies for amyotrophic lateral sclerosis: current insights into dietary interventions.

Published in:

Degenerative Neurological & Neuromuscular Disease, 2017, v. 7, p. 95, doi. 10.2147/dnnd.s120607

By:

Ngo, Shyuan T.;
Mi, Jia D.;
Henderson, Robert D.;
McCombe, Pamela A.;
Steyn, Frederik J.

Publication type:

Article

Repurposing of Trimetazidine for amyotrophic lateral sclerosis: A study in SOD1<sup>G93A</sup> mice.

Published in:

British Journal of Pharmacology, 2022, v. 179, n. 8, p. 1732, doi. 10.1111/bph.15738

By:

Scaricamazza, Silvia;
Salvatori, Illari;
Amadio, Susanna;
Nesci, Valentina;
Torcinaro, Alessio;
Giacovazzo, Giacomo;
Primiano, Aniello;
Gloriani, Michela;
Candelise, Niccolò;
Pieroni, Luisa;
Loeffler, Jean‐Philippe;
Renè, Frederique;
Quessada, Cyril;
Tefera, Tesfaye W.;
Wang, Hao;
Steyn, Frederik J.;
Ngo, Shyuan T.;
Dobrowolny, Gabriella;
Lepore, Elisa;
Urbani, Andrea

Publication type:

Article

Dysregulation of microRNA biogenesis machinery and microRNA/RNA ratio in skeletal muscle of amyotrophic lateral sclerosis mice.

Published in:

2018

By:

Russell, Aaron P.;
Ghobrial, Lobna;
Ngo, Shyuan;
Yerbury, Justin;
Zacharewicz, Evelyn;
Chung, Roger;
Lamon, Séverine

Publication type:

journal article

Characterization of the skeletal muscle arginine methylome in health and disease reveals remodeling in amyotrophic lateral sclerosis.

Published in:

FASEB Journal, 2024, v. 38, n. 10, p. 1, doi. 10.1096/fj.202400045R

By:

Wong, Julian P. H.;
Blazev, Ronnie;
Ng, Yaan‐Kit;
Goodman, Craig A.;
Montgomery, Magdalene K.;
Watt, Kevin I.;
Carl, Christian S.;
Watt, Matthew J.;
Voldstedlund, Christian T.;
Richter, Erik A.;
Crouch, Peter J.;
Steyn, Frederik J.;
Ngo, Shyuan T.;
Parker, Benjamin L.

Publication type:

Article

An open-label Phase 2a study to assess the safety and tolerability of trimetazidine in patients with amyotrophic lateral sclerosis.

Published in:

Brain Communications, 2025, v. 7, n. 1, p. 1, doi. 10.1093/braincomms/fcaf063

By:

Eijk, Ruben P A van;
Steyn, Frederik J;
Mantgem, Mark R Janse van;
Schmidt, Angela;
Meyjes, Myrte;
Allen, Sally;
Daygon, Dara V;
Loeffler, Jean-Philippe;
Al-Chalabi, Ammar;
Berg, Leonard H van den;
Henderson, Robert D;
Ngo, Shyuan T

Publication type:

Article

Development of a high-throughput method for real-time assessment of cellular metabolism in intact long skeletal muscle fibre bundles.

Published in:

Journal of Physiology, 2016, v. 594, n. 24, p. 7197, doi. 10.1113/JP272988

By:

Li, Rui;
Steyn, Frederik J.;
Stout, Michael B.;
Lee, Kevin;
Cully, Tanya R.;
Calderón, Juan C.;
Ngo, Shyuan T.

Publication type:

Article

Functional characterisation of the amyotrophic lateral sclerosis risk locus GPX3/TNIP1.

Published in:

Genome Medicine, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13073-021-01006-6

By:

Restuadi, Restuadi;
Steyn, Frederik J.;
Kabashi, Edor;
Ngo, Shyuan T.;
Cheng, Fei-Fei;
Nabais, Marta F.;
Thompson, Mike J.;
Qi, Ting;
Wu, Yang;
Henders, Anjali K.;
Wallace, Leanne;
Bye, Chris R.;
Turner, Bradley J.;
Ziser, Laura;
Mathers, Susan;
McCombe, Pamela A.;
Needham, Merrilee;
Schultz, David;
Kiernan, Matthew C.;
van Rheenen, Wouter

Publication type:

Article

Use of hip- versus wrist-based actigraphy for assessing functional decline and disease progression in patients with motor neuron disease.

Published in:

Journal of Neurology, 2023, v. 270, n. 5, p. 2597, doi. 10.1007/s00415-023-11584-7

By:

Holdom, Cory J.;
van Unnik, Jordi W. J.;
van Eijk, Ruben P. A.;
van den Berg, Leonard H.;
Henderson, Robert D.;
Ngo, Shyuan T.;
Steyn, Frederik J.

Publication type:

Article

Patient perspectives on digital healthcare technology in care and clinical trials for motor neuron disease: an international survey.

Published in:

Journal of Neurology, 2022, v. 269, n. 11, p. 6003, doi. 10.1007/s00415-022-11273-x

By:

Helleman, Jochem;
Johnson, Barbara;
Holdom, Cory;
Hobson, Esther;
Murray, Deirdre;
Steyn, Frederik J.;
Ngo, Shyuan T.;
Henders, Anjali;
Lokeshappa, Madhura B.;
Visser-Meily, Johanna M. A.;
van den Berg, Leonard H.;
Hardiman, Orla;
Beelen, Anita;
McDermott, Chris;
van Eijk, Ruben P. A.

Publication type:

Article