Works by Newton, Alexandra C.

Results: 39

Cancer-associated mutations in protein kinase C theta are loss-of-function.

Published in:

Biochemical Journal, 2024, v. 481, n. 12, p. 759, doi. 10.1042/bcj20240148

By:

Hodapp, Stefanie J.;
Gravel, Nathan;
Kannan, Natarajan;
Newton, Alexandra C.

Publication type:

Article

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration.

Published in:

Biochemical Journal, 2023, v. 480, n. 16, p. 1299, doi. 10.1042/BCJ20220397

By:

Jones, Alexander C.;
Kornev, Alexandr P.;
Jui-Hung Weng;
Manning, Gerard;
Taylor, Susan S.;
Newton, Alexandra C.

Publication type:

Article

Protein kinase C showcases allosteric control: activation of LRRK1.

Published in:

Biochemical Journal, 2023, v. 480, n. 3, p. 219, doi. 10.1042/BCJ20220507

By:

Tovell, Hannah;
Newton, Alexandra C.

Publication type:

Article

PHLPPing the balance: restoration of protein kinase C in cancer.

Published in:

Biochemical Journal, 2021, v. 478, n. 2, p. 341, doi. 10.1042/BCJ20190765

By:

Tovell, Hannah;
Newton, Alexandra C.

Publication type:

Article

Spatiotemporal dynamics of lipid signaling: Protein kinase C as a paradigm.

Published in:

IUBMB Life, 2008, v. 60, n. 12, p. 782, doi. 10.1002/iub.122

By:

Gallegos, Lisa L.;
Newton, Alexandra C.

Publication type:

Article

Protein kinase C.

Published in:

IUBMB Life, 2008, v. 60, n. 11, p. 765, doi. 10.1002/iub.118

By:

Newton, Alexandra C.

Publication type:

Article

Induced Fit and Wit: Celebrating the Life of Daniel E. Koshland, Jr. (1920 - 2007).

Published in:

2007

By:

Newton, Alexandra C.;
Mochly-Rosen, Daria

Publication type:

Obituary

Pathway Illuminated: Visualizing Protein Kinase C Signaling.

Published in:

IUBMB Life, 2003, v. 55, n. 12, p. 653, doi. 10.1080/152165401310001642216

By:

Violin, Jonathan D.;
Newton, Alexandra C.

Publication type:

Article

Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter.

Published in:

Science Signaling, 2019, v. 12, n. 562, p. N.PAG, doi. 10.1126/scisignal.aat6662

By:

Kajimoto, Taketoshi;
Caliman, Alisha D.;
Tobias, Irene S.;
Okada, Taro;
Pilo, Caila A.;
Van, An-Angela N.;
Andrew McCammon, J.;
Nakamura, Shun-ichi;
Newton, Alexandra C.

Publication type:

Article

Gain-of-function mutations in protein kinase Cα (PKCα) may promote synaptic defects in Alzheimer's disease.

Published in:

Science Signaling, 2016, v. 9, n. 427, p. 1, doi. 10.1126/scisignal.aaf6209

By:

Alfonso, Stephanie I.;
Callender, Julia A.;
Hooli, Basavaraj;
Antal, Corina E.;
Mullin, Kristina;
Sherman, Mathew A.;
Lesné, Sylvain E.;
Leitges, Michael;
Newton, Alexandra C.;
Tanzi, Rudolph E.;
Malinow, Roberto

Publication type:

Article

Divalent cation driven liquid‐liquid phase separation of disordered acidic proteins.

Published in:

FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3785

By:

Mayfield, Joshua E.;
Newton, Alexandra C.;
Dixon, Jack E.

Publication type:

Article

Protein kinase C mutations in cancer.

Published in:

FASEB Journal, 2013, v. 27, p. 1045.1, doi. 10.1096/fasebj.27.1_supplement.1045.1

By:

Antal, Corina E.;
Kang, Emily;
Newton, Alexandra C.

Publication type:

Article

Akt Signaling is Differentially Terminated by the Phosphatase PHLPP and a New Isoform, PHLPP2.

Published in:

FASEB Journal, 2007, v. 21, n. 5, p. A619, doi. 10.1096/fasebj.21.5.a619

By:

Brognard, John;
Sierecki, Emma;
Tianyan Gao;
Newton, Alexandra C.

Publication type:

Article

Novel C1A Domain Variant in Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Decreases Autoinhibition.

Published in:

Cerebellum, 2025, v. 24, n. 3, p. 1, doi. 10.1007/s12311-025-01818-x

By:

Raj Ghosh, Gayatri;
Kao, Tiffany H.;
Steigerwald, Connolly G.;
Chan, Nora L.;
Newton, Alexandra C.;
Abreu, Nicolas J.

Publication type:

Article

Enhanced activity of Alzheimer disease-associated variant of protein kinase Cα drives cognitive decline in a mouse model.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-34679-7

By:

Lordén, Gema;
Wozniak, Jacob M.;
Doré, Kim;
Dozier, Lara E.;
Cates-Gatto, Chelsea;
Patrick, Gentry N.;
Gonzalez, David J.;
Roberts, Amanda J.;
Tanzi, Rudolph E.;
Newton, Alexandra C.

Publication type:

Article

Inhibition of the insulin receptor tyrosine kinase by phosphatidic acid.

Published in:

Journal of Cellular Biochemistry, 1996, v. 62, n. 4, p. 516, doi. 10.1002/(SICI)1097-4644(19960915)62:4<516::AID-JCB9>3.0.CO;2-P

By:

Arnold, Rebecca S.;
Newton, Alexandra C.

Publication type:

Article

Tatenda Murigo: A passionate advocate for science in Africa (June 17, 2000–July 14, 2023).

Published in:

IUBMB Life, 2024, v. 76, n. 2, p. 101, doi. 10.1002/iub.2781

By:

Patten, Victoria;
Fischer, Elyse;
Penndorf, Patrick;
Newton, Alexandra C.

Publication type:

Article

Preface to IUBMB life special issue on protein phosphorylation dedicated to Eddy Fischer.

Published in:

IUBMB Life, 2023, v. 75, n. 4, p. 282, doi. 10.1002/iub.2715

By:

Newton, Alexandra C.;
Alessi, Dario R.

Publication type:

Article

Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes.

Published in:

IUBMB Life, 2020, v. 72, n. 12, p. 2584, doi. 10.1002/iub.2401

By:

Jones, Alexander C.;
Taylor, Susan S.;
Newton, Alexandra C.;
Kornev, Alexandr P.

Publication type:

Article

Protein kinases in tune.

Published in:

IUBMB Life, 2019, v. 71, n. 6, p. 670, doi. 10.1002/iub.2065

By:

Newton, Alexandra C.

Publication type:

Article

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19937-w

By:

Zhou, Xin;
Zhong, Yanghao;
Molinar-Inglis, Olivia;
Kunkel, Maya T.;
Chen, Mingyuan;
Sun, Tengqian;
Zhang, Jiao;
Shyy, John Y.-J.;
Trejo, JoAnn;
Newton, Alexandra C.;
Zhang, Jin

Publication type:

Article

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition.

Published in:

Science Signaling, 2022, v. 15, n. 753, p. 1, doi. 10.1126/scisignal.abk1147

By:

Pilo, Caila A.;
Baffi, Timothy R.;
Kornev, Alexandr P.;
Kunkel, Maya T.;
Malfavon, Mario;
Chen, Dong-Hui;
Rossitto, Leigh-Ana;
Chen, Daniel X.;
Huang, Liang-Chin;
Longman, Cheryl;
Kannan, Natarajan;
Raskind, Wendy H.;
Gonzalez, David J.;
Taylor, Susan S.;
Gorrie, George;
Newton, Alexandra C.

Publication type:

Article

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.

Published in:

Science Signaling, 2021, v. 14, n. 678, p. 1, doi. 10.1126/scisignal.abe4509

By:

Baffi, Timothy R.;
Lordén, Gema;
Wozniak, Jacob M.;
Feichtner, Andreas;
Yeung, Wayland;
Kornev, Alexandr P.;
King, Charles C.;
Del Rio, Jason C.;
Limaye, Ameya J.;
Bogomolovas, Julius;
Gould, Christine M.;
Chen, Ju;
Kennedy, Eileen J.;
Kannan, Natarajan;
Gonzalez, David J.;
Stefan, Eduard;
Taylor, Susan S.;
Newton, Alexandra C.

Publication type:

Article

Tuning the signalling output of protein kinase C.

Published in:

Biochemical Society Transactions, 2014, v. 42, n. 6, p. 1477, doi. 10.1042/BST20140172

By:

Antal, Corina E.;
Newton, Alexandra C.

Publication type:

Article

Characterization of Protein Kinase C in Photoreceptor Outer Segments.

Published in:

Journal of Neurochemistry, 1997, v. 69, n. 4, p. 1693, doi. 10.1046/j.1471-4159.1997.69041693.x

By:

Williams, David S.;
Liu, Xinran;
Schlamp, Cassandra L.;
Ondek, Brian;
Jaken, Susan;
Newton, Alexandra C.

Publication type:

Article

Gene Expression of the Neuropeptide-Processing Enzyme Carboxypeptidase E in Rat Photoreceptor Cells.

Published in:

Journal of Neurochemistry, 1993, v. 61, n. 5, p. 1891, doi. 10.1111/j.1471-4159.1993.tb09831.x

By:

Nickells, Robert W.;
Schlamp, Cassandra L.;
Newton, Alexandra C.;
Williams, David S.

Publication type:

Article

Protein kinase C: perfectly balanced.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 2018, v. 53, n. 2, p. 208, doi. 10.1080/10409238.2018.1442408

By:

Newton, Alexandra C.

Publication type:

Article

The PHLPP2 phosphatase is a druggable driver of prostate cancer progression.

Published in:

Journal of Cell Biology, 2019, v. 218, n. 6, p. 1943, doi. 10.1083/jcb.201902048

By:

Nowak, Dawid G.;
Katsenelson, Ksenya Cohen;
Watrud, Kaitlin E.;
Muhan Chen;
Mathew, Grinu;
D'Andrea, Vincent D.;
Lee, Matthew F.;
Swamynathan, Manojit Mosur;
Casanova-Salas, Irene;
Jibilian, Megan C.;
Buckholtz, Caroline L.;
Ambrico, Alexandra J.;
Chun-Hao Pan;
Wilkinson, John E.;
Newton, Alexandra C.;
Trotman, Lloyd C.

Publication type:

Article

PKCα Is Recruited to Staphylococcus aureus- Containing Phagosomes and Impairs Bacterial Replication by Inhibition of Autophagy.

Published in:

Frontiers in Immunology, 2021, v. 11, p. N.PAG, doi. 10.3389/fimmu.2021.662987

By:

Gauron, Maria Celeste;
Newton, Alexandra C.;
Colombo, María Isabel

Publication type:

Article

Suppression of survival signalling pathways by the phosphatase PHLPP.

Published in:

FEBS Journal, 2013, v. 280, n. 2, p. 572, doi. 10.1111/j.1742-4658.2012.08537.x

By:

O’Neill, Audrey K.;
Niederst, Matthew J.;
Newton, Alexandra C.

Publication type:

Article

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C.

Published in:

Journal of Cell Biology, 2003, v. 161, n. 5, p. 899, doi. 10.1083/jcb.200302125

By:

Violin, Jonathan D.;
Jin Zhang;
Tsien, Roger Y.;
Newton, Alexandra C.

Publication type:

Article

Protein kinase Cζ exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation.

Published in:

Biochemical Journal, 2016, v. 473, n. 4, p. 509, doi. 10.1042/BJ20151013

By:

Irene S. Tobias;
Kim, Peter K.;
Simon, Nitya;
Jacinto, Estela;
Dowdy, Steven F.;
King, Charles C.;
Kaulich, Manuel;
Newton, Alexandra C.

Publication type:

Article

Protein kinase C pharmacology: refining the toolbox.

Published in:

Biochemical Journal, 2013, v. 452, n. 2, p. 195, doi. 10.1042/BJ20130220

By:

WU-ZHANG, Alyssa X.;
NEWTON, Alexandra C.

Publication type:

Article

PHLPPing through history: a decade in the life of PHLPP phosphatases.

Published in:

Biochemical Society Transactions, 2016, v. 44, n. 6, p. 1675, doi. 10.1042/BST20160170

By:

Grzechnik, Agnieszka T.;
Newton, Alexandra C.

Publication type:

Article

Protein kinase C mechanisms that contribute to cardiac remodelling.

Published in:

Clinical Science, 2016, v. 130, n. 17, p. 1499, doi. 10.1042/CS20160036

By:

Newton, Alexandra C.;
Antal, Corina E.;
Steinberg, Susan F.

Publication type:

Article

Taxonomy and function of C1 protein kinase C homology domains.

Published in:

1997

By:

Hurley, James H.;
Newton, Alexandra C.;
Parker, Peter J.;
Blumberg, Peter M.;
Nishizuka, Yasutomi

Publication type:

Other

Spinal Phosphinositide 3-Kinase—Akt—Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 6, p. 2113, doi. 10.1523/JNEUROSCI.2139-10.2011

By:

Qinghao Xu;
Fitzsimmons, Bethany;
Steinauer, Joanne;
O'Neill, Audrey;
Newton, Alexandra C.;
Xiao-Ying Hua;
Yaksh, Tony L.

Publication type:

Article

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C.

Published in:

EMBO Journal, 2008, v. 27, n. 14, p. 1932, doi. 10.1038/emboj.2008.120

By:

Facchinetti, Valeria;
Weiming Ouyang;
Hua Wei;
Soto, Nelyn;
Lazorchak, Adam;
Gould, Christine;
Lowry, Carolyn;
Newton, Alexandra C;
Yuxin Mao;
Miao, Robert Q;
Sessa, William C.;
Jun Qin;
Pumin Zhang;
Bing Su;
Jacinto, Estela

Publication type:

Article

The PHLPP1 N-Terminal Extension Is a Mitotic Cdkl Substrate and Controls an Interactome Switch.

Published in:

Molecular & Cellular Biology, 2021, v. 41, n. 3, p. 1, doi. 10.1128/MCB.00333-20

By:

Kawashima, Agnieszka T.;
Wong, Cassandra;
Lordén, Gema;
King, Charles C.;
Lara-Gonzalez, Pablo;
Desai, Arshad;
Gingras, Anne-Claude;
Newton, Alexandra C.

Publication type:

Article